Multifunctional flavonoid dioxygenases: Flavonol and anthocyanin biosynthesis in Arabidopsis thaliana L
Abstract
Flavonols and conditionally also anthocyanins, aside from flavonols, are the predominant polyphenols accumulated in various tissues of the model plant Arabidopsis thaliana L. In vitro experiments suggested that the dioxygenases involved in their biosynthesis, flavonol synthase and anthocyanidin synthase, are "multifunctional" enzymes showing distinct side activities. The in vivo relevance of the additional activities attributed to these enzymes, however, has remained obscure. In this review we summarize the most recent results and present final proof of the complementing activities of these synthases for flavonol and anthocyanidin formation in the model plant A. thaliana. The impact of their modification on the biosynthetic pathway and the pattern of flavonoids in different plant tissues are discussed.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Naringenin is a flavanone that can be transformed into different subclasses of flavonoids in Cannabis.
“Naringenin is such a flavanone, which can be transformed into different subclasses of flavonoids in Cannabis.”
Flavanones are generally modified according to three types of reaction: oxidation, hydroxylation, and displacement of the aryl group.
“Flavanones are generally modified according to three types of reaction: oxidation, hydroxylation, and displacement of the aryl group (Figure 11) [56].”
Flavanones are the dominant precursors for the biosynthesis of the different subclasses of flavonoids.
“Flavanones are the dominant precursors for the biosynthesis of the different subclasses of flavonoids.”
Intramolecular cyclization of chalcones occurs spontaneously at room temperature, whereas stereospecific cyclization requires the enzyme.
“It is noteworthy that the intramolecular cyclization of chalcones occurs spontaneously at room temperature, whereas stereospecific cyclization requires the enzyme (Figure 10) [56].”
Flavone synthase I is a dioxygenase requiring 2-oxoglutarate, while FNS II is a cytochrome P450 enzyme.
“Flavone synthase I is a dioxygenase requiring a molecule of 2-oxoglutarate to function, while FNS II is an enzyme of the cytochrome P450 family [56].”
Flavanone 3-dioxygenase is important in the regulation of flavonoid metabolism, together with flavone synthases I and II.
“Flavanone 3-dioxygenase is important in the regulation of flavonoid metabolism, concomitant with flavone synthases I and II [56,58].”
Cites
Advances in flavonoid research since 1992
Harborne, J. B., & Williams, C. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00235-1 · Cited by 3,956 · see citing works
Flavonoid Biosynthesis. A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology
Winkel, A. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.485 · Cited by 3,645 · see citing works
The biochemistry and medical significance of the flavonoids
Havsteen, B. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,672 · see citing works
D IETARY F LAVONOIDS : Bioavailability, Metabolic Effects, and Safety
Ross, J. A., & Kasum, C. M. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.111401.144957 · Cited by 2,153 · see citing works
FLAVONOIDS: Chemistry, Biochemistry and Applications
Andersen, Ø. M., & Markham, K. R. (2018) · Cited by 1,727 · see citing works
GENETICS AND BIOCHEMISTRY OF SEED FLAVONOIDS
Lepiniec, L., Debeaujon, I., Routaboul, J., Baudry, A., Pourcel, L., Nési, N., & Caboche, M. M. (2006) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.57.032905.105252 · Cited by 1,246 · see citing works
Stracke, R., Ishihara, H., Huep, G., Barsch, A., Frank, M., Niehaus, K., & Weißhaar, B. (2007) · The Plant Journal · doi:10.1111/j.1365-313x.2007.03078.x · Cited by 1,181 · see citing works
Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants
Degenhardt, J., Köllner, T. G., & Gershenzon, J. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.07.030 · Cited by 1,095 · see citing works
Frank, M., Kranz, H. D., Bednarek, P., & Weißhaar, B. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.104.058032 · Cited by 825 · see citing works
Alkaloid Biosynthesis: Metabolism and Trafficking
Ziegler, J., & Facchini, P. J. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.59.032607.092730 · Cited by 702 · see citing works
Anthocyanins and other flavonoids
Williams, C. A., & Grayer, R. J. (2004) · Natural Product Reports · doi:10.1039/b311404j · Cited by 691 · see citing works
Flavones and flavone synthases
Martens, S., & Mithöfer, A. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.07.013 · Cited by 616 · see citing works
Self-citationLandry, L., Chapple, C. C. S., & Last, R. L. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.109.4.1159 · Cited by 613 · see citing works
Ververidis, F., Trantas, E., Douglas, C. J., Vollmer, G., Kretzschmar, G., & Panopoulos, N. J. (2007) · Biotechnology Journal · doi:10.1002/biot.200700084 · Cited by 489 · see citing works
Mo, Y., NAGEL, C. W., & Taylor, L. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.7213 · Cited by 480 · see citing works
Koehntop, K. D., Emerson, J. P., & QUE, L. J. (2005) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-005-0624-x · Cited by 446 · see citing works
Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins
Clifton, I. J., McDonough, M. A., Ehrismann, D., Kershaw, N. J., Granatino, N., & Schofield, C. J. (2006) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2006.01.024 · Cited by 444 · see citing works
Broun, P. (2005) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2005.03.006 · Cited by 428 · see citing works
Leyva, A., Jarillo, J. A., Salinas, J., & Martínez-Zapater, J. M. (1995) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.1.39 · Cited by 409 · see citing works
Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes
Schofield, C. J., & Zhang, Z. (1999) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)00036-6 · Cited by 408 · see citing works
Yonekura‐Sakakibara, K., Tohge, T., Matsuda, F., Nakabayashi, R., Takayama, H., Niida, R., Watanabe‐Takahashi, A., Inoue, E., & Saito, K. (2008) · The Plant Cell · doi:10.1105/tpc.108.058040 · Cited by 399 · see citing works
Structure and Mechanism of Anthocyanidin Synthase from Arabidopsis thaliana
Wilmouth, R. C., Turnbull, J. J., Welford, R. W. D., Clifton, I. J., Prescott, A. G., & Schofield, C. J. (2002) · Structure · doi:10.1016/s0969-2126(01)00695-5 · Cited by 360 · see citing works
Flavonoid Accumulation Patterns of Transparent Testa Mutants of Arabidopsis
Peer, W. A., Brown, D. E., Tague, B. W., Muday, G. K., Taiz, L., & Murphy, A. S. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.536 · Cited by 343 · see citing works
The effect of nitrogen and phosphorus deficiency on flavonol accumulation in plant tissues
Stewart, A. J., Chapman, W., Jenkins, G. I., Graham, I., Martin, T., & Crozier, A. (2001) · Plant, Cell & Environment · doi:10.1046/j.1365-3040.2001.00768.x · Cited by 336 · see citing works
Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene.
