Review article: the role of butyrate on colonic function
Open accessAbstract
Summary: Background Butyrate, a short‐chain fatty acid, is a main end‐product of intestinal microbial fermentation of mainly dietary fibre. Butyrate is an important energy source for intestinal epithelial cells and plays a role in the maintenance of colonic homeostasis. Aim To provide an overview on the present knowledge of the bioactivity of butyrate, emphasizing effects and possible mechanisms of action in relation to human colonic function. Methods A PubMed search was performed to select relevant publications using the search terms: ‘butyrate, short‐chain fatty acid, fibre, colon, inflammation, carcinogenesis, barrier, oxidative stress, permeability and satiety’. Results Butyrate exerts potent effects on a variety of colonic mucosal functions such as inhibition of inflammation and carcinogenesis, reinforcing various components of the colonic defence barrier and decreasing oxidative stress. In addition, butyrate may promote satiety. Two important mechanisms include the inhibition of nuclear factor kappa B activation and histone deacetylation. However, the observed effects of butyrate largely depend on concentrations and models used and human data are still limited. Conclusion Although most studies point towards beneficial effects of butyrate, more human in vivo studies are needed to contribute to our current understanding of butyrate‐mediated effects on colonic function in health and disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Short chain fatty acids in human large intestine, portal, hepatic and venous blood
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119 · see citing works
Topping, D. L., & Clifton, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1031 · Cited by 3,091 · see citing works
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409 · see citing works
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515 · see citing works
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Segain, J.-P., de la Blétière, D. R., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottière, H. M., & Galmiche, J.-P. (2000) · Gut · doi:10.1136/gut.47.3.397 · Cited by 1,325 · see citing works
Bingham, S. A., Day, N., Luben, R., Ferrari, P., Slimani, N., Norat, T., Clavel‐Chapelon, F., Kesse‐Guyot, E., Nieters, A., Boeing, H., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13174-1 · Cited by 1,109 · see citing works
Microbial modulation of innate defense: goblet cells and the intestinal mucus layer
Deplancke, B., & Gaskins, H. R. (2001) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.6.1131s · Cited by 1,012 · see citing works
Gendler, S. J., & Spicer, A. P. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003135 · Cited by 1,001 · see citing works
Treatment of Diversion Colitis with Short-Chain-Fatty Acid Irrigation
Harig, J. M., Soergel, K. H., KOMOROWSKI, R. A., & Wood, C. M. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200105 · Cited by 748 · see citing works
Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis
Scheppach, W. M., Sommer, H., Kirchner, T., Paganelli, G.-M., Bartram, P., Christl, S. U., Richter, F., Dusel, G., & Kasper, H. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91094-k · Cited by 740 · see citing works
Comparison of fermentation reactions in different regions of the human colon
Macfarlane, G. T., Gibson, G. R., & Cummings, J. H. (1992) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1992.tb04882.x · Cited by 676 · see citing works
Oxidative Stress and Pathogenesis of Inflammatory Bowel Disease: An Epiphenomenon or the Cause?
Rezaie, A. R., Parker, R. D., & Abdollahi, M. R. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9622-2 · Cited by 589 · see citing works
Trock, B. J., Lanza, E., & Greenwald, P. (1990) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/82.8.650 · Cited by 558 · see citing works
Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.
McIntyre, A., Gibson, P. R., & Young, G. P. (1993) · Gut · doi:10.1136/gut.34.3.386 · Cited by 555 · see citing works
Hinnebusch, B. F., Meng, S., Wu, J. T., Archer, S. Y., & Hodin, R. A. (2002) · Journal of Nutrition · doi:10.1093/jn/132.5.1012 · Cited by 546 · see citing works
Tungland, B. C., & Meyer, D. (2002) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/j.1541-4337.2002.tb00009.x · Cited by 525 · see citing works
Peng, L., He, Z., Chen, W., Holzman, I. R., & Lin, J. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250014.92242.f3 · Cited by 518 · see citing works
Willemsen, L. E. M., Koetsier, M. A., van Deventer, S. J. H., & van Tol, E. A. F. (2003) · Gut · doi:10.1136/gut.52.10.1442 · Cited by 518 · see citing works
Howe, G. R., Benito, E., Castelleto, R., Cornée, J., Estève, J., Gallagher, R. P., Iscovich, J., Deng-ao, J., Kaaks, R., Kune, G. A., et al. (1992) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/84.24.1887 · Cited by 504 · see citing works
Inan, M. S., Rasoulpour, R. J., Yin, L., Hubbard, A. K., Rosenberg, D. W., & Giardina, C. A. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70142-9 · Cited by 502 · see citing works
Dietary Fiber Intake and Risk of Colorectal Cancer
Park, Y., Hunter, D. J., Spiegelman, D. L., Bergkvist, L., Berrino, F., van den Brandt, P. A., Buring, J. E., Colditz, G. A., Freudenheim, J. L., Fuchs, C. S., et al. (2005) · JAMA · doi:10.1001/jama.294.22.2849 · Cited by 489 · see citing works
Butyrate Inhibits NF-κB Activation in Lamina Propria Macrophages of Patients with Ulcerative Colitis
Lührs, H., Gerke, T., Müller, J. G., Melcher, R., Schauber, J., Boxberger, F., Scheppach, W. M., & Menzel, T. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202317316105 · Cited by 468 · see citing works
Karaki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 465 · see citing works
PPARγ as a new therapeutic target in inflammatory bowel diseases
Dubuquoy, L., Rousseaux, C., Thuru, X., Peyrin-Biroulet, L., Romano, O., Chavatte, P., Chamaillard, M., & Desreumaux, P. (2006) · Gut · doi:10.1136/gut.2006.093484 · Cited by 450 · see citing works
Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis
Dubuquoy, L., Jansson, E. Å., Deeb, S. S., Rakotobé, S., Karoui, M., Colombel, J., Auwerx, J. H., Pettersson, S., & Desreumaux, P. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00271-3 · Cited by 425 · see citing works
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414 · see citing works
Fernández‐Bañares, F., Hinojosa, J., Sánchez-Lombraña, J. L., Navarro, E., Martínez-Salmerón, J. F., García-Pugés, A. M., Gónzalez‐Huix, F., Riera, J., González-Lara, V., Domínguez-Abascal, F., et al. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.872_a.x · Cited by 386 · see citing works
Schauber, J. (2003) · Gut · doi:10.1136/gut.52.5.735 · Cited by 383 · see citing works
Oligofructose Promotes Satiety in Rats Fed a High‐Fat Diet: Involvement of Glucagon‐Like Peptide‐1
Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005) · Obesity Research · doi:10.1038/oby.2005.117 · Cited by 382 · see citing works
The IκB/NF-κB system: a key determinant of mucosal inflammation and protection
Jobin, C., & Sartor, R. B. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.3.c451 · Cited by 382 · see citing works
Oligofructose promotes satiety in healthy human: a pilot study
Cani, P. D., Joly, E., Horsmans, Y., & Delzenne, N. M. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602350 · Cited by 381 · see citing works
Mucin secretion is modulated by luminal factors in the isolated vascularly perfused rat colon
Barcelo, A., Claustre, J., Moro, F., Chayvialle, J.-A., Cuber, J.-C., & Plaisancié, P. (2000) · Gut · doi:10.1136/gut.46.2.218 · Cited by 375 · see citing works
Gaudier, E., Jarry, A., Blottière, H. M., de Coppet, P., Buisine, M. P., Aubert, J. P., Laboisse, C., Cherbut, C., & Hoebler, C. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00219.2004 · Cited by 365 · see citing works
The immune system: a target for functional foods?
