The relationship between human placental morphometry and ultrasonic measurements of utero-placental blood flow and fetal growth
Open accessAbstract
Introduction Ultrasonic fetal biometry and arterial Doppler flow velocimetry are widely used to assess the risk of pregnancy complications. There is an extensive literature on the relationship between pregnancy outcomes and the size and shape of the placenta. However, ultrasonic fetal biometry and arterial Doppler flow velocimetry have not previously been studied in relation to postnatal placental morphometry in detail.Methods We conducted a prospective cohort study of nulliparous women in The Rosie Hospital, Cambridge (UK). We studied a group of 2120 women who had complete data on uterine and umbilical Doppler velocimetry and fetal biometry at 20, 28 and 36 weeks' gestational age, digital images of the placenta available, and delivered a liveborn infant at term. Associations were expressed as the difference in the standard deviation (SD) score of the gestational age adjusted ultrasound measurement (z-score) comparing the lowest and highest decile of the given placental morphometric measurement.Results The lowest decile of placental surface area was associated with 0.87 SD higher uterine artery Doppler mean pulsatility index (PI) at 20 weeks (95% CI: 0.68 to 1.07, P < 0.001). The lowest decile of placental weight was associated with 0.73 SD higher umbilical artery Doppler PI at 36 weeks (95% CI: 0.54 to 0.93, P < 0.001). The lowest decile of both placental weight and placental area were associated with reduced growth velocity of the fetal abdominal circumference between 20 and 36 weeks (both P < 0.001).Conclusion Placental area and weight are associated with uterine and umbilical blood flow, respectively, and both are associated with fetal growth rate.
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Placental surface area was found to be inversely related to ultrasound measurements of umbilical arterial resistance in a prospective cohort of nulliparous pregnancies.
“With regards to the latter, placental surface area was found to be inversely related to ultrasound measurements of umbilical arterial resistance in a prospective cohort of nulliparous pregnancies (481).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [481]
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Cites
The Pathology of the Human Placenta
Benirschke, K., & Driscoll, S. G. (1967) · Springer eBooks · doi:10.1007/978-1-4612-9809-0 · Cited by 2,123 · see citing works
Sovio, U., White, I. R., Dacey, A., Pasupathy, D., & Smith, G. C. S. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00131-2 · Cited by 610 · see citing works
Self-citationDevelopment of the placental villous tree and its consequences for fetal growth
Kingdom, J. C., Huppertz, B., Seaward, G. R., & Kaufmann, P. (2000) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(00)00423-1 · Cited by 591 · see citing works
Pathology of the Human Placenta
Benirschke, K., Burton, G. J., & Baergen, R. N. (2012) · doi:10.1007/978-3-642-23941-0 · Cited by 502 · see citing works
ISUOG Practice Guidelines: use of Doppler ultrasonography in obstetrics
Bhide, A., Acharya, G., Bilardo, C. M., Brezinka, C., Cafici, D., Hernandez‐Andrade, E. A., Kalache, K. D., Kingdom, J. C., Kiserud, T., Lee, W., et al. (2013) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.12371 · Cited by 444 · see citing works
Placental Pathology in Early-Onset and Late-Onset Fetal Growth Restriction
Mifsud, W., & Sebire, N. J. (2014) · Fetal Diagnosis and Therapy · doi:10.1159/000359969 · Cited by 328 · see citing works
The Role of the Placenta in Fetal Programming—A Review
Godfrey, K. M. (2002) · Placenta · doi:10.1053/plac.2002.0773 · Cited by 305 · see citing works
Yu, C.-S., Smith, G. C. S., Papageorghiou, A. T., Cacho, A. M., & Nicolaides, K. H. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2006.06.010 · Cited by 263 · see citing works
Self-citationYu, C.-S., Smith, G. C. S., Papageorghiou, A. T., Cacho, A. M., & Nicolaides, K. H. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.12.014 · Cited by 248 · see citing works
Self-citationLackman, F., Capewell, V., Richardson, B., daSilva, O., & Gagnon, R. J. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111719 · Cited by 227 · see citing works
Fetal umbilical cord oxygen values and birth to placental weight ratio in relation to size at birth
Lackman, F., Capewell, V., Gagnon, R. J., & Richardson, B. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.116686 · Cited by 192 · see citing works
LIN, S. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00020-r · Cited by 184 · see citing works
Longtine, M. S., & Nelson, D. M. (2011) · Seminars in Reproductive Medicine · doi:10.1055/s-0031-1275515 · Cited by 163 · see citing works
