Crocus sativus L. versus citalopram in the treatment of major depressive disorder with anxious distress: a double-blind, controlled clinical trial
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Abstract Introduction: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. Methods: 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. Results: 60 participants finished the study. Patients who received either saffron or citalopram showed significant improvement in scores of the Hamilton Rating Scale for Depression (P-value<0.001 in both groups) and Hamilton Rating Scale for Anxiety (P-value<0.001 in both groups). Comparison of score changes between the 2 trial arms showed no significant difference (P-value=0.984). Frequency of side effects was not significantly different between the 2 groups. Discussion: The present study indicates saffron as a potential efficacious and tolerable treatment for major depressive disorder with anxious distress.
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Vilazodone was more effective in 708 patients with anxious depression than in 155 patients with nonanxious depression, although the sample size of those with nonanxious depression was very small.
“Also, vilazodone -a serotonin reuptake inhibitor and 5-hydroxytryptamine 1A receptor partial antagonist -was more effective in 708 patients with anxious depression than in 155 patients with nonanxious depression, although the sample size of those with nonanxious depression was very small [59].”
From Patients with anxious depression: overview of prevalence, pathophysiology and impact on course and treatment outcome (2018) · cites this paper as [59]
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Saffron and its major constituents against neurodegenerative diseases: A mechanistic review
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Self-citationClinical Evidence on the Effects of Saffron (Crocus Sativus L.) in Anxiety and Depression
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Stigma and petals of Crocus sativus L.: Review and comparison of phytochemistry and pharmacology
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Saffron as a Promising Therapy for Inflammatory Bowel Disease
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Saffron the “Red Gold” and Its CNS Activity: A Challenge for Future Applications in Nutraceuticals
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Saffron and Neurological Disorders
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Self-citationRole of Muscarinic Receptors in Hypoalgesia Induced by Crocin in Neuropathic Pain Rats
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Self-citationIs Really Crocus Sativus as Effective as Citalopram in the Treatment of Depression?
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Author’s Reply to the Letter to the Editor by Fountoulakis
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Self-citationBENEFÍCIOS DAS PLANTAS MEDICINAIS NO TRATAMENTO DA ANSIEDADE E DEPRESSÃO
da Silva, S. T., & Silva, J. E. D. S. (2021) · doi:10.22533/at.ed.4292129074
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ANSIOLÍTICOS FITOTERÁPICOS COMO ADJUVANTES NO TRATAMENTO DA ANSIEDADE: UMA REVISÃO SISTEMÁTICA
Silva, Í. R. J. E., Júnior, D. A. L., Giló, L. A., Machado, P. P. L., Marques, T. B. D., & Pereira, J. L. (2021) · doi:10.22533/at.ed.4292129073
ISOLAMENTO E ATIVIDADE ANTICOAGULANTE DE POLISSACARÍDEOS SULFATADOS DE MACROALGAS MARINHAS VERMELHAS
Nogueira, J. D. L. F., da Costa, B. B., Moreira, T. A., Gianelli, J. L. D., & Cinelli, L. P. (2021) · doi:10.22533/at.ed.4292129075
MEDICAMENTOS À BASE DE CANABIDIOL NO BRASIL: UMA REVISÃO DE LITERATURA
Pereira, L. D. S., & de Oliveira, F. G. (2021) · doi:10.22533/at.ed.42921290715
França, B. V., & de Miranda, C. V. (2021) · doi:10.22533/at.ed.4292129077
ATIVIDADES BIOATIVAS PRESENTES NO ALECRIM (Rosmarinus officinalis)
Silva, E. R. S., da Silva, J. F., & Guedes, J. P. D. M. (2021) · doi:10.22533/at.ed.4292129072
EXTRAÇÃO DE CORANTES NATURAIS: PROPOSTA DE ENSINO PARA O CLUBE DE CIÊNCIAS E OS JOVENS CIENTISTAS
Miola, G. M. D. V. F., & Scalcon, A. (2021) · doi:10.22533/at.ed.42921290714
- Authors
- Ghajar, A., Neishabouri, S., Velayati, N., Jahangard, L., Matinnia, N., Haghighi, M., Ghaleiha, A., Afarideh, M., Salimi, S., Meysamie, A., & Akhondzadeh, S.
- Affiliations
- Roozbeh Hospital (IR)
- Hamedan University of Medical Sciences (IR)
- Baharloo Hospital (IR)
- Tehran University of Medical Sciences (IR)
- ORCID
- Venue
- Pharmacopsychiatry
- Publisher
- Georg Thieme Verlag KG
- Published
- 2016-10-04
- Volume
- 50
- Issue
- 04
- Pages
- 152-160
- ISSN
- 0176-3679 (ISSN-L)
- 1439-0795
- OpenAlex
- W2528662465
- Cited by
- 110
- References
- 71
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 8 · 2022: 14 · 2021: 28 · 2020: 14 · 2019: 7 · 2018: 9 · 2017: 6
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacopsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Saffron Plant Research Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- saffron, citalopram, major depressive disorder, anxious distress, antidepressant effects, anxiolytic effects, herbal medicine
- MeSH terms
- Adolescent, Adult, Aged, Antidepressive Agents, Anxiety, Depressive Disorder, Major, Major Depressive Disorder, Double-Blind Method, Female, Humans, Male, Phytotherapy, Middle Aged, Plant Extracts, Citalopram, Treatment Outcome, Crocus, Young Adult
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