Calder, P. C., & Kew, S. (2002) · British Journal Of Nutrition · doi:10.1079/bjn2002682 · Cited by 359 · see citing works
Expression of the short-chain fatty acid receptor, GPR43, in the human colon
Karaki, S.-I., Tazoe, H., Hayashi, H., Kashiwabara, H., Tooyama, K., Suzuki, Y., & Kuwahara, A. (2007) · Journal of Molecular Histology · doi:10.1007/s10735-007-9145-y · Cited by 334 · see citing works
de Wiele, T. V., Boon, N., Possemiers, S., Jacobs, H., & Verstraete, W. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.03084.x · Cited by 331 · see citing works
Takaishi, H., Matsuki, T., Nakazawa, A., Takada, T., Kado, S., Asahara, T., Kamada, N., Sakuraba, A., Yajima, T., Higuchi, H., et al. (2007) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2007.07.016 · Cited by 325 · see citing works
Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat
Cherbut, C., Ferrier, L., Rozé, C., Anini, Y., Blottière, H. M., Lecannu, G., & Galmiche, J. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.6.g1415 · Cited by 316 · see citing works
Impact of inulin and oligofructose on gastrointestinal peptides
Delzenne, N. M., Cani, P. D., Daubioul, C., & Neyrinck, A. M. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041342 · Cited by 314 · see citing works
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Cummings, J. H., Rombeau, J. L., & 坂田, 隆. (2004) · Medical Entomology and Zoology · Cited by 313 · see citing works
Starch intake and colorectal cancer risk: an international comparison
Cassidy, A., Bingham, S., & Cummings, J. (1994) · British Journal of Cancer · doi:10.1038/bjc.1994.181 · Cited by 308 · see citing works
Selective colonization of insoluble substrates by human faecal bacteria
Leitch, E. C. M., Walker, A. W., Duncan, S. H., Holtrop, G., & Flint, H. J. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01186.x · Cited by 297 · see citing works
Pitcher, M. (2000) · Gut · doi:10.1136/gut.46.1.64 · Cited by 297 · see citing works
Li, H., Myeroff, L. L., Smiraglia, D. J., Romero, M. F., Pretlow, T. P., Kasturi, L., Lutterbaugh, J., Rerko, R. M., Casey, G., Issa, J. J., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1430846100 · Cited by 295 · see citing works
Welters, C. F. M., Heineman, E., Thunnissen, E., van den Bogaard, A. E. J. M., Soeters, P. B., & Baeten, C. G. M. I. (2002) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-6257-2 · Cited by 294 · see citing works
Breuer, R. I., Soergel, K. H., Lashner, B. A., Christ, M. L., Hanauer, S. B., Vanagunas, A., Harig, J. M., Keshavarzian, A., ROBINSON, M. G., Sellin, J. H., et al. (1997) · Gut · doi:10.1136/gut.40.4.485 · Cited by 282 · see citing works
Lipid peroxidation and antioxidant status in colorectal cancer
Skrzydlewska, E. (2005) · World Journal of Gastroenterology · doi:10.3748/wjg.v11.i3.403 · Cited by 277 · see citing works
Colonic Sulfide in Pathogenesis and Treatment of Ulcerative Colitis
Roediger, W. E. W., Moore, J., & Babidge, W. (1997) · Digestive Diseases and Sciences · doi:10.1023/a:1018851723920 · Cited by 270 · see citing works
Schauber, J., Dorschner, R. A., Yamasaki, K., Brouha, B., & Gallo, R. L. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02399.x · Cited by 263 · see citing works
Casellas, F., Borruel, N., Torrejón, A., Varela, E., Antolı́n, M., Guarner, F., & Malagelada, J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03288.x · Cited by 260 · see citing works
Velazquez, O. C., Lederer, H. M., & Rombeau, J. L. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5967-2_14 · Cited by 259 · see citing works
Rationale for the luminal provision of butyrate in intestinal diseases
Wächtershäuser, A., & Stein, J. M. (2000) · European Journal of Nutrition · doi:10.1007/s003940070020 · Cited by 258 · see citing works
Immune dysfunction in inflammatory bowel disease
Neuman, M. G. (2007) · Translational research · doi:10.1016/j.trsl.2006.11.009 · Cited by 253 · see citing works
Amylase-Resistant Starch plus Oral Rehydration Solution for Cholera
Ramakrishna, B., Venkataraman, S., Srinivasan, P., Dash, P., Young, G. P., & Binder, H. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002033420502 · Cited by 249 · see citing works
The butyrate story: old wine in new bottles?
Scheppach, W. M., & Weiler, F. (2004) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200409000-00009 · Cited by 246 · see citing works
Oral butyrate for mildly to moderately active Crohn's disease
Sabatino, A. D., Morera, R., Ciccocioppo, R., Cazzola, P., GOTTI, S., Tinozzi, F. P., Tinozzi, S., & Corazza, G. R. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02639.x · Cited by 245 · see citing works
Hylla, S., Gostner, A., Dusel, G., Anger, H. J. W., Bartram, H.-P., Christl, S., Kasper, H., & Scheppach, W. M. (1998) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/67.1.136 · Cited by 241 · see citing works
Inflammatory bowel disease: past, present, and future
Sands, B. E. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1995-7 · Cited by 239 · see citing works
Effect of Short‐Chain Fatty Acids on the Human Colonic Mucosa in Vitro
Scheppach, W. M., Bartram, P., Richter, A., Richter, F., Liepold, H., Dusel, G., Hofstetter, G., Rüthlein, J., & Kasper, H. (1992) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719201600143 · Cited by 234 · see citing works
Short‐chain fatty acid topical treatment in distal ulcerative colitis
Vernia, P., Marcheggiano, A., Caprilli, R., Frieri, G., Corrao, G., Valpiani, D., Paolo, M. C. D., Paoluzi, P., & Torsoli, A. (1995) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.1995.tb00386.x · Cited by 232 · see citing works
Piche, T., Varannes, S. B. D., Sacher‐Huvelin, S., Holst, J. J., Cuber, J. C., & Galmiche, J. P. (2003) · Gastroenterology · doi:10.1053/gast.2003.50159 · Cited by 232 · see citing works
Colonic mucin synthesis is increased by sodium butyrate.
Finnie, I. A., Dwarakanath, A. D., Taylor, B. A., & Rhodes, J. M. (1995) · Gut · doi:10.1136/gut.36.1.93 · Cited by 231 · see citing works
Increasing Fecal Butyrate in Ulcerative Colitis Patients by Diet: Controlled Pilot Study
Hallert, C., Björck, I., NYMAN, M. E., Pousette, A., Grännö, C., & Svensson, H. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200303000-00005 · Cited by 228 · see citing works
Colon carcinogens: Their metabolism and mode of action
Weisburger, J. H. (1971) · Cancer · doi:10.1002/1097-0142(197107)28:1 · Cited by 227 · see citing works
Treatment of left‐sided ulcerative colitis with butyrate enemas: a controlled trial
Steinhart, A. H., Hiruki, T., Brzezinski, A., & Baker, J. P. (1996) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1996.d01-509.x · Cited by 222 · see citing works
The starved colon—Diminished mucosal nutrition, diminished absorption, and colitis
Roediger, W. E. W. (1990) · Diseases of the Colon & Rectum · doi:10.1007/bf02051922 · Cited by 222 · see citing works
Does butyrate protect from colorectal cancer?
Sengupta, S., Muir, J. G., & Gibson, P. R. (2006) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04213.x · Cited by 219 · see citing works
Vernia, P., Annese, V., Bresci, G., D'Albasio, G., Renata D'Incà, Giaccari, S., Ingrosso, M., Mansi, C., Riegler, G., Valpiani, D., et al. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01130.x · Cited by 217 · see citing works
Trefoil peptides: from structure to function
Thim, L. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050108 · Cited by 216 · see citing works
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.
