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Tea and cardiovascular disease
Open accessAbstract
There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect. We also review observational and intervention studies that investigated an effect of tea and tea extracts on cardiovascular risk factors, including blood pressure, serum lipids, diabetes mellitus, and obesity. Finally, we review potential mechanisms of benefit, including anti-inflammatory, anti-oxidant, and anti-proliferative effects, as well as favorable effects on endothelial function. Overall, the observational data suggest a benefit, but results are mixed and likely confounded by lifestyle and background dietary factors. The weight of evidence indicates favorable effects on risk factors and a number of plausible mechanisms have been elucidated in experimental and translational human studies. Despite the growing body evidence, it remains uncertain whether tea consumption should be recommended to the general population or to patients as a strategy to reduce cardiovascular risk.
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“In addition, the consumption of L-THE is associated with antihypertensive [12,13], anti-inflammatory properties [8] as well as improvements in cognitive functioning in healthy adults [14] and when consumed in combination with caffeine [10].”
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Metadata
- Authors
- Deka, A., & Vita, J. A.
- Affiliations
- Boston University (US)
- Corresponding author
- Vita, Joseph A.
- ORCID
- Vita, Joseph A.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2011-08
- Volume
- 64
- Issue
- 2
- Pages
- 136-145
- ISSN
- 1043-6618 (ISSN-L)
- PMC
- PMC3123419
- OpenAlex
- W1966599364
- Cited by
- 184
- References
- 163
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 19 · 2013: 19 · 2012: 14
- FWCI
- 13.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- U.S. Food and Drug Administration
- DSM Nutritional Products
- National Heart, Lung, and Blood Institute (R01HL102299, HL081587, P50HL083801, HL083269, K12HL083781, P01HL081587, R01HL075795, HL75795, R01HL083269, HL083801, HL102299)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
- Keywords
- tea consumption, cardiovascular disease, cardiovascular risk factors, blood pressure, serum lipids, diabetes mellitus, obesity, anti-inflammatory activity, antioxidant activity, antiproliferative activity, endothelial function, tea extract, lifestyle confounding
- MeSH terms
- Animals, Cardiovascular Diseases, Humans, Risk Factors, Tea
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