Cited by 163Natural Compound Pharmacology StudiesNatural Antidiabetic Agents StudiesBioactive natural compounds

α-Glucosidase inhibition and antihyperglycemic activity of prenylated xanthones from Garcinia mangostana

Ryu, Hyung Won, Cho, Jung Keun, Curtis-Long, Marcus J., Yuk, Heung Joo, Kim, Young Soo, Jung, Sunin, Kim, Young Suk, Lee, Byong Won +1 more·2011·Phytochemistry

Abstract

An ethanol extract of the fruit case of Garcinia mangostan, whose most abundant chemical species are xanthones, showed potent α-glucosidase inhibitory activity (IC(50)=3.2 μg/ml). A series of isolated xanthones (1-16) demonstrated modest to high inhibition of α-glucosidase with IC(50) values of 1.5-63.5 μM. In particular, one hitherto unknown xanthone 16 has a very rare 2-oxoethyl group on C-8. Kinetic enzymatic assays with a p-nitrophenyl glucopyranoside indicated that one of them, compound (9) exhibited the highest activity (K(i)=1.4 μM) and mixed inhibition. Using, a physiologically relevant substrate, maltose, as substrate, many compounds (6, 9, 14, and 15) also showed potent inhibition which ranged between 17.5 and 53.5 μM and thus compared favorably with deoxynojirimycin (IC(50)=68.8 μM). Finally, the actual pharmacological potential of the ethanol extract was demonstrated by showing that it could elicit reduction of postprandial blood glucose levels. Furthermore, the most active α-glucosidase inhibitors (6, 9, and 14) were proven to be present in high quantities in the native seedcase by a HPLC chromatogram.

Integrity signals

Registry

Crossref · 10.1016/j.phytochem.2011.08.007

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

2 of the 26 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Ryu, H. W., Cho, J. K., Curtis-Long, M. J., Yuk, H. J., Kim, Y. S., Jung, S., Kim, Y. S., Lee, B. W., & Park, K. H.
Affiliations
  • Gyeongsang National University (KR)
  • Rural Development Administration (KR)
Corresponding author
Park, Ki Hun
Venue
Phytochemistry
Publisher
Elsevier BV
Published
2011-12
Volume
72
Issue
17
Pages
2148-2154
ISSN
0031-9422 (ISSN-L)
OpenAlex
W2058928007
Cited by
161
References
26
Citations by year
2026: 3 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 14 · 2021: 14 · 2020: 9 · 2019: 19 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 6
FWCI
9.22
Type
journal article
Language
en
Open access
closed
Locations
  • Phytochemistry (publishedVersion)
  • PubMed (publishedVersion)
Funders
Kyungpook National University
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Natural Compound Pharmacology Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
Keywords
α-glucosidase inhibition, antidiabetic activity, prenylated xanthones, Garcinia mangostana, mixed-type inhibition, maltose, postprandial blood glucose, deoxynojirimycin, enzyme kinetics
MeSH terms
Animals, Blood Glucose, Disease Models, Animal, Enzyme Inhibitors, Fruit, Hyperglycemia, Hypoglycemic Agents, Male, Maltose, Phytotherapy, Plant Extracts, Seeds, Rats, Sprague-Dawley, 1-Deoxynojirimycin, Postprandial Period, Inhibitory Concentration 50, Garcinia mangostana, Xanthones, Rats, Glycoside Hydrolase Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review