Thyroid hormone signaling and the liver

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

Thyroid Hormone Regulation of Metabolism

Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421 · see citing works

Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans

Dietschy, J., Turley, S., & Spady, D. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)35728-x · Cited by 874 · see citing works

Resmetirom (MGL-3196) for the treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

Harrison, S. A., Bashir, M. R., Guy, C. D., Zhou, R., Moylan, C. A., Frias, J. P., Alkhouri, N., Bansal, M. B., Baum, S., Neuschwander-Tetri, B. A., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)32517-6 · Cited by 802 · see citing works

Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

Shimano, H. (2001) · Progress in Lipid Research · doi:10.1016/s0163-7827(01)00010-8 · Cited by 758 · see citing works

Direct effects of thyroid hormones on hepatic lipid metabolism

Sinha, R. A., Singh, B. K., & Yen, P. M. (2018) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2018.10 · Cited by 665 · see citing works

Structural and functional organization of the animal fatty acid synthase

Smith, S., Witkowski, A., & Joshi, A. K. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(02)00067-x · Cited by 646 · see citing works

Transcriptional regulation of hepatic lipogenesis

Wang, Y., Viscarra, J., Kim, S.-J., & Sul, H. S. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4074 · Cited by 646 · see citing works

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

Hu, X., & Lazar, M. A. (1999) · Nature · doi:10.1038/47069 · Cited by 642 · see citing works

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

Hua, X., Yokoyama, C., Wu, J. I., Briggs, M. R., Brown, M. S., Goldstein, J. L., & Wang, X. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11603 · Cited by 626 · see citing works

The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis

Rader, D. J., Alexander, E. T., Weibel, G. L., Billheimer, J. T., & Rothblat, G. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800088-jlr200 · Cited by 597 · see citing works

Combinatorial roles of the nuclear receptor corepressor in transcription and development.

Jepsen, K., Hermanson, O., Onami, T. M., Gleiberman, A., Lunyak, V., Mcevilly, R., Kurokawa, R., Kumar, V., Liu, F. C., Seto, E., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00064-7 · Cited by 545 · see citing works

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development

Xu, J., Liao, L., Ning, G., Yoshida‐Komiya, H., Deng, C., & O’Malley, B. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.120166297 · Cited by 534 · see citing works

ABCG5 and ABCG8 Are Obligate Heterodimers for Protein Trafficking and Biliary Cholesterol Excretion

Graf, G. A., Yu, L., Li, W., Gerard, R. D., Tuma, P. L., Cohen, J. C., & Hobbs, H. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m310223200 · Cited by 474 · see citing works

Mammalian mitochondrial β -oxidation

Eaton, S. D., Bartlett, K., & Pourfarzam, M. (1996) · Biochemical Journal · doi:10.1042/bj3200345 · Cited by 425 · see citing works

Fuel homeostasis in exercise.

Felig, P., & Wahren, J. (1975) · New England Journal of Medicine · doi:10.1056/nejm197511202932107 · Cited by 411 · see citing works

SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron

Jepsen, K., Solum, D., Zhou, T., McEvilly, R. J., Kim, H., Glass, C. K., Hermanson, O., & Rosenfeld, M. G. (2007) · Nature · doi:10.1038/nature06270 · Cited by 399 · see citing works

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

Bhaskara, S., Chyla, B., Amann, J. M., Knutson, S. K., Cortez, D., Sun, Z., & Hiebert, S. W. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.030 · Cited by 369 · see citing works

Use of the Thyroid Hormone Analogue Eprotirome in Statin-Treated Dyslipidemia

Ladenson, P. W., Kristensen, J. D., Ridgway, E. C., OLSSON, A. G., Carlsson, B., Klein, I. L., Baxter, J. D., & Angelin, B. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0905633 · Cited by 337 · see citing works

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

Magaña, M., & Osborne, T. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32689 · Cited by 336 · see citing works

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver

Dentin, R., Girard, J. R., & Postic, C. (2004) · Biochimie · doi:10.1016/j.biochi.2004.11.008 · Cited by 328 · see citing works

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

Sinha, R. A., You, S.-H., Zhou, J., Siddique, M. M., Bay, B.-H., Zhu, X., Privalsky, M. L., Cheng, S.-Y., Stevens, R. D., Summers, S. A., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60580 · Cited by 303 · see citing works

New insights into thyroid hormone action

Mendoza, A., & Hollenberg, A. N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.012 · Cited by 281 · see citing works

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

Teumer, A., Chaker, L., Groeneweg, S., Li, Y., Di Munno, C., Barbieri, C., Schultheiss, U. T., Traglia, M., Ahluwalia, T. S., Akiyama, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06356-1 · Cited by 280 · see citing works

Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo.

