CoChat
Sign Up
Cited by 109Inflammatory mediators and NSAID effectsImmune Response and InflammationEicosanoids and Hypertension Pharmacology

Prostaglandin E 2 as a Regulator of Immunity to Pathogens

Open access
Martínez-Colón, Giovanny J., Moore, Bethany B.·2018·Pharmacology & Therapeutics
DOI 10.1016/j.pharmthera.2017.12.008PMC PMC5898978
Open this paper in CoChat — free account

Abstract

The body is exposed to foreign pathogens every day, but remarkably, most pathogens are effectively cleared by the innate immune system without the need to invoke the adaptive immune response. Key cellular components of the innate immune system include macrophages and neutrophils and the recruitment and function of these cells are tightly regulated by chemokines and cytokines in the tissue space. Innate immune responses are also known to regulate development of adaptive immune responses often via the secretion of various cytokines. In addition to these protein regulators, numerous lipid mediators can also influence innate and adaptive immune functions. In this review, we cover one particular lipid regulator, prostaglandin E 2 (PGE 2) and describe its synthesis and signaling and what is known about the ability of this lipid to regulate immunity and host defense against viral, fungal and bacterial pathogens.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pharmthera.2017.12.008

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • PGE2 is an arachadonic acid metabolite with roles in ILC2, T helper cell, macrophage, dendritic cell, and neutrophil responses.

    “PGE2 is an arachadonic acid metabolite, with roles in ILC2, T helper cell, macrophage, dendritic cell, and neutrophil responses (Martínez-Colón and Moore, 2018).”

    From Modulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules (2018) · cites this paper as Martínez-Colón and Moore, 2018

    The PGE2 synthesis section describes PGE2 as a product of arachidonic acid metabolism. The adaptive-immunity section describes effects on dendritic cells and T-helper responses, while the innate-immune sections describe effects on macrophages and neutrophils. No passage found addresses ILC2 responses (searched: ILC2 and type 2 innate lymphoid cells). Page numbers were unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

