Oxygen Sensitivity, Potassium Channels, and Regulation of Placental Vascular Tone
Abstract
The human fetoplacental vasculature is a low‐resistance circulation with deoxygenated arterial relative to venous blood. The placenta lacks neuronal innervation suggesting that local physical (e.g., oxygenation; flow rate), paracrine (e.g., endothelial cell nitric oxide), and circulating (e.g., angiotensin II) factors will contribute to blood flow regulation in small fetoplacental vessels. Oxygenation (specifically hypoxia) has received particular attention. At the macro‐level, hypoxic challenge increases vascular resistance, but the data's physiological relevance remains questionable. K+ channels are a diverse family of proteins known to play important roles in the normal physiological functions of endothelial and smooth muscle cells of a variety of vascular beds. K+ channels are categorized by their predicted transmembrane structure or gating properties. A small number of perfused placental cotyledon and isolated blood vessels studies have assessed K+ channel activity. Specific activator/inhibitor application suggests functional voltage‐gated channels, whereas toxin inhibitor studies have documented K Ca channel activity. Pharmacological K ATP channel activation significantly dilates preconstricted placental arteries and veins. There is a paucity of cell subtype‐specific expression studies of placental K+ channels. This review focuses on the roles of K+ channels and oxygenation in controlling reactivity of small fetoplacental blood vessels.
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A variety of K+ channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta.
“A variety of K + channel subtypes, many of them oxygen sensitive, are present in the vasculature of the human placenta (307, 563, 564).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [563]
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
Expression of voltage-dependent potassium channels in first trimester human placentae
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- Authors
- Wareing, M.
- Affiliations
- Manchester Academic Health Science Centre (GB)
- Corresponding author
- Wareing, Mark
- ORCID
- Wareing, Mark
- Venue
- Microcirculation
- Publisher
- Wiley
- Published
- 2014-01
- Volume
- 21
- Issue
- 1
- Pages
- 58-66
- ISSN
- 1073-9688 (ISSN-L)
- 1549-8719
- OpenAlex
- W1992792350
- Cited by
- 30
- References
- 73
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 2 · 2016: 4 · 2015: 1 · 2014: 4 · 2013: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microcirculation (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- oxygen sensitivity, hypoxia, potassium channels, fetoplacental circulation, placental arteries, calcium-activated potassium channels, ATP-sensitive potassium channels, voltage-gated potassium channels, vascular reactivity, nitric oxide, angiotensin II, placental cotyledons
- MeSH terms
- Animals, Female, Humans, Muscle, Smooth, Vascular, Oxygen, Oxygen Consumption, Placenta, Pregnancy, Potassium Channels, Placental Circulation, Myocytes, Smooth Muscle
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