Cited by 31Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesNeuropeptides and Animal Physiology

Gonadotropin-releasing hormone II (GnRH II) mediates the anorexigenic actions of α-melanocyte-stimulating hormone (α-MSH) and corticotropin-releasing hormone (CRH) in goldfish

Kang, Ki Sung, Shimizu, Kanako, Azuma, Morio, Ui, Yuhta, Nakamura, Kouta, Uchiyama, Minoru, Matsuda, Kouhei·2011·Peptides

Abstract

Intracerebroventricular (ICV) administration of gonadotropin-releasing hormone II (GnRH II), which plays a crucial role in the regulation of reproduction in vertebrates, markedly reduces food intake in goldfish. However, the neurochemical pathways involved in the anorexigenic action of GnRH II and its interaction with other neuropeptides have not yet been identified. Alpha-melanocyte-stimulating hormone (α-MSH), corticotropin-releasing hormone (CRH) and CRH-related peptides play a major role in feeding control as potent anorexigenic neuropeptides in goldfish. However, our previous study has indicated that the GnRH II-induced anorexigenic action is not blocked by treatment with melanocortin 4 receptor (MC4R) and CRH receptor antagonists. Therefore, in the present study, we further examined whether the anorexigenic effects of α-MSH and CRH in goldfish could be mediated through the GnRH receptor neuronal pathway. ICV injection of the MC4R agonist, melanotan II (80 pmol/g body weight; BW), significantly reduced food intake, and its anorexigenic effect was suppressed by ICV pre-administration of the GnRH type I receptor antagonist, antide (100 pmol/gBW). The CRH-induced (50 pmol/gBW) anorexigenic action was also blocked by treatment with antide. ICV injection of CRH (50 pmol/gBW) induced a significant increase of the GnRH II mRNA level in the hypothalamus, while ICV injection of melanotan II (80 pmol/gBW) had no effect on the level of GnRH II mRNA. These results indicate that, in goldfish, the anorexigenic actions of α-MSH and CRH are mediated through the GnRH type I receptor-signaling pathway, and that the GnRH II system regulates feeding behavior.

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Crossref · 10.1016/j.peptides.2010.10.013

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Authors
Kang, K. S., Shimizu, K., Azuma, M., Ui, Y., Nakamura, K., Uchiyama, M., & Matsuda, K.
Affiliations
University of Toyama (JP)
Corresponding author
Matsuda, Kouhei
Venue
Peptides
Publisher
Elsevier BV
Published
2011-01
Volume
32
Issue
1
Pages
31-35
ISSN
0196-9781 (ISSN-L)
OpenAlex
W2085061221
Cited by
31
References
46
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 4
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of Toyama
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
alpha-melanocyte-stimulating hormone, corticotropin-releasing factor, melanotan II, melanocortin-4 receptor, anorexigenic peptides, food intake regulation, dietary intake, hypothalamus, goldfish, antide
MeSH terms
alpha-MSH, Animals, Appetite Depressants, Corticotropin-Releasing Hormone, Goldfish, Hypothalamus, Gonadotropin-Releasing Hormone, Peptides, Cyclic, RNA, Messenger, Signal Transduction

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