Asiaticoside delays senescence and attenuate generation of ROS in UV‑exposure cells through regulates TGF‑β1/Smad pathway
Open accessAbstract
. From previous research, asiaticoside possesses the potential capability to delay skin aging and reduce wrinkles clinically, but its underlying mechanism to regulate aging have not well-investigated. The present study found that asiaticoside could improve the viability and maintains a normal morphology in ultraviolet (UV)-exposure cells. In addition, β-galactosidase release was inhibited by treatment of asiaticoside in UV damaged cells was observed. The present study confirmed that UV-induced ROS generation and SOD reduction could be attenuated by incubation of asiaticoside. By using RNA sequencing technology, differential genes between UV and asiaticoside treatment were demonstrated and enriched genes suggested that asiaticoside is able to negatively regulate cell cycle and MAPK pathways. Western blotting was employed to clarify the variation of key proteins in TGF-β1/Smad pathway and cell cycle and the result implied that asiaticoside is capable of attenuating upregulation of TGF-β1, Smad2 and Smad3 to reverse cell senescence. The present study investigated regulation of asiaticoside to TGF-β1/Smad pathway in UV-induced HaCat cells, showing its potential to against photoaging.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Jiang et al. quantified asiaticoside and demonstrated its anti-photoaging potential through TGF-β1/Smad pathway modulation in UV-exposed cells.
“Likewise, Jiang et al. [20], quantified asiaticoside and demonstrated its anti-photoaging potential through TGF-β1/Smad pathway modulation in UV-exposed cells.”
From Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice (2025) · cites this paper as [20]
The Discussion reports that asiaticoside reduced UV-induced TGF-β1, Smad2 and Smad3 upregulation and showed anti-photoaging effects in cells. The Materials and methods section specifies asiaticoside treatment concentrations, but does not report quantifying asiaticoside itself; that part of the claim is unsupported. (LLM, conf=0.86)
Experimental — accuracy not yet measuredJiang et al. showed that asiaticoside suppressed UV-induced expression of TNF-α and IL-6 in dermal fibroblasts via the TGF-β1/Smad pathway, thereby reducing oxidative and inflammatory stress.
“Moreover, Jiang et al. [20] showed that asiaticoside suppressed UV-induced expression of TNF-α and IL-6 in dermal fibroblasts via the TGF-β1/Smad pathway, thereby reducing oxidative and inflammatory stress.”
From Oral Centella asiatica Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice (2025) · cites this paper as [20]
The Results (Regulation of Asiaticoside on cell signaling pathways) report reduced UV-induced ROS and TGF-β1/Smad2/3 signaling with asiaticoside, as well as reduced expression of the inflammatory protein MMP-9. The paper does not report suppression of TNF-α or IL-6. Its Materials and methods identify the experimental cells as HaCat cells, not dermal fibroblasts. (LLM, conf=0.90)
Experimental — accuracy not yet measuredAntioxidant and cytoprotective benefits from C. asiatica are mediated through direct ROS scavenging and upregulation of endogenous antioxidant enzymes such as SOD and catalase.
“Antioxidant and cytoprotective benefits from C. asiatica are mediated through direct ROS scavenging and upregulation of endogenous antioxidant enzymes such as superoxide dismutase (SOD) and catalase (Zhao et al. 2020; Mohapatra et al. 2021; Jiang et al. 2022).”
From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Jiang et al. 2022
The Results sections on UV-induced ROS and SOD activity report that asiaticoside reduced intracellular ROS and restored SOD activity in UV-exposed cells; the Discussion describes this as scavenging excess ROS. The paper does not establish direct chemical scavenging or show that asiaticoside upregulates catalase: catalase appears only in a general explanation of how superoxide is broken down. Page numbers were not provided for these passages. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Smad-dependent and Smad-independent pathways in TGF-β family signalling
Derynck, R., & Zhang, Y. E. (2003) · Nature · doi:10.1038/nature02006 · Cited by 5,370 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Structure and function of matrix metalloproteinases and TIMPs
Nagase, H., Visse, R., & MURPHY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.002 · Cited by 3,416 · see citing works
Hallmarks of Cellular Senescence
Hernandez-Segura, A., Nehme, J., & Demaria, M. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.02.001 · Cited by 2,605 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Senescence-associated β-galactosidase is lysosomal β-galactosidase.