Feinbaum, R. L., & Ausubel, F. M. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.5.1985 · Cited by 334 · see citing works
Luo, J., Butelli, E., Hill, L. M., PARR, A. J., Niggeweg, R., Bailey, P. C. E., Weißhaar, B., & Martin, C. R. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03597.x · Cited by 331 · see citing works
Flavonoid Evolution: An Enzymic Approach
Stafford, H. A. (1991) · PLANT PHYSIOLOGY · doi:10.1104/pp.96.3.680 · Cited by 324 · see citing works
Peroxynitrite Scavenging by Flavonoids
Haenen, G. R. M. M., Paquay, J. B. G., Korthouwer, R. E. M., & Bast, A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7016 · Cited by 322 · see citing works
Functional Analysis of a Predicted Flavonol Synthase Gene Family in Arabidopsis
Owens, D. K., Alerding, A. B., Crosby, K. C., Bandara, A. B. P. A., Westwood, J. H., & Winkel, A. (2008) · PLANT PHYSIOLOGY · doi:10.1104/pp.108.117457 · Cited by 322 · see citing works
Antisense Inhibition of Flavonoid Biosynthesis in Petunia Anthers Results in Male Sterility
Meer, I. M. V. D., Stam, M. E., van Tunen, A. J., Mol, J. N. M., & Stuitje, A. R. (1992) · The Plant Cell · doi:10.1105/tpc.4.3.253 · Cited by 321 · see citing works
Pelletier, M. K., Murrell, J. R., & Shirley, B. W. (1997) · PLANT PHYSIOLOGY · doi:10.1104/pp.113.4.1437 · Cited by 283 · see citing works
Cloning and expression of flavonol synthase from Petunia hybrida
Holton, T. A., Brugliera, F., & Tanaka, Y. (1993) · The Plant Journal · doi:10.1046/j.1365-313x.1993.04061003.x · Cited by 283 · see citing works
Flavonoid diversity and biosynthesis in seed of Arabidopsis thaliana
Routaboul, J., Kerhoas, L., Debeaujon, I., Pourcel, L., Caboche, M. M., Einhorn, J., & Lepiniec, L. (2006) · Planta · doi:10.1007/s00425-005-0197-5 · Cited by 282 · see citing works
DIOXYGENASES: Molecular Structure and Role in Plant Metabolism
Prescott, A. G., & John, P. (1996) · Annual Review of Plant Physiology and Plant Molecular Biology · doi:10.1146/annurev.arplant.47.1.245 · Cited by 274 · see citing works
Environmental regulation of leaf colour in red 35S:PAP1 Arabidopsis thaliana
Rowan, D. D., Cao, M., Lin‐Wang, K., Cooney, J. M., Jensen, D. J. A., Austin, P. T., Hunt, M. B., Norling, C. L., Hellens, R. P., Schaffer, R. J., et al. (2009) · New Phytologist · doi:10.1111/j.1469-8137.2008.02737.x · Cited by 261 · see citing works
The BANYULS gene encodes a DFR‐like protein and is a marker of early seed coat development
Devic, M., Guilleminot, J., Debeaujon, I., Bechtold, N., Bensaude, E., Koornneef, M., Pelletier, G., & Delseny, M. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00529.x · Cited by 246 · see citing works
Saito, K., Kobayashi, M., Gong, Z., Tanaka, Y., & Yamazaki, M. (1999) · The Plant Journal · doi:10.1046/j.1365-313x.1999.00365.x · Cited by 237 · see citing works
Davies, K. M., Schwinn, K. E., Deroles, S. C., Manson, D. G., Lewis, D. H., Bloor, S. J., & Bradley, J. M. (2003) · Euphytica · doi:10.1023/a:1024018729349 · Cited by 230 · see citing works
Mechanistic Studies on Three 2-Oxoglutarate-dependent Oxygenases of Flavonoid Biosynthesis
Turnbull, J. J., Nakajima, J., Welford, R. W. D., Yamazaki, M., Saito, K., & Schofield, C. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309228200 · Cited by 228 · see citing works
de Almeida, J. R. M., D'Amico, E., Preuß, A., Carbone, F., Vos, C. H. R. D., Deiml, B., Mourgues, F., Perrotta, G., Fischer, T. C., Bovy, A. G., et al. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.04.040 · Cited by 224 · see citing works
Self-citationWisman, E., Hartmann, U., Sagasser, M., Baumann, E., Palme, K. J., Hahlbrock, K., Saedler, H., & Weißhaar, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12432 · Cited by 219 · see citing works
Oh, H., Kim, D.-H., Cho, J., & Kim, Y. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.08.015 · Cited by 205 · see citing works
Burbulis, I. E., Iacobucci, M., & Shirley, B. W. (1996) · The Plant Cell · doi:10.1105/tpc.8.6.1013 · Cited by 204 · see citing works
Menßen, A., Hohmann, S., Martin, W. F., Schnable, P. S., Petérson, P. A., Saedler, H., & Gierl, A. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb07501.x · Cited by 181 · see citing works
The iron(II) and 2-oxoacid-dependent dioxygenases and their role in metabolism (1967 to 1999)
Prescott, A. G., & Lloyd, M. D. (2000) · Natural Product Reports · doi:10.1039/a902197c · Cited by 180 · see citing works
Pelletier, M. K., Burbulis, I. E., & Winkel, A. (1999) · Plant Molecular Biology · doi:10.1023/a:1026414301100 · Cited by 178 · see citing works
Nakajima, J., Tanaka, Y., Yamazaki, M., & Saito, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100744200 · Cited by 168 · see citing works
Attractive and defensive functions of the ultraviolet pigments of a flower ( Hypericum calycinum )
Gronquist, M. R., Bezzerides, A. L., Attygalle, A. B., Meinwald, J., Eisner, M., & Eisner, T. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231471698 · Cited by 166 · see citing works
Hartmann, U., Valentine, W. J., Christie, J. M., Hays, J. B., Jenkins, G. I., & Weißhaar, B. (1998) · Plant Molecular Biology · doi:10.1023/a:1005921914384 · Cited by 163 · see citing works
Metabolic Engineering of Anthocyanin Biosynthesis in Escherichia coli
Yan, Y., Chemler, J. A., Huang, L., Martens, S., & Koffas, M. A. G. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.7.3617-3623.2005 · Cited by 154 · see citing works
Self-citationReddy, A. M., Reddy, V. S., Scheffler, B. E., Wienand, U., & Reddy, A. R. (2006) · Metabolic Engineering · doi:10.1016/j.ymben.2006.09.003 · Cited by 154 · see citing works