Thompson, G. R., Soutar, A. K., Spengel, F. A., Jadhav, A., GAVIGAN, S. J. P., & Myant, N. B. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.4.2591 · Cited by 272 · see citing works

Nonalcoholic Fatty Liver Disease and Hypercholesterolemia: Roles of Thyroid Hormones, Metabolites, and Agonists

Sinha, R. A., Bruinstroop, E., Singh, B. K., & Yen, P. M. (2019) · Thyroid · doi:10.1089/thy.2018.0664 · Cited by 272 · see citing works

Thyroid Hormone Regulation and Cholesterol Metabolism Are Connected through Sterol Regulatory Element-binding Protein-2 (SREBP-2)

Shin, D.-J., & Osborne, T. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305417200 · Cited by 266 · see citing works

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

Amemiya-Kudo, M., Shimano, H., Yoshikawa, T., Yahagi, N., Hasty, A. H., Okazaki, H., Tamura, Y., Shionoiri, F., Iizuka, Y., Ohashi, K., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005353200 · Cited by 257 · see citing works

Deacetylase-Independent Function of HDAC3 in Transcription and Metabolism Requires Nuclear Receptor Corepressor

Sun, Z., Feng, D., Fang, B., Mullican, S. E., You, S.-H., Lim, H., Everett, L. J., Nabel, C. S., Li, Y., Selvakumaran, V., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.10.022 · Cited by 247 · see citing works

Thyroid hormone regulation of hepatic lipid and carbohydrate metabolism

Sinha, R. A., Singh, B. K., & Yen, P. M. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.07.001 · Cited by 241 · see citing works

Human fatty acid synthase: properties and molecular cloning.

Jayakumar, A., Tai, M. H., Huang, W.-M., Al-Feel, W., Hsu, M. C., Abu-Elheiga, L. A., Chirala, S. S., & Wakil, S. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8695 · Cited by 231 · see citing works

Expression of ABCG5 and ABCG8 Is Required for Regulation of Biliary Cholesterol Secretion

Yu, L., Gupta, S. S., Xu, F., Liverman, A. D. B., Moschetta, A., Mangelsdorf, D. J., Repa, J. J., Hobbs, H. H., & Cohen, J. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411080200 · Cited by 230 · see citing works

Hyperlipidemia in Patients With Primary and Secondary Hypothyroidism

O’Brien, T., Dinneen, S. F., O'Brien, P. C., & Palumbo, P. J. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)60694-6 · Cited by 217 · see citing works

Liver X receptor and peroxisome proliferator‐activated receptor as integrators of lipid homeostasis and immunity

Kidani, Y., & Bensinger, S. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01153.x · Cited by 204 · see citing works

Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice

Johansson, L., Rudling, M. J., Scanlan, T. S., Lundåsen, T., Webb, P., Baxter, J. D., Angelin, B., & Parini, P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504379102 · Cited by 200 · see citing works

Thyroid Hormone Effects on Mitochondrial Energetics

Harper, M.-E., & Seifert, E. L. (2008) · Thyroid · doi:10.1089/thy.2007.0250 · Cited by 194 · see citing works

The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans

Berkenstam, A. L., Kristensen, J. D., Mellström, K., Carlsson, B., Malm, J., Rehnmark, S., Garg, N. K., Andersson, C., Rudling, M. J., Sjöberg, F., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705286104 · Cited by 191 · see citing works

Thyroid hormone excess and glucose intolerance

Dimitriadis, G., & Raptis, S. (2001) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2001-18584 · Cited by 179 · cited 1× · see citing works

Feedback and Hormonal Regulation of Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase: The Concept of Cholesterol Buffering Capacity

Ness, G. C., & Chambers, C. M. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22359.x · Cited by 168 · see citing works

Thyroid hormone attenuates and augments hepatic gene expression at a pretranslational level.

