Effects of curcumin supplementation on blood glucose, insulin resistance and androgens in patients with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial
Abstract
Background Curcumin is a biologically active phytochemical ingredient found in turmeric. It has several pharmacologic effects that might benefit patients with polycystic ovary syndrome (PCOS). Objective We hypothesized curcumin to be effective in improving blood sugar levels, insulin resistance and hyperandrogenism in individuals with PCOS. Methods In a randomized double-blind placebo-controlled trial, individuals with PCOS were treated with curcumin (500 mg three times daily) or placebo for 12 weeks. Primary outcome measures were fasting plasma glucose (FPG), fasting insulin (FI), sex hormone levels, and hirsutism (Ferriman-Gallwey [mFG] score). Secondary outcomes included anthropometric measurements. Results Of 72 randomized individuals, 67 completed the trial. The two groups were comparable at baseline. At the end of the study, FPG and Dehydroepiandrosterone levels had decreased significantly in the intervention group compared to control (difference of change (post-pre) between intervention and placebo groups: -4.11 mg/dL; 95% CI: -8.35, -0.35 mg/dL; p = 0.033 and -26.53 microg/dL; 95% CI: -47.99, -4.34 µg/dL; p = 0.035, respectively). We also observed a statistically non-significant increase (p = 0.082) in Estradiol levels in the intervention group compared to control. No serious adverse events were reported throughout the trial. Conclusions Curcumin might be a safe and useful supplement to ameliorate PCOS-associated hyperandrogenemia and hyperglycemia. However, longer trials investigating different dosages in longer durations are needed to underpin these findings.
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In an RCT of 67 women, curcumin supplementation (500 mg three times daily for 12 weeks) significantly decreased fasting blood glucose and DHEA levels compared to placebo, but did not change fasting insulin levels.
“In a randomized controlled trial of 67 women, curcumin supplementation (500 mg three times daily for 12 weeks) significantly decreased fasting blood glucose and DHEA levels compared to placebo. However, there was no change in fasting insulin levels [202].”
Curcumin has demonstrated hypoglycemic and anti-inflammatory effects through reducing TNF-α and inhibiting oxidative stress markers.
“Curcumin, the active compound in turmeric (Curcuma longa), has demonstrated hypoglycemic and anti-inflammatory effects through its ability to reduce TNF-α and inhibit oxidative stress markers.”
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- Authors
- Heshmati, J., Moini, A., Sepidarkish, M., Morvaridzadeh, M., Salehi, M., Palmowski, A., Mojtahedi, M. F., & Shidfar, F.
- Affiliations
- Iran University of Medical Sciences (IR)
- Royan Institute (IR)
- Babol University of Medical Sciences (IR)
- Kermanshah University of Medical Sciences (IR)
- Stiftung Charité (DE)
- Roointan Arash Hospital (IR)
- Corresponding author
- Shidfar, Farzad
- ORCID
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 80
- Pages
- 153395
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W3093833227
- Cited by
- 142
- References
- 47
- Citations by year
- 2026: 19 · 2025: 35 · 2024: 27 · 2023: 27 · 2022: 14 · 2021: 20
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Keywords
- curcumin, polycystic ovary syndrome, insulin resistance, hyperandrogenism, blood glucose, fasting insulin, dehydroepiandrosterone, estradiol, hirsutism, Ferriman-Gallwey score, dietary supplementation, phytochemicals
- MeSH terms
- Adolescent, Adult, Androgens, Blood Glucose, Curcumin, Dehydroepiandrosterone, Double-Blind Method, Female, Hirsutism, Humans, Hyperglycemia, Insulin, Insulin Resistance, Middle Aged, Placebos, Polycystic Ovary Syndrome, Treatment Outcome, Dietary Supplements, Young Adult
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