Butzner, J. D., Parmar, R., Bell, C., & Dalal, V. (1996) · Gut · doi:10.1136/gut.38.4.568 · Cited by 213 · see citing works
Increasing butyrate concentration in the distal colon by accelerating intestinal transit
Lewis, S. J., & Heaton, K. W. (1997) · Gut · doi:10.1136/gut.41.2.245 · Cited by 211 · see citing works
Comalada, M., Bailón, E., de Haro, O., Lara‐Villoslada, F., Xaus, J., Zarzuelo, A., & Gálvez, J. (2006) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-006-0092-x · Cited by 207 · see citing works
Treatment of distal ulcerative colitis with short-chain fatty acid enemas a placebo-controlled trial
Scheppach, W. M., & German-Austrian Scfa Study Group (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071409 · Cited by 204 · see citing works
Physiological and Clinical Aspects of Short-Chain Fatty Acids
Kris‐Etherton, P. M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1293a · Cited by 202 · see citing works
Hatayama, H., Iwashita, J., Kuwajima, A., & Abé, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.025 · Cited by 196 · see citing works
Butyrate reduces colonic paracellular permeability by enhancing PPARγ activation
Kinoshita, M., Suzuki, Y., & Saitō, Y. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00294-2 · Cited by 195 · see citing works
Organic anions and the diarrhea of inflammatory bowel disease
Vernia, P., Gnaedinger, A., Hauck, W., & Breuer, R. I. (1988) · Digestive Diseases and Sciences · doi:10.1007/bf01536987 · Cited by 194 · see citing works
Kanauchi, O., Suga, T., Tochihara, M., Hibi∥, T., Naganuma, M., Homma, T., Asakura, H., Nakano, H., Takahama, K., Fujiyama, Y., et al. (2002) · Journal of Gastroenterology · doi:10.1007/bf03326417 · Cited by 194 · see citing works
Morrison, D. J., Mackay, W. G., Edwards, C. A., Preston, T., Dodson, B., & Weaver, L. T. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061853 · Cited by 194 · see citing works
Gupta, N., Martin, P. M., Prasad, P. D., & Ganapathy, V. (2005) · Life Sciences · doi:10.1016/j.lfs.2005.10.028 · Cited by 190 · see citing works
Place, R. F., Noonan, E. J., & Giardina, C. A. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.030 · Cited by 189 · see citing works
Modulation of tight junction structure and function by cytokines
Walsh, S. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00048-x · Cited by 188 · see citing works
Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut
Zhou, J. F., Hegsted, M., McCutcheon, K. L., Keenan, M. J., Xi, X., Raggio, A. M., & Martin, R. J. (2006) · Obesity · doi:10.1038/oby.2006.77 · Cited by 187 · see citing works
Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?
Dashwood, R. H., Myzak, M. C., & Ho, E. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi253 · Cited by 186 · see citing works
Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model
Mariadason, J. M., Barkla, D. H., & Gibson, P. R. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.4.g705 · Cited by 182 · see citing works
Rose, D. J., DeMeo, M. T., Keshavarzian, A., & Hamaker, B. R. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00282.x · Cited by 181 · see citing works
Bourdu, S., Dapoigny, M., Chapuy, E., Artigue, F., Vasson, M.-P., Dechelotte, P., Bommelaer, G., Eschalier, A., & Ardid, D. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.03.082 · Cited by 176 · see citing works
Microarray Analysis of Butyrate Regulated Genes in Colonic Epithelial Cells
Daly, K., & Shirazi‐Beechey, S. P. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.49 · Cited by 172 · see citing works
Dietary Fructooligosaccharides Affect Intestinal Barrier Function in Healthy Men
ten Bruggencate, S., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., Katan, M., & van der Meer, R. (2006) · Journal of Nutrition · doi:10.1093/jn/136.1.70 · Cited by 169 · see citing works
Histone Deacetylase Inhibitors Up-Regulate the Expression of Tight Junction Proteins
Bordin, M., D'Atri, F., Guillemot, L., & Citi, S. (2004) · Molecular Cancer Research · doi:10.1158/1541-7786.692.2.12 · Cited by 168 · see citing works
Inhibition of interferon gamma signaling by the short chain fatty acid butyrate.
Klampfer, L., Huang, J., Sasazuki, T., Shirasawa, S., & Augenlicht, L. H. (2003) · PubMed · Cited by 166 · see citing works
Germinated barley foodstuff prolongs remission in patients with ulcerative colitis
Hanai, H., Kanauchi, O., Mitsuyama, K., Andoh, A., Takeuchi, K., Iida, T., Araki, Y., Fujiyama, Y., Toyonaga, A., Sata, M., et al. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.5.643 · Cited by 166 · see citing works
Motor effects of short-chain fatty acids and lactate in the gastrointestinal tract
Cherbut, C. (2003) · Proceedings of The Nutrition Society · doi:10.1079/pns2002213 · Cited by 166 · see citing works
Colonic fermentation and proximal gastric tone in humans
Ropert, A., Cherbut, C., Rozé, C., Quellec, A. L., Holst, J. J., Fu–Cheng, X., Varannes, S. B. D., & Jp, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v111.pm8690193 · Cited by 165 · see citing works
Physiological and Anti‐Inflammatory Roles of Dietary Fiber and Butyrate in Intestinal Functions
Andoh, A., Bamba, T., & Sasaki, M. (1999) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719902300518 · Cited by 161 · see citing works
Conley, B. A., Egorin, M. J., Tait, N. S., Rosen, D. M., Sausville, E. A., Dover, G. H., Fram, R. J., & Echo, D. A. V. (1998) · PubMed · Cited by 155 · see citing works
The G-protein-coupled receptor 40 family (GPR40–GPR43) and its role in nutrient sensing
Covington, D. K., Briscoe, C. A., Brown, A. J., & Jayawickreme, C. K. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340770 · Cited by 151 · see citing works
Ohata, A., Usami, M., & Miyoshi, M. (2005) · Nutrition · doi:10.1016/j.nut.2004.12.004 · Cited by 150 · see citing works
AGA technical review: Impact of dietary fiber on colon cancer occurrence
Kim, Y. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70377-5 · Cited by 147 · see citing works
Dietary Fructooligosaccharides Increase Intestinal Permeability in Rats
ten Bruggencate, S. J. M., Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., & van der Meer, R. (2005) · Journal of Nutrition · doi:10.1093/jn/135.4.837 · Cited by 147 · see citing works
Rosignoli, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1675 · Cited by 147 · see citing works
Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies
Reddy, B. S. (1998) · British Journal Of Nutrition · doi:10.1017/s0007114500006061 · Cited by 147 · see citing works
Ispaghula Husk May Relieve Gastrointestinal Symptoms in Ulcerative Colitis in Remission
Hallert, C., Kaldma, M., & Petersson, B. G. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529108998594 · Cited by 146 · see citing works
Topical butyrate for acute radiation proctitis: randomised, crossover trial
Vernia, P., Fracasso, P., Casale, V., Villotti, G., Marcheggiano, A., Stigliano, V., Pinnarò, P., Bagnardi, V., & Caprilli, R. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02787-2 · Cited by 139 · see citing works
Vernia, P., Monteleone, G., Grandinetti, G., Villotti, G., Giulio, E. D., Frieri, G., Marcheggiano, A., Pallone, F., Caprilli, R., & Torsoli, A. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005537411244 · Cited by 138 · see citing works
Amelioration of dextran sulfate colitis by butyrate: role of heat shock protein 70 and NF-κB