1 retracted

Flagged first, then by citations

Research works printed but not linked: 160

  1. Agard M Asakrah S Morici LA 2013 PGE(2) suppression of innate immunity during mucosal bacterial infection Front Cell Infect Microbiol 3 45 23971009 PMC3748320
  2. Ahn KB Jeon JH Baik JE Park OJ Kang SS Yun CH Park JH Han SH 2014 Muramyl dipeptide potentiates staphylococcal lipoteichoic acid induction of cyclooxygenase-2 expression in macrophages Microbes Infect 16 153 160 24211871
  3. Akaogi J Yamada H Kuroda Y Nacionales DC Reeves WH Satoh M 2004 Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production J Leukoc Biol 76 227 236 Epub 2004 Apr 2001 15075356
  4. Allie SR Randall TD 2017 Pulmonary immunity to viruses Clin Sci (Lond) 131 1737 1762 28667071
  5. Almeida PE Roque NR Magalhaes KG Mattos KA Teixeira L Maya-Monteiro C Almeida CJ Castro-Faria-Neto HC Ryffel B Quesniaux VF Bozza PT 2014 Differential TLR2 downstream signaling regulates lipid metabolism and cytokine production triggered by Mycobacterium bovis BCG infection Biochim Biophys Acta 1841 97 107 24120921
  6. Aronoff DM Bergin IL Lewis C Goel D O’Brien E Peters-Golden M Mancuso P 2012 E-prostanoid 2 receptor signaling suppresses lung innate immunity against Streptococcus pneumoniae Prostaglandins Other Lipid Mediat 98 23 30 22575745 PMC3350638
  7. Aronoff DM Canetti C Peters-Golden M 2004 Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP J Immunol 173 559 565 15210817
  8. Aronoff DM Lewis C Serezani CH Eaton KA Goel D Phipps JC Peters-Golden M Mancuso P 2009 E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection J Immunol 183 2642 2649 19635910 PMC4016992
  9. Asselin-Paturel C Trinchieri G 2005 Production of type I interferons: plasmacytoid dendritic cells and beyond J Exp Med 202 461 465 16103406 PMC2212850
  10. Assis PA Espindola MS Paula-Silva FW Rios WM Pereira PA Leao SC Silva CL Faccioli LH 2014 Mycobacterium tuberculosis expressing phospholipase C subverts PGE2 synthesis and induces necrosis in alveolar macrophages BMC Microbiol 14 128 24886263 PMC4057917
  11. Ballinger MN Aronoff DM McMillan TR Cooke KR Olkiewicz K Toews GB Peters-Golden M Moore BB 2006 Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation J Immunol 177 5499 5508 17015736
  12. Ballinger MN McMillan TR Moore BB 2007 Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation Arch Immunol Ther Exp (Warsz) 55 1 12 17221337 PMC3313470
  13. Bankhurst AD 1982 The modulation of human natural killer cell activity by prostaglandins J Clin Lab Immunol 7 85 91 6951051
  14. Barber GN 2000 The interferons and cell death: guardians of the cell or accomplices of apoptosis? Semin Cancer Biol 10 103 111 10936061
  15. Behar SM Divangahi M Remold HG 2010 Evasion of innate immunity by Mycobacterium tuberculosis: is death an exit strategy? Nat Rev Microbiol 8 668 674 20676146 PMC3221965
  16. Bhattacharjee A Majumder S Das S Ghosh S Biswas S Majumdar S 2016 Leishmania donovani-Induced Prostaglandin E2 Generation Is Critically Dependent on Host Toll-Like Receptor 2-Cytosolic Phospholipase A2 Signaling Infect Immun 84 2963 2973 27481248 PMC5038066
  17. Black HS Rhodes LE 2016 Potential Benefits of Omega-3 Fatty Acids in Non-Melanoma Skin Cancer J Clin Med 5 PMC4773779 26861407
  18. Boniface K Bak-Jensen KS Li Y Blumenschein WM McGeachy MJ McClanahan TK McKenzie BS Kastelein RA Cua DJ de Waal Malefyt R 2009 Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling J Exp Med 206 535 548 19273625 PMC2699124
  19. Bordon AP Dias-Melicio LA Acorci MJ Calvi SA Serrao Peracoli MT Victoriano de Campos Soares AM 2007 Prostaglandin E2 inhibits Paracoccidioides brasiliensis killing by human monocytes Microbes Infect 9 744 747 17400014
  20. Branzk N Lubojemska A Hardison SE Wang Q Gutierrez MG Brown GD Papayannopoulos V 2014 Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens Nat Immunol 15 1017 1025 25217981 PMC4236687
  21. Brinkmann V Reichard U Goosmann C Fauler B Uhlemann Y Weiss DS Weinrauch Y Zychlinsky A 2004 Neutrophil extracellular traps kill bacteria Science 303 1532 1535 15001782
  22. Carey MA Bradbury JA Seubert JM Langenbach R Zeldin DC Germolec DR 2005 Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection J Immunol 175 6878 6884 16272346
  23. Castro M Ralston NV Morgenthaler TI Rohrbach MS Limper AH 1994 Candida albicans stimulates arachidonic acid liberation from alveolar macrophages through alpha-mannan and beta-glucan cell wall components Infect Immun 62 3138 3145 8039882 PMC302938
