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Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids

Elbadawi, Mohamed, Ammar, Ramy M., Aziz-Kalbhenn, Heba, Rabini, Sabine, Klauck, Sabine M., Dawood, Mona, Saeed, Mohamed E M, Kampf, Christopher J., Efferth, Thomas·2021·Phytomedicine
DOI 10.1016/j.phymed.2021.153589
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Research works printed but not linked: 42

  1. Al-Sadi, 2016, TNF-α modulation of intestinal tight junction permeability is mediated by NIK/IKK-α axis activation of the canonical NF-κB pathway, Am. J. Pathol., 186, 1151, 10.1016/j.ajpath.2015.12.016 · DOI
  2. An, 2016, Expression of inducible nitric oxide synthase in mast cells contributes to the regulation of inflammatory cytokines in irritable bowel syndrome with diarrhea, Neurogastroenterol. Motil., 28, 1083, 10.1111/nmo.12811 · DOI
  3. Baniasadi, 2016, Serum immune biomarkers in irritable bowel syndrome, Clin. Res. Hepatol. Gastroenterol., 40, 631, 10.1016/j.clinre.2015.12.013 · DOI
  4. Bhat, 2019, Tight junction proteins and signaling pathways in cancer and inflammation: a functional crosstalk, Front. Physiol., 10, 1
  5. Bourgine, 2012, Gene expression profiling of systems involved in the metabolism and the disposition of xenobiotics: comparison between human intestinal biopsy samples and colon cell lines, Drug Metab. Dispos., 40, 694, 10.1124/dmd.111.042465 · DOI
  6. Carco, 2020, Increasing evidence that irritable bowel syndrome and functional gastrointestinal disorders have a microbial pathogenesis, Front. Cell. Infect. Microbiol., 10, 1, 10.3389/fcimb.2020.00468 · DOI
  7. Chao, 2017, Aquaporins 1, 3 and 8 expression in irritable bowel syndrome rats’ colon via NF-κB pathway, Oncotarget, 8, 47175, 10.18632/oncotarget.17565 · DOI
  8. Cheng, 2015, Molecular and cellular mechanisms of tight junction dysfunction in the irritable bowel syndrome, Mol. Med. Rep., 12, 3257, 10.3892/mmr.2015.3808 · DOI
  9. Choghakhori, 2017, Inflammatory cytokines and oxidative stress biomarkers in irritable bowel syndrome: Association with digestive symptoms and quality of life, Cytokine, 93, 34, 10.1016/j.cyto.2017.05.005 · DOI
  10. Devriese, 2017, T84 monolayers are superior to Caco-2 as a model system of colonocytes, Histochem. Cell Biol., 148, 85, 10.1007/s00418-017-1539-7 · DOI
  11. Dunlop, 2006, Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes, Am. J. Gastroenterol., 101, 1288, 10.1111/j.1572-0241.2006.00672.x · DOI · Paper page
  12. Gillet, 2004, Microarray-based detection of multidrug resistance in human tumor cells by expression profiling of ATP-binding cassette transporter genes, Cancer Res., 64, 8987, 10.1158/0008-5472.CAN-04-1978 · DOI
  13. Hanning, 2021, Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review, Therap. Adv. Gastroenterol., 14, 1, 10.1177/1756284821993586 · DOI · Paper page
  14. He, 2017, Modulation of inflammation by toll-like receptor 4/nuclear factor-kappa B in diarrhea-predominant irritable bowel syndrome, Oncotarget, 8, 113957, 10.18632/oncotarget.23045 · DOI
  15. Hoser, 2013, Interactions of herbal constituents influences the effects of STW 5 on inflammatory processes and disturbed motility, Planta Med., 79, PN44, 10.1055/s-0033-1352387 · DOI
  16. Khayyal, 2013, Wirkung von STW 5-II, ein pflanzliches Präparat, bei DSS-induzierter Colitis, Z. Gastroenterol., 51, K44, 10.1055/s-0033-1352684 · DOI
  17. Kulling, 2018, Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia, PLoS One, 13, 1, 10.1371/journal.pone.0193429 · DOI
  18. Lacy, 2016, Bowel disorders, Gastroenterology, 150, 1393, 10.1053/j.gastro.2016.02.031 · DOI · Paper page
  19. Lechuga, 2017, Disruption of the epithelial barrier during intestinal inflammation: quest for new molecules and mechanisms, Biochim. Biophys. Acta - Mol. Cell Res., 1864, 1183, 10.1016/j.bbamcr.2017.03.007 · DOI
  20. Liang, 2014, Molecular aspects of tight junction barrier function, Curr. Opin. Pharmacol., 19, 84, 10.1016/j.coph.2014.07.017 · DOI
  21. Linsalata, 2018, Noninvasive biomarkers of gut barrier function identify two subtypes of patients suffering from diarrhoea predominant-IBS: a case-control study, BMC Gastroenterol., 18, 1, 10.1186/s12876-018-0888-6 · DOI
  22. Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 · DOI · Paper page