Britsch, L., Heller, W. E., & Grisebach, H. (1981) · Zeitschrift für Naturforschung C · doi:10.1515/znc-1981-9-1009 · Cited by 150 · see citing works
Flavonol synthase from Citrus unshiu is a bifunctional dioxygenase
Lukačin, R., Wellmann, F., Britsch, L., Martens, S., & Matern, U. (2003) · Phytochemistry · doi:10.1016/s0031-9422(02)00567-8 · Cited by 143 · see citing works
Self-citationFlavonoid 6-Hydroxylase from Soybean (Glycine maxL.), a Novel Plant P-450 Monooxygenase
Latunde‐Dada, A. O., Cabello‐Hurtado, F., Czittrich, N., Didierjean, L., Schopfer, C. R., Hertkorn, N., Werck‐Reichhart, D., & Ebel, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006277200 · Cited by 141 · see citing works
A Journey of Twenty-Five Years through the Ecological Biochemistry of Flavonoids
Tahara, S. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70028 · Cited by 140 · see citing works
Major Flavonoids from Arabidopsis thaliana Leaves
Veit, M., & Pauli, G. F. (1999) · Journal of Natural Products · doi:10.1021/np990080o · Cited by 138 · see citing works
Stracke, R., de Vos, R. C. H., Bartelniewoehner, L., Ishihara, H., Sagasser, M., Martens, S., & Weißhaar, B. (2008) · Planta · doi:10.1007/s00425-008-0841-y · Cited by 131 · see citing works
Self-citationBöhm, H., Boeing, H., Hempel, J., RAAB, B., & Kroke, A. (1998) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/pl00007376 · Cited by 130 · see citing works
Fujita, A., Goto‐Yamamoto, N., ARAMAKI, I., & Hashizume, K. (2006) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.70.632 · Cited by 129 · see citing works
In vitro properties of a recombinant flavonol synthase from Arabidopsis thaliana
Prescott, A. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00155-3 · Cited by 127 · see citing works
A Dilemma of Dioxygenases (or Where Biochemistry and Molecular Biology Fail to Meet)
Prescott, A. G. (1993) · Journal of Experimental Botany · doi:10.1093/jxb/44.5.849 · Cited by 127 · see citing works
Cloning of parsley flavone synthase I
Martens, S., Forkmann, G., Matern, U., & Lukačin, R. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00191-1 · Cited by 117 · see citing works
Self-citationMolecular evolution of flavonoid dioxygenases in the family Apiaceae
Gebhardt, Y. H., Witte, S., Forkmann, G., Lukačin, R., Matern, U., & Martens, S. (2005) · Phytochemistry · doi:10.1016/j.phytochem.2005.03.030 · Cited by 112 · see citing works
Self-citationBiochemical and genetic characterization of Arabidopsis flavanone 3β-hydroxylase
Owens, D. K., Crosby, K. C., Runac, J., Howard, B. A., & Winkel, A. (2008) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2008.06.004 · Cited by 111 · see citing works
Divergent evolution of flavonoid 2‐oxoglutarate‐dependent dioxygenases in parsley1
Martens, S., Forkmann, G., Britsch, L., Wellmann, F., Matern, U., & Lukačin, R. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00479-4 · Cited by 110 · see citing works
Self-citationVerveridis, F., Trantas, E., Douglas, C. J., Vollmer, G., Kretzschmar, G., & Panopoulos, N. J. (2007) · Biotechnology Journal · doi:10.1002/biot.200700184 · Cited by 110 · see citing works
Nakamura, N., Fukuchi‐Mizutani, M., Miyazaki, K., Suzuki, K., & Tanaka, Y. (2006) · Plant Biotechnology · doi:10.5511/plantbiotechnology.23.13 · Cited by 108 · see citing works
2-Oxoglutarate-dependent dioxygenase and related enzymes: Biochemical characterization
Carolis, E. D., & Luca, V. D. (1994) · Phytochemistry · doi:10.1016/s0031-9422(00)89621-1 · Cited by 105 · see citing works
Arabidopsis thaliana expresses a second functional flavonol synthase
Preuß, A., Stracke, R., Weißhaar, B., Hillebrecht, A., Matern, U., & Martens, S. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.05.006 · Cited by 92 · see citing works
Self-citationWellmann, F., Griesser, M., Schwab, W. G., Martens, S., Eisenreich, W., Matern, U., & Lukačin, R. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.02.004 · Cited by 82 · see citing works
Self-citationAntisense flavonol synthase alters copigmentation and flower color in lisianthus
Nielsen, K., Deroles, S. C., Markham, K. R., Bradley, M. J., Podivinsky, E., & Manson, D. (2002) · Molecular Breeding · doi:10.1023/a:1020320809654 · Cited by 81 · see citing works
Evolution of Flavone Synthase I from Parsley Flavanone 3β-Hydroxylase by Site-Directed Mutagenesis
Gebhardt, Y. H., Witte, S., Steuber, H., Matern, U., & Martens, S. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.107.098392 · Cited by 77 · see citing works
Self-citationA single-base deletion in soybean flavonol synthase gene is associated with magenta flower color
Takahashi, R., Githiri, S. M., Hatayama, K., Dubouzet, E. G., Shimada, N., Aoki, T., Ayabe, S., Iwashina, T., Toda, K., & Matsumura, H. (2006) · Plant Molecular Biology · doi:10.1007/s11103-006-9077-z · Cited by 76 · see citing works
Functional expression and mutational analysis of flavonol synthase from Citrus unshiu
Wellmann, F., Lukačin, R., Moriguchi, T., Britsch, L., Schiltz, E., & Matern, U. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.03108.x · Cited by 75 · see citing works
Self-citationEnzymatic rearrangement of flavanone to isoflavone
Hagmann, M., & Grisebach, H. (1984) · FEBS Letters · doi:10.1016/0014-5793(84)80736-x · Cited by 75 · see citing works
Flavonol synthase gene expression during citrus fruit development
Moriguchi, T., Kita, M., Ogawa, K., Tomono, Y., Endo, T., & Omura, M. (2002) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2002.1140211.x · Cited by 63 · see citing works
