Large-Vessel Vasculopathy in Children With Sickle Cell Disease: A Magnetic Resonance Imaging Study of Infarct Topography and Focal Atrophy
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Background Large-vessel vasculopathy (LVV) increases stroke risk in pediatric sickle cell disease beyond the baseline elevated stroke risk in this vulnerable population. The mechanisms underlying this added risk and its unique impact on the developing brain are not established.Methods We analyzed magnetic resonance imaging and angiography scans of 66 children with sickle cell disease and infarcts by infarct density heatmaps and Jacobian determinants, a metric utilized to delineate focal volume change, to investigate if infarct location, volume, frequency, and cerebral atrophy differed among hemispheres with and without LVV.Results Infarct density heatmaps demonstrated infarct "hot spots" within the deep white matter internal border zone region in both LVV and non-LVV hemispheres, but with greater infarct density and larger infarct volumes in LVV hemispheres (2.2 mL versus 0.25 mL, P < 0.001). Additional scattered cortical infarcts in the internal carotid artery territory occurred in LVV hemispheres, but were rare in non-LVV hemispheres. Jacobian determinants revealed greater atrophy in gray and white matter of the parietal lobes of LVV compared with non-LVV hemispheres.Conclusion Large-vessel vasculopathy in sickle cell disease appears to increase ischemic vulnerability in the borderzone region, as demonstrated by the increased frequency and extent of infarction within deep white matter, and increased risk of focal atrophy. Scattered infarctions across the LVV-affected hemispheres suggest additional stroke etiologies of vasculopathy (i.e., thromboembolism) in addition to chronic hypoxia-ischemia.
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Cortical brain areas and cortical and white matter watershed areas are particularly vulnerable to ischemia and may undergo acute infarction.
“cortical brain areas and cortical and white matter watershed (border zone) areas (134, 141, 142), which are particularly vulnerable to ischemia, may undergo acute infarction.”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [142]
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Pathophysiology of Sickle Cell Disease
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- Authors
- Guilliams, K. P., Fields, M. E., Ragan, D. K., Chen, Y., Eldeniz, C., Hulbert, M. L., Binkley, M. M., Rhodes, J. N., Shimony, J. S., McKinstry, R. C., Vo, K. D., An, H., Lee, J.-M., & Ford, A. L.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Lee, Jin-Moo
- Ford, Andria L.
- ORCID
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2017-04
- Volume
- 69
- Pages
- 49-57
- ISSN
- 0887-8994 (ISSN-L)
- PMC
- PMC5365370
- OpenAlex
- W2560424466
- Cited by
- 51
- References
- 51
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 2
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (UL1TR000448)
- National Heart, Lung, and Blood Institute (R01HL129241, K12HL087107)
- National Institute of Neurological Disorders and Stroke (R01NS085419, R01NS082561, P01NS032636)
- National Center for Advancing Translational Sciences
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD087011)
- Topics
- Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- sickle cell disease, pediatric stroke, Jacobian determinant, hemispheric lateralization, hypoxia-ischemia, thromboembolism
- MeSH terms
- Adolescent, Anemia, Sickle Cell, Atrophy, Brain, Cerebral Angiography, Cerebral Infarction, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Retrospective Studies, Young Adult
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