Anti-photoaging activity of triterpenoids isolated from Centella asiatica
Abstract
Centella asiatica (L.) Urban is a medical plant rich in triterpenoids, frequently used in Asia to treat skin conditions such as acne. To search for anti-photoaging agents, 16 known triterpenoids and five undescribed triterpenoids, including three ursane, one oleanane and one nor-ursane were isolated from the whole herb of C. asiatica. The structures and relative stereochemistry of these compounds were elucidated by detailed NMR spectra and HRESIMS. Compounds 1 and 2 were isomers of ursane-type and oleane-type triterpenes with rare aldehyde groups on C-23. Compound 4 was a unique example of a nor-ursane type triterpenoid. The Ultraviolet B (UVB) induced HaCaT cell damage model was used to measure the in vitro anti-photoaging activity of all 21 compounds. Twenty compounds significantly increased HaCaT viability and inhibited lactate dehydrogenase (LDH) release after UVB exposure. These findings highlight the protective effects of C. asiatica-derived triterpenoids against UVB damage and indicate their potential as natural agents that can protect the skin against photoaging.
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Centellasiaticoside and isomadecassic acid have demonstrated protective effects in keratinocytes under UVB stress, reducing LDH leakage and maintaining cellular viability.
“Specific triterpenes such as centellasiaticoside and isomadecassic acid have demonstrated protective effects in keratinocytes under UVB stress, reducing LDH leakage and maintaining cellular viability (Dang et al. 2024).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Dang et al. 2024
Cites
Therapeutic Potential of Centella asiatica and Its Triterpenes: A Review
Sun, B., Wu, L., Wu, Y., Zhang, C., Qin, L., Hayashi, M., Kudo, M., Gao, M., & Liu, T. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.568032 · Cited by 353 · see citing works
Self-citationJiang, H., Zhou, X., & Chen, L. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11603 · Cited by 27 · see citing works
Masi, F., Chianese, G., Peterlongo, F., Riva, A., & Taglialatela-Scafati, O. (2022) · Fitoterapia · doi:10.1016/j.fitote.2022.105163 · Cited by 11 · see citing works
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Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works
- Authors
- Dang, Y.-Y., Liu, T., Liu, Y.-D., Li, J.-Y., Jing, Y., Yang, M.-J., Zhang, H., Jiang, M.-M., Wu, H.-H., Yang, W.-Z., Li, N., & Zhang, P.
- Affiliations
- Tianjin University of Traditional Chinese Medicine (CN)
- Corresponding author
- Zhang, Han
- Li, Nan
- Zhang, Peng
- Venue
- Phytochemistry
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 228
- Pages
- 114246
- ISSN
- 0031-9422 (ISSN-L)
- OpenAlex
- W4401672751
- Cited by
- 14
- References
- 3
- Citations by year
- 2026: 8 · 2025: 6
- FWCI
- 5.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Phytochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- Centella asiatica, triterpenoids, UVB-induced skin damage, HaCaT keratinocytes, ursane triterpenoids, oleanane triterpenoids, structure elucidation
- MeSH terms
- HaCaT Cells, Cell Survival, Dose-Response Relationship, Drug, Humans, L-Lactate Dehydrogenase, Structure-Activity Relationship, Triterpenes, Ultraviolet Rays, Molecular Structure, Skin Aging, Centella
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