The effect of dehydroglyasperin C on UVB-mediated MMPs expression in human HaCaT cells
Abstract
Background The ultraviolet B (UVB) from solar radiation increases the generation of reactive oxygen species (ROS), which mediate the production of matrix metalloproteinases (MMPs), and acts mainly on the epidermis layer of the skin. This study was aimed at assessing the anti-photoaging effects of dehydroglyasperin C isolated from Glycyrrhiza uralensis Fisch on MMPs levels in HaCaT human keratinocytes and to elucidate the underlying mechanism. Methods The cell viability was measured by MTT assay. Expression, phosphorylation and enzymatic activity of the protein were examined using ELISA, Western blot or gelatin zymography. Intracellular ROS measurement was evaluated by fluorescent ELISA and 2',7'-dichlorodihydrofluorescein diacetate (H 2 DCF-DA) assay. Results In the present study, we found that dehydroglyasperin C markedly inhibited UVB-mediated expression of collagenase (MMP-1) and gelatinase (MMP-9) by inhibiting ROS generation. Dehydroglyasperin C treatment also decreased the UVB irradiation-mediated activation of mitogen-activated protein kinase (MAPK), c-Jun phosphorylation, and c-Fos expression. In addition, the down-regulation of UVB-induced c-Jun phosphorylation caused by dehydroglyasperin C treatment was more than the down-regulation of c-Fos expression in the HaCaT human keratinocytes. Conclusion Our results indicated that dehydroglyasperin C may function as a potential anti-photoaging agent by inhibiting UVB-mediated MMPs expression via suppression of MAPK and AP-1…
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Dehydroglyasperin C treatment decreases UV-B irradiation-mediated activation of MAPK, c-Jun phosphorylation, and c-fos expression.
“Dehydroglyasperin C treatment also decreased the UV-B irradiation-mediated activation of mitogen-activated protein kinase (MAPK), c-Jun phosphorylation, and c-fos expression.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [66]
Dehydroglyasperin C may work as a potential anti-photoaging agent by inhibiting UV-B-mediated MMPs expression via suppression of MAPK and AP-1 signaling.
“In conclusion, it appeared that dehydroglyasperin C may work as a potential anti-photoaging agent by inhibiting UV-Bmediated MMPs expression via suppression of MAPK and AP-1 signaling (Figure 4) [66].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [66]
The down-regulation of UV-B-induced c-Jun phosphorylation caused by dehydroglyasperin C treatment is more intense than the down-regulation of c-fos expression.
“In addition, the down-regulation of UV-B-induced c-Jun phosphorylation caused by dehydroglyasperin C treatment was more intense than the down-regulation of c-fos expression.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [66]
Dehydroglyasperin C represses UV-B-mediated expression of collagenase (MMP-1) and gelatinase (MMP-9) by inhibiting ROS generation.
“Dehydroglyasperin C noticeably repressed UV-B-mediated expression of collagenase (MMP-1) and gelatinase (MMP-9) by inhibiting ROS generation.”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [66]
Cites
Oxidation events and skin aging
Kammeyer, A., & Luiten, R. M. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.01.001 · Cited by 980 · see citing works
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Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
Kang, Y.-M., Hong, C.-H., Kang, S.-H., Seo, D.-S., Kim, S.-O., Lee, H.-Y., Sim, H.-J., & An, H.-J. (2020) · Journal of Functional Biomaterials · doi:10.3390/jfb11010003 · Cited by 45 · see citing works
- Authors
- Xuan, S. H., Park, Y. M., Ha, J. H., Jeong, Y. J., & Park, S. N.
- Affiliations
- Seoul National University of Science and Technology (KR)
- Corresponding author
- Park, Soo Nam
- Venue
- Pharmacological Reports
- Published
- 2017-12
- Volume
- 69
- Issue
- 6
- Pages
- 1224-1231
- ISSN
- 1734-1140 (ISSN-L)
- OpenAlex
- W2621149962
- Cited by
- 30
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 7 · 2018: 4 · 2017: 1
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacological Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- Glycyrrhiza uralensis, UV-B radiation, photoaging, matrix metalloproteinases, MMP-1, MMP-9, reactive oxygen species, HaCaT keratinocytes, MAPK signaling, c-Jun phosphorylation, c-fos, AP-1 signaling
- MeSH terms
- Benzopyrans, Cell Line, Cell Survival, Enzyme-Linked Immunosorbent Assay, Humans, Phosphorylation, Ultraviolet Rays, Signal Transduction, Keratinocytes, Proto-Oncogene Proteins c-fos, Reactive Oxygen Species, Transcription Factor AP-1, Matrix Metalloproteinase 9, Matrix Metalloproteinase 1, Glycyrrhiza uralensis
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