Welford, R. W. D., Clifton, I. J., Turnbull, J. J., Wilson, S. C., & Schofield, C. J. (2005) · Organic & Biomolecular Chemistry · doi:10.1039/b507153d · Cited by 59 · see citing works
Characterization of flavone synthase I from rice
Lee, Y. J., Kim, J. H., Kim, B. G., Lim, Y., & Ahn, J. (2008) · BMB Reports · doi:10.5483/bmbrep.2008.41.1.068 · Cited by 59 · see citing works
CH 3 Molecular Biology and Biotechnology of Flavonoid Biosynthesis
Andersen, O. M., & Markham, K. R. (2005) · CRC Press eBooks · doi:10.1201/9781420039443-7 · Cited by 58 · see citing works
Chua, C. S., Biermann, D., Goo, K. S., & Sim, T. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.07.006 · Cited by 58 · see citing works
Martens, S., Knott, J. M., Seitz, C. A., Jánvári, L., Yu, S.-N., & Forkmann, G. (2003) · Biochemical Engineering Journal · doi:10.1016/s1369-703x(02)00224-3 · Cited by 54 · see citing works
Self-citationEvidence for oxidation at C-3 of the flavonoid C-ring during anthocyanin biosynthesis
Welford, R. W. D., Turnbull, J. J., Claridge, T. D. W., Schofield, C. J., & Prescott, A. G. (2001) · Chemical Communications · doi:10.1039/b105576n · Cited by 54 · see citing works
van Eldik, G. J., Reijnen, W. H., Ruiter, R. K., van Herpen, M. M. A., Schrauwen, J. A. M., & Wullems, G. J. (1997) · The Plant Journal · doi:10.1046/j.1365-313x.1997.11010105.x · Cited by 53 · see citing works
Britsch, L. (1990) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(90)90731-d · Cited by 52 · see citing works
Kim, B. G., Kim, J. H., Kim, J., Lee, C., & Ahn, J. (2008) · Molecules and Cells · doi:10.1016/s1016-8478(23)17577-7 · Cited by 51 · see citing works
Molecular Biology and Biotechnology of Flavonoid Biosynthesis
Davies, K. M., & Schwinn, K. E. (2005) · CRC Press eBooks · doi:10.1201/9781420039443.ch3 · Cited by 49 · see citing works
Turnbull, J. J., Nagle, M. J., Seibel, J., Welford, R. W. D., Grant, G. H., & Schofield, C. J. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(03)00711-x · Cited by 48 · see citing works
Witte, S., Moco, S., Vervoort, J. J. M., Matern, U., & Martens, S. (2009) · Planta · doi:10.1007/s00425-009-0902-x · Cited by 44 · see citing works
Self-citationLukačin, R., Gröning, I., Schiltz, E., Britsch, L., & Matern, U. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1676 · Cited by 43 · see citing works
Self-citationMolecular characterization and functional expression of flavonol 6-hydroxylase
Anzellotti, D., & Ibrahim, R. K. (2004) · BMC Plant Biology · doi:10.1186/1471-2229-4-20 · Cited by 39 · see citing works
Lukačin, R., Gröning, I., Pieper, U., & Matern, U. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01064.x · Cited by 39 · see citing works
Self-citationAncestral U.S. Soybean Cultivars Characterized for Tolerance to Ultraviolet‐B Radiation
Reed, H. E., Teramura, A. H., & Kenworthy, W. J. (1992) · Crop Science · doi:10.2135/cropsci1992.0011183x003200050031x · Cited by 39 · see citing works
Turnbull, J. J., Prescott, A. G., Schofield, C. J., & Wilmouth, R. C. (2001) · Acta Crystallographica Section D Biological Crystallography · doi:10.1107/s0907444900019818 · Cited by 25 · see citing works
Yoshitama, K., Ishikura, N., Fuleki, T., & Nakamura, S. (1992) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)80361-5 · Cited by 16 · see citing works
Flagged first, then by citations
1 of the 95 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Flavonoids: biosynthesis, biological functions, and biotechnological applications
Ferreyra, M. L. F., Rius, S. P., & Casati, P. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00222 · Cited by 1,840 · see citing works
The Flavonoid Biosynthesis Network in Plants
Liu, W., Feng, Y., Yu, S., Fan, Z., Li, X., Li, J., & Yin, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312824 · Cited by 1,056 · see citing works
The flavonoid biosynthetic pathway in Arabidopsis: Structural and genetic diversity
Saito, K., Yonekura‐Sakakibara, K., Nakabayashi, R., Higashi, Y., Yamazaki, M., Tohge, T., & Fernie, A. R. (2013) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2013.02.001 · Cited by 902 · see citing works
Light-controlled flavonoid biosynthesis in fruits
Zoratti, L., Karppinen, K., Escobar, A. L., Häggman, H., & Jaakola, L. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00534 · Cited by 537 · see citing works
Diverse Physiological Roles of Flavonoids in Plant Environmental Stress Responses and Tolerance
Shomali, A., Das, S., Arif, N., Sarraf, M., Zahra, N., Yadav, V., Aliniaeifard, S., Chauhan, D. K., & Hasanuzzaman, M. (2022) · Plants · doi:10.3390/plants11223158 · Cited by 441 · see citing works
Vuolo, M. M., Lima, V. S., & Maróstica, M. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814774-0.00002-5 · Cited by 412 · see citing works
Evolution and diversity of the 2–oxoglutarate‐dependent dioxygenase superfamily in plants
Kawai, Y., Ono, E., & Mizutani, M. (2014) · The Plant Journal · doi:10.1111/tpj.12479 · Cited by 386 · see citing works
Role of Phenolic Compounds in Plant-Defensive Mechanisms
Kumar, S., Abedin, M. M., Singh, A. K., & Das, S. (2020) · Springer eBooks · doi:10.1007/978-981-15-4890-1_22 · Cited by 376 · see citing works
Reshi, Z. A., Ahmad, W., Lukatkin, A. S., & Javed, S. B. (2023) · Metabolites · doi:10.3390/metabo13080895 · Cited by 268 · see citing works
Hepatoprotective effect of quercetin: From chemistry to medicine