Lee, B. Y., Han, J. A., Im, J. S., Morrone, A., Johung, K., Goodwin, E. C., Kleijer, W. J., DiMaio, D., & Hwang, E. S. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00199.x · Cited by 1,444 · see citing works
Role of Matrix Metalloproteinases in Photoaging and Photocarcinogenesis
Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., & Ohtsuki, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060868 · Cited by 1,099 · see citing works
Matrix-Degrading Metalloproteinases in Photoaging
Quan, T., Qin, Z., Xia, W., Shao, Y., Voorhees, J. J., & Fisher, G. J. (2009) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/jidsymp.2009.8 · Cited by 740 · see citing works
Tobin, D. J. (2017) · Journal of Tissue Viability · doi:10.1016/j.jtv.2016.03.002 · Cited by 701 · see citing works
Pharmacological review on Centella asiatica: A potential herbal cure-all
Gohil, K., Patel, J. A., & Gajjar, A. (2010) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.78519 · Cited by 666 · see citing works
Photoaging: mechanisms and repair
Rabe, J. H., Mamelak, A. J., McElgunn, P. J. S., Morison, W. L., & Sauder, D. N. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2005.05.010 · Cited by 610 · see citing works
Varga, J., Rosenbloom, J., & Jimenez, S. A. (1987) · Biochemical Journal · doi:10.1042/bj2470597 · Cited by 591 · see citing works
Chemical, pharmacological and clinical profile of the East Asian medical plant Centella aslatica
Brinkhaus, B., Lindner, M., Schuppan, D., & Hahn, E. G. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80065-3 · Cited by 525 · see citing works
Ultraviolet A and melanoma: A review
Wang, S. Q., Setlow, R. B., Berwick, M., Polsky, D., Marghoob, A. A., Kopf, A. W., & Bart, R. S. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.114594 · Cited by 454 · see citing works
In Vitro and in Vivo Wound Healing Activity of Asiaticoside Isolated from Centella Asiatica
Shukla, A., Rasik, A. M., Jain, G. K., Shankar, R., Kulshrestha, D. K., & Dhawan, B. N. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00141-x · Cited by 428 · see citing works
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works
Brennan, M. M., Bhatti, H., Nerusu, K. C., Bhagavathula, N., Kang, S., Fisher, G. J., Varani, J., & Voorhees, J. J. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)0780043mmitmc2.0.co2 · Cited by 358 · see citing works
Cavinato, M., & Jansen-Dürr, P. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.01.009 · Cited by 284 · see citing works
Debacq‐Chainiaux, F., Borlon, C., Pascal, T. G., Royer, V., Eliaers, F., Ninane, N., Carrard, G., Friguet, B., de Longueville, F., Boffe, S., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.01651 · Cited by 267 · see citing works
Biotechnology and bioprocess engineering
Hu, W.-S., & Liao, J. C. (2013) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2013.10.004 · Cited by 246 · see citing works
Quantitative assay of senescence-associated β-galactosidase activity in mammalian cell extracts
Gary, R. K., & Kindell, S. M. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.06.003 · Cited by 195 · see citing works
Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014) · Skin Pharmacology and Physiology · doi:10.1159/000355523 · Cited by 191 · see citing works
Damage to Skin Extracellular Matrix Induced by UV Exposure
Watson, R. E. B., Gibbs, N. K., Griffiths, C. E. M., & Sherratt, M. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5653 · Cited by 179 · see citing works
Wijeweera, P., Arnason, J. T., Koszycki, D., & Merali, Z. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.01.011 · Cited by 171 · see citing works
CURRENT TOPICS IN NUTRACEUTICAL RESEARCH
(2023) · Current Topics in Nutraceutical Research · doi:10.37290/ctnr · Cited by 158 · see citing works
