Cited by 1,298Vitamin D Research StudiesNutrition and Health StudiesVitamin K Research Studies

Vitamin D for health: a global perspective

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Hossein-nezhad, Arash, Holick, Michael F.·2013·Mayo Clinic Proceedings

Abstract

It is now generally accepted that vitamin D deficiency is a worldwide health problem that affects not only musculoskeletal health but also a wide range of acute and chronic diseases. However, there remains cynicism about the lack of randomized controlled trials to support the association studies regarding the nonskeletal health benefits of vitamin D. This review was obtained by searching English-language studies published up to April 1, 2013, in PubMed, MEDLINE, and the Cochrane Central Register of Controlled Trials (search terms: vitamin D and supplementation) and focuses on recent challenges regarding the definition of vitamin D deficiency and how to achieve optimal serum 25-hydroxyvitamin D concentrations from dietary sources, supplements, and sun exposure. The effect of vitamin D on fetal programming epigenetics and gene regulation could potentially explain why vitamin D has been reported to have such wide-ranging health benefits throughout life. There is potentially a great upside to increasing the vitamin D status of children and adults worldwide for improving musculoskeletal health and reducing the risk of chronic illnesses, including some cancers, autoimmune diseases, infectious diseases, type 2 diabetes mellitus, neurocognitive disorders, and mortality.

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Crossref · 10.1016/j.mayocp.2013.05.011

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  • Estimates indicate that 20% to 80% of US, Canadian, and European adults have serum 25(OH)D levels below 50 nmol/L.

    “but estimates indicate that 20% to 80% of US, Canadian, and European adults have serum 25(OH)D levels below this [289]”

    From Nutritional Considerations for the Vegan Athlete (2023) · cites this paper as [289]

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Authors
Hossein-nezhad, A., & Holick, M. F.
Affiliations
Boston University (US)
Corresponding author
Holick, Michael F.
Venue
Mayo Clinic Proceedings
Publisher
Elsevier BV
Published
2013-07
Volume
88
Issue
7
Pages
720-755
ISSN
0025-6196 (ISSN-L)
OpenAlex
W1994006843
Cited by
1,298
References
283
Citations by year
2026: 27 · 2025: 72 · 2024: 94 · 2023: 127 · 2022: 101 · 2021: 123 · 2020: 140 · 2019: 103 · 2018: 130 · 2017: 97 · 2016: 103 · 2015: 92 · 2014: 77 · 2013: 9 · 2012: 1
FWCI
70.20
Type
journal article
Language
en
Open access
Locations
  • Mayo Clinic Proceedings (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • School of Medicine, Boston University
  • National Center for Research Resources (UL-1-RR-25711, UL1RR025771)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Vitamin K Research Studies
Keywords
vitamin D, vitamin D deficiency, vitamin D supplementation, 25-hydroxyvitamin D, sun exposure, dietary sources of vitamin D, fetal programming, epigenetics, gene expression regulation, musculoskeletal health, chronic disease risk, cancer, autoimmune disease, infectious diseases, type 2 diabetes, neurocognitive disorders, mortality
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Child, Female, Health Status, Humans, Male, Metabolic Diseases, Middle Aged, Musculoskeletal Diseases, Osteoporosis, Sunlight, Vitamin D, Vitamin D Deficiency, Health Behavior, Young Adult

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