Venkatraman, A., Ramakrishna, B., Velayudhan, S. R., Kumar, N. S. N., Pulimood, A. B., & Patra, S. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00307.2002 · Cited by 138 · see citing works
Treatment of diversion colitis by short-chain fatty acids
Guillemot, F., Colombel, J., Neut, C., Verplanck, N., Lecomte, M., Romond, C., Paris, J., & Cortot, A. (1991) · Diseases of the Colon & Rectum · doi:10.1007/bf02049697 · Cited by 138 · see citing works
Kanauchi, O., Mitsuyama, K., Homma, T., Takahama, K., Fujiyama, Y., Andoh, A., Araki, Y., Toshihiro, S., Hibi∥, T., Naganuma, M., et al. (2003) · International Journal of Molecular Medicine · doi:10.3892/ijmm.12.5.701 · Cited by 137 · see citing works
Role of mucins in inflammatory bowel disease: important lessons from experimental models
Einerhand, A. W. C., Renes, I. B., Makkink, M. K., van der Sluis, M., Büller, H. A., & Dekker, J. P. (2002) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200207000-00008 · Cited by 136 · see citing works
Butyrate enemas in experimental colitis and protection against large bowel cancer in a rat model
D’Argenio, G., Cosenza, V., Cave, M. D., Iovino, P., Valle, N. D., Lombardi, G., & Mazzacca, G. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964397 · Cited by 136 · see citing works
Clausen, M. R., Bonnén, H., & Mortensen, P. B. (1991) · Gut · doi:10.1136/gut.32.8.923 · Cited by 135 · see citing works
Lambert, D., Wood, I. S., Ellis, A., & Shirazi‐Beechey, S. P. (2002) · British Journal of Cancer · doi:10.1038/sj.bjc.6600264 · Cited by 135 · see citing works
Abrahamse, S. L., Pool-Zobel, B. L., & Rechkemmer, G. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.629 · Cited by 135 · see citing works
Stempelj, M., Kédinger, M., Augenlicht, L. H., & Klampfer, L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609426200 · Cited by 134 · see citing works
Schwab, M., Reynders, V., Loitsch, S. M., Steinhilber, D., Stein, J. M., & Schröder, O. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.010 · Cited by 133 · see citing works
Leu, R. K. L., Brown, I. L., Hu, Y., Morita, T., Esterman, A., & Young, G. P. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl245 · Cited by 133 · see citing works
Weaver, G. A., Krause, J. A., Miller, T. L., & Wolin, M. J. (1988) · Gut · doi:10.1136/gut.29.11.1539 · Cited by 126 · see citing works
Arvans, D. L., Vavricka, S. R., Ren, H., Musch, M. W., Kang, L. H., Rocha, F. G., Lucioni, A., Turner, J. R., Alverdy, J. C., & Chang, E. B. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00206.2004 · Cited by 126 · see citing works
Mentschel, J., & Claus, R. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00318-4 · Cited by 124 · see citing works
Paroder, V., Spencer, S. R., Paroder, M., Arango, D., Schwartz, S., Mariadason, J., Augenlicht, L., Eskandari, S., & Carrasco, N. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0602365103 · Cited by 123 · see citing works
Short-chain fatty acids in the treatment of radiation proctitis
TALLEY, N., Chen, F., King, D. W., Jones, M., & Talley, N. J. (1997) · Diseases of the Colon & Rectum · doi:10.1007/bf02050927 · Cited by 121 · see citing works
In vivo butyrate metabolism and colonic permeability in extensive ulcerative colitis
Hond, E. D., Hiele, M. I., Evenepoel, P., Peeters, M., Ghoos, Y. F., & Rutgeerts, P. J. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70137-4 · Cited by 121 · see citing works
Plasmin/Plasminogen System in Colorectal Cancer
Berger, D. H. (2002) · World Journal of Surgery · doi:10.1007/s00268-002-4050-8 · Cited by 118 · see citing works
Nilsson, U. J., & NYMAN, M. E. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051531 · Cited by 118 · see citing works
Bauer‐Marinovic, M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl025 · Cited by 115 · see citing works
Serum acetate:propionate ratio is related to serum cholesterol in men but not women.
Wolever, T., Fernandes, J., & Rao, A. (1996) · Journal of NutriLife · doi:10.1093/jn/126.11.2790 · Cited by 115 · see citing works
Ebert, M. N. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg122 · Cited by 112 · see citing works
Ren, H., Musch, M. W., Kojima, K., Boone, D. L., Ma, A. I., & Chang, E. B. (2001) · Gastroenterology · doi:10.1053/gast.2001.27028 · Cited by 112 · see citing works
Delmée, E., Cani, P. D., Gual, G., Knauf, C., Burcelin, R., Maton, N., & Delzenne, N. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.013 · Cited by 111 · see citing works
Ibekwe, V. C., Liu, F., Fadda, H. M., Khela, M. K., Evans, D. F., Parsons, G. E., & Basit, A. W. (2006) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20742 · Cited by 111 · see citing works
Acarbose Enhances Human Colonic Butyrate Production
Weaver, G. A., Tangel, C. T., Krause, J. A., Parfitt, M. M., Jenkins, P., Rader, J. M., LEWIS, B. A., Miller, T. L., & Wolin, M. J. (1997) · Journal of Nutrition · doi:10.1093/jn/127.5.717 · Cited by 110 · see citing works
Effect of isomalt consumption on faecal microflora and colonic metabolism in healthy volunteers
Gostner, A., Blaut, M., Schäffer, V., Kozianowski, G., Theis, S., Klingeberg, M., Dombrowski, Y., Martin, D., Ehrhardt, S., Taras, D., et al. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20051589 · Cited by 108 · see citing works
Ohkawara, S., Furuya, H., Nagashima, K., Asanuma, N., & Hino, T. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2878 · Cited by 108 · see citing works
Hodin, R. A., Meng, S., Archer, S. Y., & Tang, R. (1996) · PubMed · Cited by 105 · see citing works
Tsukahara, T., IWASAKI, Y., Nakayama, K., & Ushida, K. (2003) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.49.414 · Cited by 105 · see citing works
Dankert, J., Zijlstra, J. B., & Wolthers, B. G. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90359-4 · Cited by 104 · see citing works
Matsumoto, N., Riley, S., Fraser, D. J., Al‐Assaf, S., Ishimura, E., Wolever, T. M. S., Phillips, G. O., & Phillips, A. O. (2006) · Kidney International · doi:10.1038/sj.ki.5000028 · Cited by 103 · see citing works
Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis
Pinto, A., Fidalgo, P. O., Cravo, M. L., Midões, J., Chaves, P. P., Rosa, J. C., Birto, M. D. A., & Leitão, C. N. (1999) · Diseases of the Colon & Rectum · doi:10.1007/bf02236937 · Cited by 101 · see citing works
Short-chain fatty acids promote the migration of colonic epithelial cells in vitro
Wilson, A., & Gibson, P. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9247468 · Cited by 101 · see citing works
PPAR-γ Is Selectively Upregulated in Caco-2 Cells by Butyrate
Wächtershäuser, A., Loitsch, S. M., & Stein, J. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2793 · Cited by 100 · see citing works
Time of day and glucose tolerance status affect serum short-chain fatty concentrations in humans
Wolever, T. M. S., Josse, R. G., Leiter, L. A., & Chiasson, J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90127-x · Cited by 99 · see citing works
Senagore, A. J., MacKeigan, J. M., Scheider, M., & Ebrom, S. J. (1992) · Diseases of the Colon & Rectum · doi:10.1007/bf02253492 · Cited by 95 · see citing works
Sodium Butyrate Inhibits Carcinoma Development in a 1,2‐Dimethylhydrazine‐Induced Rat Colon Cancer
Medina, V., Afonso, J., Álvarez‐Argüelles, H., Hernández, C., & González, F. (1998) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719802200114 · Cited by 90 · see citing works
