Bisphenol A in human placental and fetal liver tissues collected from Greater Montreal area (Quebec) during 1998-2008
Abstract
In this study, the presence of bisphenol A (BPA) in human placental and fetal liver samples collected from 1998 to 2008 was investigated to provide a more detailed analysis of the transfer of BPA across the placenta and fetal exposure to BPA. The average concentrations in placental samples were 12.6 ng g(-1) for free BPA, 17.2 ng g(-1) for BPA-glu, and 30.2 ng g(-1) for total BPA. The highest concentrations in placental samples were 165 ng g(-1) for free BPA, 178 ng g(-1) for BPA-glu, and 280 ng g(-1) for total BPA. Samples with higher levels of BPA-glu had higher levels of free BPA in general. Fetal age was observed to have a significant effect on BPA-glu levels in placental samples, but not on free or total BPA. The percentages of free BPA relative to total BPA for the placental samples varied considerably from 4.2% to 100%, suggesting that the ability of maternal liver and/or the placenta to conjugate BPA is highly variable during early to mid-gestation. The average concentrations in fetal liver samples were 9.02 ng g(-1) for free BPA, 19.1 ng g(-1) for BPA-glu, and 25.8 ng g(-1) for total BPA. The highest concentrations in fetal liver samples were 37.7 ng g(-1) for free BPA, 93.9 ng g(-1) for BPA-glu, and 123 ng g(-1) for total BPA. The percentages of free BPA level relative to total BPA for all fetal liver samples varied from 12.4% to 99.1%, indicating extensive variability in the ability of the human feto-placental unit to glucuronidate BPA.
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Analysis of bisphenol A by Cao et al. suggests an increasing trend over time.
“For example, analysis of bisphenol A by Cao et al. suggests an increasing trend over time (Cao et al., 2012).”
From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Cao et al., 2012
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- Authors
- Cao, X.-L., Zhang, J., Goodyer, C. G., Hayward, S., Cooke, G. M., & Curran, I. H. A.
- Affiliations
- Health Canada (CA)
- Montreal Children's Hospital (CA)
- Corresponding author
- Cao, Xu-Liang
- Venue
- Chemosphere
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 89
- Issue
- 5
- Pages
- 505-511
- ISSN
- 0045-6535 (ISSN-L)
- OpenAlex
- W2067779844
- Cited by
- 93
- References
- 38
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 12 · 2018: 2 · 2017: 5 · 2016: 8 · 2015: 14 · 2014: 11 · 2013: 2 · 2012: 2
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemosphere (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
- Keywords
- bisphenol A, placenta, fetal liver, placental transfer, prenatal exposure, BPA glucuronide, glucuronidation, gestational age, human biomonitoring, endocrine disruptors
- MeSH terms
- Bisphenol A Compounds, Benzhydryl Compounds, Environmental Pollutants, Female, Fetus, Humans, Liver, Maternal-Fetal Exchange, Phenols, Placenta, Pregnancy, Quebec
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