  24. Cayeux SJ Beverly PCL Schulz R Dorken B 1993 Elevated plasma prostaglandin E2 levels found in 14 patients undergoing autologous or stem cell transplantation Bone Marrow Transplant 12 603 608 7907905
  25. Chen H Chen L Cheng B Jiang C 2015 Cyclic mechanical stretching induces autophagic cell death in tenofibroblasts through activation of prostaglandin E2 production Cell Physiol Biochem 36 24 33 25924624
  26. Chen M Divangahi M Gan H Shin DS Hong S Lee DM Serhan CN Behar SM Remold HG 2008 Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2 and LXA4 in the induction of macrophage death J Exp Med 205 2791 2801 18955568 PMC2585850
  27. Cheng X Ji Z Tsalkova T Mei F 2008 Epac and PKA: a tale of two intracellular cAMP receptors Acta Biochim Biophys Sin (Shanghai) 40 651 662 18604457 PMC2630796
  28. Choi J Jo M Lee E Choi D 2014 ERK1/2 is involved in luteal cell autophagy regulation during corpus luteum regression via an mTOR-independent pathway Mol Hum Reprod 20 972 980 25107837
  29. Cockeran R Steel HC Mitchell TJ Feldman C Anderson R 2001 Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils Infect Immun 69 3494 3496 11292782 PMC98318
  30. Coomes SM Hubbard LL Moore BB 2011 Impaired pulmonary immunity post-bone marrow transplant Immunol Res 50 78 86 21170739 PMC3310400
  31. Coulombe F Jaworska J Verway M Tzelepis F Massoud A Gillard J Wong G Kobinger G Xing Z Couture C Joubert P Fritz JH Powell WS Divangahi M 2014 Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages Immunity 40 554 568 24726877
  32. Crofford LJ 1997 COX-1 and COX-2 tissue expression: implications and predictions J Rheumatol Suppl 49 15 19 9249646
  33. Degraaf AJ Zaslona Z Bourdonnay E Peters-Golden M 2014 Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation Am J Respir Cell Mol Biol 51 242 250 24601788 PMC4148041
  34. Dejani NN Brandt SL Pineros A Glosson-Byers NL Wang S Son YM Medeiros AI Serezani CH 2016 Topical Prostaglandin E Analog Restores Defective Dendritic Cell-Mediated Th17 Host Defense Against Methicillin-Resistant Staphylococcus Aureus in the Skin of Diabetic Mice Diabetes 65 3718 3729 27605625 PMC5127243
  35. Dennis EA Norris PC 2015 Eicosanoid storm in infection and inflammation Nat Rev Immunol 15 511 523 26139350 PMC4606863
  36. Deva R Shankaranarayanan P Ciccoli R Nigam S 2003 Candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in HeLa cells: pivotal roles of Toll-like receptors, p38 mitogen-activated protein kinase, and NF-kappa B J Immunol 171 3047 3055 12960330
  37. Dey I Lejeune M Chadee K 2006 Prostaglandin E2 receptor distribution and function in the gastrointestinal tract Br J Pharmacol 149 611 623 17016496 PMC2014644
  38. Divangahi M Desjardins D Nunes-Alves C Remold HG Behar SM 2010 Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis Nat Immunol 11 751 758 20622882 PMC3150169
  39. Dolan JM Weinberg JB O’Brien E Abashian A Procario MC Aronoff DM Crofford LJ Peters-Golden M Ward L Mancuso P 2016 Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice Am J Physiol Lung Cell Mol Physiol 310 L1111 1120 27059285 PMC4935474
  40. Domingo-Gonzalez R Katz S Serezani CH Moore TA Levine AM Moore BB 2013 Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant J Immunol 190 5809 5817 23630358 PMC3660503
  41. Domingo-Gonzalez R Martinez-Colon GJ Smith AJ Smith CK Ballinger MN Xia M Murray S Kaplan MJ Yanik GA Moore BB 2016 Inhibition of Neutrophil Extracellular Trap Formation after Stem Cell Transplant by Prostaglandin E2 Am J Respir Crit Care Med 193 186 197 26417909 PMC4731709
  42. Domingo-Gonzalez R Moore BB 2013 Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system Front Immunol 4 126 23745124 PMC3662877
  43. Domingo-Gonzalez R Wilke CA Huang SK Laouar Y Brown JP Freeman CM Curtis JL Yanik GA Moore BB 2015 Transforming growth factor-beta induces microRNA-29b to promote murine alveolar macrophage dysfunction after bone marrow transplantation Am J Physiol Lung Cell Mol Physiol 308 L86 95 25361568 PMC4281703
  44. Ejima K Layne MD Carvajal IM Kritek PA Baron RM Chen YH Vom Saal J Levy BD Yet SF Perrella MA 2003 Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death FASEB J 17 1325 1327 12738799
  45. Ells R Kock JL Albertyn J Pohl CH 2012 Arachidonic acid metabolites in pathogenic yeasts Lipids Health Dis 11 100 22873782 PMC3475069
  46. Erb-Downward JR Huffnagle GB 2007 Cryptococcus neoformans produces authentic prostaglandin E2 without a cyclooxygenase Eukaryot Cell 6 346 350 17158733 PMC1797952
  47. Erb-Downward JR Noverr MC 2007 Characterization of prostaglandin E2 production by Candida albicans Infect Immun 75 3498 3505 17470538 PMC1932954