SEELIG, S. A., Liaw, C. W., Towle, H. C., et al. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.8.4733 · Cited by 167 · see citing works

Blood Cholesterol Values in Hyperthyroidism and Hypothyroidism — Their Significance

Mason, R. L., HUNT, H. M., & Hurxthal, L. M. (1930) · New England Journal of Medicine · doi:10.1056/nejm193012252032601 · Cited by 167 · see citing works

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

Oberoi, J., Fairall, L., Watson, P. J., Yang, J.-C., Czimmerer, Z., Kampmann, T., Goult, B. T., Greenwood, J. A., Gooch, J. T., Kallenberger, B. C., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1983 · Cited by 165 · see citing works

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature

Flamant, F., Cheng, S.-Y., Hollenberg, A. N., Moeller, L. C., Samarut, J., Wondisford, F. E., Yen, P. M., & Refetoff, S. (2017) · Endocrinology · doi:10.1210/en.2017-00250 · Cited by 165 · see citing works

Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist

Taub, R. A., Chiang, E., Chabot-Blanchet, M., Kelly, M. J., Reeves, R. A., Guertin, M., & Tardif, J. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.07.056 · Cited by 164 · see citing works

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

Ericsson, J., Jackson, S. M., Lee, B. C., & Edwards, P. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.945 · Cited by 161 · see citing works

Association Between Primary Hypothyroidism and Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis

Mantovani, A., Nascimbeni, F., Lonardo, A., Zoppini, G., Bonora, E., Mantzoros, C. S., & Targher, G. (2018) · Thyroid · doi:10.1089/thy.2018.0257 · Cited by 154 · see citing works

Direct Evidence for a Role of the “Spot 14” Protein in the Regulation of Lipid Synthesis

Kinlaw, W. B., Church, J. L., Harmon, J. S., & Mariash, C. N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16615 · Cited by 150 · see citing works

The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo

Astapova, I. I., Lee, L. J., Morales, C., Tauber, S., Bilban, M., & Hollenberg, A. N. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804604105 · Cited by 149 · see citing works

Effect of thyroid hormone on hepatic cholesterol 7α hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats

Ness, G. C., Pendleton, L. C., Li, Y. C., & Chiang, J. Y. L. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91568-d · Cited by 148 · see citing works

Thyroid hormone (T3) and TRβ agonist GC‐1 inhibit/reverse nonalcoholic fatty liver in rats

Perra, A., Simbula, G., Simbula, M., Pibiri, M., Kowalik, M. A., Sulas, P., Cocco, M. T., Ledda‐Columbano, G. M., & Columbano, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-108464 · Cited by 147 · see citing works

Association of non-alcoholic fatty liver disease with thyroid function: A systematic review and meta-analysis

Guo, Z., Li, M., Han, B., & Qi, X. (2018) · Digestive and Liver Disease · doi:10.1016/j.dld.2018.08.012 · Cited by 147 · see citing works

Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C.-Y., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aam5855 · Cited by 145 · see citing works

Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study

Sjouke, B., Langslet, G., Češka, R., Nicholls, S. J., Nissen, S. E., Öhlander, M., Ladenson, P. W., OLSSON, A. G., Hovingh, G. K., & Kastelein, J. J. P. (2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70006-3 · Cited by 142 · see citing works

Regulation and Functions of Autophagic Lipolysis

Cingolani, F., & Czaja, M. J. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.06.003 · Cited by 140 · see citing works

Activation of the hepatic LDL receptor promoter by thyroid hormone

Lopez, D., Abisambra, J. F., Bedi, M., & Ness, G. C. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.05.001 · Cited by 126 · see citing works

Rapid Effect of Triiodothyronine on the Mitochondrial Pathway in Rat Liver in Vivo

Sterling, K., Brenner, M. A., & SAKURADA, T. (1980) · Science · doi:10.1126/science.7423197 · Cited by 122 · see citing works

Presence of two polypeptide chains comprising fatty acid synthetase.

