Phytochemical profile of Centevita®, a Centella asiatica leaves extract, and isolation of a new oleanane-type saponin
Abstract
Centella asiatica is a popular medicinal plant and several phytotherapic products in the market include its extracts as active constituents. A LC-MS guided phytochemical investigation on the commercial C. asiatica leaves extract named Centevita® allowed characterization and quantification of 24 secondary metabolites including 10 polyphenols and 14 ursane- or oleanane-type triterpenoids in the sapogenin or saponin form. This metabolomic analysis, besides confirming that the triterpenoid fraction roughly accounts for 45% of the extract weight, also resulted in the discovery of isoterminoloside, a new triglycoside saponin of the unprecedented 2α,3β,6β,23-tetrahydroxyolean-13(18)-en-28-oic acid (isoterminolic acid). The structure of isoterminoloside was characterized by a detailed ESI-MS and NMR investigation.
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Other triterpenoid derivatives such as ursane and oleanane derivatives and bayogenin provide additional antioxidant and antifibrotic activities by inhibiting elastase and fibrosis-related signaling molecules.
“Other triterpenoid derivatives, such as ursane and oleanane derivatives and bayogenin, provide additional antioxidant and antifibrotic activities by inhibiting key enzymes like elastase and fibrosis-related signaling molecules (Masi et al. 2022; Gayathri et al. 2024).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Masi et al. 2022
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- Authors
- Masi, F., Chianese, G., Peterlongo, F., Riva, A., & Taglialatela-Scafati, O.
- Affiliations
- University of Naples Federico II (IT)
- Indena (Italy) (IT)
- Venue
- Fitoterapia
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 158
- Pages
- 105163
- ISSN
- 0367-326X (ISSN-L)
- OpenAlex
- W4212911763
- Cited by
- 11
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Fitoterapia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Natural product bioactivities and synthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical Studies and Bioactivities
- Keywords
- Centella asiatica, phytochemical composition, oleanane saponins, triterpenoids, ursane-type triterpenoids, polyphenols, sapogenins, structure elucidation, medicinal plant extracts
- MeSH terms
- Oleanolic Acid, Plant Extracts, Saponins, Triterpenes, Molecular Structure, Plant Leaves, Centella, Phytochemicals
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