Miltonprabu, S., Tomczyk, M., Skalicka‐Woźniak, K., Rastrelli, L., Daglia, M., Nabavi, S. F., Alavian, S. M., & Nabavi, S. M. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.08.034 · Cited by 217 · see citing works
Flavonols Accumulate Asymmetrically and Affect Auxin Transport in Arabidopsis
Kuhn, B. M., Geisler, M. M., Bigler, L., & Ringli, C. (2011) · PLANT PHYSIOLOGY · doi:10.1104/pp.111.175976 · Cited by 213 · see citing works
The Evolution of Flavonoid Biosynthesis: A Bryophyte Perspective
Davies, K. M., Jibran, R., Zhou, Y., Albert, N. W., Brummell, D. A., Jordan, B. R., Bowman, J. L., & Schwinn, K. E. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00007 · Cited by 212 · see citing works
Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism
Farrow, S. C., & Facchini, P. J. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00524 · Cited by 208 · see citing works
Wang, H., Fan, W., Li, H., Yang, J. M., Huang, J., & Zhang, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078484 · Cited by 204 · see citing works
Onkokesung, N., Reichelt, M., van Doorn, A., Schuurink, R. C., van Loon, J. J. A., & Dicke, M. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru096 · Cited by 202 · see citing works
Page, M. T., SULTANA, N., Paszkiewicz, K. H., Florance, H., & Smirnoff, N. (2011) · Plant Cell & Environment · doi:10.1111/j.1365-3040.2011.02369.x · Cited by 194 · see citing works
The role of phenolic compounds in plant resistance
Kulbat-Warycha, K. (2023) · Wydawnictwo Politechniki Łódzkiej · doi:10.34658/bfs.2016.80.2.97-108 · Cited by 190 · see citing works
Vos, C., Schouteden, N., van Tuinen, D., Chatagnier, O., Elsen, A., Waele, D. D., Panis, B., & Gianinazzi-Pearson, V. (2013) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2013.01.013 · Cited by 181 · see citing works
Araújo, W. L., Martins, A. O., Fernie, A. R., & Tohge, T. (2014) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00552 · Cited by 155 · see citing works
Research on Orchid Biology and Biotechnology
Hsiao, Y.-Y., Pan, Z., Hsu, C., Yang, Y., Hsu, Y.-C., Chuang, Y.-C., Shih, H.-H., Chen, W., Tsai, W., & Chen, H.-H. (2011) · Plant and Cell Physiology · doi:10.1093/pcp/pcr100 · Cited by 154 · see citing works
Fruit skin color and the role of anthocyanin
Kayesh, E., Shangguan, L., Korir, N. K., Sun, X., Bilkish, N., Zhang, Y., Han, J., Song, C., Cheng, Z., & Fang, J. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1332-8 · Cited by 148 · see citing works
Appelhagen, I., Thiedig, K., Nordholt, N., Schmidt, N., Huep, G., Sagasser, M., & Weißhaar, B. (2014) · Planta · doi:10.1007/s00425-014-2088-0 · Cited by 138 · see citing works
Tian, J., Han, Z., Zhang, J., Hu, Y., Song, T., & Yao, Y. (2015) · Scientific Reports · doi:10.1038/srep12228 · Cited by 131 · see citing works
Salicylic Acid Induction of Flavonoid Biosynthesis Pathways in Wheat Varies by Treatment
Gondor, O. K., Janda, T., Soós, V., Pál, M., Majláth, I., Adak, M. K., Balázs, E., & Szalai, G. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01447 · Cited by 121 · see citing works
Dynamic changes in plant secondary metabolites during UV acclimation in Arabidopsis thaliana
Hectors, K., Oevelen, S. V., Geuns, J., Guisez, Y., Jansen, M. A. K., & Prinsen, E. (2014) · Physiologia Plantarum · doi:10.1111/ppl.12168 · Cited by 115 · see citing works
Flavonoids: Classification, Biosynthesis and Chemical Ecology
dos Santos, É. L., Maia, B. H. L. D. N. S., Ferriani, Á. P., & Teixeira, S. D. (2017) · InTech eBooks · doi:10.5772/67861 · Cited by 110 · see citing works
Flavonols Protect Arabidopsis Plants against UV-B Deleterious Effects
Emiliani, J., Erich Grotewold, A., Ferreyra, M. L. F., & Casati, P. (2013) · Molecular Plant · doi:10.1093/mp/sst021 · Cited by 103 · see citing works
Zhou, C., Mei, X., Rothenberg, D. O., Yang, Z., Zhang, W., Wan, S., Yang, H., & Zhang, L. (2020) · Molecules · doi:10.3390/molecules25010190 · Cited by 103 · see citing works
A Review of Strawberry Photobiology and Fruit Flavonoids in Controlled Environments
Warner, R., Wu, B.-S., MacPherson, S., & Lefsrud, M. G. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.611893 · Cited by 102 · see citing works
Ben-Simhon, Z., Judeinstein, S., Trainin, T., Harel‐Beja, R., Bar-Ya’akov, I., Borochov‐Neori, H., & Holland, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142777 · Cited by 102 · see citing works
Manipulation of microRNA expression to improve nitrogen use efficiency
Fischer, J. J., Beatty, P. H., Good, A. G., & Muench, D. G. (2013) · Plant Science · doi:10.1016/j.plantsci.2013.05.009 · Cited by 94 · see citing works
Wang, M., Chen, L., Liang, Z., He, X., Liu, W., Jiang, B., Yan, J., Sun, P., Cao, Z., Peng, Q., et al. (2020) · BMC Plant Biology · doi:10.1186/s12870-020-02597-9 · Cited by 92 · see citing works
Ghafoor, S., Mansha, A., & de Visser, S. P. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10526 · Cited by 91 · see citing works
Rothenberg, D. O., Yang, H., Chen, M., Zhang, W., & Zhang, L. (2019) · Molecules · doi:10.3390/molecules24061064 · Cited by 90 · see citing works
Kumar, A., Mosa, K. A., Ji, L., Kage, U., Dhokane, D., Karre, S., Madalageri, D. M., & Pathania, N. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1285752 · Cited by 90 · see citing works
Natural products – modifying metabolite pathways in plants
Staniek, A., Bouwmeester, H. J., Fraser, P. D., Kayser, O., Martens, S., Tissier, A. F., van der Krol, A. R., Wessjohann, L. A., & Warzecha, H. (2013) · Biotechnology Journal · doi:10.1002/biot.201300224 · Cited by 89 · see citing works
Self-citationAn insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn.
