Placental Pathology in Early-Onset and Late-Onset Fetal Growth Restriction

Mifsud, William; Sebire, Neil J.

doi:10.1159/000359969

Cited by 328Pregnancy and preeclampsia studiesBirth, Development, and HealthNeurological Complications and Syndromes

Placental Pathology in Early-Onset and Late-Onset Fetal Growth Restriction

Mifsud, William, Sebire, Neil J.·2014·Fetal Diagnosis and Therapy

DOI 10.1159/000359969

Open this paper in CoChat — free account

Abstract

Several histopathological features are found more frequently in placentas from pregnancies complicated by fetal growth restriction (FGR), including villous infarction, maternal vascular changes and villous morphological alterations, although around one quarter of placentas associated with FGR lack any morphological abnormality on routine examination. Since similar changes may also affect clinically uncomplicated pregnancies, the positive predictive value of such findings for pathological FGR in an unselected case remains low. However, the pattern of placental pathologies varies with clinical subgroup. The combination of placental bed and parenchymal lesions in FGR with abnormal uterine artery Doppler velocimetry is essentially identical to preterm pre-eclampsia (PET), and there is an association between FGR with abnormal umbilical artery Doppler findings and lesions of fetal stem arteries and terminal villous hypovascularity. Conversely, placentas from pregnancies complicated by PET or FGR presenting at or near term have a significantly lower frequency of histological abnormalities compared to early-onset disease and absence of a distinctive biochemical profile. The histological placental findings in FGR are therefore varied, from morphologically unremarkable through to severe uteroplacental vasculopathy, with no single pathological feature associated with high sensitivity or specificity. Severe early-onset FGR, overlapping with severe early-onset PET, is mainly associated with features of impaired maternal uteroplacental perfusion secondary to defective extravillous trophoblast invasion, and its consequences. Late-onset FGR probably represents a more heterogeneous group with less characteristic histological changes. Future research using histopathological assessment of aggregated data from multiple studies into larger datasets with centralised pathology review will allow delineation of distinctive clinicopathological associations and further understanding of pathophysiology.

Integrity signals

Registry

Crossref · 10.1159/000359969

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

In pregnancies complicated by hypertensive disorders of pregnancy (HDP), placental insufficiency disrupts fetal lung maturation through hypoxia-mediated pathways.
“These challenges are exacerbated in high-risk cohorts, including pregnancies complicated by hypertensive disorders of pregnancy (HDP), where placental insufficiency disrupts fetal lung maturation through hypoxia-mediated pathways (4).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [4]

Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288 · see citing works
NCBI GEO: archive for functional genomics data sets—update
Barrett, T., Wilhite, S. E., Ledoux, P., Evangelista, C., Kim, I. F., Tomashevsky, M., Marshall, K. A., Phillippy, K. H., Sherman, P. M., Holko, M., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks1193 · Cited by 10,418 · see citing works
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
Maynard, S. E., Min, J.-Y., Merchan, J., Lim, K.-H., Li, J., Mondal, S., Libermann, T. A., Morgan, J. P., Sellke, F. W., Stillman, I. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17189 · Cited by 4,101 · see citing works
Circulating angiogenic factors and the risk of preeclampsia
Levine, R. J., Maynard, S. E., Qian, C., Lim, K.-H., England, L. J., Yu, K. F., Schisterman, E. F., Thadhani, R., Sachs, B. P., Epstein, F. H., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031884 · Cited by 3,720 · see citing works
Circulating angiogenic factors and the risk of preeclampsia*
(2004) · Obstetrics and Gynecology · doi:10.1097/00006250-200405000-00028 · Cited by 2,623 · see citing works
Inadequate maternal vascular response to placentation in pregnancies complicated by pre‐eclampsia and by small‐for‐gestational age infants
KHONG, T. Y., DE WOLF, F., ROBERTSON, W. B., & BROSENS, I. (1986) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1986.tb07830.x · Cited by 1,591 · see citing works
Pre-eclampsia: more than pregnancy-induced hypertension
Roberts, J. M., & Redman, C. W. G. (1993) · The Lancet · doi:10.1016/0140-6736(93)90889-o · Cited by 1,239 · see citing works
The role of the spiral arteries in the pathogenesis of pre-eclampsia.
Brosens, I. A., Robertson, W. B., & Dixon, H. G. (1970) · PubMed · Cited by 894 · see citing works
A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate
Romero, R. J., Nien, J. K., Espinoza, J., Todem, D., Fu, W., Chung, H., Kusanovic, J. P., Gotsch, F., Erez, O., Mazaki‐Tovi, S., et al. (2008) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050701830480 · Cited by 675 · see citing works
Amniotic Infection Syndrome: Nosology and Reproducibility of Placental Reaction Patterns
Redline, R. W., Faye-Petersen, O. M., Heller, D. S., Qureshi, F., Savell, V., & Vogler, C. A. (2003) · Pediatric and Developmental Pathology · doi:10.1007/s10024-003-7070-y · Cited by 674 · see citing works
Fetal umbilical artery flow velocity waveforms and placental resistance: clinical significance
Trudinger, B., Giles, W. B., Cook, C. M., Bombardieri, J., & Collins, L. T. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01044.x · Cited by 559 · see citing works
Multicenter screening for pre‐eclampsia and fetal growth restriction by transvaginal uterine artery Doppler at 23 weeks of gestation
Papageorghiou, A. T., Yu, C.-S., Bindra, R., Pandis, G. K., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00572.x · Cited by 538 · see citing works
Screening for pre‐eclampsia and fetal growth restriction by uterine artery Doppler at 11–14 weeks of gestation
Martin, A., Bindra, R. R., Curcio, P., Cicero, S., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics and Gynecology · doi:10.1046/j.0960-7692.2001.00594.x · Cited by 452 · see citing works
Clinical significance of absent or reversed end diastolic velocity waveforms in umbilical artery
Karsdorp, V. H. M., van Vugt, J. M. G., van Geijn, H. P., Kostense, P. J., Arduim, D., Montenegro, N., & Todros, T. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90457-x · Cited by 445 · see citing works
Preeclampsia and fetal growth
ÃdegÃ¥rd, R. (2000) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(00)01040-1 · Cited by 436 · see citing works
Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree
Krebs, C., Macara, L., Leiser, R., BOWMAN, A. W., Greer, I. A., & Kingdom, J. C. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70103-5 · Cited by 427 · see citing works
Non-invasive measurement of human fetal circulation using ultrasound: a new method.
Fitzgerald, D. E., & Drumm, J. (1977) · BMJ · doi:10.1136/bmj.2.6100.1450 · Cited by 398 · see citing works
Maternal Vascular Underperfusion: Nosology and Reproducibility of Placental Reaction Patterns
Redline, R. W., Boyd, T. K., Campbell, V. S., Hyde, S., Kaplan, C. G., Khong, T. Y., Prashner, H. R., & Waters, B. L. (2004) · Pediatric and Developmental Pathology · doi:10.1007/s10024-003-8083-2 · Cited by 375 · see citing works
