Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

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Items 301–400 of 920

1. Multicellular tumor spheroids bridge the gap between two-dimensional cancer cells and solid tumors: The role of lipid metabolism and distribution
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2. Tumor Spheroids as Model to Design Acoustically Mediated Drug Therapies: A Review
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3. A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach
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4. Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements
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5. Thermoresponsive microgels containing trehalose as soft matrices for 3D cell culture
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6. Rapid prototyping of PMMA-based microfluidic spheroid-on-a-chip models using micromilling and vapour-assisted thermal bonding
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7. Applications of Organoids in Advancing Drug Discovery and Development
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8. High-throughput screening in multicellular spheroids for target discovery in the tumor microenvironment
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9. Bioprinting and its Use in Tumor-On-A-Chip Technology for Cancer Drug Screening: A Review
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10. Targeting telomerase utilizing zeolitic imidazole frameworks as non-viral gene delivery agents across different cancer cell types
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11. Utilizing two-dimensional monolayer and three-dimensional spheroids to enhance radiotherapeutic potential by combining gold nanoparticles and docetaxel
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12. Cell Type-Specific TGF-β Mediated EMT in 3D and 2D Models and Its Reversal by TGF-β Receptor Kinase Inhibitor in Ovarian Cancer Cell Lines
    Wafa Al Ameri, Ikhlak Ahmed, Fatima M. Al-Dasim, Yasmin Ali Mohamoud, Iman K. Al-Azwani, Joel A. Malek, Thasni Karedath · 2019 · International Journal of Molecular Sciences
13. Deep learning unlocks label-free viability assessment of cancer spheroids in microfluidics
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14. Exploiting Matrix Stiffness to Overcome Drug Resistance
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15. The Evolution of Anticancer 3D In Vitro Models: The Potential Role of Machine Learning and AI in the Next Generation of Animal-Free Experiments
    Carolina Momoli, Beatrice Costa, Lorenzo Lenti, Matilde Tubertini, Marco Parenti, Elisa Martella, Greta Varchi, Claudia Ferroni · 2025 · Cancers
16. L-Glucose: Another Path to Cancer Cells
    Koki Ono, Shota Takigawa, Katsuya Yamada · 2020 · Cancers
17. Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing
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18. Bioartificial livers: a review of their design and manufacture
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19. Miniaturized and multiplexed high-content screening of drug and immune sensitivity in a multichambered microwell chip
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20. 3D Bioprinting: An Enabling Technology to Understand Melanoma
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21. Fabrication of a self-assembled and vascularized tumor array via bioprinting on a microfluidic chip
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22. Patient‐Derived Prostate Cancer Explants: A Clinically Relevant Model to Assess siRNA‐Based Nanomedicines
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23. Rational designing of glyco-nanovehicles to target cellular heterogeneity
    Prashant Ankur Jain, Chethan D. Shanthamurthy, Preeti Madhukar Chaudhary, Raghavendra V Kikkeri · 2021 · Chemical Science
24. Characterization and quantification of necrotic tissues and morphology in multicellular ovarian cancer tumor spheroids using optical coherence tomography
    Feng Yan, Gokhan Gunay, Trisha I. Valerio, Chen Wang, Jayla A. Wilson, Majood Haddad, Maegan Watson, Michael O. Connell, Noah Davidson, Kar-Ming A. Fung et al. · 2021 · Biomedical Optics Express
25. Surface Hydrophobicity Modulates the Key Characteristics of Cancer Spheroids through the Interaction with the Adsorbed Proteins
    Min-Seok Lee, Yesol Kim, Seung Jung Yu, Sun Young Lee, Jin Gyeng Son, Tae Geol Lee, Youngbin Cho, Jennifer Hyunjong Shin, Eunjung Lee, Sung Gap Im · 2021 · Advanced Functional Materials
26. Ca 2+ ‐activated K + channel K Ca 1.1 as a therapeutic target to overcome chemoresistance in three‐dimensional sarcoma spheroid models
    Susumu Ohya, Junko Kajikuri, Kyoko Endo, Hiroaki Kito, Elghareeb E. Elboray, Takayoshi Suzuki · 2021 · Cancer Science
27. Multicellular spheroids formation: The synergistic effects of halloysite nanoclay and cationic magnetic nanoparticles
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28. Induction of T cell-mediated immune response by dendritic cells pulsed with mRNA of sphere-forming cells isolated from patients with gastric cancer
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29. The Construction and Application of Three‐Dimensional Biomaterials
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30. Devices and techniques used to obtain and analyze three‐dimensional cell cultures
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31. A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
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32. Synthetic Tuning of Domain Stoichiometry in Nanobody–Enzyme Megamolecules
