Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease

Fields, Melanie E.; Guilliams, Kristin P.; Ragan, Dustin K.; Binkley, Michael M.; Eldeniz, Cihat; Chen, Yasheng; Hulbert, Monica L.; McKinstry, Robert C.; Shimony, Joshua S.; Vo, Katie D.; Doctor, Allan; An, Hongyu; Ford, Andria L.; Lee, Jin-Moo

doi:10.1212/wnl.0000000000005194

Cited by 113Hemoglobinopathies and Related DisordersAdvanced MRI Techniques and ApplicationsAcute Ischemic Stroke Management

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Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease

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Fields, Melanie E., Guilliams, Kristin P., Ragan, Dustin K., Binkley, Michael M., Eldeniz, Cihat, Chen, Yasheng, Hulbert, Monica L., McKinstry, Robert C., Shimony, Joshua S., Vo, Katie D., Doctor, Allan, An, Hongyu, Ford, Andria L., Lee, Jin-Moo·2018·Neurology

DOI 10.1212/wnl.0000000000005194PMC PMC5880632

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Abstract

OBJECTIVE: ) in children with SCD. METHODS: . An infarct heat map was created from an independent pediatric SCD cohort with silent infarcts and compared to prospectively obtained OEF maps. RESULTS: < 0.001). Furthermore, this peak OEF region colocalized with regions of greatest infarct density derived from an independent SCD cohort. CONCLUSIONS: Elevated OEF in the deep white matter identifies a signature of metabolically stressed brain tissue at increased stroke risk in pediatric patients with SCD. We propose that border zone physiology, exacerbated by chronic anemic hypoxia, explains the high risk in this region.

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The oxygen extraction fraction is increased at baseline in sickle cell disease.
“the oxygen extraction fraction is also increased at baseline (139, 140).”
From Pathophysiology of Sickle Cell Disease (2019) · cites this paper as [139]

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Abstract WMP97: Regional Cerebral Oxygen Extraction is Elevated in Tissue at High Risk of Stroke in Pediatric Sickle Cell Disease
Ford, A. L., Guilliams, K. P., Fields, M. E., Ragan, D. K., Eldeniz, C., Binkley, M. M., Rhodes, T., McKinstry, R. C., Shimony, J. S., Vo, K. D., et al. (2016) · Stroke · doi:10.1161/str.47.suppl_1.wmp97
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Elevations in MR Measurements of Whole Brain and Regional Cerebral Blood Flow and Oxygen Extraction Fraction Suggest Cerebral Metabolic Stress in Children with Sickle Cell Disease Unaffected By Overt Stroke
Fields, M. E., Guilliams, K. P., Ragan, D. K., Eldeniz, C., Binkley, M. M., Hulbert, M. L., Vo, K. D., McKinstry, R. C., Shimony, J. S., An, H., et al. (2015) · Blood · doi:10.1182/blood.v126.23.69.69 · Cited by 6
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Cerebral Oxygen Metabolic Stress, Microstructural Injury, and Infarction in Adults With Sickle Cell Disease
Wang, Y., Fellah, S., Fields, M. E., Guilliams, K. P., Binkley, M. M., Eldeniz, C., Shimony, J. S., Reis, M. N., Vo, K. D., Chen, Y., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012404 · Cited by 32
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Cerebral vascular shunting and oxygen metabolism in sickle cell disease
Song, A. K., Richerson, W. T., Aumann, M. A., Waddle, S. L., Jones, R. S., Davis, S. M., Milner, L., Custer, C., Davis, L. T., Pruthi, S., et al. (2024) · Blood Advances · doi:10.1182/bloodadvances.2024014201 · Cited by 4
Abstract TMP57: Cerebral Oxygen Metabolism as a Biomarker to Stratify Stroke Risk in Young Adults with Sickle Cell Disease
Ford, A. L., Guilliams, K. P., Fields, M. E., Ragan, D. K., Eldeniz, C., Binkley, M. M., Blinder, M. A., Chen, Y., Hulbert, M. L., & An, H. (2017) · Stroke · doi:10.1161/str.48.suppl_1.tmp57
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Authors: Fields, M. E., Guilliams, K. P., Ragan, D. K., Binkley, M. M., Eldeniz, C., Chen, Y., Hulbert, M. L., McKinstry, R. C., Shimony, J. S., Vo, K. D., Doctor, A., An, H., Ford, A. L., & Lee, J.-M.
Affiliations: Washington University in St. Louis (US)
Corresponding author: Fields, Melanie E.
Guilliams, Kristin P.
Ford, Andria L.
Lee, Jin-Moo
ORCID: Fields, Melanie E.
Guilliams, Kristin P.
Ragan, Dustin K.
Binkley, Michael M.
Eldeniz, Cihat
Chen, Yasheng
Hulbert, Monica L.
McKinstry, Robert C.
Shimony, Joshua S.
Vo, Katie D.
Doctor, Allan
An, Hongyu
Ford, Andria L.
Lee, Jin-Moo
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2018-03-27
Volume: 90
Issue: 13
Pages: e1134-e1142
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.0000000000005194
PMC: PMC5880632
OpenAlex: W2793607856
Cited by: 113
References: 41
Citations by year: 2026: 12 · 2025: 9 · 2024: 11 · 2023: 12 · 2022: 21 · 2021: 15 · 2020: 13 · 2019: 14 · 2018: 5
FWCI: 6.66
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (UL1TR000448, UL1TR002345)
National Heart, Lung, and Blood Institute (R01HL129241, K12HL087107, K23HL136904)
National Institute of General Medical Sciences (R01GM113838)
National Institute of Neurological Disorders and Stroke (K23NS099472, R01NS085419, R01NS082561, P30NS098577)
National Center for Advancing Translational Sciences
Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD087011)
Topics: Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: sickle cell disease, stroke risk, border zone, silent cerebral infarction, deep white matter, pediatric stroke, anemic hypoxia
MeSH terms: Adolescent, Anemia, Sickle Cell, Brain, Cerebrovascular Circulation, Child, Child, Preschool, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Oxygen, Oxygen Consumption, Cohort Studies, Stroke, Young Adult

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Regional oxygen extraction predicts border zone vulnerability to stroke in sickle cell disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

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