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Cited by 20Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesSkin Protection and Aging

The DOI matches its Crossref record; 17 of the 18 references it cites were found in a registry or an index.

No room for pain: A prospective study showing effective and nearly pain-free treatment of actinic keratosis with simulated daylight photodynamic therapy (SDL-PDT) using the IndoorLux® System in combination with BF-200 ALA (Ameluz®)

Open access
Bai-Habelski, Jon Chim, Medrano, Karla, Palacio, Ariana, Reinhold, Uwe·2022·Photodiagnosis and Photodynamic Therapy
DOI 10.1016/j.pdpdt.2021.102692
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Abstract

BACKGROUND: Photodynamic therapy (PDT) with natural daylight is effective and less painful than conventional PDT when treating actinic keratosis (AK), however its weather dependency is restrictive. This prospective open-label observational single-arm study examined efficacy and safety of simulated daylight (SDL)-PDT using the IndoorLux® system in combination with 5-aminolevulinic acid gel (BF-200 ALA). METHODS: 12 patients with mild/moderate AK on the face or scalp received two SDL-PDTs. BF-200 ALA was applied prior to a 2 h illumination with the IndoorLux® System. Patients evaluated pain during and after SDL-PDT on visual analogue scales (VAS). Primary endpoint was lesion count reduction three months after the second SDL-PDT. Secondary endpoint was pain during and after illumination. RESULTS: Median individual clearance rate was 83.75% (66.7-100.0%); 33.3% of the patients and 84.9% of the lesions were completely cleared. Median size of the remaining partially cleared lesions decreased by 42.9%. The first SDL-PDT was pain-free for 7 patients (58.3%, VAS=0). Median VAS during and after the first treatment was 0 (0.0-0.3). For the second SDL-PDT, median VAS was 0.1 (0.0-5.5, during) and 0 (0.0-4.5, after). Both SDL-PDTs were pain-free for 6 patients. CONCLUSION: SDL-PDT was effective and nearly pain-free, emphasizing its advantages and potential for common practice.

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Crossref · 10.1016/j.pdpdt.2021.102692

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17 of 17 references verified0 citation errors · 0 not checkable

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  • In a recent clinical study, BF-200 ALA-PDT using the IndoorLux system, a simulated daylight source, completely cleared about 85% of lesions in AK patients with virtually no pain.

    “In a recent clinical study, BF-200 ALA-PDT using the IndoorLux system, a simulated daylight source, was shown to be able to completely clear about 85% of lesions in AK patients with virtually no pain [73].”

    From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [73]

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Metadata

Authors
Bai-Habelski, J. C., Medrano, K., Palacio, A., & Reinhold, U.
ORCID
Venue
Photodiagnosis and Photodynamic Therapy
Publisher
Elsevier BV
Published
2022-03
Volume
37
Pages
102692
ISSN
1572-1000 (ISSN-L)
DOI
10.1016/j.pdpdt.2021.102692
OpenAlex
W4200233290
Cited by
20
References
18
Citations by year
2026: 2 · 2025: 4 · 2024: 6 · 2023: 5 · 2022: 3
FWCI
2.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Photodiagnosis and Photodynamic Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
actinic keratosis, 5-aminolevulinic acid, treatment pain, lesion clearance, facial and scalp lesions
MeSH terms
Aminolevulinic Acid, Humans, Pain, Photochemotherapy, Prospective Studies, Scalp, Treatment Outcome, Photosensitizing Agents, Keratosis, Actinic

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