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33. Microengineered 3D Tumor Models for Anti-Cancer Drug Discovery in Female-Related Cancers
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34. An in vitro tumorigenesis model based on live-cell-generated oxygen and nutrient gradients
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35. New Scenarios in Pharmacological Treatments of Head and Neck Squamous Cell Carcinomas
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36. Factors Influencing the Therapeutic Efficacy of the PSMA Targeting Radioligand 212Pb-NG001
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37. In Vitro Models of Head and Neck Cancer: From Primitive to Most Advanced
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38. High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches
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39. Thermoresponsive poly(N-isopropylacrylamide) hydrogel substrates micropatterned with poly(ethylene glycol) hydrogel for adipose mesenchymal stem cell spheroid formation and retrieval
    Gyeongju Kim, Yuna Jung, Kanghee Cho, Hyun Jong Lee, W. Koh · 2020 · Materials Science and Engineering C
40. Leveraging and manufacturing in vitro multicellular spheroid-based tumor cell model as a preclinical tool for translating dysregulated tumor metabolism into clinical targets and biomarkers
    Tong Wang, Lin Wang, Guan Wang, Yingping Zhuang · 2020 · Bioresources and Bioprocessing
41. Modelling the tumor microenvironment in vitro in prostate cancer: current and future perspectives
    Kedi Yuan, Xinxing Du, Liang Dong, Jiahua Pan, Wei Xue · 2024 · Open Research (University of Surrey)
42. 3D Bioprinting Models for Glioblastoma: From Scaffold Design to Therapeutic Application
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43. Multicellular spheroids from normal and neoplastic thyroid tissues as a suitable model to test the effects of multikinase inhibitors
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44. Evolution of Metastasis Study Models toward Metastasis‐On‐A‐Chip: The Ultimate Model?
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45. A Novel SimpleDrop Chip for 3D Spheroid Formation and Anti-Cancer Drug Assay
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46. Optimization of Tumor Spheroid Preparation and Morphological Analysis for Drug Evaluation
    Jun Ho Lee, Youngwon Kim, Jiseok Lim, Hyo‐Il Jung, Gastone Castellani, Filippo Piccinini, Bongseop Kwak · 2024 · BioChip Journal
47. In Vitro 3D Cultures to Reproduce the Bone Marrow Niche
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48. The Role of C-X-C Chemokine Receptor Type 4 (CXCR4) in Cell Adherence and Spheroid Formation of Human Ewing’s Sarcoma Cells under Simulated Microgravity
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49. Rapid Clearing for High Resolution 3D Imaging of Ex Vivo Pancreatic Cancer Spheroids
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50. Pumpless, unidirectional microphysiological system for testing metabolism‐dependent chemotherapeutic toxicity
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51. Emerging Neuroblastoma 3D In Vitro Models for Pre-Clinical Assessments
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52. Modeling the Efficacy of Oncolytic Adenoviruses In Vitro and In Vivo: Current and Future Perspectives
    Mary Kathryn McKenna, Amanda Rosewell Shaw, Masataka Suzuki · 2020 · Cancers
53. Continual proteomic divergence of HepG2 cells as a consequence of long-term spheroid culture
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54. Fabrication of Size-Controllable and Arrangement-Orderly HepG2 Spheroids for Drug Screening via Decellularized Liver Matrix-Derived Micropattern Array Chips
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55. DNA-assembled visible nanodandelions with explosive hydrogen-bond breakage achieving uniform intra-tumor distribution (UITD)-guided photothermal therapy
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56. The Antitumoral/Antimetastatic Action of the Flavonoid Brachydin A in Metastatic Prostate Tumor Spheroids In Vitro Is Mediated by (Parthanatos) PARP-Related Cell Death
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57. Comparison of EMT-Related and Multi-Drug Resistant Gene Expression, Extracellular Matrix Production, and Drug Sensitivity in NSCLC Spheroids Generated by Scaffold-Free and Scaffold-Based Methods
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58. Evaluation of respiratory and secretory activities of multicellular spheroids via electrochemiluminescence imaging
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59. GelMA hydrogel: A game-changer in 3D tumor modeling
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60. Bone Sialoprotein Shows Enhanced Expression in Early, High-Proliferation Stages of Three-Dimensional Spheroid Cell Cultures of Breast Cancer Cell Line MDA-MB-231
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61. Fully Human Tumor-based Matrix in Three-dimensional Spheroid Invasion Assay
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62. Recapitulating Glioma Stem Cell Niches Using 3D Spheroid Models for Glioblastoma Research
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63. Advances in organoid-on-a-chip for recapitulation of human physiological events
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64. STAT3 is activated in multicellular spheroids of colon carcinoma cells and mediates expression of IRF9 and interferon stimulated genes
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65. Diverse Stakeholders of Tumor Metabolism: An Appraisal of the Emerging Approach of Multifaceted Metabolic Targeting by 3-Bromopyruvate