  23. Madisch, 2004, Treatment of functional dyspepsia with a herbal preparation: a double-blind, randomized, placebo-controlled, multicenter trial, Digestion, 69, 45, 10.1159/000076546 · DOI
  24. Madisch, 2004, Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial, Aliment. Pharmacol. Ther., 19, 271, 10.1111/j.1365-2036.2004.01859.x · DOI · Paper page
  25. Merker, 2016, Gastrointestinal organoids: how they gut it out, Dev. Biol., 420, 239, 10.1016/j.ydbio.2016.08.010 · DOI
  26. Mueller, 2009, A novel herbal preparation desensitizes mesenteric afferents to bradykinin in the rat small intestine, Neurogastroenterol. Motil., 21, 467, 10.1111/j.1365-2982.2008.01232.x · DOI
  27. Neurotransmission, 2018, Experimental models of irritable bowel syndrome and the role of the enteric neurotransmission, J. Clin. Med., 7, 4, 10.3390/jcm7010004 · DOI
  28. Ng, 2018, The role of inflammation in irritable bowel syndrome (IBS), J. Inflamm. Res., 11, 345, 10.2147/JIR.S174982 · DOI · Paper page
  29. Paragomi, 2014, Antinociceptive and antidiarrheal effects of pioglitazone in a rat model of diarrhoea-predominant irritable bowel syndrome: role of nitric oxide, Clin. Exp. Pharmacol. Physiol., 41, 118, 10.1111/1440-1681.12188 · DOI
  30. Pautz, 2010, Regulation of the expression of inducible nitric oxide synthase, Nitric Oxide - Biol. Chem., 23, 75, 10.1016/j.niox.2010.04.007 · DOI · Paper page
  31. Pearce, 2018, Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types, BMC Biol., 16, 1, 10.1186/s12915-018-0481-z · DOI
  32. Piche, 2014, Tight junctions and IBS - the link between epithelial permeability, low-grade inflammation, and symptom generation?, Neurogastroenterol. Motil., 26, 296, 10.1111/nmo.12315 · DOI
  33. Rösch, 2002, A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia, Z. Gastroenterol., 40, 401, 10.1055/s-2002-32130 · DOI
  34. Sayuk, 2015, Irritable bowel syndrome: modern concepts and management options, Am. J. Med., 128, 817, 10.1016/j.amjmed.2015.01.036 · DOI
  35. Schneider, 2016, Anti-inflammatory effects of herbal preparations STW5 and STW5-II in cytokine-challenged normal human colon cells, Front. Pharmacol., 7, 1, 10.3389/fphar.2016.00393 · DOI
  36. Shulman, 2014, Associations among gut permeability, inflammatory markers, and symptoms in patients with irritable bowel syndrome, J. Gastroenterol., 49, 1467, 10.1007/s00535-013-0919-6 · DOI
  37. Tornatore, 2012, The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation, Trends Cell Biol., 22, 557, 10.1016/j.tcb.2012.08.001 · DOI · Paper page
  38. Tsai, 2019, Protective effects of rosmarinic acid against selenite-induced cataract and oxidative damage in rats, Int. J. Med. Sci., 16, 729, 10.7150/ijms.32222 · DOI
  39. Vinson, 2020, Efficacy and safety of STW 5 II in patients with functional dyspepsia: results from a double-blind, randomized, multicenter trial, Z Gastroenterol., 58, 090
  40. Witt, 2019, Interactions between gut permeability and brain structure and function in health and irritable bowel syndrome, NeuroImage Clin., 21, 10.1016/j.nicl.2018.11.012 · DOI
  41. Yang, 2018, MicroRNA-221 induces autophagy through suppressing hdac6 expression and promoting apoptosis in pancreatic cancer, Oncol. Lett., 16, 7295
  42. Zhang, 2018, ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination, BMC Cancer, 18, 1, 10.1186/s12885-018-4539-7 · DOI

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Metadata

Authors
Elbadawi, M., Ammar, R. M., Aziz-Kalbhenn, H., Rabini, S., Klauck, S. M., Dawood, M., Saeed, M. E. M., Kampf, C. J., & Efferth, T.
ORCID
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2021-07
Volume
88
Pages
153589
ISSN
0944-7113
DOI
10.1016/j.phymed.2021.153589
Cited by
39
References
3
Language
en
Licence
Funders
Bayer AG

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CoChat. (2026). Citation check: Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids. https://app.cochat.ai/papers/10.1016/j.phymed.2021.153589
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Elbadawi, M., Ammar, R. M., Aziz-Kalbhenn, H., Rabini, S., Klauck, S. M., Dawood, M., Saeed, M. E. M., Kampf, C. J., & Efferth, T. (2021). Anti-inflammatory and tight junction protective activity of the herbal preparation STW 5-II on mouse intestinal organoids. Phytomedicine. https://doi.org/10.1016/j.phymed.2021.153589

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.