MORPHOLOGICAL CHANGES OF THE SPIRAL ARTERIES IN THE PLACENTAE BED IN RELATION TO PRE‐ECLAMPSIA AND FETAL GROWTH RETARDATION
Gerretsen, G., Huisjes, H. J., & Elema, J. D. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb02222.x · Cited by 370 · see citing works
Prospective Study of Placental Angiogenic Factors and Maternal Vascular Function Before and After Preeclampsia and Gestational Hypertension
Noori, M., Donald, A. E., Angelakopoulou, A., Hingorani, A. D., & Williams, D. J. (2010) · Circulation · doi:10.1161/circulationaha.109.895458 · Cited by 361 · see citing works
Villitis of unknown etiology: noninfectious chronic villitis in the placenta
Redline, R. W. (2007) · Human Pathology · doi:10.1016/j.humpath.2007.05.025 · Cited by 360 · see citing works
Plasma soluble vascular endothelial growth factor receptor-1 concentration is elevated prior to the clinical diagnosis of pre-eclampsia
Chaiworapongsa, T., Romero, R., Kim, Y. M., Kim, G. J., Kim, M. R., Espinoza, J., Bujold, E., Gonçalves, L., Gomez, R., Edwin, S., et al. (2005) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767050400028816 · Cited by 359 · see citing works
Progression of Doppler abnormalities in intrauterine growth restriction
Turan, O. M., Turan, S., Gungor, S., Berg, C., Moyano, D., Gembruch, U., Nicolaides, K. H., Harman, C. R., & Baschat, A. A. (2008) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.5386 · Cited by 353 · see citing works
Structural analysis of placental terminal villi from growth-restricted pregnancies with abnormal umbilical artery doppler waveforms
Macara, L., Kingdom, J. C., Kaufmann, P., Kohnen, G., Hair, J., More, I. A. R., Lyall, F., & Greer, I. A. (1996) · Placenta · doi:10.1016/s0143-4004(05)80642-3 · Cited by 352 · see citing works
Qualitative assessment of uteroplacental blood flow: early screening test for high-risk pregnancies.
Campbell, S. C., Pearce, J. M., Hackett, G. A., Cohen‐Overbeek, T. E., & Hernandez, C. (1986) · PubMed · Cited by 352 · see citing works
The frequency and severity of placental findings in women with preeclampsia are gestational age dependent
Moldenhauer, J. S., Stanek, J. W., Warshak, C. R., Khoury, J. C., & Sibai, B. M. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00576-3 · Cited by 323 · see citing works
Intrauterine growth restriction in infants of less than thirty-two weeks' gestation: Associated placental pathologic features
Salafia, C. M., MINIOR, V. K., Pezzullo, J. C., Popek, E. J., Rosenkrantz, T. S., & Vintzileos, A. M. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91325-4 · Cited by 308 · see citing works
Placental lesions associated with maternal underperfusion are more frequent in early-onset than in late-onset preeclampsia
Oggè, G., Chaiworapongsa, T., Romero, R. J., Hussein, Y., Kusanovic, J. P., Yeo, L., Kim, C. J., & Hassan, S. S. (2011) · Journal of Perinatal Medicine · doi:10.1515/jpm.2011.098 · Cited by 298 · see citing works
Absence of end diastolic frequencies in umbilical artery: a sign of fetal hypoxia and acidosis.
Nicolaides, K. H., Bilardo, C. M., SOOTHILL, P. W., & Campbell, S. C. (1988) · BMJ · doi:10.1136/bmj.297.6655.1026 · Cited by 296 · see citing works
AN ULTRASTRUCTURAL STUDY OF UTERO‐PLACENTAL SPIRAL ARTERIES IN HYPERTENSIVE AND NORMOTENSIVE PREGNANCY AND FETAL GROWTH RETARDATION
SHEPPARD, B. L., & Bonnar, J. (1981) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1981.tb01268.x · Cited by 288 · see citing works
Stereological Investigation of Placental Morphology in Pregnancies Complicated by Pre-eclampsia with and without Intrauterine Growth Restriction
Mayhew, T. M., Ohadike, C., Baker, P. N., Crocker, I. P., Mitchell, C. A., & Ong, S. S. (2003) · Placenta · doi:10.1053/plac.2002.0900 · Cited by 278 · see citing works
A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
Kusanovic, J. P., Romero, R. J., Chaiworapongsa, T., Erez, O., Mittal, P., Vaisbuch, E., Mazaki‐Tovi, S., Gotsch, F., Edwin, S. S., Gómez, R., et al. (2009) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767050902994754 · Cited by 277 · see citing works
Fetal Vascular Obstructive Lesions: Nosology and Reproducibility of Placental Reaction Patterns