Mazumdar, A. B., Banerjee, A., & Chattopadhyay, S. (2022) · The Nucleus · doi:10.1007/s13237-022-00409-z · Cited by 88 · see citing works
Patel, K., Kumar, V., Rahman, M., Verma, A., & Patel, D. K. (2017) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1016/j.bjbas.2017.05.009 · Cited by 86 · see citing works
Engineering de novo anthocyanin production in Saccharomyces cerevisiae
Levisson, M., Patinios, C., Hein, S., de Groot, P. A., Daran, J.-M. G., Hall, R. D., Martens, S., & Beekwilder, J. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0951-6 · Cited by 85 · see citing works
Self-citationYang, M. H., Chowdhury, R., Ge, W., Hamed, R. B., McDonough, M. A., Claridge, T. D. W., Kessler, B. M., Cockman, M. E., Ratcliffe, P. J., & Schofield, C. J. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08022.x · Cited by 82 · see citing works
Lai, Y., Li, H., & Yamagishi, M. (2013) · Frontiers in Biology · doi:10.1007/s11515-013-1281-z · Cited by 82 · see citing works
Quero, J., Mármol, I., Cerrada, E., & Rodriguez‐Yoldi, M. J. (2020) · Food & Function · doi:10.1039/d0fo00216j · Cited by 77 · see citing works
Jan, R., Khan, M. A., Asaf, S., Lubna, Park, J., Lee, I., & Kim, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116152 · Cited by 76 · see citing works
Li, Y., Liu, X., Cai, X., Shan, X., Gao, R., Song, Y., Han, T., Wang, S., Wang, L., & Gao, X. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00428 · Cited by 76 · see citing works
Chen, L., Liu, Y., Liu, H., Kang, L., Geng, J., Gai, Y., Ding, Y., Sun, H., & Li, Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118578 · Cited by 75 · see citing works
Wei, M., Song, M., Fan, S., & Yu, S. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-97 · Cited by 74 · see citing works
EkFLS overexpression promotes flavonoid accumulation and abiotic stress tolerance in plant
Wang, M., Zhang, Y., Zhu, C., Yao, X., Zheng, Z., Tian, Z., & Cai, X. (2021) · Physiologia Plantarum · doi:10.1111/ppl.13407 · Cited by 73 · see citing works
Ye, Z., Yu, J. H., Yan, W., Zhang, J., Yang, D., Yao, G., Liu, Z., Wu, Y., & Hou, X. (2021) · Horticulture Research · doi:10.1038/s41438-021-00591-2 · Cited by 72 · see citing works
De novo biosynthesis of anthocyanins in Saccharomyces cerevisiae
Eichenberger, M., Hansson, A., Fischer, D., Dürr, L., & Næsby, M. (2018) · FEMS Yeast Research · doi:10.1093/femsyr/foy046 · Cited by 71 · see citing works
de Visser, S. P., Lin, Y., Ali, H. S., Bagha, U. K., Mukherjee, G., & Sastri, C. V. (2021) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.213914 · Cited by 71 · see citing works
Molecular Basis for Chemical Evolution of Flavones to Flavonols and Anthocyanins in Land Plants
Li, D.-D., Ni, R., Wang, P., Zhang, X., Wang, P.-Y., Zhu, T., Sun, C., Liu, C., Lou, H., & Cheng, A. (2020) · PLANT PHYSIOLOGY · doi:10.1104/pp.20.01185 · Cited by 68 · see citing works
Wang, H., Liu, S., Wang, T., Liu, H., Xu, X., Chen, K., & Zhang, P. (2020) · Plant Science · doi:10.1016/j.plantsci.2020.110591 · Cited by 65 · see citing works
Activation of MKK 9‐ MPK 3/ MPK 6 enhances phosphate acquisition in Arabidopsis thaliana
Lei, L., Li, Y., Wang, Q., Xu, J., Chen, Y., Yang, H., & Ren, D. (2014) · New Phytologist · doi:10.1111/nph.12872 · Cited by 65 · see citing works
Effects of Latitude and Weather Conditions on Phenolic Compounds in Currant (Ribes spp.) Cultivars
Yang, B., Zheng, J., Laaksonen, O. A., Tahvonen, R., & Kallio, H. P. T. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4000456 · Cited by 62 · see citing works
Li, J., Ding, X., Han, S., He, T., Zhang, H., Yang, L., Yang, S., & Gai, J. (2016) · Journal of Proteomics · doi:10.1016/j.jprot.2016.02.017 · Cited by 60 · see citing works
Wang, M., Ren, T., Huang, R.-H., Li, Y., Zhang, C., & Xu, Z. (2021) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2021.03.034 · Cited by 59 · see citing works
Barrera, A., Hereme, R., Ruíz-Lara, S., Larrondo, L. F., Gundel, P. E., Pollmann, S., Molina‐Montenegro, M. A., & Ramos, P. (2020) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2020.00122 · Cited by 57 · see citing works
Ali, H. S., Henchman, R. H., Warwicker, J., & de Visser, S. P. (2021) · The Journal of Physical Chemistry A · doi:10.1021/acs.jpca.1c00141 · Cited by 56 · see citing works
González-Ponce, H. A., Rincón‐Sánchez, A. R., Jaramillo‐Juárez, F., & Moshage, H. J. (2018) · Nutrients · doi:10.3390/nu10020117 · Cited by 54 · see citing works
An, Y., Feng, X., Liu, L., Xiong, L., & Wang, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.01713 · Cited by 53 · see citing works
