Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa
Open accessAbstract
BACKGROUND: Alzheimer's disease (AD) is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD, secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for their cholinesterase inhibitory activity. RESULTS: Four sesquiterpene lactones have been isolated from the ethyl acetate soluble fraction of Amberboa ramosa. In which one compound Amberbin C (1) was found to be new while other three Amberin (2), Amberbin A (3), and Amberbin B (4) were previously reported ones. The structures of the isolated compounds were elucidated using different spectroscopic techniques. Isolated compounds were tested for their inhibitory potential against acetyl cholinesterase and butyryl cholinesterase enzymes. All compounds showed excellent inhibitory activities against acetyl cholinesterase and butyryl cholinesterase. CONCLUSIONS: A new sesquiterpene lactone has been isolated and fully characterized, the sesquiterpene lactones from Amberboa ramosa showed good inhibitory activities against acetyl cholinesterase and butyryl cholinesterase enzymes, this study indicated that sesquiterpene lactone can become interesting lead molecules in drug development against Alzheimer's disease (AD).
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The same four sesquiterpene lactones from Amberboa ramosa had BChE IC50 values: Amberin 3 ± 0.02, Amberin-A 5 ± 0.2, Amberin-B 2.5 ± 0.2, and Amberin-C 18 ± 0.05 μM.
“and for BChE inhibition was at 3 ± 0.02 (Amberin), 5 ± 0.2 (Amberin-A), 2.5 ± 0.2 (Amberin-B) and 18 ± 0.05 (Amberin-C).”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [124]
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- Authors
- Ibrahim, M., Farooq, T., Hussain, N., Hussain, A., Gulzar, T., Hussain, I., Akash, M. S. H., & Rehmani, F. S.
- Affiliations
- Government College University, Faisalabad (PK)
- University of Karachi (PK)
- Zhejiang University (CN)
- Corresponding author
- Ibrahim, Muhammad
- ORCID
- Venue
- Chemistry Central Journal
- Published
- 2013-07-10
- Volume
- 7
- Issue
- 1
- Pages
- 116-116
- ISSN
- 1752-153X (ISSN-L)
- PMC
- PMC3718625
- OpenAlex
- W2147578520
- Cited by
- 38
- References
- 17
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 7 · 2013: 3
- FWCI
- 1.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Chemistry Central Journal (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greater South Information System
- Funders
- University of Karachi
- Directorate for Biological Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- sesquiterpene lactones, acetylcholinesterase inhibition, butyrylcholinesterase inhibition, Alzheimer's disease, natural product isolation, structure elucidation, lead molecules
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