  48. Fernandes RK Bachiega TF Rodrigues DR de Golim MA Dias-Melicio LA de Balderramas HA Kaneno R Soares AM 2015 Paracoccidioides brasiliensis interferes on dendritic cells maturation by inhibiting PGE2 production PLoS One 10 e0120948 25793979 PMC4368678
  49. Fleming BD Chandrasekaran P Dillon LA Dalby E Suresh R Sarkar A El-Sayed NM Mosser DM 2015 The generation of macrophages with anti-inflammatory activity in the absence of STAT6 signaling J Leukoc Biol 98 395 407 26048978 PMC4541501
  50. Full F Gack MU 2014 Prostaglandin E2: the villain in the host response to influenza virus Immunity 40 453 454 24745327
  51. Funk CD 2001 Prostaglandins and leukotrienes: advances in eicosanoid biology Science (New York, NY) 294 1871 1875 11729303
  52. Gerrard JM Stuart MJ Rao GH Steffes MW Mauer SM Brown DM White JG 1980 Alteration in the balance of prostaglandin and thromboxane synthesis in diabetic rats J Lab Clin Med 95 950 958 6445927
  53. Gill SK Yao Y Kay LJ Bewley MA Marriott HM Peachell PT 2016 The anti-inflammatory effects of PGE2 on human lung macrophages are mediated by the EP4 receptor Br J Pharmacol 173 3099 3109 27460634 PMC5056231
  54. Gordon S Pluddemann A Martinez Estrada F 2014 Macrophage heterogeneity in tissues: phenotypic diversity and functions Immunol Rev 262 36 55 25319326 PMC4231239
  55. Guo H Callaway JB Ting JP 2015 Inflammasomes: mechanism of action, role in disease, and therapeutics Nat Med 21 677 687 26121197 PMC4519035
  56. Gurczynski SJ Moore BB 2017 IL-17 in the lung: The Good, the Bad, and the Ugly Am J Physiol Lung Cell Mol Physiol ajplung 00344 02017 PMC6048455 28860146
  57. Hattermann K Picard S Borgeat M Leclerc P Pouliot M Borgeat P 2007 The Toll-like receptor 7/8-ligand resiquimod (R-848) primes human neutrophils for leukotriene B4, prostaglandin E2 and platelet-activating factor biosynthesis FASEB J 21 1575 1585 17264163
  58. Heckmann BL Boada-Romero E Cunha LD Magne J Green DR 2017 LC3-Associated Phagocytosis and Inflammation J Mol Biol PMC5743439 28847720
  59. Hua KF Chou JC Ka SM Tasi YL Chen A Wu SH Chiu HW Wong WT Wang YF Tsai CL Ho CL Lin CH 2015 Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1beta production J Cell Physiol 230 863 874 25294243
  60. Huang CY Tan TH 2012 DUSPs, to MAP kinases and beyond Cell Biosci 2 24 22769588 PMC3406950
  61. Hubbard L Wilke C White E Moore B 2011 PTEN Limits Alveolar Macrophage Function Against Pseudomonas aeruginosa Following Bone Marrow Transplantation Am J Respir Cell Mol Biol 45 1050 1058 21527775 PMC3361361
  62. Hubbard LL Ballinger MN Thomas PE Wilke CA Standiford TJ Kobayashi KS Flavell RA Moore BB 2010 A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation J Immunol 184 6299 6308 20439918 PMC4040537
  63. Hubbard LL Ballinger MN Wilke CA Moore BB 2008 Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant Exp Lung Res 34 263 275 18465404 PMC3309395
  64. Hurley BP Pirzai W Mumy KL Gronert K McCormick BA 2011 Selective eicosanoid-generating capacity of cytoplasmic phospholipase A2 in Pseudomonas aeruginosa-infected epithelial cells Am J Physiol Lung Cell Mol Physiol 300 L286 294 21097525 PMC3043809
  65. Iwahashi H Takeshita A Hanazawa S 2000 Prostaglandin E2 stimulates AP-1-mediated CD14 expression in mouse macrophages via cyclic AMP-dependent protein kinase A J Immunol 164 5403 5408 10799905
  66. Janssens S Beyaert R 2003 Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members Mol Cell 11 293 302 12620219
  67. Jarnaess E Tasken K 2007 Spatiotemporal control of cAMP signalling processes by anchored signalling complexes Biochem Soc Trans 35 931 937 17956249
  68. Jimenez R Belcher E Sriskandan S Lucas R McMaster S Vojnovic I Warner TD Mitchell JA 2005 Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle Proc Natl Acad Sci U S A 102 4637 4642 15755814 PMC555494
  69. Jonjic S Babic M Polic B Krmpotic A 2008 Immune evasion of natural killer cells by viruses Curr Opin Immunol 20 30 38 18206359 PMC2700287
  70. Kabashima K Sakata D Nagamachi M Miyachi Y Inaba K Narumiya S 2003 Prostaglandin E2-EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells Nat Med 9 744 749 12740571
  71. Kalinski P 2012 Regulation of immune responses by prostaglandin E2 J Immunol 188 21 28 22187483 PMC3249979
  72. Kalinski P Hilkens CM Snijders A Snijdewint FG Kapsenberg ML 1997 IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells J Immunol 159 28 35 9200435
  73. Kalo-Klein A Witkin SS 1990 Prostaglandin E2 enhances and gamma interferon inhibits germ tube formation in Candida albicans Infect Immun 58 260 262 2152888 PMC258440