Song, M., Xia, B., & Li, J. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2005.037945 · Cited by 90 · see citing works
Colonic epithelial cell activation and the paradoxical effects of butyrate
Gibson, P. R., Rosella, O., Wilson, A. J., Mariadason, J. M., Rickard, K., Byron, K., & Barkla, D. H. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.539 · Cited by 90 · see citing works
Andoh, A., Fujiyama, Y., Hata, K., Araki, Y., Takaya, H., Shimada, M., & Bamba, T. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.01038.x · Cited by 89 · see citing works
Toden, S., Bird, A. R., Topping, D. L., & Conlon, M. A. (2007) · Cancer Biology & Therapy · doi:10.4161/cbt.6.2.3627 · Cited by 88 · see citing works
A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon
Roda, A. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i7.1079 · Cited by 86 · see citing works
Zgouras, D., Wächtershäuser, A., Frings, D., & Stein, J. M. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02916-9 · Cited by 84 · see citing works
Cuff, M. A., Dyer, J., Jones, M., & Shirazi‐Beechey, S. P. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.12.003 · Cited by 83 · see citing works
Luminal peptide YY-releasing factors in the isolated vascularly perfused rat colon
Plaisancié, P., Dumoulin, V., Chayvialle, J. A., & Cuber, J.-C. (1996) · Journal of Endocrinology · doi:10.1677/joe.0.1510421 · Cited by 80 · see citing works
Plaisancié, P., Dumoulin, V., Chayvialle, J. A., & Cuber, J.-C. (1995) · Journal of Endocrinology · doi:10.1677/joe.0.1450521 · Cited by 79 · see citing works
Lin, J., Nafday, S. M., Chauvin, S. N., Magid, M. S., Pabbatireddy, S., Holzman, I. R., & Babyatsky, M. W. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200210000-00016 · Cited by 79 · see citing works
Roediger, W. E. W., Heyworth, M. F., Willoughby, P. H., Piris, J., Moore, A., & Truelove, S. C. (1982) · Journal of Clinical Pathology · doi:10.1136/jcp.35.3.323 · Cited by 76 · see citing works
Mortensen, F. V., Hessov, I., Birke, H., Korsgaard, N., & Nielsen, H. K. (1991) · British journal of surgery · doi:10.1002/bjs.1800781019 · Cited by 75 · see citing works
Short-Chain Fatty Acids Induce Colonic Mucosal Injury in Rats with Various Postnatal Ages
Nafday, S. M., Chen, W., Peng, L., Babyatsky, M. W., Holzman, I. R., & Lin, J. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000150721.83224.89 · Cited by 73 · see citing works
Upregulation of BAK by butyrate in the colon is associated with increased Sp3 binding
Chirakkal, H., Leech, S. H., Brookes, K. E., Prais, A. L., Waby, J. S., & Corfe, B. M. (2006) · Oncogene · doi:10.1038/sj.onc.1209702 · Cited by 72 · see citing works
In vivo measurement of colonic butyrate metabolism in patients with quiescent ulcerative colitis
Simpson, E. J., Chapman, M. A. S., Dawson, J. M., Berry, D., Macdonald, I. A., & Cole, A. (2000) · Gut · doi:10.1136/gut.46.1.73 · Cited by 71 · see citing works
Lončar, M. B. (2003) · Gut · doi:10.1136/gut.52.9.1297 · Cited by 68 · see citing works
Prolonged Butyrate Treatment Inhibits the Migration and Invasion Potential of HT1080 Tumor Cells
Zeng, H., & Briske‐Anderson, M. (2005) · Journal of Nutrition · doi:10.1093/jn/135.2.291 · Cited by 67 · see citing works
Augenlicht, L. H., Shi, L., Mariadason, J. M., LABOISSE, C. L., & Velcich, A. (2003) · Oncogene · doi:10.1038/sj.onc.1206521 · Cited by 67 · see citing works
Tarrerias, L. A., Millecamps, M., Alloui, A., Beaughard, C., Kemeny, L. J., Bourdu, S., Bommelaer, G., Eschalier, A., Dapoigny, M. C., & Ardid, D. (2002) · Pain · doi:10.1016/s0304-3959(02)00234-8 · Cited by 66 · see citing works
Gee, J. M., & Johnson, I. T. (2005) · Nutrition · doi:10.1016/j.nut.2005.03.002 · Cited by 64 · see citing works
D’Argenio, G., Cosenza, V., Sorrentini, I., Ritis, F. D., Gatto, A., Cave, M. D., D’Armiento, F. P., & Mazzacca, G. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90598-3 · Cited by 63 · see citing works
Wehkamp, J., & Stange, E. F. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.030 · Cited by 63 · see citing works
Rectal cell proliferation and colon cancer risk in ulcerative colitis.
Biasco, G., Paganelli, G. M., Miglioli, M., Brillanti, S., Febo, G. D., Gizzi, G., de Leòn, M. P., Campieri, M., & Barbara, L. (1990) · PubMed · Cited by 62 · see citing works
Short-Chain Fatty Acid Release of Peptide YY in the Isolated Rabbit Distal Colon
Longo, W. E., Ballantyne, G. H., Savoca, P., Adrian, T. E., Bilchik, A. J., & Modlin, I. M. (1991) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529108996507 · Cited by 62 · see citing works
Acarbose raises serum butyrate in human subjects withimpaired glucose tolerance
Wolever, T. M. S., & Chiasson, J. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500001239 · Cited by 62 · see citing works
Histological changes in the colonic mucosa following irrigation with short-chain fatty acids
Scheppach, W., Müller, J. G., Boxberger, F., Dusel, G., Richter, F., Bartram, H.-P., Christl, S. U., Dempfle, C.-E. H., & Kasper, H. (1997) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199702000-00010 · Cited by 61 · see citing works
Bajka, B. H., Topping, D. L., Cobiac, L., & Clarke, J. M. (2006) · British Journal Of Nutrition · doi:10.1079/bjn20061807 · Cited by 60 · see citing works
Nilsson, U. J., Johansson, M., Nilsson, Å., Björck, I., & NYMAN, M. E. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602816 · Cited by 59 · see citing works
Short-chain fatty acids inhibit intestinal trefoil factor gene expression in colon cancer cells
Tran, C. P., Familari, M., Parker, L. M., Whitehead, R. H., & Giraud, A. S. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.1.g85 · Cited by 59 · see citing works
Effect of butyrate on paracellular permeability in rat distal colonic mucosa ex vivo
Mariadason, J. M., Kilias, D., Catto‐Smith, A. G., & Gibson, P. R. (1999) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.1999.01972.x · Cited by 58 · see citing works
Stimulation of Sodium Chloride Absorption from Secreting Rat Colon by Short-Chain Fatty Acids
Krishnan, S., Ramakrishna, B., & Binder, H. J. (1999) · Digestive Diseases and Sciences · doi:10.1023/a:1018871412748 · Cited by 57 · see citing works
Molecular weight of guar gum affects short‐chain fatty acid profile in model intestinal fermentation
Stewart, M., & Slavin, J. L. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600024 · Cited by 57 · see citing works
Schwab, M., Reynders, V., Ulrich, S., Zahn, N., Stein, J. M., & Schröder, O. (2006) · APOPTOSIS · doi:10.1007/s10495-006-9788-2 · Cited by 56 · see citing works
Malago, J. J., Koninkx, J. F. J. G., Tooten, P. C. J., van Liere, E. A., & van Dijk, J. E. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02810.x · Cited by 55 · see citing works
Dietary Sodium Gluconate Protects Rats from Large Bowel Cancer by Stimulating Butyrate Production
Kameue, C., Tsukahara, T., Yamada, K., Koyama, H., Iwasaki, Y., Nakayama, K., & Ushida, K. (2004) · Journal of Nutrition · doi:10.1093/jn/134.4.940 · Cited by 53 · see citing works
Evaluation of short-chain fatty acid enemas: treatment of radiation proctitis.
al-Sabbagh, R., Sinicrope, F. A., Sellin, J. H., Shen, Y., & Roubein, L. D. (1996) · PubMed · Cited by 53 · see citing works
Rectal absorption of short chain fatty acids in the absence of chloride.