Stoops, J. K., Arslanian, M. J., Oh, Y. H., Aune, K. C., VANAMAN, T. C., & Wakil, S. J. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.5.1940 · Cited by 121 · see citing works

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J. G., Liao, X.-H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706801115 · Cited by 116 · see citing works

Genetics and phenomics of thyroid hormone transport by MCT8

Friesema, E. C. H., Visser, W. E., & Visser, T. J. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.01.016 · Cited by 115 · see citing works

3,5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet

Mollica, M. P., Lionetti, L., Moreno, M., Lombardi, A., de Lange, P., Antonelli, A., Lanni, A., Cavaliere, G., Barletta, A., & Goglia, F. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.03.023 · Cited by 109 · see citing works

Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

Bruinstroop, E., Dalan, R., Cao, Y., Bee, Y. M., Chandran, K., Cho, L. W., Soh, S. B., Teo, E. K., Toh, S.-A., Leow, M. K. S., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-00475 · Cited by 108 · see citing works

Thyroid hormone reduces PCSK9 and stimulates bile acid synthesis in humans

Bonde, Y., Breuer, O., Lütjohann, D., Sjöberg, S., Angelin, B., & Rudling, M. J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m051664 · Cited by 103 · see citing works

Effects of l-Triiodothyronine and the Thyromimetic L-94901 on Serum Lipoprotein Levels and Hepatic Low-Density Lipoprotein Receptor, 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase, and Apo A-I Gene Expression

Ness, G. C., Lopez, D., Chambers, C. M., Newsome, W. P., Cornelius, P. K., Long, C., & Harwood, H. J. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00119-1 · Cited by 99 · see citing works

SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCα transcription in hepatocytes

Zhang, Y., Yin, L., & Hillgartner, F. B. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200283-jlr200 · Cited by 97 · see citing works

A Thyroid Hormone Response Unit Formed between the Promoter and First Intron of the Carnitine Palmitoyltransferase-Iα Gene Mediates the Liver-specific Induction by Thyroid Hormone

Jackson‐Hayes, L., Song, S., Lavrentyev, E. N., Jansen, M. S., Hillgartner, F. B., Tian, L., Wood, P. A., Cook, G. A., & Park, E. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211062200 · Cited by 94 · see citing works

Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect.

Stapleton, S. R., Mitchell, D. A., Salati, L. M., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44772-7 · Cited by 91 · see citing works

Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations

Valdemarsson, S. V., Hansson, P., Hedner, P., & Nilsson‐Ehle, P. (1983) · European Journal of Endocrinology · doi:10.1530/acta.0.1040050 · Cited by 89 · see citing works

The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis

Astapova, I. I., Vella, K. R., Ramadoss, P., Holtz, K. A., Rodwin, B. A., Liao, X.-H., Weiss, R. E., Rosenberg, M. A., Rosenzweig, A., & Hollenberg, A. N. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0462 · Cited by 88 · see citing works

Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone

Holness, M. J., Bulmer, K., Smith, N. D., & Sugden, M. C. (2003) · Biochemical Journal · doi:10.1042/bj20021509 · Cited by 85 · see citing works

Effect of Thyroid Dysfunction on High-Density Lipoprotein Subfraction Metabolism: Roles of Hepatic Lipase and Cholesteryl Ester Transfer Protein1

Tan, K. C. B., Shiu, S. W. M., & Kung, A. W. C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.8.4938 · Cited by 85 · see citing works

Role of Sirtuin 1 in the Regulation of Hepatic Gene Expression by Thyroid Hormone

Thakran, S., Sharma, P., Attia, R. R., Hori, R. T., Deng, X., Elam, M. B., & Park, E. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.437970 · Cited by 84 · see citing works

LBP-20-VK2809, a Novel Liver-Directed Thyroid Receptor Beta Agonist, Significantly Reduces Liver Fat with Both Low and High Doses in Patients with Non-Alcoholic Fatty Liver Disease: A Phase 2 Randomized, Placebo-Controlled Trial

Loomba, R. S., Neutel, J., Mohseni, R., et al. (2019) · Journal of Hepatology · doi:10.1016/s0618-8278(19)30266-x · Cited by 84 · see citing works