Redline, R. W., Ariel, I., Baergen, R. N., deSa, D. J., Kraus, F. T., Roberts, D. J., & Sander, C. (2004) · Pediatric and Developmental Pathology · doi:10.1007/s10024-004-2020-x · Cited by 274 · see citing works
Placental pathologic features of preterm preeclampsia
Salafia, C. M., Pezzullo, J. C., López-Zeno, J., Simmens, S. J., MINIOR, V. K., & Vintzileos, A. M. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91333-5 · Cited by 254 · see citing works
Intrauterine growth restriction, human placental development and trophoblast cell death
Scifres, C., & Nelson, D. M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173252 · Cited by 244 · see citing works
Second-trimester uterine artery Doppler screening in unselected populations: a review
Papageorghiou, A. T., Yu, C.-S., Cicero, S., Bower, S. J., & Nicolaides, K. H. (2002) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/jmf.12.2.78.88 · Cited by 243 · see citing works
Fetal thrombotic vasculopathy: The clinical significance of extensive avascular villi
Redline, R. W., & Pappin, A. (1995) · Human Pathology · doi:10.1016/0046-8177(95)90118-3 · Cited by 240 · see citing works
Reduced placental villous tree elaboration in small-for-gestational-age pregnancies: Relationship with umbilical artery Doppler waveforms
Jackson, M. R., Walsh, A. J., Morrow, R. J., Muller, B. M., Lye, S. J., & Ritchie, J. W. K. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90566-9 · Cited by 230 · see citing works
Doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre‐eclampsia and intrauterine growth retardation
Bewley, S., COOPER, D., & Campbell, S. C. (1991) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1991.tb13508.x · Cited by 221 · see citing works
Umbilical artery blood flow characteristics in normal and growth‐retarded fetuses.
EKSKINE, R. L. A., & Ritchie, J. W. K. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01399.x · Cited by 212 · see citing works
Uterine Artery Doppler Velocimetry in Relation to Trophoblast Migration into the Myometrium of the Placental Bed
LIN, S. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(95)00020-r · Cited by 184 · see citing works
A high uterine artery pulsatility index reflects a defective development of placental bed spiral arteries in pregnancies complicated by hypertension and fetal growth retardation
Olofsson, P., Laurini, R., & Maršál, K. (1993) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(93)90265-e · Cited by 174 · see citing works
FETAL GROWTH RETARDATION AND THE MATERNAL ARTERIAL SUPPLY OF THE HUMAN PLACENTA IN THE ABSENCE OF SUSTAINED HYPERTENSION
Wolf, F. D., Brosens, I. A., & Renaer, M. (1980) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1980.tb04601.x · Cited by 173 · see citing works
Placental pathology of absent and reversed end-diastolic flow in growth-restricted fetuses
Salafia, C., Pezzullo, J. C., MINIOR, V. K., & Divon, M. Y. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(97)00473-0 · Cited by 162 · see citing works
Clinical and pathologic aspects of recurrent placental villitis
Redline, R. W., & Abramowsky, C. R. (1985) · Human Pathology · doi:10.1016/s0046-8177(85)80159-3 · Cited by 159 · see citing works
Placental pathology suggesting that preeclampsia is more than one disease
Nelson, D. B., Ziadie, M. S., McIntire, D. D., Rogers, B. B., & Leveno, K. J. (2013) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2013.09.010 · Cited by 158 · see citing works
Umbilical doppler waveforms and placental villous angiogenesis in pregnancies complicated by fetal growth restriction
Todros, T. (1999) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(98)00440-2 · Cited by 155 · see citing works
Clinical characterization and outcomes of preeclampsia with normal angiogenic profile
Rana, S., Schnettler, W. T., Powe, C. E., Wenger, J., Salahuddin, S., Cerdeira, A. S., Verlohren, S., Perschel, F. H., Arany, Z. P., Lim, K.-H., et al. (2013) · Hypertension in Pregnancy · doi:10.3109/10641955.2013.784788 · Cited by 155 · see citing works
Placental Pathology of Idiopathic Intrauterine Growth Retardation at Term
Salafia, C., Vintzileos, A. M., Silberman, L., Bantham, K., & Vogel, C. (1992) · American Journal of Perinatology · doi:10.1055/s-2007-999316 · Cited by 150 · see citing works
First‐trimester uterine artery Doppler indices in term and preterm pre‐eclampsia
Melchiorre, K., Wormald, B. W., Leslie, K., Bhide, A., & Thilaganathan, B. (2008) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.5400 · Cited by 143 · see citing works