  74. Kaul V Bhattacharya D Singh Y Van Kaer L Peters-Golden M Bishai WR Das G 2012 An important role of prostanoid receptor EP2 in host resistance to Mycobacterium tuberculosis infection in mice J Infect Dis 206 1816 1825 23033144 PMC3502376
  75. Kawai T Akira S 2011 Toll-like receptors and their crosstalk with other innate receptors in infection and immunity Immunity 34 637 650 21616434
  76. Kim SH Serezani CH Okunishi K Zaslona Z Aronoff DM Peters-Golden M 2011 Distinct protein kinase A anchoring proteins direct prostaglandin E2 modulation of Toll-like receptor signaling in alveolar macrophages J Biol Chem 286 8875 8883 21247892 PMC3058957
  77. Kim SO Dozier BL Kerry JA Duffy DM 2013 EP3 receptor isoforms are differentially expressed in subpopulations of primate granulosa cells and couple to unique G-proteins Reproduction 146 625 635 24062570 PMC3832896
  78. Klenerman P 2012 Viral infection and immunity: balancing protection and pathology QJM 105 103 104 22119919 PMC3235333
  79. Kobayashi H Kobayashi O Kawai S 2009 Pathogenesis and clinical manifestations of chronic colonization by Pseudomonas aeruginosa and its biofilms in the airway tract J Infect Chemother 15 125 142 19554398
  80. Kobayashi K Hernandez LD Galan JE Janeway CA Jr Medzhitov R Flavell RA 2002 IRAK-M is a negative regulator of Toll-like receptor signaling Cell 110 191 202 12150927
  81. Krause J Geginat G Tammer I 2015 Prostaglandin E2 from Candida albicans Stimulates the Growth of Staphylococcus aureus in Mixed Biofilms PLoS One 10 e0135404 26262843 PMC4532413
  82. Krause P Bruckner M Uermosi C Singer E Groettrup M Legler DF 2009 Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4–1BBL on dendritic cells Blood 113 2451 2460 19029446
  83. Kundu G Noverr MC 2011 Exposure to host or fungal PGE(2) abrogates protection following immunization with Candida-pulsed dendritic cells Med Mycol 49 380 394 21077736
  84. Laegreid WW Liggitt HD Silflow RM Evermann JR Taylor SM Leid RW 1989 Reversal of virus-induced alveolar macrophage bactericidal dysfunction by cyclooxygenase inhibition in vitro J Leukoc Biol 45 293 300 2539425
  85. Lee HS Lee CS Yang CJ Su SL Salter DM 2009 Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway Arthritis Res Ther 11 R48 19327173 PMC2688198
  86. Legler DF Krause P Scandella E Singer E Groettrup M 2006 Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors J Immunol 176 966 973 16393982
  87. Lehrer RI Ganz T Selsted ME Babior BM Curnutte JT 1988 Neutrophils and host defense Ann Intern Med 109 127 142 3289431
  88. Levitin A Whiteway M 2007 The effect of prostaglandin E2 on transcriptional responses of Candida albicans Microbiol Res 162 201 210 17433645
  89. Li H Edin ML Bradbury JA Graves JP DeGraff LM Gruzdev A Cheng J Dackor RT Wang PM Bortner CD Garantziotis S Jetten AM Zeldin DC 2013 Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB Am J Respir Crit Care Med 187 812 822 23449692 PMC3707371
  90. Li H Edin ML Gruzdev A Cheng J Bradbury JA Graves JP DeGraff LM Zeldin DC 2013 Regulation of T helper cell subsets by cyclooxygenases and their metabolites Prostaglandins Other Lipid Mediat 104–105 74 83 PMC3620713 23201570
  91. Liang L Zhang Q Luo LL Yue J Zhao YL Han M Liu LR Xiao HP 2016 Polymorphisms in the prostaglandin receptor EP2 gene confers susceptibility to tuberculosis Infect Genet Evol 46 23 27 27780787
  92. Lin CH Kuan IH Lee HM Lee WS Sheu JR Ho YS Wang CH Kuo HP 2001 Induction of cyclooxygenase-2 protein by lipoteichoic acid from Staphylococcus aureus in human pulmonary epithelial cells: involvement of a nuclear factor-kappa B-dependent pathway Br J Pharmacol 134 543 552 11588108 PMC1572984
  93. Lin CK Tseng CK Wu YH Liaw CC Lin CY Huang CH Chen YH Lee JC 2017 Cyclooxygenase-2 facilitates dengue virus replication and serves as a potential target for developing antiviral agents Sci Rep 7 44701 28317866 PMC5357798
  94. Liu G Yang H Chen X Wang X Chu Y 2013 Modulation of neutrophil development and homeostasis Curr Mol Med 13 1270 1283 23865426
  95. Liu Y Shepherd EG Nelin LD 2007 MAPK phosphatases--regulating the immune response Nat Rev Immunol 7 202 212 17318231
  96. Liu YC Zou XB Chai YF Yao YM 2014 Macrophage polarization in inflammatory diseases Int J Biol Sci 10 520 529 24910531 PMC4046879
  97. Martinez-Colon GJ Taylor QM Wilke CA Podsiad AB Moore BB 2017 Elevated prostaglandin E2 post-bone marrow transplant mediates interleukin-1beta-related lung injury Mucosal Immunol PMC5720939 28589946
  98. Medeiros AI Serezani CH Lee SP Peters-Golden M 2009 Efferocytosis impairs pulmonary macrophage and lung antibacterial function via PGE2/EP2 signaling J Exp Med 206 61 68 19124657 PMC2626688