TGF-β1/p53 signaling in renal fibrogenesis
Higgins, S. P., Tang, Y., Higgins, C. E., Mian, B. M., Zhang, W., Czekay, R., Samarakoon, R., Conti, D. J., & Higgins, P. J. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.11.005 · Cited by 150 · see citing works
Facilitating action of asiaticoside at low doses on burn wound repair and its mechanism
Kimura, Y., Sumiyoshi, M., Samukawa, K.-I., Satake, N., & Sakanaka, M. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.036 · Cited by 126 · see citing works
Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging
Xu, Y., & Fisher, G. J. (2005) · Journal of Dermatological Science Supplement · doi:10.1016/j.descs.2005.06.002 · Cited by 116 · see citing works
Proteins of the Extracellular Matrix Are Sensitizers of Photo-oxidative Stress in Human Skin Cells
Wondrak, G. T., Roberts, M. J., Cervantes-Laurean, D., Jacobson, M. K., & Jacobson, E. L. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12414.x · Cited by 115 · see citing works
Anand, S., Rajinikanth, P. S., Arya, D. K., Pandey, P. K., Gupta, R. K., Sankhwar, R., & Chidambaram, K. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14020273 · Cited by 97 · see citing works
Kim, M., Kim, Y. K., Cho, K. H., & Chung, J. H. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.09.007 · Cited by 92 · see citing works
Hwang, E., Lee, D.-G., Park, S. H., Oh, M. S., & Kim, S. Y. (2014) · Journal of Medicinal Food · doi:10.1089/jmf.2013.2999 · Cited by 90 · see citing works
UVB-induced premature senescence of human diploid skin fibroblasts.
Chainiaux, F., Magalhães, J., Eliaers, F., Remacle, J., & Toussaint, O. (2002) · International Journal of Biochemistry and Cell Biology · doi:10.1016/s1357-2725(02)00022-5 · Cited by 90 · see citing works
Vedrenne, N., Coulomb, B., Danigo, A., Bonté, F., & Desmoulière, A. (2012) · Pathologie Biologie · doi:10.1016/j.patbio.2011.10.002 · Cited by 89 · see citing works
Su, J., Guo, K., Huang, M., Liu, Y., Zhang, J., Sun, L., Li, D., Pang, K., Wang, G., Chen, L., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00906 · Cited by 89 · see citing works
Namviriyachote, N., Muangman, P., Chinaroonchai, K., Chuntrasakul, C., & Ritthidej, G. C. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.166 · Cited by 68 · see citing works
Guo, K., Liu, Y., Tang, L., & Shubhra, Q. T. H. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131120 · Cited by 63 · see citing works
Chen, C., Chiang, A.-N., Liu, H., & Chang, Y.-T. (2014) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2014.04.001 · Cited by 61 · see citing works
Shubhra, Q. T. H., Guo, K., Liu, Y., Razzak, M., Manir, M. S., & Alam, A. K. M. M. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.06.016 · Cited by 61 · see citing works
Guo, K., Xiao, N.-Y., Liu, Y., Wang, Z.-M., Tóth, J., Gyenis, J., Thakur, V., Oyane, A., & Shubhra, Q. T. (2021) · Nano Materials Science · doi:10.1016/j.nanoms.2021.12.001 · Cited by 61 · see citing works
Zhao, J., Shi, J., Shan, Y., Yu, M., Zhu, X., Zhu, Y., Liu, L., & Sheng, M. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00226-9 · Cited by 55 · see citing works
Anti-allergic, anti-pruritic, and anti-inflammatory activities of Centella asiatica extracts
George, M., & Joseph, L. (2010) · African Journal of Traditional Complementary and Alternative Medicines · doi:10.4314/ajtcam.v6i4.57206 · Cited by 54 · see citing works
Ji, L., Xu, J., Liu, J., Amjad, A., Zhang, K., Liu, Q., Zhou, L., Xiao, J., & Li, X. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.639351 · Cited by 47 · see citing works
Russo, P. A. J., & Halliday, G. M. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2006.07339.x · Cited by 41 · see citing works
Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication
Graindorge, D., Martineau, S., Machon, C., Arnoux, P., Guitton, J., Francesconi, S., Frochot, C., Sage, É., & Girard, P.-M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140645 · Cited by 38 · see citing works
Liu, Y., Ding, M., Guo, K., Wang, Z., Zhang, C., & Shubhra, Q. T. H. (2022) · Smart Materials in Medicine · doi:10.1016/j.smaim.2022.05.003 · Cited by 38 · see citing works
Liu, S.-C., Mizu, H., & Yamauchi, H. (2010) · Free Radical Biology & Medicine · doi:10.1016/j.freeradbiomed.2009.12.014 · Cited by 37 · see citing works
Shubhra, Q. T. H., Oyane, A., Araki, H., Nakamura, M., & Tsurushima, H. (2017) · Biomaterials Science · doi:10.1039/c6bm00870d · Cited by 35 · see citing works
Feczkó, T., Fodor-Kardos, A., Sivakumaran, M., & Shubhra, Q. T. H. (2016) · Nanomedicine · doi:10.2217/nnm-2016-0058 · Cited by 34 · see citing works
Shubhra, Q. T. H., Kardos, A. F., Feczkó, T., Macková, H., Horák, D., Tóth, J. S., Dósa, G., & Gyenis, J. (2013) · Journal of Microencapsulation · doi:10.3109/02652048.2013.814729 · Cited by 32 · see citing works
Effects of Galla chinensis extracts on UVB-irradiated MMP-1 production in hairless mice
Sun, Z., Hwang, E., Lee, H. J., Lee, T. Y., Song, H. G., Park, S., Shin, H., Lee, D., & Yi, T. (2014) · Journal of Natural Medicines · doi:10.1007/s11418-014-0856-6 · Cited by 32 · see citing works
Hasham, R., Choi, H.-K., Sarmidi, M. R., & Park, C. S. (2013) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-012-0353-2 · Cited by 32 · see citing works
Park, D., Lee, Y., Jeong, Y.-J., Jeon, H., & Kang, S. C. (2021) · Antioxidants · doi:10.3390/antiox10040613 · Cited by 27 · see citing works
Georgetti, S. R., Casagrande, R., Vicentini, F. T. M. C., Baracat, M. M., Verri, W. A., Jr., & Fonseca, M. J. V. (2013) · BioMed Research International · doi:10.1155/2013/340626 · Cited by 20 · see citing works
Kurosaki, Y., Abe, H., Morioka, H., Hirayama, J., Ikebuchi, K., Kamo, N., Nikaido, O., Azuma, H., & Ikeda, H. (2003) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2003)078 · Cited by 18 · see citing works
Luo, P., Huang, Q.-S., Chen, S., Wang, Y., & Dou, H. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108864 · Cited by 17 · see citing works
Sun, L., Xu, C., Lin, P., Quigg, A. S., Chin, W., & Santschi, P. H. (2020) · Marine Chemistry · doi:10.1016/j.marchem.2020.103907 · Cited by 15 · see citing works
Qin, H., Zhang, G., & Zhang, L. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5863 · Cited by 11 · see citing works
Ribeiro, F. M., Ratti, B. A., Rando, F. D. S., Fernandez, M. A., Ueda‐Nakamura, T., Silva, S. D. O., & Nakamura, C. V. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111387 · Cited by 11 · see citing works
Raharjo, A. B., Putra, R. D. A., Indayaningsih, N., Srifiana, Y., Hardiansyah, A., Irmawati, Y., Widodo, H., & Destyorini, F. (2020) · AIP conference proceedings · doi:10.1063/5.0014545 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
How to Promote Skin Repair? In-Depth Look at Pharmaceutical and Cosmetic Strategies
Torres, A., Rego, L., Martins, M., Ferreira, M. S., Cruz, M. T., Sousa, E., & Almeida, I. F. (2023) · Pharmaceuticals · doi:10.3390/ph16040573 · Cited by 42 · see citing works
Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing
Razif, R., Fadilah, N. I. M., Ahmad, H., Hao, D. L. Q., Maarof, M., & Fauzi, M. B. (2025) · Biomedicines · doi:10.3390/biomedicines13020277 · Cited by 26 · see citing works
Xu, C., Xia, L., Xu, D., Liu, Y., Jin, P., Zhai, M., Mao, Y., Wang, Y., Wen, A., Yang, J. Z., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18055 · Cited by 24 · see citing works
“13 It has been confirmed that it has antioxidant, anti-inflammatory, antiviral, wound-healing promoting and other pharmacological effects.”
