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Cited by 53Probiotics and Fermented FoodsGestational Diabetes Research and ManagementNatural Antidiabetic Agents Studies

Probiotics and synbiotics show clinical efficacy in treating gestational diabetes mellitus: A meta-analysis

Zhou, Lushan, Ding, Caifei, Wu, Ji, Chen, Xiaoling, Ng, Derry Minyao, Wang, Hezhenrong, Zhang, Yingying, Shi, Nanjing·2021·Primary care diabetes
DOI 10.1016/j.pcd.2021.08.005
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Abstract

Background This study performed a systematic and meta-analysis of randomized controlled trials (RCTs) to explore the efficacy of probiotic- and symbiotic-based supplements in the treatment of gestational diabetes mellitus (GDM).Methods We performed a meta-analysis to evaluate the efficacy of probiotics/synbiotics in GDM treatment, following a systematic search in Web of Science, PubMed, Cochrane Library, and EBSCO databases for articles published up to July 2020.Results In total, 12 RCTs comprising 894 participants, were analyzed. Compared to the placebo, patients administered with probiotic and synbiotic supplements benefited more with regards to glucose and lipid metabolism as well as anti-inflammation and antioxidant capacity including insulin of change (WMD: 3.57, 95%CI: -5.26, -1.88), very-low-density lipoprotein (VLDL) (WMD: -5.03, 95%CI: -8.26, -1.79), nitric oxide (NO) at the end of trial (WMD: 2.31, 95%CI: 0.91, 3.70), total antioxidant capacity (TAC) at the end of trial (SMD: 0.74, 95%CI: 0.21, 1.27), high-sensitivity C-reactive protein (hsCRP) at the end of trial (SMD: -1.23, 95%CI: -1.97, -0.49). Besides, probiotic and synbiotic supplements improved outcomes on fetal hyperbilirubinemia risk (RR: 0.26, 95%CI: 0.12, 0.55), fetal macrosomia risk (RR: 0.47, 95%CI: 0.27, 0.83) and newborn weight (SMD: -0.29, 95%CI: -0.50, -0.09).Conclusions Findings from this work demonstrate that probiotic/symbiotic-based interventions improve glucose and lipid metabolism, anti-inflammatory and antioxidant ability in diet-controlled GDM patients, and exert beneficial outcomes on fetal hyperbilirubinemia, fetal macrosomia, and newborn weight.

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  • Consumption of probiotics can improve inflammatory markers (C-reactive protein) and glycemic control and insulin metabolism in patients diagnosed with type 2 diabetes or metabolic syndrome, including pregnant women with gestational diabetes.

    “Studies also show that the consumption of probiotics can improve inflammatory markers (C-reactive protein) and glycemic control and insulin metabolism in patients diagnosed with type 2 diabetes or metabolic syndrome [143,144,145,146,147], including pregnant women with gestational diabetes [143,144].”

    From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [147]

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Authors
Zhou, L., Ding, C., Wu, J., Chen, X., Ng, D. M., Wang, H., Zhang, Y., & Shi, N.
Affiliations
  • Zhejiang Chinese Medical University (CN)
  • Ningbo University (CN)
  • Zhejiang University (CN)
Corresponding author
Shi, Nanjing
ORCID
Venue
Primary care diabetes
Publisher
Elsevier BV
Published
2021-12
Volume
15
Issue
6
Pages
937-947
ISSN
1751-9918 (ISSN-L)
DOI
10.1016/j.pcd.2021.08.005
OpenAlex
W3193804950
Cited by
53
References
61
Citations by year
2026: 7 · 2025: 10 · 2024: 15 · 2023: 14 · 2022: 7
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Primary care diabetes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Keywords
probiotics, synbiotics, gestational diabetes mellitus, glucose metabolism, lipid metabolism, insulin sensitivity, anti-inflammatory activity, antioxidant capacity, C-reactive protein, nitric oxide, total antioxidant capacity, macrosomia, newborn weight, dietary management
MeSH terms
Female, Humans, Infant, Newborn, Insulin, Pregnancy, Diabetes, Gestational, Treatment Outcome, Probiotics, Synbiotics

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