Liu, Y., Feng, X., Zhang, Y., Zhou, F., & Zhu, P. (2021) · BMC Genomics · doi:10.1186/s12864-021-07785-x · Cited by 52 · see citing works
Park, S., Kim, D., Lee, J.-Y., Ha, S., & Lim, S. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b01036 · Cited by 49 · see citing works
Irmisch, S., Ruebsam, H., Jancsik, S., Yuen, M. M. S., Madilao, L. L., & Bohlmann, J. (2019) · PLANT PHYSIOLOGY · doi:10.1104/pp.19.00254 · Cited by 49 · see citing works
Evolution and Expression of Tandem Duplicated Maize Flavonol Synthase Genes
Ferreyra, M. L. F., Casas, M. I., Questa, J. I., Valderrama, A. L. H., DeBlasio, S. L., Wang, J., Jackson, D. P., Erich Grotewold, A., & Casati, P. (2012) · Frontiers in Plant Science · doi:10.3389/fpls.2012.00101 · Cited by 49 · see citing works
Gifford, I., Battenberg, K., Vaniya, A., Wilson, A. E., Tian, L., Fiehn, O., & Berry, A. M. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01463 · Cited by 49 · see citing works
Wei, Z., Yang, H., Shi, J., Duan, Y., Wu, W., Lyu, L., & Li, W. (2023) · Cells · doi:10.3390/cells12091225 · Cited by 44 · see citing works
Phenolic Compounds Against Fungal and Viral Plant Diseases
Rashad, Y. M., Aseel, D. G., & Hammad, S. M. (2020) · Springer eBooks · doi:10.1007/978-981-15-4890-1_9 · Cited by 43 · see citing works
Zhou, X., Shi, F., Zhou, L., Zhou, Y., Liu, Z., Ji, R., & Feng, H. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2019.103395 · Cited by 41 · see citing works
Li, X., Kim, J. K., Park, S.-Y., Zhao, S., Kim, Y. B., Lee, S., & Park, S. U. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf4049534 · Cited by 40 · see citing works
Arabidopsis ROOT HAIR DEFECTIVE3 is involved in nitrogen starvation‐induced anthocyanin accumulation
Wang, J., Wang, Y., Yang, J. H., Ma, C., Zhang, Y., Ge, T., Qi, Z., & Kang, Y. (2014) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12320 · Cited by 39 · see citing works
Schmidt, A., Li, C., Jones, A. D., & Pichersky, E. (2012) · Planta · doi:10.1007/s00425-012-1676-0 · Cited by 39 · see citing works
Two loci in sorghum with NB-LRR encoding genes confer resistance to Colletotrichum sublineolum
Biruma, M., Martin, T., Fridborg, I., Okori, P., & Dixelius, C. (2011) · Theoretical and Applied Genetics · doi:10.1007/s00122-011-1764-8 · Cited by 38 · see citing works
Zhang, H., Wu, Z., Suo, Y., Wang, J., Zheng, L., & Wang, Y. (2017) · Biologia Plantarum · doi:10.1007/s10535-017-0725-8 · Cited by 37 · see citing works
Guo, X., Liu, Q., Du, J., Guo, Y., Hu, X., Yu, J., Bai, J., Li, X., & Kou, L. (2022) · Postharvest Biology and Technology · doi:10.1016/j.postharvbio.2022.112048 · Cited by 37 · see citing works
Rosado, A., Hicks, G. R., Norambuena, L., Rogachev, I., Meir, S., Pourcel, L., Zouhar, J., Brown, M. Q., Boirsdore, M. P., Puckrin, R., et al. (2011) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.11.015 · Cited by 35 · see citing works
Cloning and expression analysis of Ficus carica anthocyanidin synthase 1 gene
Cao, L., Xu, X., Chen, S., & Ma, H. (2016) · Scientia Horticulturae · doi:10.1016/j.scienta.2016.09.015 · Cited by 35 · see citing works
Wang, Y., Zhou, L., Wang, D., Geng, Z., Liu, S., Chen, C., Chen, S., Jiang, J., & Chen, F. (2021) · Plant Molecular Biology · doi:10.1007/s11103-021-01206-z · Cited by 35 · see citing works
Potential of plants-based alkaloids, terpenoids and flavonoids as antibacterial agents: An update
Das, A., & Ruhal, R. (2025) · Process Biochemistry · doi:10.1016/j.procbio.2025.01.003 · Cited by 34 · see citing works
Biosynthesis of Secondary Metabolites in Plants as Influenced by Different Factors
Satish, L., Shamili, S., Yolcu, S., Lavanya, G., Alavilli, H., & Swamy, M. K. (2020) · Springer eBooks · doi:10.1007/978-981-15-1761-7_3 · Cited by 34 · see citing works
Elucidation of myricetin biosynthesis in Morella rubra of the Myricaceae
Xing, M., Cao, Y., Ren, C., Liu, Y., Li, J., Grierson, D. S., Martin, C. R., Sun, C., Chen, K., Xu, C., et al. (2021) · The Plant Journal · doi:10.1111/tpj.15449 · Cited by 34 · see citing works
Feng, X., Bai, S., Zhou, L., Song, Y., Jia, S., Guo, Q., & Zhang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011135 · Cited by 33 · see citing works
Ponce, C., Kühn, N., Arellano, M., Time, A., Multari, S., Martens, S., Carrera, E., Sagredo, B., Donoso, J. M., & Meisel, L. A. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c01140 · Cited by 33 · see citing works
Self-citationAnthocyanins and flavonols are responsible for purple color of Lablab purpureus (L.) sweet pods
Cui, B., Hu, Z., Zhang, Y., Hu, J., Yin, W., Feng, Y., Xie, Q., & Chen, G. (2016) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2016.03.011 · Cited by 33 · see citing works
