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Cited by 281Thyroid Disorders and TreatmentsEstrogen and related hormone effectsThyroid Cancer Diagnosis and Treatment

New insights into thyroid hormone action

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Mendoza, Arturo, Hollenberg, Anthony N.·2017·Pharmacology & Therapeutics
DOI 10.1016/j.pharmthera.2017.02.012PMC PMC5407910
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Abstract

Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) levels in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Indeed, recent work in the field has identified that TH transporters, deiodinases and thyroid hormone receptor coregulators can strongly control tissue-specific sensitivity to a set amount of TH. Furthermore, the mechanism by which the thyroid hormone receptors regulate target gene expression can vary by gene, tissue and cellular context. This review will highlight novel insights into the machinery that controls the cellular response to TH, which include unique signaling cascades. These findings shed new light into the pathophysiology of human diseases caused by abnormal TH signaling.

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Cited by

Sorted by citations

Authors
Mendoza, A., & Hollenberg, A. N.
Affiliations
Beth Israel Deaconess Medical Center (US)
Corresponding author
Hollenberg, Anthony N.
ORCID
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2017-05
Volume
173
Pages
135-145
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/j.pharmthera.2017.02.012
PMC
PMC5407910
OpenAlex
W2585988261
Cited by
281
References
4
Citations by year
2026: 21 · 2025: 33 · 2024: 42 · 2023: 37 · 2022: 31 · 2021: 33 · 2020: 29 · 2019: 19 · 2018: 25 · 2017: 10 · 2012: 1
FWCI
3.30
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • CONACyT (250095)
  • NIH (DK056123, DK098525, DK105029)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroid hormone action, thyroid hormone transporters, deiodinases, thyroid hormone receptor, hypothalamic-pituitary-thyroid axis
MeSH terms
Animals, Gene Expression Regulation, Humans, Hypothalamo-Hypophyseal System, Receptors, Thyroid Hormone, Thyroid Hormones, Thyroxine, Triiodothyronine, Signal Transduction

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