Proctor, L., Toal, M., Keating, S. J., Chitayat, D. A., Okun, N. B., Windrim, R. C., Smith, G. C. S., & Kingdom, J. C. (2009) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7308 · Cited by 151 · see citing works
Self-citationGhosh, G., & Gudmundsson, S. (2009) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2008.02057.x · Cited by 131 · see citing works
Placental surface shape, function, and effects of maternal and fetal vascular pathology
Salafia, C. M., Yampolsky, M., Misra, D. P., Shlakhter, O., Haas, D., Eucker, B., & Thorp, J. M. (2010) · Placenta · doi:10.1016/j.placenta.2010.09.005 · Cited by 126 · see citing works
Uterine artery Doppler flow studies in obstetric practice
Sciscione, A. C., & Hayes, E. J. (2009) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2009.03.027 · Cited by 114 · see citing works
Maternal Uterine Artery Doppler Flow Velocimetry and the Risk of Stillbirth
Smith, G. C. S., Yu, C.-S., Papageorghiou, A. T., Cacho, A. M., & Nicolaides, K. H. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000248536.94919.e3 · Cited by 108 · see citing works
Self-citationThe Placenta and Human Developmental Programming
(2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511933806 · Cited by 105 · see citing works
In preeclampsia, the placenta grows slowly along its minor axis
Kajantie, E., Thornburg, K. L. R., Eriksson, J. G., Osmond, C., & Barker, D. J. P. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082833ek · Cited by 100 · see citing works
Pasupathy, D., Dacey, A., Cook, E., et al. (2008) · BMC Pregnancy and Childbirth · doi:10.1186/1471-2393-8-51 · Cited by 78 · see citing works
Odibo, A. O., Zhong, Y., Longtine, M. S., Tuuli, M. G., Odibo, L., Cahill, A. G., Macones, G. A., & Nelson, D. M. (2011) · Placenta · doi:10.1016/j.placenta.2011.01.016 · Cited by 66 · see citing works
Ducray, J., Naicker, T., & Moodley, J. (2011) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2010.12.038 · Cited by 47 · see citing works
Persistence of increased uterine artery resistance in the third trimester and pregnancy outcome
Ghi, T., Contro, E., Youssef, A., Giorgetta, F., Farina, A., Pilu, G., & Pelusi, G. (2010) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.7602 · Cited by 46 · see citing works
Uterine artery Doppler flow studies in obstetric practice.
Giordano, R., Cacciatore, A., Romano, M., et al. (2010) · PubMed · Cited by 22 · see citing works
Is the placental disk really an ellipse?
Yampolsky, M., Salafia, C. M., Misra, D. P., Shlakhter, O., & Gill, J. S. (2013) · Placenta · doi:10.1016/j.placenta.2012.12.002 · Cited by 13 · see citing works
Lindqvist, P. G., Procházka, M., Laurini, R., et al. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.791269 · Cited by 7 · see citing works
Sovio, U., White, I. R., Dacey, A., Pasupathy, D., & Smith, G. C. S. (2016) · Obstetrical & Gynecological Survey · doi:10.1097/ogx.0000000000000305 · Cited by 5 · see citing works
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Research works printed but not linked: 1
- Burton GJ, Jauniaux E. The maternal circulation and placental shape: villus remodelling induced through haemodynamics and oxidative and endoplasmic reticulum stress In: Burton GJ, Barker DJP, Moffett A, Thornburg K, editors. The Placenta and Human Developmental Programming. Cambridge: Cambridge University Press; 2010. p. 161-74.
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Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717 · see citing works
- Authors
- Salavati, N., Sovio, U., Mayo, R. P., Charnock-Jones, D. S., & Smith, G. C. S.
- Affiliations
- University Medical Center Groningen (NL)
- University of Cambridge (GB)
- Corresponding author
- Smith, G.C.S.
- Venue
- Placenta
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 38
- Pages
- 41-48
- ISSN
- 0143-4004 (ISSN-L)
- OpenAlex
- W2189842546
- Cited by
- 35
- References
- 28
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 4
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- Locations
- Placenta (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Apollo (University of Cambridge) (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- National Institute for Health and Care Research (A019057)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- placental morphometry, placental surface area, placental weight, uteroplacental blood flow, uterine artery Doppler, umbilical artery Doppler, pulsatility index, fetal growth rate, fetal abdominal circumference, fetal biometry, nulliparous women, pregnancy complications
- MeSH terms
- Blood Flow Velocity, Female, Gestational Age, Humans, Infant, Newborn, Maternal-Fetal Exchange, Organ Size, Placenta, Pregnancy, Umbilical Arteries, Cohort Studies, Ultrasonography, Prenatal, Fetal Development, Uterine Artery
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