Thyroid Hormone-Responsive SPOT 14 Homolog Promotes Hepatic Lipogenesis, and Its Expression Is Regulated By Liver X Receptor α Through a Sterol Regulatory Element-Binding Protein 1c–Dependent Mechanism in Mice

Wu, J., Wang, C., Li, S., Li, S., Wang, W., Li, J., Chi, Y., Yang, H., Kong, X., Zhou, Y., et al. (2013) · Hepatology · doi:10.1002/hep.26272 · Cited by 81 · see citing works

Mouse Sterol Response Element Binding Protein-1c Gene Expression Is Negatively Regulated by Thyroid Hormone

Hashimoto, K., Yamada, M., Matsumoto, S., Monden, T., Satoh, T., & Mori, M. (2006) · Endocrinology · doi:10.1210/en.2006-0116 · Cited by 80 · see citing works

Changes in Carnitine Palmitoyltransferase-I mRNA Abundance Produced by Hyperthyroidism and Hypothyroidism Parallel Changes in Activity

Mynatt, R. L., Park, E. A., Thorngate, F. E., Das, H. K., & Cook, G. A. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1791 · Cited by 77 · see citing works

Transcriptional and posttranscriptional regulation of rat hepatic 3-hydroxy-3-methylglutaryl-coenzyme A reductase by thyroid hormones.

Simonet, W. S., & Ness, G. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37775-5 · Cited by 73 · see citing works

Sterol Regulatory Element-binding Protein-1 Interacts with the Nuclear Thyroid Hormone Receptor to Enhance Acetyl-CoA Carboxylase-α Transcription in Hepatocytes

Yin, L., Zhang, Y., & Hillgartner, F. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111771200 · Cited by 71 · see citing works

Augmented Hepatic and Skeletal Thyromimetic Effects of Tiratricol in Comparison with Levothyroxine

Sherman, S. I., Ringel, M. D., Smith, M. J., Kopelen, H. A., Zoghbi, W. A., & Ladenson, P. W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2153 · Cited by 71 · see citing works

Role of CCAAT Enhancer-binding Protein β in the Thyroid Hormone and cAMP Induction of Phosphoenolpyruvate Carboxykinase Gene Transcription

Park, E. A., Song, S., Vinson, C., & Roesler, W. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.1.211 · Cited by 71 · see citing works

Benefits of Levothyroxine Replacement Therapy on Nonalcoholic Fatty Liver Disease in Subclinical Hypothyroidism Patients

Liu, L., Yu, Y., Zhao, M., Zheng, D., Zhang, X., Guan, Q., Xu, C., Gao, L., Zhao, J., & Zhang, H. (2017) · International Journal of Endocrinology · doi:10.1155/2017/5753039 · Cited by 71 · see citing works

Carbohydrate Response Element Binding Protein Gene Expression Is Positively Regulated by Thyroid Hormone

Hashimoto, K., Ishida, E., Matsumoto, S., Okada, S., Yamada, M., Satoh, T., Monden, T., & Mori, M. (2009) · Endocrinology · doi:10.1210/en.2009-0059 · Cited by 64 · see citing works

Thyroid Hormone Receptor β (TRβ) and Liver X Receptor (LXR) Regulate Carbohydrate-response Element-binding Protein (ChREBP) Expression in a Tissue-selective Manner

Gauthier, K. C., Billon, C., Bissler, M., Beylot, M., Lobaccaro, J. A., Vanacker, J.-M., & Samarut, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.146241 · Cited by 64 · see citing works

Triiodothyronine stimulates and cyclic AMP inhibits transcription of the gene for malic enzyme in chick embryo hepatocytes in culture

Salati, L. M., Ma, X. J., McCormick, C. C., Stapleton, S. R., & Goodridge, A. G. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)67894-4 · Cited by 63 · see citing works

Plasma Cholesteryl Ester Transfer Protein Activity in Hyper- and Hypothyroidism1

Tan, K. C. B., Shiu, S. W. M., & Kung, A. W. C. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.1.4491 · Cited by 63 · see citing works