Reduced Cystathionine γ-Lyase and Increased miR-21 Expression Are Associated with Increased Vascular Resistance in Growth-Restricted Pregnancies
Cindrova-Davies, T., Herrera, E. A., Niu, Y., Kingdom, J., Giussani, D. A., & Burton, G. J. (2013) · The American Journal of Pathology · doi:10.1016/j.ajpath.2013.01.001 · Cited by 135 · see citing works
Placental histology and clinical characteristics of patients with preterm premature rupture of membranes
ARIAS, F., Victoria, A., Cho, K. H., & Kraus, F. T. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(96)00451-6 · Cited by 130 · see citing works
Frequency and clinical significance of placental histological lesions in an unselected population at or near term
Pathak, S., Lees, C. C., Hackett, G. A., Jessop, F. A., & Sebire, N. J. (2011) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-011-1157-z · Cited by 129 · see citing works
Self-citation
Uterine Doppler Velocimetry and Placental Hypoxic-ischemic Lesion in Pregnancies with Fetal Intrauterine Growth Restriction
Ferrazzi, E. M., Bulfamante, G., Mezzopane, R., Barbera, A. F., Ghidini, A., & Pardi, G. (1999) · Placenta · doi:10.1053/plac.1999.0395 · Cited by 127 · see citing works
Chronic villitis of unknown aetiology in placentae of idiopathic small for gestational age infants
Labarrere, C. A., ALTHABE, O. H., & Telenta, M. (1982) · Placenta · doi:10.1016/s0143-4004(82)80007-6 · Cited by 123 · see citing works
The correlation of arterial lesions with umbilical artery Doppler velocimetry in the placentas of small-for-dates pregnancies.
Ry, F., Pavlova, Z., Benirschke, K., Rh, P., & Ld, P. (1990) · PubMed · Cited by 117 · see citing works
Placental villitis of unknown origin: Epidemiologic associations
Becroft, D. M. O., Thompson, J., & Mitchell, E. A. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.06.062 · Cited by 115 · see citing works
Quantitative structural studies on human placentas associated with pre‐eclampsia, essential hypertension and intrauterine growth retardation
Boyd, P. A., & SCOTT, A. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01454.x · Cited by 115 · see citing works
Hypoxia-induced fetoplacental vasoconstriction in perfused human placental cotyledons
Howard, R. B., Hosokawa, T., & Maguire, M. H. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80307-1 · Cited by 114 · see citing works
The placental pathology of small-for-gestational age infants
Altshuler, G. P., Russell, P., & Ermocilla, R. (1975) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(75)90011-3 · Cited by 112 · see citing works
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition
Hampl, V., Bı́bová, J., Straňák, Z., Wu, X., Michelakis, E. D., Hashimoto, K., & Archer, S. L. (2002) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01033.2001 · Cited by 104 · see citing works
Alterações morfológicas placentárias de recém-nascidos pequenos para a idade gestacional
de Oliveira, L. H., Xavier, C. C., & Lana, A. M. A. (2002) · Jornal de Pediatria · doi:10.1590/s0021-75572002000500010 · Cited by 97 · see citing works
Idiopathic intrauterine growth retardation: Histomorphometry of the human placenta
Teasdale, F. (1984) · Placenta · doi:10.1016/s0143-4004(84)80051-x · Cited by 97 · see citing works
Low target birth weight or growth retardation? Umbilical Doppler flow velocity waveforms and histometric analysis of fetoplacental vascular tree
Hitschold, T., Weiss, E., BECK, T. M., Huntefering, H., & Berle, P. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(93)90377-u · Cited by 93 · see citing works
Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity
Sebire, N. J., Goldin, R. D., & Regan, L. (2005) · Journal of Obstetrics and Gynaecology · doi:10.1080/014436105400041396 · Cited by 92 · see citing works
Self-citation
Pregnancy hypertension, placental evidences of low uteroplacental blood flow, and spontaneous premature delivery
Naeye, R. L. (1989) · Human Pathology · doi:10.1016/0046-8177(89)90008-7 · Cited by 88 · see citing works
Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction
Kovo, M., Schreiber, L., Ben‐Haroush, A., Wand, S., Golan, A., & Bar, J. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.01.012 · Cited by 87 · see citing works