BackgroundHong, C., Fu, L., Teng, Y., He, J., Shen, Y.-Y., Bian, Q., Wang, T., Wang, M., Pang, X.-W., Lin, Z., et al. (2024) · Biomaterials Research · doi:10.34133/bmr.0121 · Cited by 21 · see citing works
“Photoaging is reportedly closely related to the Smad signaling pathway, and the Smad proteins are involved in signal transduction and transcriptional regulation [ 40 , 41 ].”
Hu, X., Chen, M., Nawaz, J., & Duan, X. (2024) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s478666 · Cited by 19 · see citing works
“42–44 NF-κ B signaling pathways NF-κ B is a family of transcription factors whose consortium proteins can be divided into the following “Rel” proteins, including RelA, c-Bel, RelB, NF-κ B1 and NF-κ B2.”
BackgroundGravina, C., Formato, M., Piccolella, S., Fiorentino, M., Stinca, A., Pacifico, S., & Esposito, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098038 · Cited by 16 · see citing works
Anti-photoaging activity of triterpenoids isolated from Centella asiatica
Dang, Y.-Y., Liu, T., Liu, Y.-D., Li, J.-Y., Jing, Y., Yang, M.-J., Zhang, H., Jiang, M.-M., Wu, H.-H., Yang, W.-Z., et al. (2024) · Phytochemistry · doi:10.1016/j.phytochem.2024.114246 · Cited by 14 · see citing works
Zhang, Y., Liu, J., Yang, G., Zou, J., Tan, Y., Xi, E.-P., Geng, Q., & Wang, Z. (2024) · Environmental Toxicology · doi:10.1002/tox.24359 · Cited by 9 · see citing works
Jin, M. J., He, K., Zhen, S., Wang, Y., Guo, H., Shen, H., & Ping, F. (2024) · Drug Development Research · doi:10.1002/ddr.22242 · Cited by 8 · see citing works
“The regulative effect of AC on the ROS level is also reported in various diseases, such as diabetic wounds (Liang et al., 2022), aging (Jiang et al., 2022) and myocardial ischemia/ reperfusion (Zeng et al., 2022).”
Zheng, M., Yuan, G., Han, J., Li, J., Jiang, Y., Li, Z., & Yao, Y. (2025) · Immunologic Research · doi:10.1007/s12026-025-09646-1 · Cited by 8 · see citing works
Zheng, Y., Lei, J., Zhang, A., Cao, C., Xu, A., Zhou, M., & Lin, F. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112900 · Cited by 6 · see citing works
Handayani, R., Febriyanti, R. M., Muhaimin, M., & Chearunisaa, A. Y. (2025) · Pharmacia · doi:10.3897/pharmacia.72.e167217 · Cited by 5 · see citing works
Barinda, A. J., Arozal, W., Dwita, N. C., Safutra, M. S., Shimizu, I., Hsiao, Y., Sandora, N., Hakim, R. W., Khatimah, N. G., & Hardi, H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1589444 · Cited by 4 · see citing works
Engineered Exosomes Complexed with Botulinum Toxin Type A for Enhanced Anti-Aging Effects on Skin
Wang, Y., Wang, K., Ben, X., Tian, M., Liu, X., Li, Z., Ni, P., Liu, Q., Ma, Z., Yi, X., et al. (2025) · Biology · doi:10.3390/biology14081040 · Cited by 4 · see citing works
“Type I collagen accounts for approximately 80% of total human collagen, and its reduction is a key biomarker of skin aging [31].”