Hepatic regulation of fatty acid synthase by insulin and T3: evidence for T3genomic and nongenomic actions

Radenne, A., Akpa, M. M., Martel, C., Sawadogo, S., Mauvoisin, D., & Mounier, C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90438.2008 · Cited by 60 · see citing works

Thyroid Hormone Stimulates Acetyl-CoA Carboxylase-α Transcription in Hepatocytes by Modulating the Composition of Nuclear Receptor Complexes Bound to a Thyroid Hormone Response Element

Zhang, Y., Yin, L., & Hillgartner, F. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005894200 · Cited by 59 · see citing works

Insulin resistance in Graves' disease: a quantitative<i>in‐vivo</i>evaluation

CAVALLO‐PERIN, P., BRUNO, A., BOINE, L., CASSADER, M., LENTI, G., & PAGANO, G. (1988) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1988.tb01275.x · Cited by 58 · cited 1× · see citing works

T3stimulates resting metabolism and UCP-2 and UCP-3 mRNA but not nonphosphorylating mitochondrial respiration in mice

Jekabsons, M. B., Gregoire, F. M., SCHONFELD-WARDEN, N. A., Warden, C. H., & Horwitz, B. A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.2.e380 · Cited by 58 · see citing works

3,5,3′triiodo‐L‐thyronine induces SREBP‐1 expression by non‐genomic actions in human HEP G2 cells

Gnoni, G. V., Rochira, A., Leone, A., et al. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22974 · Cited by 57 · see citing works

Thyroid Hormone Rapidly Induces Hepatic LDL Receptor mRNA Levels in Hypophysectomized Rats

Ness, G. C., & Zhao, Z. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1490 · Cited by 56 · see citing works

Reductions in serum levels of LDL cholesterol, apolipoprotein B, triglycerides and lipoprotein(a) in hypercholesterolaemic patients treated with the liver‐selective thyroid hormone receptor agonist eprotirome

Angelin, B., Kristensen, J. D., Eriksson, M., Carlsson, B., Klein, I. L., OLSSON, A. G., Ridgway, E. C., & Ladenson, P. W. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12261 · Cited by 55 · see citing works

NCoR1 and SMRT Play Unique Roles in Thyroid Hormone Action In Vivo

Shimizu, H., Astapova, I. I., Ye, F., Bilban, M., Cohen, R., & Hollenberg, A. N. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01208-14 · Cited by 54 · see citing works

Metabolomic analysis shows differential hepatic effects of T2 and T3 in rats after short-term feeding with high fat diet

Iannucci, L. F., Cioffi, F., Senese, R., Goglia, F., Lanni, A., Yen, P. M., & Sinha, R. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-02205-1 · Cited by 53 · see citing works

Thyroid hormone induction of human cholesterol 7 alpha-hydroxylase (Cyp7a1) in vitro

Lindemann, J. A. L., Angajala, A., Engler, D. A., Webb, P., & Ayers, S. D. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.02.003 · Cited by 52 · see citing works

Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex

Bonde, Y., Plösch, T., Kuipers, F., et al. (2012) · Hepatology · doi:10.1002/hep.25861 · Cited by 51 · see citing works

Steroid Receptor Coactivator-1 Deficiency Causes Variable Alterations in the Modulation of T3-Regulated Transcription of Genes in Vivo

Takeuchi, Y., Murata, Y., Sadow, P. M., Hayashi, Y., Seo, H., Xu, J., O’Malley, B. W., Weiss, R. E., & Refetoff, S. (2002) · Endocrinology · doi:10.1210/endo.143.4.8730 · Cited by 50 · see citing works

Relative rates of sterol synthesis in the liver and various extrahepatic tissues of normal and cholesterol-fed rabbits

Andersen, J. M., Turley, S. D., & Dietschy, J. M. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90056-x · Cited by 48 · see citing works

Stimulation of Hepatic β-Hydroxy-β-methylglutaryl Coenzyme A Reductase Activity in Hypophysectomized Rats by L-Triiodothyronine

Ness, G. C., Dugan, R. E., Lakshmanan, M. R., et al. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.12.3839 · Cited by 45 · see citing works

Identification of thyroid hormone response elements in the human fatty acid synthase promoter