  99. Moreno JJ 2017 Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis Eur J Pharmacol 796 7 19 27940058
  100. Mortimer L Moreau F MacDonald JA Chadee K 2016 NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations Nat Immunol 17 1176 1186 27548431
  101. Munoz-Planillo R Kuffa P Martinez-Colon G Smith BL Rajendiran TM Nunez G 2013 K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter Immunity 38 1142 1153 23809161 PMC3730833
  102. Nagamachi M Sakata D Kabashima K Furuyashiki T Murata T Segi-Nishida E Soontrapa K Matsuoka T Miyachi Y Narumiya S 2007 Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1 J Exp Med 204 2865 2874 17967902 PMC2118516
  103. Nauseef WM Borregaard N 2014 Neutrophils at work Nat Immunol 15 602 611 24940954
  104. Nishimura T Zhao X Gan H Koyasu S Remold HG 2013 The prostaglandin E2 receptor EP4 is integral to a positive feedback loop for prostaglandin E2 production in human macrophages infected with Mycobacterium tuberculosis FASEB J 27 3827 3836 23759445 PMC3752535
  105. Noverr MC Toews GB Huffnagle GB 2002 Production of prostaglandins and leukotrienes by pathogenic fungi Infect Immun 70 400 402 11748207 PMC127633
  106. O’Callaghan G Houston A 2015 Prostaglandin E2 and the EP receptors in malignancy: possible therapeutic targets? Br J Pharmacol 172 5239 5250 26377664 PMC5341220
  107. O’Dwyer DN Moore BB 2017 The role of periostin in lung fibrosis and airway remodeling Cell Mol Life Sci PMC5659879 28918442
  108. Ojielo CI Cooke K Mancuso P Standiford TJ Olkiewicz KM Clouthier S Corrion L Ballinger MN Toews GB Paine R 3rd Moore BB 2003 Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation J Immunol 171 4416 4424 14530368
  109. Omori K Kida T Hori M Ozaki H Murata T 2014 Multiple roles of the PGE2 -EP receptor signal in vascular permeability Br J Pharmacol 171 4879 4889 24923772 PMC4294111
  110. Pilli M Arko-Mensah J Ponpuak M Roberts E Master S Mandell MA Dupont N Ornatowski W Jiang S Bradfute SB Bruun JA Hansen TE Johansen T Deretic V 2012 TBK-1 promotes autophagy-mediated antimicrobial defense by controlling autophagosome maturation Immunity 37 223 234 22921120 PMC3428731
  111. Rangel Moreno J Estrada Garcia I De La Luz Garcia Hernandez M Aguilar Leon D Marquez R Hernandez Pando R 2002 The role of prostaglandin E2 in the immunopathogenesis of experimental pulmonary tuberculosis Immunology 106 257 266 12047755 PMC1782721
  112. Regan JW 2003 EP2 and EP4 prostanoid receptor signaling Life Sci 74 143 153 14607241
  113. Reid GK Kargman S Vickers PJ Mancini JA Leveille C Ethier D Miller DK Gillard JW Dixon RA Evans JF 1990 Correlation between expression of 5-lipoxygenase-activating protein, 5-lipoxygenase, and cellular leukotriene synthesis J Biol Chem 265 19818 19823 2174053
  114. Ricciotti E FitzGerald GA 2011 Prostaglandins and inflammation Arterioscler Thromb Vasc Biol 31 986 1000 21508345 PMC3081099
  115. Rogers LM Thelen T Fordyce K Bourdonnay E Lewis C Yu H Zhang J Xie J Serezani CH Peters-Golden M Aronoff DM 2014 EP4 and EP2 receptor activation of protein kinase A by prostaglandin E2 impairs macrophage phagocytosis of Clostridium sordellii Am J Reprod Immunol 71 34 43 23902376 PMC3864121
  116. Russel FG Koenderink JB Masereeuw R 2008 Multidrug resistance protein 4 (MRP4/ABCC4): a versatile efflux transporter for drugs and signalling molecules Trends Pharmacol Sci 29 200 207 18353444
  117. Sakata D Yao C Narumiya S 2010 Emerging roles of prostanoids in T cell-mediated immunity IUBMB Life 62 591 596 20665621
  118. Salina AC Souza TP Serezani CH Medeiros AI 2017 Efferocytosis-induced prostaglandin E2 production impairs alveolar macrophage effector functions during Streptococcus pneumoniae infection Innate Immun 23 219 227 28359217
  119. Sander WJ O’Neill HG Pohl CH 2017 Prostaglandin E2 As a Modulator of Viral Infections Front Physiol 8 89 28261111 PMC5306375
  120. Sanjuan MA Dillon CP Tait SW Moshiach S Dorsey F Connell S Komatsu M Tanaka K Cleveland JL Withoff S Green DR 2007 Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 450 1253 1257 18097414
  121. Schambelan M Blake S Sraer J Bens M Nivez MP Wahbe F 1985 Increased prostaglandin production by glomeruli isolated from rats with streptozotocin-induced diabetes mellitus J Clin Invest 75 404 412 3156147 PMC423505
  122. Serezani CH Chung J Ballinger MN Moore BB Aronoff DM Peters-Golden M 2007 Prostaglandin E2 suppresses bacterial killing in alveolar macrophages by inhibiting NADPH oxidase Am J Respir Cell Mol Biol 37 562 570 17585108 PMC2048683
