Cited by 634Neutrophil, Myeloperoxidase and Oxidative MechanismsAntimicrobial Peptides and ActivitiesBlood disorders and treatments

NETs: a new strategy for using old weapons

Papayannopoulos, Venizelos, Zychlinsky, Arturo·2009·Trends in Immunology

Abstract

As key players in the host innate immune response, neutrophils are recruited to sites of infection and constitute the first line of defense. They employ three strategies to eliminate invading microbes: microbial uptake, the secretion of antimicrobials, and the recently described release of Neutrophil Extracellular Traps (NETs). Composed of decondensed chromatin and antimicrobial proteins, NETs bind and kill a variety of microbes including bacteria, fungi, and parasites. In addition to using a repertoire of known antimicrobials, NETs incorporate histones into the antimicrobial arsenal. Furthermore, NETs may contribute to microbial containment by forming a physical barrier and a scaffold, to enhance antimicrobial synergy while minimizing damage to host tissues. Their role in innate immunity is only now being uncovered.

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Crossref · 10.1016/j.it.2009.07.011

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  • Neutrophils can eliminate organisms residing in the extracellular environment through the deployment of neutrophil extracellular traps (NETs).

    “More recent evidence indicates that neutrophils can also eliminate organisms residing in the extracellular environment through the deployment of neutrophil extracellular traps (NETs).”

    From Immunology of Wound Healing (2018) · cites this paper as [41]

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Authors
Papayannopoulos, V., & Zychlinsky, A.
Affiliations
Max Planck Society (DE)
Corresponding author
Papayannopoulos, Venizelos
Venue
Trends in Immunology
Publisher
Elsevier BV
Published
2009-11
Volume
30
Issue
11
Pages
513-521
ISSN
1471-4906 (ISSN-L)
OpenAlex
W2101674426
Cited by
634
References
101
Citations by year
2026: 13 · 2025: 15 · 2024: 28 · 2023: 30 · 2022: 34 · 2021: 31 · 2020: 30 · 2019: 39 · 2018: 45 · 2017: 45 · 2016: 50 · 2015: 35 · 2014: 51 · 2013: 46 · 2012: 68
FWCI
3.72
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Blood disorders and treatments
Keywords
neutrophil extracellular traps, neutrophils, innate immunity, antimicrobial peptides, histones, chromatin, antimicrobial synergy
MeSH terms
Animals, Bacterial Infections, Chromatin, Histones, Humans, Immunity, Innate, Inflammation, Neutrophils, Phagocytosis, Cell Degranulation, Autoimmunity, Reactive Oxygen Species

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