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Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety

Pitsikas, N., Boultadakis, A., Georgiadou, G., Tarantilis, P.A., Sakellaridis, N.·2008·Phytomedicine
DOI 10.1016/j.phymed.2008.06.005
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Abstract

Crocus sativus L. is a plant cultivated in various parts of the world. Crocins are among the active components of Crocus sativus L. The present study was designed to investigate in the rat whether or not crocins possess anxiolytic properties. For this aim, the light/dark test was selected. Either crocins, at a dose which did not influence animals' motor activity (50mg/kg), or diazepam (1.5 mg/kg), significantly increased the latency to enter the dark compartment and prolonged the time spent in the lit chamber in the rats. Conversely, lower doses of crocins (15-30 mg/kg) did not substantially modify animals' behaviour. The present results indicate that treatment with these active constituents of Crocus sativus L. induce anxiolytic-like effects in the rat.

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Research works printed but not linked: 24

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Metadata

Authors
Pitsikas, N., Boultadakis, A., Georgiadou, G., Tarantilis, P. A., & Sakellaridis, N.
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2008-12
Volume
15
Issue
12
Pages
1135-1139
ISSN
0944-7113
DOI
10.1016/j.phymed.2008.06.005
Cited by
114
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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