Placental concentrations of bisphenol A and birth weight from births in the Southeastern U.S.
Abstract
Introduction Bisphenol A (BPA) is a weakly estrogenic compound that has been detected in a wide variety of food products and biological matrices (saliva, blood, urine, etc). Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy. The aim of this study is to evaluate the correlation between placental BPA concentration, infant birth weight and calculated birth weight centile, and several other maternal and infant parameters. Methods Placental sample were collected from 200 subjects. BPA levels were measured by isotope dilution GC-MS. Additional maternal and infant data were gathered from medical charts and were potential correlates with placental BPA levels. Results Placental BPA concentrations ranged from 4.4 ng/g to 273.9 ng/g in oven-dried tissue (average 103.4 ± 61.8 ng/g). There was a significant negative correlation between calculated birth weight centile and levels of placental BPA (p Discussion Placental BPA concentrations are correlated with the growth potential of the fetus and may play a role in reduced fetal growth.
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Bisphenol A exposure is linked to altered methylation profiles in the human placenta and lower birth weight.
“Also, bisphenol A has been linked to altered methylation profiles in the human placenta, as well as lower birth weight (Nahar et al., 2015; Troisi et al., 2014).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Troisi et al., 2014
Cites
Transfer of bisphenol A across the human placenta
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Nahar, M. S., Liao, C., Kannan, K., Harris, C., & Dolinoy, D. C. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2014.10.071 · Cited by 146 · see citing works
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103 · see citing works
Pregnancy-related maternal physiological adaptations and fetal chemical exposure
Vinnars, M.-T., Bixo, M., & Damdimopoulou, P. (2023) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2023.112064 · Cited by 32 · see citing works
- Authors
- Troisi, J., Mikelson, C., Richards, S., Symes, S., Adair, D., Zullo, F., & Guida, M.
- Affiliations
- University of Salerno (IT)
- University of Tennessee at Chattanooga (US)
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 35
- Issue
- 11
- Pages
- 947-952
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2021604539
- Cited by
- 82
- References
- 3
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 6 · 2023: 6 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 5 · 2016: 6 · 2015: 7 · 2014: 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- bisphenol A, birth weight, low birth weight, small for gestational age, fetal growth, maternal exposure, placental transfer, African American mothers, Hispanic mothers, endocrine disruptors, pregnancy
- MeSH terms
- Bisphenol A Compounds, Adolescent, Adult, Benzhydryl Compounds, Birth Weight, Environmental Monitoring, Female, Humans, Phenols, Placenta, Pregnancy, Southeastern United States, Young Adult
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