McNeil, N. I., Cummings, J. H., & James, W. P. T. (1979) · Gut · doi:10.1136/gut.20.5.400 · Cited by 52 · see citing works
Kiehne, K. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1056 · Cited by 51 · see citing works
Araki, Y. (2000) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655200451180 · Cited by 50 · see citing works
Araki, Y., Andoh, A., Takizawa, J., Takizawa, W., & Fujiyama, Y. (2004) · International Journal of Molecular Medicine · doi:10.3892/ijmm.13.4.577 · Cited by 49 · see citing works
Volatile fatty acids in the human intestine: Studies in surgical patients
Mitchell, B. L., Lawson, M. J., Davies, M., Grant, A. K., Roediger, W. E. W., Illman, R. J., & Topping, D. L. (1985) · Nutrition Research · doi:10.1016/s0271-5317(85)80140-8 · Cited by 47 · see citing works
Colonic Luminal Hydrogen Sulfide Is Not Elevated in Ulcerative Colitis
Moore, J., Babidge, W., Millard, S. M., & Roediger, W. E. W. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018848709769 · Cited by 44 · see citing works
Fredstrom, S., Lampe, J., Jung, H.-S., & Slavin, J. (1994) · JPEN - Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860719401800114 · Cited by 44 · see citing works
Wong, C. S., Sengupta, S., Tjandra, J. J., & Gibson, P. R. (2005) · Diseases of the Colon & Rectum · doi:10.1007/s10350-004-0810-x · Cited by 41 · see citing works
Probiotics, prebiotics, synbiotics: ecological treatment for inflammatory bowel disease?
Marteau, P. R. (2006) · Gut · doi:10.1136/gut.2004.051458 · Cited by 38 · see citing works
Dietary Fiber and Colorectal Cancer
Baron, J. A. (2005) · JAMA · doi:10.1001/jama.294.22.2904 · Cited by 36 · see citing works
Nordgaard, I., Hove, H., Clausen, M. R., & Mortensen, P. B. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609003122 · Cited by 35 · see citing works
Andoh, M. S. A. (2002) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-001-0239-1 · Cited by 35 · see citing works
Impaired Detoxication of Hydrogen Sulfide in Ulcerative Colitis?
Picton, R., Eggo, M. C., Langman, M. J. S., & Singh, S. V. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9529-y · Cited by 32 · see citing works
The intracellular target of butyrate's actions: HDAC or HDON'T?
Gibson, P. R. (2000) · Gut · doi:10.1136/gut.46.4.447 · Cited by 32 · see citing works
D’Argenio, G., Calvani, M., Valle, N. D., Cosenza, V., Matteo, G. D., Giorgio, P., Margarucci, S., Petillo, O., Jori, F. P., Galderisi, U., et al. (2005) · Gut · doi:10.1136/gut.2004.049411 · Cited by 32 · see citing works
Mortensen, F. V., Langkilde, N. C., Joergensen, J. C. R., & Hessov, I. (1999) · International Journal of Colorectal Disease · doi:10.1007/s003840050201 · Cited by 31 · see citing works
Butyrate is a potent inhibitor of urokinase secretion by normal colonic epithelium in vitro
Gibson, P. R., Rosella, O., Rosella, G., & Young, G. P. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90166-x · Cited by 30 · see citing works
Propionate absorption associated with bicarbonate secretion in vitro in the mouse cecum
Kawamata, K., Hayashi, H., & Suzuki, Y. (2007) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0200-4 · Cited by 29 · see citing works
Lin, J., Peng, L., Itzkowitz, S. H., Holzman, I. R., & Babyatsky, M. W. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000179659.09210.ff · Cited by 26 · see citing works
Effect of Topical Butyrate on Rectal Epithelial Kinetics and Mucosal Enzyme Activities
Gibson, P. R., Kilias, D., Rosella, O., Day, J. M., Abbott, M., Finch, C. F., & Young, G. P. (1998) · Clinical Science · doi:10.1042/cs0940671 · Cited by 25 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048 · see citing works
Self-citationParada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,836 · see citing works
The role of short chain fatty acids in health and disease
Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology · doi:10.1016/b978-0-12-800100-4.00003-9 · Cited by 2,425 · see citing works
Singh, N., Gurav, A., Sivaprakasam, S., Brady, E., Padia, R., Shi, H., Thangaraju, M., Prasad, P. D., Manicassamy, S., Munn, D. H., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.12.007 · Cited by 2,368 · see citing works
The role of the gut microbiota in nutrition and health
Flint, H. J., Scott, K. P., Louis, P., & Duncan, S. H. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.156 · Cited by 2,203 · see citing works
Louis, P., & Flint, H. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01514.x · Cited by 2,179 · see citing works
Phillips, G. O., & Williams, P. A. (2009) · Woodhead Publishing Limited eBooks · doi:10.1533/9781845695873 · Cited by 2,112 · see citing works
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon
Donohoe, D. R., Garge, N., Zhang, X., Sun, W., O'Connell, T. M., Bunger, M. K., & Bultman, S. J. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.018 · Cited by 2,003 · see citing works
“In fact, butyrate enema therapy has been shown to ameliorate the inflammation associated with colitis in mouse models and in human clinical trials (Hamer et al., 2008).”
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,773 · see citing works
Rivière, A., Selak, M., Lantin, D., Leroy, F., & Vuyst, L. D. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00979 · Cited by 1,746 · see citing works
Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works
The abundance and variety of carbohydrate-active enzymes in the human gut microbiota
Kaoutari, A. E., Armougom, F., Gordon, J. I., Raoult, D., & Henrissat, B. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3050 · Cited by 1,683 · see citing works
SCFA: mechanisms and functional importance in the gut
Martin‐Gallausiaux, C., Marinelli, L., Blottière, H. M., Larraufie, P., & Lapaque, N. (2020) · Proceedings of The Nutrition Society · doi:10.1017/s0029665120006916 · Cited by 1,533 · see citing works
How glycan metabolism shapes the human gut microbiota
Koropatkin, N. M., Cameron, E. A., & Martens, E. C. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2746 · Cited by 1,419 · see citing works
Microbes in Gastrointestinal Health and Disease
Neish, A. S. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.080 · Cited by 1,388 · see citing works
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381 · see citing works
Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A., van der Post, S., Svensson, F., Rodríguez‐Piñeiro, A. M., Nyström, E. E. L., et al. (2014) · Immunological Reviews · doi:10.1111/imr.12182 · Cited by 1,363 · see citing works
Reichardt, N., Duncan, S. H., Young, P., Belenguer, Á., Leitch, E. C. M., Scott, K. P., Flint, H. J., & Louis, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.14 · Cited by 1,302 · see citing works
Colonic bacterial composition in Parkinson's disease
Keshavarzian, A., Green, S. J., Engen, P. A., Voigt, R. M., Naqib, A., Forsyth, C. B., Mutlu, E., & Shannon, K. M. (2015) · Movement Disorders · doi:10.1002/mds.26307 · Cited by 1,281 · see citing works
Revealing the Bacterial Butyrate Synthesis Pathways by Analyzing (Meta)genomic Data
Vital, M., Howe, A. C., & Tiedje, J. M. (2014) · mBio · doi:10.1128/mbio.00889-14 · Cited by 1,189 · see citing works
The first 1000 cultured species of the human gastrointestinal microbiota
Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works
Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.028 · Cited by 1,166 · see citing works
Butyrate: A Double-Edged Sword for Health?
