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Cited by 340

The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.

Vitamin D effects on pregnancy and the placenta

Open access
Shin, J.S., Choi, M.Y., Longtine, M.S., Nelson, D.M.·2010·Placenta
DOI 10.1016/j.placenta.2010.08.015
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Abstract

Vitamin D is a pleiotropic secosteroid hormone important for health and disease prevention. The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of vitamin D [1,25(OH)2D] to induce both transcriptional and non-genomic responses. Vitamin D has well known classical functions in calcium uptake and bone metabolism, but more recent work highlights the importance of the nonclassical actions of vitamin D in a variety of cell types. These actions include modulation of the innate and adaptive immune systems and regulation of cell proliferation. Adequate vitamin D intake is essential for maternal and fetal health during pregnancy, and epidemiological data indicate that many pregnant women have sub-optimal vitamin D levels. Notably, vitamin D deficiency correlates with preeclampsia, gestational diabetes mellitus, and bacterial vaginosis, and an increased risk for C-section delivery. Recent work emphasizes the importance of nonclassical roles of vitamin D in pregnancy and the placenta. The placenta produces and responds to vitamin D where vitamin D functions as a modulator of implantation, cytokine production and the immune response to infection. We describe vitamin D metabolism and the cellular responses to vitamin D, and then summarize the role of vitamin D in placental trophoblast, pregnancy and the fetus.

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Metadata

Authors
Shin, J. S., Choi, M. Y., Longtine, M. S., & Nelson, D. M.
Venue
Placenta
Publisher
Elsevier BV
Published
2010-12
Volume
31
Issue
12
Pages
1027-1034
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/j.placenta.2010.08.015
OpenAlex
W1987935181
Cited by
340
References
122
FWCI
8.46
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Vitamin D effects on pregnancy and the placenta. https://app.cochat.ai/papers/10.1016/j.placenta.2010.08.015
The paper
Shin, J. S., Choi, M. Y., Longtine, M. S., & Nelson, D. M. (2010). Vitamin D effects on pregnancy and the placenta. Placenta. https://doi.org/10.1016/j.placenta.2010.08.015

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.