Jianpi Huayu decoction enhances the antitumor effect of doxorubicin via piezo1-mediated autophagy in hepatocellular carcinoma

Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024) · CA: a cancer journal for clinicians · doi:10.3322/caac.21834 · Cited by 27,064 · see citing works

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, L., Wei, J., & Liu, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.019 · Cited by 785 · see citing works

Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

Xu, Z., Han, X., Ou, D., Liu, T., Li, Z., Jiang, G., Liu, J., & Zhang, J. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10257-8 · Cited by 620 · see citing works

Risk Factors, Patterns, and Outcomes of Late Recurrence After Liver Resection for Hepatocellular Carcinoma: A Multicenter Study From China

Xu, X.-F., Xing, H., Han, J., Li, Z.-L., Lau, W.-Y., Zhou, Y.-H., Gu, W.-M., Wang, H., Chen, T.-H., Zeng, Y.-Y., et al. (2019) · JAMA Surgery · doi:10.1001/jamasurg.2018.4334 · Cited by 532 · see citing works

Inhibition of PI3K/Akt/mTOR pathway by apigenin induces apoptosis and autophagy in hepatocellular carcinoma cells

Yang, J., Pi, C., & Wang, G. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.072 · Cited by 457 · see citing works

Diverse Cellular Roles of Autophagy

Morishita, H., & Mizushima, N. (2019) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100818-125300 · Cited by 376 · see citing works

YAP signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation

Hasegawa, K., Fujii, S., Matsumoto, S., Tajiri, Y., Kikuchi, A., & Kiyoshima, T. (2020) · The Journal of Pathology · doi:10.1002/path.5553 · Cited by 193 · see citing works

Activation of Piezo1 contributes to matrix stiffness‐induced angiogenesis in hepatocellular carcinoma

Li, M., Zhang, X., Wang, M., Wang, Y., Qian, J., Xing, X., Wang, Z., You, Y., Guo, K., Chen, J., et al. (2022) · Cancer Communications · doi:10.1002/cac2.12364 · Cited by 181 · see citing works

Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle

Yu, H., Liu, C., Zhang, D., Men, H., Huo, L., Geng, Q., Wang, S., Gao, Y., Zhang, W., Zhang, Y., et al. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4839 · Cited by 138 · see citing works

Piezo1 impairs hepatocellular tumor growth via deregulation of the MAPK-mediated YAP signaling pathway

Liu, S., Xu, X., Fang, Z., Ning, Y., Deng, B., Pan, X., He, Y., Yang, Z., Huang, K., & Li, J. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102367 · Cited by 104 · see citing works

Tanshinone IIA synergistically enhances the antitumor activity of doxorubicin by interfering with the PI3K/AKT/mTOR pathway and inhibition of topoisomerase II: in vitro and molecular docking studies

Ghanem, A., Emara, H. A., Muawia, S., Maksoud, A. I. A. E., Al-Karmalawy, A. A., & Elshal, M. F. (2020) · New Journal of Chemistry · doi:10.1039/d0nj04088f · Cited by 91 · see citing works

Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice

Luo, S., Zhao, X., Jiang, J., Deng, B., Liu, S., Xu, H., Tan, Q., Chen, Y., Zhang, Z., Pan, X., et al. (2023) · Theranostics · doi:10.7150/thno.86103 · Cited by 76 · see citing works

Piezo1 promoted hepatocellular carcinoma progression and EMT through activating TGF-β signaling by recruiting Rab5c

Li, Y.-M., Xu, C., Sun, B., Zhong, F.-J., Cao, M., & Yang, L.-Y. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02574-2 · Cited by 52 · see citing works

Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway

Song, C., Hu, Y., Mang, Z., Zeng, Y., Chen, H.-D., Jing, D., Fan, G., Ji, S., Yu, X., Xu, X., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-01006-1 · Cited by 47 · see citing works

Novel PI3K/Akt/mTOR signaling inhibitor, W922, prevents colorectal cancer growth via the regulation of autophagy