Liu, H., Wang, J., He, T., Becker, S. R., Zhang, G., Li, D., & Ma, X. (2018) · Advances in Nutrition · doi:10.1093/advances/nmx009 · Cited by 1,158 · see citing works
Short chain fatty acids in human gut and metabolic health
Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., et al. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0057 · Cited by 1,103 · see citing works
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Genes and Molecules of Lactobacilli Supporting Probiotic Action
Lebeer, S., Vanderleyden, J., & De Keersmaecker, S. C. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00017-08 · Cited by 1,013 · see citing works
Immunological aspects of intestinal mucus and mucins
Johansson, M. E. V., & Hansson, G. C. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.88 · Cited by 1,007 · see citing works
Donohoe, D. R., Collins, L. B., Wali, A., Bigler, R., Sun, W., & Bultman, S. J. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.033 · Cited by 993 · see citing works
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · see citing works
Nogal, A., Valdes, A. M., & Menni, C. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1897212 · Cited by 917 · see citing works
Intestinal barrier function in health and gastrointestinal disease
Camilleri, M., Madsen, K., Spiller, R., Van Meerveld, B. G., & Verne, G. N. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01921.x · Cited by 908 · see citing works
A bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · see citing works
The neuropharmacology of butyrate: the bread and butter of the microbiota-gut-brain axis
Stilling, R. M., van de Wouw, M., Clarke, G., Stanton, C., Dinan, T. G., & Cryan, J. F. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.06.011 · Cited by 891 · see citing works
Obesity, inflammation, and the gut microbiota
Cox, A. J., West, N. P., & Cripps, A. W. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70134-2 · Cited by 869 · see citing works
Carbohydrate metabolism in Bifidobacteria
Pokusaeva, K., Fitzgerald, G. F., & van Sinderen, D. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0206-6 · Cited by 855 · see citing works
The gut microbiota and obesity: from correlation to causality
Zhao, L. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro3089 · Cited by 847 · see citing works
Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827 · see citing works
Actinobacteria: A relevant minority for the maintenance of gut homeostasis
Binda, C., Lopetuso, L. R., Rizzatti, G., Gibiino, G., Cennamo, V., & Gasbarrini, A. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.02.012 · Cited by 814 · see citing works
From the gut to the peripheral tissues: the multiple effects of butyrate
Guilloteau, P., Martin, L., Eeckhaut, V., Ducatelle, R., Zabielski, R., & Immerseel, F. V. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000247 · Cited by 813 · see citing works
Metabolic reprogramming and epigenetic modifications on the path to cancer
Sun, L., Zhang, H., & Gao, P. (2021) · Protein & Cell · doi:10.1007/s13238-021-00846-7 · Cited by 796 · see citing works
Thangaraju, M., Cresci, G. A., Liu, K., Ananth, S., Gnanaprakasam, J. P., Browning, D. D., Mellinger, J. D., Smith, S. B., Digby, G. J., Lambert, N. A., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4466 · Cited by 789 · see citing works
Human Intestinal Barrier Function in Health and Disease
König, J., Wells, J. M., Cani, P. D., García‐Ródenas, C. L., MacDonald, T. T., Mercenier, A., Whyte, J., Troost, F. J., & Brummer, R. J. (2016) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.54 · Cited by 787 · see citing works
Self-citationLiu, P., Wang, Y., Yang, G., Zhang, Q., Meng, L., Xin, Y., & Jiang, X. M. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105420 · Cited by 787 · see citing works
The role of pH in determining the species composition of the human colonic microbiota
Duncan, S. H., Louis, P., Thomson, J. M., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.01931.x · Cited by 786 · see citing works
Louis, P., Young, P., Holtrop, G., & Flint, H. J. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02066.x · Cited by 783 · see citing works
Brown, C. T., Davis-Richardson, A. G., Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Casella, G., Drew, J. C., Ilonen, J., Knip, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025792 · Cited by 778 · see citing works
Russell, W. R., Gratz, S. W., Duncan, S. H., Holtrop, G., Ince, J., Scobbie, L., Duncan, G., Johnstone, A. M., Lobley, G. E., Wallace, R. J., et al. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002188 · Cited by 775 · see citing works
Shifting the balance: antibiotic effects on host–microbiota mutualism
Willing, B. P., Russell, S. L., & Finlay, B. B. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2536 · Cited by 747 · see citing works
The human gut microbiota: Metabolism and perspective in obesity
Gomes, A. C., Hoffmann, C., & Mota, J. F. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1465157 · Cited by 745 · see citing works
Singh, V., Lee, G., Son, H., Koh, H., Kim, E. S., Unno, T., & Shin, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1103836 · Cited by 745 · see citing works
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 742 · see citing works
Intestinal microbiota in human health and disease: the impact of probiotics
Gerritsen, J., Smidt, H., Rijkers, G. T., & de Vos, W. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0229-7 · Cited by 724 · see citing works
Vinolo, M. A. R., Rodrigues, H. G., Hatanaka, E., Sato, F. T., Sampaio, S. C., & Curi, R. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.07.009 · Cited by 714 · see citing works
Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709 · see citing works
Romano, S., Savva, G. M., Bedarf, J. R., Charles, I. G., Hildebrand, F., & Narbad, A. (2021) · npj Parkinson's Disease · doi:10.1038/s41531-021-00156-z · Cited by 707 · see citing works
de la Cuesta-Zuluaga, J., Mueller, N. T., Corrales-Agudelo, V., Velásquez-Mejía, E. P., Carmona, J. A., Abad, J. M., & Escobar, J. S. (2017) · Diabetes Care · doi:10.2337/dc16-1324 · Cited by 704 · see citing works
Nutrients, foods, and colorectal cancer prevention
Song, M., Garrett, W. S., & Chan, A. T. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.035 · Cited by 700 · see citing works
Relevance of protein fermentation to gut health
Windey, K., De Preter, V., & Verbeke, K. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100542 · Cited by 692 · see citing works
Interactions of gut microbiota with functional food components and nutraceuticals
Laparra, J. M., & Sanz, Y. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.11.001 · Cited by 684 · see citing works
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670 · see citing works
Homeostasis of the gut barrier and potential biomarkers
Wells, J. M., Brummer, R. J., Derrien, M., MacDonald, T. T., Troost, F. J., Cani, P. D., Théodorou, V., Dekker, J. P., Méheust, A., de Vos, W. M., et al. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00048.2015 · Cited by 616 · see citing works
Self-citationAl-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614 · see citing works
Self-citationFiber-utilizing capacity varies in Prevotella- versus Bacteroides-dominated gut microbiota
Chen, T., Long, W., Zhang, C., Liu, S., Zhao, L., & Hamaker, B. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-02995-4 · Cited by 608 · see citing works
Review article: dietary fibre-microbiota interactions
Simpson, H. L., & Campbell, B. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13248 · Cited by 602 · see citing works
Spermidine improves gut barrier integrity and gut microbiota function in diet-induced obese mice
Ma, L., Ni, Y., Wang, Z., Tu, W., Ni, L., Zhuge, F., Zheng, A., Hu, L., Zhao, Y., Zheng, L., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1832857 · Cited by 596 · see citing works
Propionate as a health-promoting microbial metabolite in the human gut
