Expression of voltage-dependent potassium channels in first trimester human placentae
Open accessAbstract
Potassium channel α-subunits encoded by KCNQ1-5 genes form voltage-dependent channels (KV7), modulated by KCNE1-5 encoded accessory proteins. The aim was to determine KCNQ and KCNE mRNA expression and assess protein expression/localisation of the KCNQ3 and KCNE5 isoforms in first trimester placental tissue. Placentae were obtained from women undergoing elective surgical termination of pregnancy (TOP) at ≤ 10 weeks' (early TOP) and >10 weeks' (mid TOP) gestations. KCNQ1-5 expression was unchanged during the first trimester. KCNE5 expression increased in mid TOP vs. early TOP samples (P = 0.022). This novel study reports mRNA and protein expression of KV7 channels in first trimester placentae.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Voltage-dependent K+ channels have been immunolocalized to the syncytiotrophoblast, cytotrophoblast and some stromal cells in the first trimester and term placenta.
“Voltage-dependent K + channels have also been immunolocalized to the syncytiotrophoblast, cytotrophoblast and some stromal cells in the first trimester and term placenta (382, 383), and so they may play a broader role in placental biology, including regulating the secretion of hCG (574).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [382]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A constitutively open potassium channel formed by KCNQ1 and KCNE3
Schroeder, B. C., Waldegger, S., Fehr, S., Bleich, M., Warth, R., Greger, R. F., & Jentsch, T. J. (2000) · Nature · doi:10.1038/35003200 · Cited by 494 · see citing works
Aspects of Human Fetoplacental Vasculogenesis and Angiogenesis. II. Changes During Normal Pregnancy
Kaufmann, P., Mayhew, T. M., & Jones, D. S. (2003) · Placenta · doi:10.1016/j.placenta.2003.10.009 · Cited by 437 · see citing works
Archer, S. L., & Michelakis, E. D. (2002) · Physiology · doi:10.1152/nips.01388.2002 · Cited by 138 · see citing works
Differential expression of KvLQT1 and its regulator IsK in mouse epithelia
Demolombe, S., Franco, D., de Boer, P. A. J., et al. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.2.c359 · Cited by 114 · see citing works
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition
Hampl, V., Bı́bová, J., Straňák, Z., Wu, X., Michelakis, E. D., Hashimoto, K., & Archer, S. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01033.2001 · Cited by 104 · see citing works
Expression of AT1R, AT2R and AT4R and Their Roles in Extravillous Trophoblast Invasion in the Human
Williams, P. J., Mistry, H. D., Innes, B. A., et al. (2010) · Placenta · doi:10.1016/j.placenta.2010.02.014 · Cited by 83 · see citing works
Self-citationExpression and function of potassium channels in the human placental vasculature
Wareing, M., Bai, X., Seghier, F., et al. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00040.2006 · Cited by 66 · see citing works
Basolateral membrane K+channels in renal epithelial cells
Hamilton, K. L., & Devor, D. C. (2012) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00646.2011 · Cited by 62 · see citing works
Hydrogen Sulfide: Potent Regulator of Vascular Tone and Stimulator of Angiogenesis
Gollasch, M., Huang, Y., Köhn, C., et al. (2012) · International Journal of Biomedical Science · doi:10.59566/ijbs.2012.8081 · Cited by 61 · see citing works
Mistry, H. D., McCallum, L. A., Kurlak, L. O., Greenwood, I. A., Broughton Pipkin, F., & Tribe, R. M. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.173740 · Cited by 48 · see citing works
Self-citationStemness and angiogenic gene expression changes of serial-passage human amnion mesenchymal cells
Fatimah, S. S., Tan, G. C., Chua, K. H., Manzor, N. F. M., Tan, A. E., & Hayati, A. R. (2012) · Microvascular Research · doi:10.1016/j.mvr.2012.12.004 · Cited by 45 · see citing works
Skeletal muscle Kv7 (KCNQ) channels in myoblast differentiation and proliferation
Roura‐Ferrer, M., Solé, L., Martínez‐Mármol, R., et al. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.02.152 · Cited by 44 · see citing works
Luo, Y., Kumar, P., & Mendelson, C. R. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1038 · Cited by 38 · see citing works
MacVinish, L. J., Guo, Y., Dixon, A. K., Murrell‐Lagnado, R. D., & Cuthbert, A. W. (2001) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)12302-4 · Cited by 31 · see citing works
Oxygen Sensitivity, Potassium Channels, and Regulation of Placental Vascular Tone
Wareing, M. (2014) · Microcirculation · doi:10.1111/micc.12069 · Cited by 30 · see citing works
KCNQ-encoded channels regulate Na+ transport across H441 lung epithelial cells
Greenwood, I. A., Yeung, S. Y. M., Hettiarachi, S., et al. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0557-7 · Cited by 16 · see citing works
Guiet-Bara, A., Ibrahim, B., Leveteau, J., et al. (1999) · Bioelectrochemistry and Bioenergetics · doi:10.1016/s0302-4598(99)00020-3 · Cited by 16 · see citing works
Bisseling, T. M., Versteegen, M. G. J., van der Wal, S., et al. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.09.031 · Cited by 10 · see citing works
Evidence of K and Ca channels in endothelial cells of human allantochorial placental vessels.
Guiet-Bara, A., & Bara, M. (2002) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Mills TA, Shweikh Y, Greenwood SL, Jones RL and Wareing M. Control of human chorionic plate arterial tone: a role for Kv7 Channels? 2009. pp. 163A. Reproductive Sciences.
Cited by
Sorted by citations
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
- Authors
- Mistry, H. D., Kurlak, L. O., Whitley, G. S., Cartwright, J. E., Broughton Pipkin, F., & Tribe, R. M.
- Affiliations
- University of Bern (CH)
- University of Nottingham (GB)
- St George's, University of London (GB)
- St Thomas' Hospital (GB)
- Corresponding author
- Mistry, H.D.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 35
- Issue
- 5
- Pages
- 337-340
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W1970325521
- Cited by
- 5
- References
- 19
- Citations by year
- 2024: 2 · 2022: 1 · 2016: 2
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Repository@Nottingham (University of Nottingham) (acceptedVersion, other-oa)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by-nc-nd)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Tommy's (1060508)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- voltage-gated potassium channels, Kv7 channels, KCNQ3, KCNE5, first trimester placenta, mRNA expression, protein localization, elective termination of pregnancy, gestational age
- MeSH terms
- Adult, Female, Humans, Placenta, Pregnancy, Pregnancy Trimester, First, Potassium Channels, Voltage-Gated
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