Xiong, S., Chirala, S. S., Hsu, M. H., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12260 · Cited by 45 · see citing works

Plasma Cholesteryl Ester Transfer Protein Activity in Hyper- and Hypothyroidism

Tan, K. C. B. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.1.140 · Cited by 45 · see citing works

Human spot 14 protein interacts physically and functionally with the thyroid receptor

Chou, W., Cheng, Y., Ho, C., et al. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.103 · Cited by 41 · see citing works

Human Spot 14 Glucose and Thyroid Hormone Response: Characterization and Thyroid Hormone Response Element Identification

Campbell, M. C., Anderson, G. W., & Mariash, C. N. (2003) · Endocrinology · doi:10.1210/en.2002-0008 · Cited by 41 · see citing works

The Nuclear Receptor—Co-repressor Complex in Control of Liver Metabolism and Disease

Liang, N., Jakobsson, T., Fan, R., & Treuter, E. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00411 · Cited by 41 · see citing works

Atherogenic Lipoproteins in Subclinical Hypothyroidism and Their Relationship with Hepatic Lipase Activity: Response to Replacement Treatment with Levothyroxine

Brenta, G., Berg, G. A., Miksztowicz, V., Lopez, G. I., Lucero, D., Faingold, C., Murakami, M., Machima, T., Nakajima, K., & Schreier, L. E. (2016) · Thyroid · doi:10.1089/thy.2015.0140 · Cited by 36 · see citing works

The Chicken Malic Enzyme Gene: Structural Organization and Identification of Triiodothyronine Response Elements in the 5′-Flanking DNA

Hodnett, D. W., Fantozzi, D. A., Thurmond, D. C., et al. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0460 · Cited by 33 · see citing works

Metabolic Reprogramming by 3-Iodothyronamine (T1AM): A New Perspective to Reverse Obesity through Co-Regulation of Sirtuin 4 and 6 Expression

Assadi‐Porter, F. M., Reiland, H., Sabatini, M., Lorenzini, L., Carnicelli, V., Rogowski, M. P., Alpergin, E. S. S., Tonelli, M., Ghelardoni, S., Saba, A., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051535 · Cited by 32 · see citing works

Tissue-specific regulation of medium-chain acyl-CoA dehydrogenase gene by thyroid hormones in the developing rat

Djouadi, F., Riveau, B., Merlet-Bénichou, C., & Bastin, J. (1997) · Biochemical Journal · doi:10.1042/bj3240289 · Cited by 31 · see citing works

Comparative Efficacy and Side Effects of the Treatment of Euthyroid Goiter with Levo-Thyroxine or Triiodothyroacetic Acid

Brenta, G., Schnitman, M., Fretes, O., Facco, E., Gurfinkel, M., Damilano, S., Pacenza, N., Blanco, A., Gonzalez, E., & Pisarev, M. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030095 · Cited by 31 · see citing works

Regulation of hepatic triglyceride lipase by thyroid hormone in HepG2 cells

Kihara, S., Wölle, J., Ehnholm, C., et al. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39682-6 · Cited by 27 · see citing works

Age-related changes in the responsiveness of apolipoprotein A1 to thyroid hormone

Mooradian, A. D., Wong, N. C., & Shah, G. N. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.6.r1602 · Cited by 27 · see citing works

Role of CCAAT/enhancer-binding protein, histone acetylation, and coactivator recruitment in the regulation of malic enzyme transcription by thyroid hormone

Yin, L., Wang, Y., Dridi, S., et al. (2005) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2005.10.002 · Cited by 26 · see citing works

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels by L-triiodothyronine

Sample, C. E., Pendleton, L. C., & Ness, G. C. (1987) · Biochemistry · doi:10.1021/bi00377a011 · Cited by 25 · see citing works

T3-induced liver AMP-activated protein kinase signaling: Redox dependency and upregulation of downstream targets

Videla, L. A. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i46.17416 · Cited by 21 · see citing works

The influence of subclinical hypothyroidism on serum lipid profile, PCSK9 levels and CD36 expression on monocytes

Fazaeli, M., Khoshdel, A., Shafiepour, M., et al. (2018) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2018.08.021 · Cited by 18 · see citing works

