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Anti-nociceptive effect of STW 5-II in rodent models of stress and post-inflammatory visceral hypersensitivity
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“At the same time, STW 5-II reduces neuronal activation (ERK1/2 phosphorylation) in the DRGs, thereby decreasing intestinal afferent sensitivity and reversing stress- and post-inflammatory-induced colonic hypersensitivity [39].”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [39]
In the citing paper
“More specifically, STW 5 desensitizes DRG sensory afferents (TRPA1/TRPV1) in the small intestine.”
From Plant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines (2026) · cites this paper as [39]
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Cites
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666
Castro, J., Harrington, A. M., Hughes, P. A., Martin, C. M., Ge, P., Shea, C. M., Jin, H., Jacobson, S., Hannig, G., Mann, E., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.017 · Cited by 295
Epigenetic modulation of chronic anxiety and pain by histone deacetylation
Tran, L., Schulkin, J., Ligon, C. O., & Greenwood-Van Meerveld, B. (2015) · Molecular Psychiatry · doi:10.1038/mp.2014.122 · Cited by 148
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Cited by
Pastras, P., Aggeletopoulou, I., Bali, M., & Triantos, C. (2026) · Nutrients · doi:10.3390/nu18020183 · Cited by 1
Metadata
- Authors
- Noor-Mohammadi, E., Yuan, T., Ligon, C. O., Ammar, R. M., Rabini, S., Johnson, A. C., & Greenwood-Van Meerveld, B.
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 135
- Pages
- 156167
- ISSN
- 0944-7113
- Cited by
- 5
- References
- 3
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Funders
- Bayer Consumer Health
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