The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Antioxidant gene therapy against neuronal cell death
Open accessAbstract
Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy.
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Cites
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“It is important to state that amyloid-independent mechanisms have also been proposed to contribute to AD (Karran et al., 2011; Pimplikar et al., 2010).”
Amyloid Precursor Protein Processing and Alzheimer's Disease
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Cited by
Oxidative Stress: Harms and Benefits for Human Health
Pizzino, G., Irrera, N., Cucinotta, M., Pallio, G., Mannino, F., Arcoraci, V., Squadrito, F., Altavilla, D., & Bitto, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8416763 · Cited by 4,837
Which NADPH Oxidase Isoform Is Relevant for Ischemic Stroke? The Case for Nox 2
Kahles, T., & Brandes, R. P. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4721 · Cited by 125
Metadata
- Authors
- Navarro-Yepes, J., Zavala-Flores, L., Anandhan, A., Wang, F., Skotak, M., Chandra, N., Li, M., Pappa, A., Martinez-Fong, D., Del Razo, L. M., Quintanilla-Vega, B., & Franco, R.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 142
- Issue
- 2
- Pages
- 206-230
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2026072954
- Cited by
- 176
- References
- 48
- FWCI
- 5.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Navarro-Yepes, J., Zavala-Flores, L., Anandhan, A., Wang, F., Skotak, M., Chandra, N., Li, M., Pappa, A., Martinez-Fong, D., Del Razo, L. M., Quintanilla-Vega, B., & Franco, R. (2014). Antioxidant gene therapy against neuronal cell death. Pharmacology & Therapeutics. https://doi.org/10.1016/j.pharmthera.2013.12.007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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