Hosseini, E., Grootaert, C., Verstraete, W., & de Wiele, T. V. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00388.x · Cited by 586 · see citing works
Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis
Sivaprakasam, S., Prasad, P. D., & Singh, N. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.007 · Cited by 573 · see citing works
Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation
Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572 · see citing works
Gut microbiota, obesity and diabetes
Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552 · see citing works
Zheng, L., Kelly, C. J., Battista, K. D., Schaefer, R., Lanis, J. M., Alexeev, E. E., Wang, R. X., Onyiah, J. C., Kominsky, D. J., & Colgan, S. P. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700105 · Cited by 549 · see citing works
Intestinal luminal nitrogen metabolism: Role of the gut microbiota and consequences for the host
Davila, A.-M., Blachier, F., Gotteland, M., Andriamihaja, M., Benetti, P.-H., Sanz, Y., & Tomé, D. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.11.005 · Cited by 548 · see citing works
Beta Glucan: Health Benefits in Obesity and Metabolic Syndrome
Khoury, D. T. D. E., Cuda, C., Luhovyy, B. L., & Anderson, G. H. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2012/851362 · Cited by 548 · see citing works
Signaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546 · see citing works
Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota
Karl, J. P., Hatch‐McChesney, A., Arcidiacono, S. M., Pearce, S., Pantoja-Feliciano, I. G., Doherty, L. A., & Soares, J. W. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02013 · Cited by 535 · see citing works
De la Cuesta-Zuluaga, J., Mueller, N., Álvarez-Quintero, R., Velásquez-Mejía, E., Sierra, J., Corrales-Agudelo, V., Carmona, J., Abad, J., & Escobar, J. (2018) · Nutrients · doi:10.3390/nu11010051 · Cited by 533 · see citing works
Dillon, S. M., Lee, E. J., Kotter, C. V., Austin, G. L., Dong, Z. M., Hecht, D. K., Gianella, S., Siewe, B. T., Smith, D. M., LANDAY, A. L., et al. (2014) · Mucosal Immunology · doi:10.1038/mi.2013.116 · Cited by 533 · see citing works
Short-Chain Fatty Acids Regulate the Enteric Neurons and Control Gastrointestinal Motility in Rats
Soret, R., Chevalier, J., De Coppet, P., Poupeau, G., Derkinderen, P., Segain, J. P., & Neunlist, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.053 · Cited by 530 · see citing works
Fusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 516 · see citing works
Han, J., Lin, K., Sequeira, C., & Borchers, C. H. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.11.015 · Cited by 516 · see citing works
Zhang, L., & Davies, S. S. (2016) · Genome Medicine · doi:10.1186/s13073-016-0296-x · Cited by 499 · see citing works
Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria
Fu, X., Liu, Z., Zhu, C., Mou, H., & Kong, Q. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1542587 · Cited by 497 · see citing works
The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces
Statovci, D., Aguilera, M., MacSharry, J. A., & Melgar, S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00838 · Cited by 490 · see citing works
Donohoe, D. R., Holley, D., Collins, L. B., Montgomery, S. A., Whitmore, A. C., Hillhouse, A., Curry, K. P., Renner, S. W., Greenwalt, A., Ryan, E. P., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0501 · Cited by 479 · see citing works
Estaki, M., Pither, J., Baumeister, P., Little, J. P., Gill, S. K., Ghosh, S., Ahmadi-Vand, Z., Marsden, K. R., & Gibson, D. L. (2016) · Microbiome · doi:10.1186/s40168-016-0189-7 · Cited by 476 · see citing works
Intestinal microbiota, diet and health
Power, S. E., O'Toole, P. W., Stanton, C., Ross, R. P., & Fitzgerald, G. F. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002560 · Cited by 476 · see citing works
Sex, body mass index, and dietary fiber intake influence the human gut microbiome
Dominianni, C., Sinha, R., Goedert, J. J., Pei, Z., Yang, L., Hayes, R. B., & Ahn, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0124599 · Cited by 468 · see citing works
Implications of butyrate and its derivatives for gut health and animal production
Bedford, A., & Gong, J. (2017) · Animal nutrition · doi:10.1016/j.aninu.2017.08.010 · Cited by 459 · see citing works
Prebiotic stimulation of human colonic butyrate-producing bacteria and bifidobacteria,in vitro
Scott, K. P., Martin, J. C., Duncan, S. H., & Flint, H. J. (2013) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12186 · Cited by 452 · see citing works
Geirnaert, A., Calatayud, M., Grootaert, C., Laukens, D., Devriese, S., Smagghe, G. J., Vos, M. D., Boon, N., & de Wiele, T. V. (2017) · Scientific Reports · doi:10.1038/s41598-017-11734-8 · Cited by 452 · see citing works
Ananthakrishnan, A. N., Luo, C., Yajnik, V., Khalili, H., Garber, J. J., Stevens, B. W., Cleland, T., & Xavier, R. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.04.010 · Cited by 451 · see citing works
Zaura, E., Brandt, B. W., de Mattos, M. J. T., Buijs, M. J., Caspers, M. P. M., Rashid, M.-U., Weintraub, A., Nord, C. E., Savell, A., Hu, Y., et al. (2015) · mBio · doi:10.1128/mbio.01693-15 · Cited by 449 · see citing works
Dysbiosis of gut microbiota and microbial metabolites in Parkinson's disease
Sun, M.-F., & Shen, Y.-Q. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.04.004 · Cited by 445 · see citing works
Boets, E., Gomand, S. V., Deroover, L., Preston, T., Vermeulen, K., De Preter, V., Hamer, H. M., Van den Mooter, G., De Vuyst, L., Courtin, C. M., et al. (2017) · The Journal of Physiology · doi:10.1113/jp272613 · Cited by 443 · see citing works
Self-citationThe role of the microbiome for human health: From basic science to clinical applications
Mohajeri, M. H., Brummer, R. J. M., Rastall, R. A., Weersma, R. K., Harmsen, H. J. M., Faas, M., & Eggersdorfer, M. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1703-4 · Cited by 440 · see citing works
Self-citationFiber and Functional Gastrointestinal Disorders
Eswaran, S. L., Muir, J. G., & Chey, W. D. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.63 · Cited by 440 · see citing works
The Role of Intestinal Microbiota in the Development and Severity of Chemotherapy-Induced Mucositis
van Vliet, M. J., Harmsen, H. J. M., de Bont, E. S. J. M., & Tissing, W. J. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000879 · Cited by 439 · see citing works
Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier
Liu, Q., Yu, Z., Tian, F., Zhao, J., Zhang, H., Zhai, Q., & Chen, W. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-1289-4 · Cited by 438 · see citing works
- Authors
- HAMER, H. M., JONKERS, D., VENEMA, K., VANHOUTVIN, S., TROOST, F. J., & BRUMMER, R. ‐.
- Affiliations
- Maastricht University (NL)
- TiFN (NL)
- Corresponding author
- HAMER, H. M.
- Venue
- Alimentary Pharmacology & Therapeutics
- Publisher
- Wiley
- Published
- 2007-10-26
- Volume
- 27
- Issue
- 2
- Pages
- 104-119
- ISSN
- 0269-2813 (ISSN-L)
- 1365-2036
- OpenAlex
- W1934624334
- Cited by
- 2,721
- References
- 213
- Citations by year
- 2026: 116 · 2025: 195 · 2024: 203 · 2023: 203 · 2022: 207 · 2021: 238 · 2020: 201 · 2019: 196 · 2018: 176 · 2017: 147 · 2016: 159 · 2015: 134 · 2014: 124 · 2013: 113 · 2012: 78
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Alimentary Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- butyrate, short-chain fatty acids, colonic function, colonic mucosa, intestinal epithelial cells, dietary fiber fermentation, colonic inflammation, colorectal carcinogenesis, intestinal barrier, oxidative stress, satiety, NF-κB inhibition, histone deacetylation
- MeSH terms
- Animals, Butyrates, Child, Preschool, Colon, Colonic Neoplasms, Dietary Fiber, Enema, Fatty Acids, Volatile, Humans, Infant, Newborn, Inflammation, Intestinal Mucosa, Rabbits, Satiation, Oxidative Stress, Carbohydrate Metabolism, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review