Cited by 184Tea Polyphenols and EffectsPhytochemicals and Antioxidant ActivitiesCoffee research and impacts

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Tea and cardiovascular disease

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Deka, Apranta, Vita, Joseph A.·2011·Pharmacological Research

DOI 10.1016/j.phrs.2011.03.009PMC PMC3123419

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Abstract

There is increasing evidence for a protective effect of tea consumption against cardiovascular disease. This review summarizes the available epidemiological data providing evidence for and against such an effect. We also review observational and intervention studies that investigated an effect of tea and tea extracts on cardiovascular risk factors, including blood pressure, serum lipids, diabetes mellitus, and obesity. Finally, we review potential mechanisms of benefit, including anti-inflammatory, anti-oxidant, and anti-proliferative effects, as well as favorable effects on endothelial function. Overall, the observational data suggest a benefit, but results are mixed and likely confounded by lifestyle and background dietary factors. The weight of evidence indicates favorable effects on risk factors and a number of plausible mechanisms have been elucidated in experimental and translational human studies. Despite the growing body evidence, it remains uncertain whether tea consumption should be recommended to the general population or to patients as a strategy to reduce cardiovascular risk.

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Authors: Deka, A., & Vita, J. A.
Affiliations: Boston University (US)
Corresponding author: Vita, Joseph A.
ORCID: Vita, Joseph A.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2011-08
Volume: 64
Issue: 2
Pages: 136-145
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2011.03.009
PMC: PMC3123419
OpenAlex: W1966599364
Cited by: 184
References: 163
Citations by year: 2026: 5 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 17 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 15 · 2017: 9 · 2016: 9 · 2015: 13 · 2014: 19 · 2013: 19 · 2012: 14
FWCI: 13.46
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
U.S. Food and Drug Administration
DSM Nutritional Products
National Heart, Lung, and Blood Institute (R01HL102299, HL081587, P50HL083801, HL083269, K12HL083781, P01HL081587, R01HL075795, HL75795, R01HL083269, HL083801, HL102299)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Tea Polyphenols and Effects
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
Keywords: tea consumption, cardiovascular disease, cardiovascular risk factors, blood pressure, serum lipids, diabetes mellitus, obesity, anti-inflammatory activity, antioxidant activity, antiproliferative activity, endothelial function, tea extract, lifestyle confounding
MeSH terms: Animals, Cardiovascular Diseases, Humans, Risk Factors, Tea

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