The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis
Open accessAbstract
Epidemiological studies have linked increased incidence of inflammatory diseases and intestinal cancers in the developed parts of the world to the consumption of diets poor in dietary fibers and rich in refined carbohydrates. Gut bacteria residing in the intestinal lumen exclusively metabolize dietary fibers. Butyrate, propionate and acetate, which are collectively called short-chain fatty acids (SCFAs), are generated by fermentation of dietary fibers by gut microbiota. Evidences indicate that SCFAs are key players in regulating beneficial effect of dietary fibers and gut microbiota on our health. SCFAs interact with metabolite-sensing G protein-coupled receptors GPR41, GPR43 and GPR109A expressed in gut epithelium and immune cells. These interactions induce mechanisms that play a key role in maintaining homeostasis in gut and other organs. This review summarizes the protective roles of GPR41, GPR43 and GPR109A in dietary fibers-, gut microbiota- and SCFAs- mediated suppression of inflammation and carcinogenesis in gut and other organs.
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Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
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Cited by
Short-chain fatty acids in diseases
Zhang, D., Jian, Y.-P., Zhang, Y.-N., Li, Y., Gu, L.-T., Sun, H.-H., Liu, M.-D., Zhou, H.-L., Wang, Y.-S., & Xu, Z.-X. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01219-9 · Cited by 718
Chen, G., Ran, X., Li, B., Li, Y., He, D., Huang, B., Fu, S., Liu, J., & Wang, W. (2018) · eBioMedicine · doi:10.1016/j.ebiom.2018.03.030 · Cited by 580
Hodgkinson, K., El Abbar, F., Dobranowski, P., Manoogian, J., Butcher, J., Figeys, D., Mack, D., & Stintzi, A. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2022.10.024 · Cited by 423
The interaction among gut microbes, the intestinal barrier and short chain fatty acids
Ma, J., Piao, X., Mahfuz, S., Long, S., & Wang, J. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2021.09.012 · Cited by 398
Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer
Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383
Metadata
- Authors
- Sivaprakasam, S., Prasad, P. D., & Singh, N.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 164
- Pages
- 144-151
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W2344885638
- Cited by
- 571
- References
- 34
- FWCI
- 10.98
- Type
- journal article
- Language
- en
- Open access
- green
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