CYP7A1Gene Polymorphism Located in the 5′ Upstream Region Modifies the Risk of Coronary Artery Disease

Iwanicki, T., Balcerzyk, A., Niemiec, P., et al. (2015) · Disease Markers · doi:10.1155/2015/185969 · Cited by 16 · see citing works

In vivo identification of promoter elements and transcription factors mediating activation of hepatic HMG-CoA reductase by T3

Boone, L. R., Niesen, M. I., Jaroszeski, M. J., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.05.093 · Cited by 16 · see citing works

Relationship between CYP7A1 -204A > C polymorphism with gallbladder stone disease and serum lipid levels: a meta-analysis

Cai, Q., Wang, Z., Cai, Q., et al. (2014) · Lipids in Health and Disease · doi:10.1186/1476-511x-13-126 · Cited by 15 · see citing works

A PHASE 1 RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTIPLE ASCENDING DOSE STUDY TO EVALUATE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF THE LIVER-SELECTIVE TR-BETA AGONIST VK2809 (MB07811) IN HYPERCHOLESTEROLEMIC SUBJECTS

Lian, B., Hanley, R. M., & Schoenfeld, S. (2016) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(16)31933-7 · Cited by 14 · see citing works

Nuclear corepressor SMRT is a strong regulator of body weight independently of its ability to regulate thyroid hormone action

Shimizu, H., Lu, Y., Vella, K. R., Damilano, F., Astapova, I. I., Amano, I., Ritter, M. J., Gallop, M. R., Rosenzweig, A. N., Cohen, R., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220717 · Cited by 12 · see citing works

Regulation of gene S-14 by triiodothyronine in liver.

Oppenheimer, J. H., Kinlaw, W. B., Wong, N. C., et al. (1987) · PubMed · Cited by 7 · see citing works

SREBP-1 integrates the actions of thyroid hormone, insulin, cAMP, and medium-chain fatty acids on ACCalpha transcription in hepatocytes

Zhang, Y., Yin, L., & Hillgartner, F. B. (2002) · The Research Repository @ WVU (West Virginia University) · Cited by 7 · see citing works

EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD).

Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works

Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans

Pafili, K., & Roden, M. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101122 · Cited by 330 · see citing works

NAFLD and thyroid function: pathophysiological and therapeutic considerations

Hatziagelaki, E., Paschou, S. A., Schön, M., Psaltopoulou, T., & Roden, M. (2022) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2022.08.001 · Cited by 93 · see citing works

Thyroid hormone resistance: mechanisms and therapeutic development

Yao, B., Yang, C., Pan, C., & Li, Y. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111679 · Cited by 26 · see citing works

Exercise Is Medicine for Nonalcoholic Fatty Liver Disease: Exploration of Putative Mechanisms

Heinle, J. W., DiJoseph, K., Sabag, A., Oh, S., Kimball, S. R., Keating, S., & Stine, J. G. (2023) · Nutrients · doi:10.3390/nu15112452 · Cited by 26 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

ИСПОЛЬЗОВAНИЕ ПОТЕНЦИAЛA СОЦИAЛЬНЫХ ПAРТНЕРОВ В ПОДГОТОВКЕ БУДУЩИХ ПЕДAГОГОВ

Атабекова, Б. Б. (2024) · Habaršy. Pedagogika ġylymdary seriâsy · doi:10.51889/2959-5762.2023.80.4.019

Exogenous Glucocorticoids and a High-Fat Diet Cause Severe Hyperglycemia and Hyperinsulinemia and Limit Islet Glucose Responsiveness in Young Male Sprague-Dawley Rats

Beaudry, J. L., D'souza, A. M., Teich, T., Tsushima, R. G., & Riddell, M. C. (2013) · Endocrinology · doi:10.1210/en.2012-2114 · Cited by 44 · see citing works

The Effect of Fasting on Tissue Cyclic cAMP and Plasma Glucagon in the Obese Hyperglycemic Mouse

VINE, R. L. L., Voyles, N. R., Perrino, P. V., & Recant, L. (1975) · Endocrinology · doi:10.1210/endo-97-3-615 · Cited by 38 · see citing works