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Drug-induced liver injury: A 2-year retrospective study of 1169 hospitalized patients in a single medical center

Woo, Hong Jung, Kim, Ha Yeon, Choi, Eun Sol, Cho, Young-hwan, Kim, Youngchul, Lee, Jang-Hoon, Jang, Eungyeong·2015·Phytomedicine
DOI 10.1016/j.phymed.2015.10.002
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Abstract

Background Although herbal medicines (HMs) are widely used in Asian and Western countries, medicinal information concerning their hepatic toxicity or interaction with conventional medicines (CMs) is sparse. Purpose The aim of our study was to estimate the prevalence of drug-induced liver injury (DILI) among total inpatients prescribed HMs or CMs. Furthermore, we noted all medications suspected to be associated with hepatotoxicity in the liver injury group during the period of hospitalization. Study design We retrospectively observed medical records of 1169 inpatients in a single medical center from January 2012 to July 2014. Methods Based on a database of the 1169 inpatients at a single medical center, we researched the occurrence rate and type of liver injury according to the criteria of the Council for International Organization of Medical Science (CIOMS). We also utilized a simplified Roussel Uclaf Causality Assessment Method (RUCAM) score for probable causality assessment between drugs and liver injury. Results Among a total of 1169 inpatients, 13 cases whose baseline LFTs had been in the normal range at admission had abnormal liver parameters at the time of follow-up, and 11 of them (0.94%) were attributed to drugs: 0.43% (5 of 1169) to HMs, 0.43% (5 of 1169) to CMs, and 0.09% (1 of 1169) to combined drug classes. Two of them were found to have liver injury because of pneumonia and sepsis. As for liver injury type, 8 cases were hepatocellular, 2 were cholestatic, and 1 w…

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Research works printed but not linked: 29

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Metadata

Authors
Woo, H. J., Kim, H. Y., Choi, E. S., Cho, Y.-H., Kim, Y., Lee, J.-H., & Jang, E.
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2015-12
Volume
22
Issue
13
Pages
1201-1205
ISSN
0944-7113
DOI
10.1016/j.phymed.2015.10.002
Cited by
30
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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