Choi, Y. J., Cho, E.-C., Lim, S., Lee, J., Bae, J., Oh, T. K., Lee, J. K., & Kim, E. J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010204 · Cited by 3 · see citing works
Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms
Korkina, L., Kharaeva, Z., Shokarova, A., Barokova, E., Mayer, W., Trakhtman, I., Dal Toso, R., & De Luca, C. (2024) · Biomolecules · doi:10.3390/biom14091176 · Cited by 3 · see citing works
Fan, Y., Chen, R. E., Tang, L., Fu, P., Zhou, J., & Chen, X. (2025) · Journal of Separation Science · doi:10.1002/jssc.70128 · Cited by 2 · see citing works
Wang, C., Hao, Y., Zhang, Z., Ou, X., Guo, Z., Wang, S., & Yang, J. (2026) · The Crop Journal · doi:10.1016/j.cj.2026.02.003 · Cited by 1 · see citing works
Susilawati, E., Rochman, A., Kaniawati, M., Sulaeman, A., & Putra, H. (2001) · IALLT Journal of Language Learning Technologies · doi:10.17161/iallt.v33i1.8314
Efficacy and Safety of Tranexamic Acid Combined with Hydroquinone Cream in the Treatment of Chloasma
Wu, Y. J., Wu, S. F., Ma, Y., & Hong, F. (2023) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.spl.652
METTL3 and METTL14 Mediated RNAs Methylation Facilitates UVB-Induced PhotoagingPreprint
Zhang, S., Wu, M. Y., Lu, T., Tian, X., Gao, L., Yan, S., Wang, D., Zeng, J., & Tan, L. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4859735
RNAs m6A modification facilitates UVB-induced photoaging
Zhang, S., Wu, M. Y., Lu, T., Tian, X., Gao, L., Yan, S., Wang, D., Zeng, J., & Tan, L. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e39532
“The early pathological changes in photoaging involve DNA damage, inflammatory responses, increased production of ROS and enhanced secretion of senescence-associated secretory phenotypes (SASP), resulting in premature senescence of major skin cells [29,30].”
BackgroundA Polyherbal Formulation That Mitigates Cellular Damage in Narrowband UVB-Irradiated HaCaT Cells
Teerapatpaisan, S., Naladta, A., Thapphasaraphong, S., & Nualkaew, N. (2025) · Cosmetics · doi:10.3390/cosmetics12060241
Ma, G., Liu, Z., Li, Y., & Tao, Y. (2026) · Journal of Visualized Experiments · doi:10.3791/70099
Gan, G., Chang, Y., Deng, W., Zhou, W., Yang, L., & Ren, Z. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05418-2
“AS possesses multiple biological functions, including anti-inflammatory, anti-oxidation, anti-cancer, anti-apoptosis, and promoting wound healing (He et al. 2023; Jiang et al. 2022; Yao et al. 2023).”
Liu, Y., Chen, K., Pei, J., Qi, S., Wang, X., Ma, C., Li, Y., & Yu, L. (2026) · Drug Delivery · doi:10.1080/10717544.2026.2708405
“Furthermore, IF staining revealed that UVB exposure markedly decreased Upregulation of TGF-β1 mRNA (Figure 9G), a central regulator of collagen biosynthesis (Jiang et al. 2022), may contribute to the promotive effects of DPP-LIP-SA on matrix repair.”
Cosmetic and personal care applications of polysaccharides
Fang, D., Shen, W., Wang, H., Cheng, N., Zhang, M., Han, S., Du, Z., & Zhang, Y. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44049-6.00011-9
- Authors
- Jiang, H., Zhou, X., & Chen, L.
- Affiliations
- Wuhan No.1 Hospital (CN)
- Corresponding author
- Zhou, Xiaoyong
- Chen, Liuqing
- Venue
- Experimental and Therapeutic Medicine
- Publisher
- Spandidos Publications
- Published
- 2022-09-08
- Volume
- 24
- Issue
- 5
- Pages
- 667-667
- ISSN
- 1792-0981 (ISSN-L)
- 1792-1015
- PMC
- PMC9500490
- OpenAlex
- W4296117850
- Cited by
- 27
- References
- 62
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 8 · 2023: 4
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Experimental and Therapeutic Medicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- asiaticoside, cellular senescence, photoaging, ultraviolet radiation, reactive oxygen species, TGF-β1/Smad signaling, Smad2, Smad3, superoxide dismutase, HaCaT keratinocytes, cell cycle, MAPK signaling, skin aging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