  123. Serezani CH Kane S Medeiros AI Cornett AM Kim SH Marques MM Lee SP Lewis C Bourdonnay E Ballinger MN White ES Peters-Golden M 2012 PTEN directly activates the actin depolymerization factor cofilin-1 during PGE2-mediated inhibition of phagocytosis of fungi Sci Signal 5 ra12 22317922 PMC3400468
  124. Serhan CN Chiang N Dalli J Levy BD 2014 Lipid mediators in the resolution of inflammation Cold Spring Harb Perspect Biol 7 a016311 25359497 PMC4315926
  125. Sharma-Chawla N Sender V Kershaw O Gruber AD Volckmar J Henriques-Normark B Stegemann-Koniszewski S Bruder D 2016 Influenza A Virus Infection Predisposes Hosts to Secondary Infection with Different Streptococcus pneumoniae Serotypes with Similar Outcome but Serotype-Specific Manifestation Infect Immun 84 3445 3457 27647871 PMC5116722
  126. Shen L Liu Y 2015 Prostaglandin E2 blockade enhances the pulmonary anti-Cryptococcus neoformans immune reaction via the induction of TLR-4 Int Immunopharmacol 28 376 381 26122137
  127. Shi CS Kehrl JH 2010 TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy Sci Signal 3 ra42 20501938 PMC6335036
  128. Shibutani ST Saitoh T Nowag H Munz C Yoshimori T 2015 Autophagy and autophagy-related proteins in the immune system Nat Immunol 16 1014 1024 26382870
  129. Shinomiya S Naraba H Ueno A Utsunomiya I Maruyama T Ohuchida S Ushikubi F Yuki K Narumiya S Sugimoto Y Ichikawa A Oh-ishi S 2001 Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists Biochem Pharmacol 61 1153 1160 11301049
  130. Shishikura K Horiuchi T Sakata N Trinh DA Shirakawa R Kimura T Asada Y Horiuchi H 2016 Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP Br J Pharmacol 173 319 331 26505736 PMC5341226
  131. Singh SB Davis AS Taylor GA Deretic V 2006 Human IRGM induces autophagy to eliminate intracellular mycobacteria Science 313 1438 1441 16888103
  132. Smeekens SP van de Veerdonk FL van der Meer JW Kullberg BJ Joosten LA Netea MG 2010 The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2 Int Immunol 22 889 895 21059767
  133. Sokolowska M Chen LY Liu Y Martinez-Anton A Qi HY Logun C Alsaaty S Park YH Kastner DL Chae JJ Shelhamer JH 2015 Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages J Immunol 194 5472 5487 25917098 PMC4433768
  134. Somayaji SN Ritchie S Sahraei M Marriott I Hudson MC 2008 Staphylococcus aureus induces expression of receptor activator of NF-kappaB ligand and prostaglandin E2 in infected murine osteoblasts Infect Immun 76 5120 5126 18765718 PMC2573315
  135. Sugimoto Y Namba T Honda A Hayashi Y Negishi M Ichikawa A Narumiya S 1992 Cloning and expression of a cDNA for mouse prostaglandin E receptor EP3 subtype J Biol Chem 267 6463 6466 1372606
  136. Sugimoto Y Narumiya S 2007 Prostaglandin E receptors J Biol Chem 282 11613 11617 17329241
  137. Sui Z Shi Y Gao Z Yang D Wang Z 2017 Expression of programmed cell death1 in T follicular helper cells is regulated by prostaglandin E2 secreted by HBV-infected HepG2.2.1.5 cells Mol Med Rep 15 4305 4311 28440484
  138. Suram S Silveira LJ Mahaffey S Brown GD Bonventre JV Williams DL Gow NA Bratton DL Murphy RC Leslie CC 2013 Cytosolic phospholipase A(2)alpha and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation PLoS One 8 e69002 23950842 PMC3742295
  139. Szymanski KV Toennies M Becher A Fatykhova D N’Guessan PD Gutbier B Klauschen F Neuschaefer-Rube F Schneider P Rueckert J Neudecker J Bauer TT Dalhoff K Dromann D Gruber AD Kershaw O Temmesfeld-Wollbrueck B Suttorp N Hippenstiel S Hocke AC 2012 Streptococcus pneumoniae-induced regulation of cyclooxygenase-2 in human lung tissue Eur Respir J 40 1458 1467 22441740
  140. Tamma G Wiesner B Furkert J Hahm D Oksche A Schaefer M Valenti G Rosenthal W Klussmann E 2003 The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho J Cell Sci 116 3285 3294 12829746
  141. Tanaka K Hirai H Takano S Nakamura M Nagata K 2004 Effects of prostaglandin D2 on helper T cell functions Biochem Biophys Res Commun 316 1009 1014 15044085
  142. Tattoli I Sorbara MT Vuckovic D Ling A Soares F Carneiro LA Yang C Emili A Philpott DJ Girardin SE 2012 Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program Cell Host Microbe 11 563 575 22704617
  143. Tonby K Wergeland I Lieske NV Kvale D Tasken K Dyrhol-Riise AM 2016 The COX- inhibitor indomethacin reduces Th1 effector and T regulatory cells in vitro in Mycobacterium tuberculosis infection BMC Infect Dis 16 599 27776487 PMC5078976
  144. Uchiya K Nikai T 2004 Salmonella enterica serovar Typhimurium infection induces cyclooxygenase 2 expression in macrophages: involvement of Salmonella pathogenicity island 2 Infect Immun 72 6860 6869 15557607 PMC529151