Liu, Y., Wang, L., Zhang, J., Yu, B., Wang, J., & Wang, D. (2017) · Journal of Plant Biology · doi:10.1007/s12374-016-0199-9 · Cited by 33 · see citing works
Fungi's treasure in cosmeceuticals-a comprehensive chemical approach
Mukherjee, A., Das, S., Chakraborty, D., Pal, N., & Das, N. (2024) · South African Journal of Botany · doi:10.1016/j.sajb.2024.01.036 · Cited by 32 · see citing works
Identification and Functional Analysis of a Flavonol Synthase Gene from Grape Hyacinth
Liu, H., Su, B., Zhang, H., Gong, J., Zhang, B., Liu, Y., & Du, L. (2019) · Molecules · doi:10.3390/molecules24081579 · Cited by 32 · see citing works
Sun, Y., He, J., & Kong, J. (2019) · BMC Plant Biology · doi:10.1186/s12870-019-1787-x · Cited by 31 · see citing works
ALA reverses ABA-induced stomatal closure by modulating PP2AC and SnRK2.6 activity in apple leaves
Chen, Z., An, Y., & Wang, L. (2023) · Horticulture Research · doi:10.1093/hr/uhad067 · Cited by 30 · see citing works
A Genomic Approach to Study Anthocyanin Synthesis and Flower Pigmentation in Passionflowers
Aizza, L. C. B., & Dornelas, M. C. (2011) · Journal of Nucleic Acids · doi:10.4061/2011/371517 · Cited by 30 · see citing works
Ascorbate as a Key Player in Plant Abiotic Stress Response and Tolerance
Veljovic-Jovanovic, S. D., Vidović, M., & Morina, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-74057-7_3 · Cited by 29 · see citing works
Nie, T., Wang, D., Ma, X., Yue, C., & Chen, Q. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.00603 · Cited by 29 · see citing works
Zhang, J., Cheng, K., Liu, X., Dai, Z., Zheng, L., & Wang, Y. (2023) · Frontiers in Plant Science · doi:10.3389/fpls.2023.1118984 · Cited by 29 · see citing works
Involvement of kaempferol in the defence response of virus infected Arabidopsis thaliana
Likić, S., Šola, I., Ludwig‐Müller, J., & Rusak, G. (2013) · European Journal of Plant Pathology · doi:10.1007/s10658-013-0326-0 · Cited by 29 · see citing works
Carletti, G., Lucini, L., Busconi, M., Marocco, A., & Bernardi, J. (2013) · Plant Physiology and Biochemistry · doi:10.1016/j.plaphy.2013.05.030 · Cited by 29 · see citing works
Ma, X., Hou, Y., Umar, A. W., Wang, Y., Yu, L., Ahmad, N., Yao, N., Zhang, M., & Liu, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105546 · Cited by 28 · see citing works
Myricetin: a potential plant-derived anticancer bioactive compound—an updated overview
Kumar, S., Swamy, N., Tuli, H. S., Rani, S., Garg, A., Mishra, D., Abdulabbas, H. S., & Sandhu, S. S. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02479-5 · Cited by 28 · see citing works
Biologically Active Compounds from the Genus Centaurium s.l. (Gentianaceae)
Šiler, B., & Mišić, D. M. (2016) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63601-0.00011-9 · Cited by 28 · see citing works
Association of Bitter Metabolites and Flavonoid Synthesis Pathway in Jujube Fruit
Shi, Q., Li, X., Du, J., Liu, Y., Shen, B., & Li, X. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.901756 · Cited by 27 · see citing works
Chen, C., Wei, K., Wang, L., Ruan, L., Li, H., Zhou, X., Lin, Z., Shan, R.-Y., & Cheng, H. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.00702 · Cited by 27 · see citing works
Discovery of modules involved in the biosynthesis and regulation of maize phenolic compounds
Gomez-Cano, L., Gómez-Cano, F., Dillon, F. M., Alers-Velazquez, R., Doseff, A. I., Erich Grotewold, A., & Gray, J. C. (2019) · Plant Science · doi:10.1016/j.plantsci.2019.110364 · Cited by 27 · see citing works
- Authors
- Martens, S., Preuß, A., & Matern, U.
- Affiliations
- Philipps University of Marburg (DE)
- Technical University of Munich (DE)
- Corresponding author
- Martens, Stefan
- ORCID
- Martens, Stefan
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 71
- Issue
- 10
- Pages
- 1040-1049
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W2047382548
- Cited by
- 258
- References
- 95
- Citations by year
- 2026: 17 · 2025: 18 · 2024: 24 · 2023: 18 · 2022: 23 · 2021: 21 · 2020: 18 · 2019: 16 · 2018: 16 · 2017: 20 · 2016: 10 · 2015: 7 · 2014: 15 · 2013: 16 · 2012: 10
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant Gene Expression Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- flavonol biosynthesis, anthocyanin biosynthesis, flavonol synthase, anthocyanidin synthase, multifunctional enzyme, Arabidopsis thaliana, polyphenols, flavonoid biosynthesis
- MeSH terms
- Anthocyanins, Flavonoids, Arabidopsis, Flavonols, Dioxygenases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review