Wang, J., Dong, L., Zhang, X., He, C., Cao, L., Zhang, S., Xiao, X., Li, S., & Cao, Y. (2020) · International Journal of Oncology · doi:10.3892/ijo.2020.5151 · Cited by 39 · see citing works

Mechanically activated ion channel Piezo1 contributes to melanoma malignant progression through AKT/mTOR signaling

Zhang, S., Cao, S., Gong, M., Zhang, W., Zhang, W., Zhu, Z., Wu, S., Yue, Y., Qian, W., Ma, Q., et al. (2022) · Cancer Biology & Therapy · doi:10.1080/15384047.2022.2060015 · Cited by 37 · see citing works

Shufeng Jiedu Capsule and its active ingredients induce apoptosis, inhibit migration and invasion, and enhances doxorubicin therapeutic efficacy in hepatocellular carcinoma

Xia, J., Rong, L., Sawakami, T., Inagaki, Y., Song, P., Hasegawa, K., Sakamoto, Y., & Tang, W. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.163 · Cited by 34 · see citing works

Huganpian, a traditional chinese medicine, inhibits liver cancer growth in vitro and in vivo by inducing autophagy and cell cycle arrest

Gao, X. J., Wang, Y., Li, Y., Wang, Y., Yan, M., Sun, H., Chen, S., & Pan, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109469 · Cited by 32 · see citing works

Chinese herbal medicine Feiyanning cooperates with cisplatin to enhance cytotoxicity to non-small-cell lung cancer by inhibiting protective autophagy

Zheng, Z., Ma, Y., Wang, L., Deng, H., Wang, Z., Li, J., & Zhen-ye, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.114196 · Cited by 24 · see citing works

Isoginkgetin Synergizes with Doxorubicin for Robust Co-delivery to Induce Autophagic Cell Death in Hepatocellular Carcinoma.

Wang, Y., Yi, Y.-F., Yao, J., Wan, H.-Q., Yu, M., Ge, L., Zeng, X.-B., Wu, M., & Mei, L. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.09.035 · Cited by 23 · see citing works

TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells

Yang, C., Li, Y., Hu, W., Wang, X., Hu, J., Chen, Y., Zhou, C., Wang, H., Du, J., Wang, Y., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.734818 · Cited by 21 · see citing works

Piezo1 Mediates Glycolysis-Boosted Pancreatic Ductal Adenocarcinoma Chemoresistance within a Biomimetic Three-Dimensional Matrix Stiffness.

Pan, H., Zhang, X., Zhu, S.-J., Zhu, B.-W., Wu, D., Yan, J., Guan, X., Huang, Y., Zhao, Y.-H., Yang, Y.-M., et al. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01319 · Cited by 20 · see citing works

The dual role of autophagy in suppressing and promoting hepatocellular carcinoma

Mohammed, W. H., Sulaiman, G. M., Abomughaid, M. M., Klionsky, D. J., & Abu-Alghayth, M. H. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1472574 · Cited by 19 · see citing works

PIEZO1 Promotes Odontoblast-Mediated Reactionary Dentinogenesis via SEMA3A

Huang, P., Jiang, R. X., Wang, F., Qiao, W., Ji, Y. T., Meng, L., & Bian, Z. (2024) · Journal of Dental Research · doi:10.1177/00220345241257866 · Cited by 19 · see citing works

SCF FBXW5 -mediated degradation of AQP3 suppresses autophagic cell death through the PDPK1-AKT-MTOR axis in hepatocellular carcinoma cells

Liang, Y., Chen, P., Wang, S., Cai, L., Zhu, F., Jiang, Y., Li, L., Zhu, L., Heng, Y., Zhang, W., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2353497 · Cited by 18 · see citing works

Taohong Siwu decoction enhances the chemotherapeutic efficacy of doxorubicin by promoting tumor vascular normalization

Cheng, Y., Li, J., Feng, X., Wu, Y., Wu, X., Lau, B. W.-M., Ng, S. S. M., Lee, S. M., Seto, S. W., Leung, G., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155995 · Cited by 17 · see citing works