  145. Valdez PA Vithayathil PJ Janelsins BM Shaffer AL Williamson PR Datta SK 2012 Prostaglandin E2 suppresses antifungal immunity by inhibiting interferon regulatory factor 4 function and interleukin-17 expression in T cells Immunity 36 668 679 22464170 PMC3334441
  146. Venkataprasad N Shiratsuchi H Johnson JL Ellner JJ 1996 Induction of prostaglandin E2 by human monocytes infected with Mycobacterium avium complex--modulation of cytokine expression J Infect Dis 174 806 811 8843220
  147. Venza I Visalli M Cucinotta M Teti D Venza M 2013 NOD2 triggers PGE2 synthesis leading to IL-8 activation in Staphylococcus aureus-infected human conjunctival epithelial cells Biochem Biophys Res Commun 440 551 557 24099766
  148. Villamon E Roig P Gil ML Gozalbo D 2005 Toll-like receptor 2 mediates prostaglandin E(2) production in murine peritoneal macrophages and splenocytes in response to Candida albicans Res Microbiol 156 115 118 15636756
  149. Wang D Dubois RN 2010 Eicosanoids and cancer Nat Rev Cancer 10 181 193 20168319 PMC2898136
  150. Wang Q 2004 Neutrophils in innate immunity Semin Respir Crit Care Med 25 33 41 16088447
  151. Wang SH Wang SC Chen PC Wang ST Liu YW 2017 Induction of cyclooxygenase-2 gene by Candida albicans through EGFR, ERK, and p38 pathways in human urinary epithelium Med Mycol 55 314 322 27664170
  152. Wang Y Ren B Zhou X Liu S Zhou Y Li B Jiang Y Li M Feng M Cheng L 2017 Growth and adherence of Staphylococcus aureus were enhanced through the PGE2 produced by the activated COX-2/PGE2 pathway of infected oral epithelial cells PLoS One 12 e0177166 28472126 PMC5417706
  153. Watabe A Sugimoto Y Honda A Irie A Namba T Negishi M Ito S Narumiya S Ichikawa A 1993 Cloning and expression of cDNA for a mouse EP1 subtype of prostaglandin E receptor J Biol Chem 268 20175 20178 7690750
  154. Wiktorowska-Owczarek A Berezinska M Nowak JZ 2015 PUFAs: Structures, Metabolism and Functions Adv Clin Exp Med 24 931 941 26771963
  155. Xing M Post S Ostrom RS Samardzija M Insel PA 1999 Inhibition of phospholipase A2-mediated arachidonic acid release by cyclic AMP defines a negative feedback loop for P2Y receptor activation in Madin-Darby canine kidney D1 cells J Biol Chem 274 10035 10038 10187781
  156. Yuan K Huang C Fox J Laturnus D Carlson E Zhang B Yin Q Gao H Wu M 2012 Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages J Cell Sci 125 507 515 22302984 PMC3283879
  157. Yun B Lee H Jayaraja S Suram S Murphy RC Leslie CC 2016 Prostaglandins from Cytosolic Phospholipase A2alpha/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages J Biol Chem 291 7070 7086 26841868 PMC4807289
  158. Zaslona Z Palsson-McDermott EM Menon D Haneklaus M Flis E Prendeville H Corcoran SE Peters-Golden M O’Neill LAJ 2017 The Induction of Pro-IL-1beta by Lipopolysaccharide Requires Endogenous Prostaglandin E2 Production J Immunol 198 3558 3564 28298525
  159. Zoccal KF Sorgi CA Hori JI Paula-Silva FW Arantes EC Serezani CH Zamboni DS Faccioli LH 2016 Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality Nat Commun 7 10760 26907476 PMC4766425
  160. Zuniga EI Macal M Lewis GM Harker JA 2015 Innate and Adaptive Immune Regulation During Chronic Viral Infections Annu Rev Virol 2 573 597 26958929 PMC4785831

Cited by

Sorted by citations

Authors
Martínez-Colón, G. J., & Moore, B. B.
Affiliations
University of Michigan (US)
Corresponding author
Moore, Bethany B.
ORCID
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
2018-05
Volume
185
Pages
135-146
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/j.pharmthera.2017.12.008
PMC
PMC5898978
OpenAlex
W2779758548
Cited by
109
References
6
Citations by year
2026: 9 · 2025: 14 · 2024: 15 · 2023: 8 · 2022: 17 · 2021: 21 · 2020: 16 · 2019: 5 · 2018: 4
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (5t32ai007413-32)
  • National Heart, Lung, and Blood Institute (R01HL119682, R01HL127805)
  • National Institute of General Medical Sciences (R25GM086262)
  • National Institute of Allergy and Infectious Diseases (T32-AI-007413, R01AI117229)
Topics
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
prostaglandin E2, innate immunity, host defense, macrophages, neutrophils, chemokines, cytokines, lipid mediators, viral pathogens, fungal pathogens, pathogenic bacteria, adaptive immune regulation
MeSH terms
Animals, Autophagy, Humans, Immunity, Innate, Infections, Dinoprostone, Toll-Like Receptors, Interleukin-1beta, Adaptive Immunity, Extracellular Traps

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review