Cited by 336Peroxisome Proliferator-Activated ReceptorsParaoxonase enzyme and polymorphismsLipid metabolism and disorders

The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.

The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

Yoon, Michung·2009·Pharmacological Research

DOI 10.1016/j.phrs.2009.02.004

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Abstract

Peroxisome proliferator-activated receptor alpha (PPARalpha) is a ligand-activated transcription factor that belongs to the steroid hormone receptor superfamily. PPARalpha is expressed predominantly in tissues that have a high level of fatty acid catabolism, such as liver, heart, and muscle. PPARalpha regulates the expression of a number of genes critical for lipid and lipoprotein metabolism. PPARalpha ligand fibrates have been used for the treatment of dyslipidemia due to their ability to lower plasma triglyceride levels and elevate HDL cholesterol levels. PPARalpha activators have been shown to regulate obesity in rodents by both increasing hepatic fatty acid oxidation and decreasing the levels of circulating triglycerides responsible for adipose cell hypertrophy and hyperplasia. However, these effects of PPARalpha on obesity and lipid metabolism may be exerted with sexual dimorphism and seem to be influenced by estrogen. Estrogen inhibits the actions of PPARalpha on obesity and lipid metabolism through its effects on PPARalpha-dependent regulation of target genes. Thus, the use of fibrates seems to be effective in men and postmenopausal women with obesity and lipid disorders, but not in premenopausal women with functioning ovaries.

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The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,115
Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116
Roles of PPARs in health and disease
Kersten, S., Desvergne, B., & Wahli, W. (2000) · Nature · doi:10.1038/35013000 · Cited by 1,956
The PPARs: From Orphan Receptors to Drug Discovery
Willson, T. M., Brown, P. J., Sternbach, D. D., & Henke, B. R. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990554g · Cited by 1,816
Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism
Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E., & Fruchart, J.-C. (1998) · Circulation · doi:10.1161/01.cir.98.19.2088 · Cited by 1,786
Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators
Lee, S. S. T., Pineau, T., Drago, J., Lee, E. J., Owens, J. W., Kroetz, D. L., Fernández‐Salguero, P. M., Westphal, H., & Gonzalez, F. J. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3012 · Cited by 1,652

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Kang, H. S., Kim, M., Kim, S.-J., Lee, J., Kim, Y.-D., Seo, Y., Bae, J., Oh, G.-T., Song, D., Ahn, Y., et al. (2015) · Biochemical Journal · doi:10.1042/bj20141248 · Cited by 18
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Asyifah, M. R., Lu, K., Yip, Y. M., & Zhang, D. (2015) · Food & Function · doi:10.1039/c5fo01208b · Cited by 18
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Zhao, Q., Zhu, Y., Best, L. G., Umans, J. G., Uppal, K., Tran, V. T., Jones, D. P., Lee, E. T., Howard, B. V., & Zhao, J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159548 · Cited by 18
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Mukai, K., Hara, S., Sakima, K., Nozu, R., Yazawa, T., & Kitano, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.878286 · Cited by 17
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Dinda, B., & Dinda, M. (2022) · Springer eBooks · doi:10.1007/978-3-030-92196-5_4 · Cited by 20
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Shin, S. S., Park, D., Lee, H. Y., Hong, Y., Choi, J., Oh, J.-H., Lee, H., Lee, H. R., Kim, M.-R., Shen, Z. B., et al. (2011) · Pharmaceutical Biology · doi:10.3109/13880209.2011.618502 · Cited by 18
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Authors: Yoon, M.
Affiliations: Mokwon University (KR)
Corresponding author: Yoon, Michung
ORCID: Yoon, Michung
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2009-09
Volume: 60
Issue: 3
Pages: 151-159
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2009.02.004
OpenAlex: W2026756943
Cited by: 336
References: 155
Citations by year: 2026: 12 · 2025: 25 · 2024: 13 · 2023: 23 · 2022: 33 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 25 · 2017: 15 · 2016: 16 · 2015: 15 · 2014: 18 · 2013: 14 · 2012: 17
FWCI: 7.11
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: PPARα, estrogen, obesity, lipid metabolism, fibrates, dyslipidemia, hepatic fatty acid oxidation, triglycerides, HDL cholesterol, sexual dimorphism, postmenopausal women, premenopausal women, lipoprotein metabolism
MeSH terms: Animals, Estrogens, Female, Humans, Male, Obesity, PPAR alpha, Lipid Metabolism

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The role of PPARα in lipid metabolism and obesity: Focusing on the effects of estrogen on PPARα actions

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