Hippocampal mossy fiber sprouting induced by forced and voluntary physical exercise
Open accessAbstract
Alterations in the function and organization of synapses have been proposed to induce learning and memory. Previous studies have demonstrated that mossy fiber induced by overtraining in a spatial learning task can be related with spatial long-term memory formation. In this work we analyzed whether physical exercise could induce mossy fiber sprouting by using a zinc-detecting histologic technique (Timm). Rats were submitted to 3 and 5days of forced or voluntary exercise. Rat brains were processed for Timm's staining to analyze mossy fiber projection at 7, 12 and 30days after the last physical exercise session. A significant increase of mossy fiber terminals in the CA3 stratum oriens region was observed after 5days of forced or voluntary exercise. Interestingly, the pattern of Timm's staining in CA3 mossy fibers was significantly altered when analyzed 12days after exercise but not at 7days post-exercise. In contrast, animals trained for only 3days did not show increments of mossy fiber terminals in the stratum oriens. Altogether, these results demonstrate that sustained or programmed exercise can alter mossy fiber sprouting. Further Investigations are necessary to determine whether mossy fiber sprouting induced by exercise is also involved in learning and memory processes.
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Physical exercise has been reported to grow mossy fibers in the rat hippocampus, but these fibers are not myelinated.
“Growth of mossy fibers in the rat hippocampus with physical exercise has been previously reported (Toscano-Silva et al., 2010), however these fibers are not myelinated.”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Toscano-Silva et al., 2010
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“Growth of mossy fibers in the rat hippocampus with physical exercise has been previously reported (Toscano-Silva et al., 2010), however these fibers are not myelinated.”
Background
- Authors
- Toscano-Silva, M., da Silva, S. G., Scorza, F. A., Bonvent, J. J., Cavalheiro, E. A., & Arida, R. M.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Universidade de Mogi das Cruzes (BR)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 101
- Issue
- 2
- Pages
- 302-308
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1998724989
- Cited by
- 27
- References
- 49
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 4 · 2012: 4
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- mossy fiber sprouting, hippocampus, physical activity, forced exercise, voluntary exercise, zinc ion detection, Timm staining, synaptic plasticity, learning and memory, spatial memory
- MeSH terms
- Animals, Physical Exertion, Hippocampus, Male, Motor Activity, Neuronal Plasticity, Physical Conditioning, Animal, Staining and Labeling, Time Factors, Rats, Wistar, Lactic Acid, Mossy Fibers, Hippocampal, Rats
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