Curcumin-induced cell death depends on the level of autophagic flux in A172 and U87MG human glioblastoma cells

Lee, J., Yoon, S.-S., Lee, J., & Moon, E. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)30012-1 · Cited by 15 · see citing works

Jianpi Huayu Decoction Inhibits the Epithelial–Mesenchymal Transition of Hepatocellular Carcinoma Cells by Suppressing Exosomal miR-23a-3p/Smad Signaling

Xie, C., Feng, K.-L., Wang, J.-N., Luo, R., Fang, C., Zhang, Y., Shen, C., & Zhong, C. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115360 · Cited by 14 · see citing works

JPHYD Inhibits miR-21-5p/Smad7-Mediated Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma Cells

Liu, L.-H., Fang, C., Ge, F.-C., Wang, J.-N., Zhang, X.-B., Luo, R., Zhang, Y., Feng, K.-L., Qiu, Z., & Zhong, C. (2022) · Journal of Oncology · doi:10.1155/2022/7823433 · Cited by 12 · see citing works

Hepatectomy versus transcatheter arterial chemoembolization for resectable BCLC stage A/B hepatocellular carcinoma beyond Milan criteria: A randomized clinical trial

Fang, C., Luo, R., Zhang, Y., Wang, J., Feng, K.-L., Liu, S., Chen, C., Yao, R., Shi, H., & Zhong, C. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1101162 · Cited by 12 · see citing works

Adjuvant therapy with Jianpi Huayu decoction improves overall and recurrence-free survival after hepatectomy for hepatocellular carcinoma: a retrospective propensity score-matching study

Luo, R., Fang, C., Chen, C., Zhang, Y., Yao, R., Wang, J., Shi, H., Feng, K.-L., Hu, M., & Zhong, C. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1212116 · Cited by 10 · see citing works

Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice

Lu, Y. Q., Zhang, S., Zhu, X., Wang, K., He, Y., Liu, C., Sun, J. M., Pan, J., Zheng, L., Liu, W., et al. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115968 · Cited by 10 · see citing works

Mechanistic insights into Yifei Sanjie pill's regulation of EMT to enhance gefitinib treatment effect in NSCLC by in silico analysis and experimental validation

Zhou, R.-S., Qin, B., Zhuang, Z., Li, J., Shi, Y., Gao, T., Wu, D., Yuan, Y., Tang, Y. C., & Lizhu, L. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118343 · Cited by 4 · see citing works

Qing Yan Li Ge Tang, a Chinese Herbal Formula, Induces Autophagic Cell Death through the PI3K/Akt/mTOR Pathway in Nasopharyngeal Carcinoma Cells In Vitro

Yang, C.-H., Tung, K.-L., Wu, Y.-T., Liu, C., Lin, S., Yang, C.-C., Wu, C., Chang, H., Wu, S.-Y., Huang, B., et al. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9925684 · Cited by 4 · see citing works

The dual role of Piezo1 in tumor cells and immune cells: a new target for cancer therapy

Qu, P., & Zhang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1635388 · Cited by 31 · see citing works

Mechanosensitive calcium ion channels Piezo1: A therapeutic target in liver disease

Liu, J., Wang, X., He, F., Chen, X., & Yi, X. (2025) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2025.102695 · Cited by 10 · see citing works

Jianpi-huayu Decotion regulates TREM1/DAP12 pathway to improve the immunosuppressive tumor microenvironment and enhance the anti-hepatocellular carcinoma effect of PD-1 inhibitors

Yao, R., Zhang, Y., Yu, W., Chen, X., Shi, H., Luo, R., Fang, C., Zhao, X., Zhu, X., Lai, Y., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120846 · Cited by 4 · see citing works

Chinese herbal medicines: the modifier of hepatocellular carcinoma targeting Wnt/β-catenin signaling pathway

Zhang, Y., Li, H., Jiang, N., & Ru, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1626251 · Cited by 2 · see citing works

