Inhibitory effect of chicken gonadotropin-releasing hormone II on food intake in the goldfish, Carassius auratus
Abstract
Gonadotropin-releasing hormone (GnRH) is an evolutionarily conserved neuropeptide with 10 amino acid residues, which possesses some structural variants. A molecular form known as chicken GnRH II ([His(5) Trp(7) Tyr(8)] GnRH, cGnRH II) is widely distributed in vertebrates, and has recently been implicated in the regulation of sexual behavior and food intake in an insectivore, the musk shrew. However, the influence of cGnRH II on feeding behavior has not yet been studied in model animals such as rodents and teleost fish. In this study, therefore, we investigated the role of cGnRH II in the regulation of feeding behavior in the goldfish, and examined its involvement in food intake after intracerebroventricular (ICV) administration. ICV-injected cGnRH II at graded doses, from 0.1 to 10 pmol/g body weight (BW), induced a decrease of food consumption in a dose-dependent manner during 60 min after treatment. Cumulative food intake was significantly decreased by ICV injection of cGnRH II at doses of 1 and 10 pmol/g BW during the 60-min post-treatment observation period. ICV injection of salmon GnRH ([Trp(7) Leu(8)] GnRH, sGnRH) at doses of 0.1-10 pmol/g BW did not affect food intake. The anorexigenic action of cGnRH II was completely blocked by treatment with the GnRH type I receptor antagonist, Antide. However, the anorexigenic action of cGnRH II was not inhibited by treatment with the corticotropin-releasing hormone (CRH) 1/2 receptor antagonist, *-helical CRH((9-41)), and the melanocortin 4 receptor antagonist, HS024. These results suggest that, in the goldfish, cGnRH II, but not sGnRH, acts as an anorexigenic factor, as is the case in the musk shrew, and that the anorexigenic action of cGnRH II is independent of CRH- and melanocortin-signaling pathways.
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GnRH-like peptides affect body mass and feeding in Aplysia, while in Drosophila, both CRZ and AKH regulate carbohydrate and lipid metabolism, as well as feeding and stress response.
“In addition, GnRH-like peptides affect body mass and feeding in Aplysia (36, 37), while in Drosophila, both CRZ and AKH regulate carbohydrate and lipid metabolism (38–41), as well as feeding (41, 42) and stress response (43, 44).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [39]
Goldfish and zebrafish GnRH2 exhibits an anorexigenic function upon injection.
“Goldfish and zebrafish GnRH2 exhibits an anorexigenic function upon injection (39, 47, 48).”
From Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in <i>Platynereis</i> (2020) · cites this paper as [39]
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- Authors
- Matsuda, K., Nakamura, K., Shimakura, S.-I., Miura, T., Kageyama, H., Uchiyama, M., Shioda, S., & Ando, H.
- Affiliations
- University of Toyama (JP)
- SHOWA Medical University (JP)
- Kyushu University (JP)
- Corresponding author
- Matsuda, Kouhei
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 54
- Issue
- 1
- Pages
- 83-89
- ISSN
- 0018-506X (ISSN-L)
- OpenAlex
- W2009097402
- Cited by
- 96
- References
- 81
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 6 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 6 · 2012: 9
- FWCI
- 11.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- chicken GnRH-II, gonadotropin-releasing hormone, dietary intake, feeding behavior, anorectic effect, goldfish, intracerebroventricular administration, antide, corticotropin-releasing factor, melanocortin-4 receptor, teleosts
- MeSH terms
- Animals, Anorexia, Chickens, Corticotropin-Releasing Hormone, Eating, Female, Goldfish, Hormone Antagonists, Injections, Intraventricular, Gonadotropin-Releasing Hormone, Male, Oligopeptides, Peptide Fragments, Peptides, Cyclic, Sex Characteristics, Receptors, Corticotropin
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