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66. Ultrasound-Based Scaffold-Free Core-Shell Multicellular Tumor Spheroid Formation
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67. Low‐Temperature Plasma‐Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways
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68. Growth and adaptation mechanisms of tumour spheroids with time-dependent oxygen availability
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69. Microfabrication methods for 3D spheroids formation and their application in biomedical engineering
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70. Differences in boundary behavior in the 3D vertex and Voronoi models
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71. Application of Single Cell Type-Derived Spheroids Generated by Using a Hanging Drop Culture Technique in Various In Vitro Disease Models: A Narrow Review
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72. 3D bioprinted GelMA scaffolds for clinical applications: Promise and challenges
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73. A multilayered cancer-on-a-chip model to analyze the effectiveness of new-generation photosensitizers
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74. Activation of Wnt signalling reduces the population of cancer stem cells in ameloblastoma
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75. Reproduction of the Antitumor Effect of Cisplatin and Cetuximab Using a Three-dimensional Spheroid Model in Oral Cancer
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76. Linking Metastatic Behavior and Metabolic Heterogeneity of Circulating Tumor Cells at Single‐Cell Level Using an Integrative Microfluidic System
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77. Spatial omics in 3D culture model systems: decoding cellular positioning mechanisms and microenvironmental dynamics
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78. Fabrication of Tunable 3D Cellular Structures in High Volume Using Magnetic Levitation Guided Assembly
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79. The Molecular Basis of Different Approaches for the Study of Cancer Stem Cells and the Advantages and Disadvantages of a Three-Dimensional Culture
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80. Fluorescence‐based thermometry for precise estimation of nanoparticle laser‐induced heating in cancerous cells at nanoscale
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81. Versatile Red Blood Cells for Triple‐Negative Breast Cancer Treatment via Stepwise Photoactivations
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82. Optimization of 3D-aggregated spheroid model (3D-ASM) for selecting high efficacy drugs
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83. Reconstruction of tumor microenvironment via in vitro three-dimensional models
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84. Bioluminescence Imaging of Spheroids for High‐throughput Longitudinal Studies on 3D Cell Culture Models
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85. Fluid Shear Stress Induces Drug Resistance to Doxorubicin and Paclitaxel in the Breast Cancer Cell Line MCF7
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86. Inflammatory breast cancer cells are characterized by abrogated TGFβ1-dependent cell motility and SMAD3 activity
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87. Fast compressive lens-free tomography for 3D biological cell culture imaging
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88. One-Step Dip-Coating-Fabricated Core–Shell Silk Fibroin Rice Paper Fibrous Scaffolds for 3D Tumor Spheroid Formation
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89. Targeting EYA3 in Ewing Sarcoma Retards Tumor Growth and Angiogenesis
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90. 3D bioprinted tissue-specific spheroidal multicellular microarchitectures for advanced cell therapy
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91. Radiotherapy on-chip: microfluidics for translational radiation oncology
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92. Scalable Formation of Highly Viable and Functional Hepatocellular Carcinoma Spheroids in an Oxygen‐Permeable Microwell Device for Anti‐Tumor Drug Evaluation
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93. Tumor homing-penetrating and nanoenzyme-augmented 2D phototheranostics against hypoxic solid tumors
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94. Therapeutic Potential of a Water-Soluble Silver-Diclofenac Coordination Polymer on 3D Pancreatic Cancer Spheroids
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95. 3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies
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96. 3D multicellular tumor spheroids used for in vitro preclinical therapeutic screening
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97. In vitro hepatic 3D cell models and their application in genetic toxicology: A systematic review
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98. CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids
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99. Comparative Study of the Cellular Uptake and Intracellular Behavior of a Library of Cyclic Peptide–Polymer Nanotubes with Different Self-Assembling Properties
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100. Microfluidic 3D intestine tumor spheroid model for efficient in vitro investigation of nanoparticular formulations
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