Amberboin and lipidiol: X-ray crystalographic data, absolute configuration and inhibition of cholinesterase
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Amberboin also inhibited BChE with IC50 = 0.6 ± 0.13 μM.
“Further, amberboin also inhibited the BChE at IC50 of 0.6 ± 0.13 µM.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [121]
Cites
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Sesquiterpenoids Lactones: Benefits to Plants and People
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“18 ) [59].”
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“As reported by Elsebay et Al., sesquiterpene lactones like amberboin and lipidiol, isolated from Volutaria abyssinica A. Rich (Asteraceae), inhibited AchE more than galantamine used as a reference compound [19].”
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“[21] The effect could improve Aβ plaque, neuron excitability, and oxidative stress, which had a function to alleviate neuroinflammation.”
Background
- Authors
- Elsebai, M. F., Ghabbour, H. A., Marzouk, A. M., Salmas, R. E., Orhan, I. E., & Senol, F. S.
- Affiliations
- Mansoura University (EG)
- Istanbul Technical University (TR)
- Corresponding author
- Elsebai, Mahmoud Fahmi
- Venue
- Phytochemistry Letters
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 27
- Pages
- 44-48
- ISSN
- 1874-3900 (ISSN-L)
- OpenAlex
- W2809178296
- Cited by
- 5
- References
- 17
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 1
- FWCI
- 0.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytochemistry Letters (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Istanbul Technical University Academic Open Archive (Istanbul Technical University) (submittedVersion)
- Funders
- Deanship of Scientific Research, King Saud University (RGP-1436-038)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive Natural Diterpenoids Research
- Keywords
- sesquiterpene lactones, guaianolides, absolute configuration, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, cholinesterase inhibitors, structure-activity relationship, molecular docking
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