Piezo1-Mediated Mechanotransduction in Cancer: A Comprehensive Up-to-Date Review of Emerging Mechanistic and Therapeutic Insights

Beyranvand, P. (2026) · Journal of Cancer Biomoleculars and Therapeutics · doi:10.62382/jcbt.v3i1.83 · Cited by 2 · see citing works

Downregulation of PIEZO1 Activity Promotes Breast Cancer Cell Survival under Shear Stress by Modulating β-Catenin and BCL2

Dattachoudhury, S., Sharma, A., Sharma, R. R., Pal, S., Sukumar, P., & Jaganathan, B. G. (2026) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0749 · Cited by 2 · see citing works

Jianpi Huayu decoction alleviates hepatic fibrosis involving coordinated modulation of PPARα-mediated lipid metabolic reprogramming and the ROCK pathway

Luo, R., Lai, Y., Zhang, S., Yao, R., He, P., Liu, S., Li, H., Chen, X., Shi, H., Huang, J.-M., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158496 · Cited by 1 · see citing works

The metastasis landscape of Clonorchis sinensis-associated hepatocellular carcinoma: an integrated multi-omics and clinical study

Zhou, L., Sun, L., Huang, X., Chen, J., Huang, T., Xu, Y., Luo, X., Wei, C., Liu, F., Pan, X., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1723156

Pachymic acid exhibits synergistic antitumor efficacy with lenvatinib in hepatocellular carcinoma by targeting PPARγ to inhibit glycolysis

Wang, Z., Wu, P., Zhang, C., Zhang, T., Gu, C., Xie, X., Feng, X., Zhou, Q., & Jiang, Z. (2026) · Medical Oncology · doi:10.1007/s12032-026-03398-0

The Dual Role of Piezo1 in Cancer: Mechanotransduction, Microenvironment Remodelling, and Therapeutic Opportunities

Jiang, H., Liu, Y., Xue, F., Sun, H., Ji, Y., & Qi, L. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s640902

Activation of mechanosensitive ion channel Piezo1 linking metabolic reprogramming and pro-inflammatory responses in hepatocellular carcinoma

Mo, J., Zhang, Y., Cao, C., Zheng, W., Zheng, L., Wang, X., Wang, S., Wu, J., & Bao, Y. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02289-7 · Cited by 14 · see citing works

Xiaoai Jiedu recipe reduces cell survival and induces apoptosis in hepatocellular carcinoma by stimulating autophagy via the AKT/mTOR pathway

Ji, Y., Li, L., Li, W., Li, L., Ma, Y., Li, Q., Chen, X., Zhao, W., Zhu, H., Huo, J., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.119135 · Cited by 11 · see citing works

Jianpi Huayu decoction induces hepatocellular carcinoma apoptosis through flavonoid components targeting tumor protein p53 activation and serine-threonine protein kinase 1/B-cell lymphoma 2 inhibition: a network pharmacology-based study with experimental validation.

Xiaokai, C. H. E. N., Yingjie, X. I. E., Hui, W. U., Yong, L. I., Yantong, L. U., Wei, T. A. N., Changjun, W. A. N. G., & HUANG, X. (2026) · PubMed Central · doi:10.19852/j.cnki.jtcm.2026.05.012

Isoginkgetin Synergizes with Doxorubicin for Robust Co-delivery to Induce Autophagic Cell Death in Hepatocellular Carcinoma.

Wang, Y., Yi, Y.-F., Yao, J., Wan, H.-Q., Yu, M., Ge, L., Zeng, X.-B., Wu, M., & Mei, L. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.09.035 · Cited by 23 · see citing works

Bushen-Jianpi dedoction prolong survival of hepatocellular carcinoma patients involved in apoptosis induction of hepatoma cells by regulating PI3K-Akt-mTOR signal pathway

Su, S.-B., Wu, R., Li, X., Cai, F., & Yang, M. (2018) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.wcp2018.0_po1-9-13