Patterns of placental injury. Correlations with gestational age, placental weight, and clinical diagnoses.
Redline, R. W., & Patterson, P. H. (1994) · PubMed · Cited by 84 · see citing works
Placental pathology and pregnancy outcomes in donor and non-donor oocyte in vitro fertilization pregnancies
Perni, S. C., Predanik, M., Cho, J. E., & Baergen, R. N. (2005) · Journal of Perinatal Medicine · doi:10.1515/jpm.2005.004 · Cited by 82 · see citing works
Doppler flow measurements and histomorphology of the placental bed in uteroplacental insufficiency
Voigt, H., & Becker, V. (1992) · Journal of Perinatal Medicine · doi:10.1515/jpme.1992.20.2.139 · Cited by 81 · see citing works
Chronic villitis of unknown etiology and maternal arterial lesions in preeclamptic pregnancies
Labarrere, C. A., & ALTHABE, O. H. (1985) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(85)90077-2 · Cited by 71 · see citing works
Elaboration of stem villous vessels in growth restricted pregnancies with abnormal umbilical artery Doppler waveforms
Macara, L., Kingdom, J. C., Kohnen, G., BOWMAN, A. W., Greer, I. A., & Kaufmann, P. (1995) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1995.tb10847.x · Cited by 71 · see citing works
MORPHOLOGICAL VARIATIONS IN THE INSUFFICIENT PLACENTA
Wigglesworth, J. S. (1964) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1964.tb04374.x · Cited by 69 · see citing works
Recurrent reproductive failure due to severe placental villitis of unknown etiology.
Russell, P., Atkinson, K., & Krishnan, L. (1980) · PubMed · Cited by 69 · see citing works
Preterm Delivery: Correlations of Fetal Growth and Placental Pathology
Salafia, C. M., Vogel, C., Bantham, K., Vintzileos, A. M., Pezzullo, J. C., & Silberman, L. (1992) · American Journal of Perinatology · doi:10.1055/s-2007-999318 · Cited by 69 · see citing works
Chronic villitis of unknown aetiology and intrauterine growth-retarded infants of normal and low ponderal index
Althabe, O., & Labarrere, C. A. (1985) · Placenta · doi:10.1016/s0143-4004(85)80047-3 · Cited by 68 · see citing works
Umbilical artery Doppler revisited: pathophysiology of changes in intrauterine growth restriction revealed
Sebire, N. J. (2003) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.133 · Cited by 65 · see citing works
Self-citation
Placental vessel morphometry in growth retardation and increased resistance of the umbilical artery doppler flow
Mitra, S. C., Seshan, S. V., & Riachi, L. E. (2000) · The Journal of Maternal-Fetal Medicine · doi:10.1002/1520-6661(200009/10)9:5 · Cited by 64 · see citing works
Chronic villitis in untreated neonatal alloimmune thrombocytopenia: An etiology for severe early intrauterine growth restriction and the effect of intravenous immunoglobulin therapy
Althaus, J., Weir, E. G., Askin, F., Kickler, T. S., & Blakemore, K. J. (2005) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.06.043 · Cited by 58 · see citing works
Placental morphology in relation to umbilical artery blood velocity waveforms
Nordenvall, M., Ullberg, U., Laurin, J., Lingman, G., Sandstedt, B., & Ulmsten, U. (1991) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/0028-2243(91)90115-2 · Cited by 55 · see citing works
Placental villitis of unclear etiology during ovum donor in vitro fertilization pregnancy
Styer, A. K., Parker, H. J., Roberts, D. J., Palmer-Toy, D. E., Toth, T. L., & Ecker, J. L. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00577-5 · Cited by 48 · see citing works
Term and preterm (<34 and <37 weeks gestation) placental pathologies associated with fetal growth restriction
Apel‐Sarid, L., Levy, A., Holcberg, G., & Sheiner, E. (2009) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-009-1255-1 · Cited by 47 · see citing works
The human placenta in idiopathic intrauterine growth retardation: a light and electron microscopic study
van der Veen, F., & Fox, H. (1983) · Placenta · doi:10.1016/s0143-4004(83)80018-6 · Cited by 41 · see citing works
Reactivity of human placental chorionic plate vessels is modified by level of oxygenation: Differences between arteries and veins
Wareing, M., Greenwood, S. L., & Baker, P. N. (2005) · Placenta · doi:10.1016/j.placenta.2004.11.008 · Cited by 40 · see citing works
Observer reliability in assessing villitis of unknown aetiology.
Khong, T. Y., Staples, A., Moore, L., & Byard, R. W. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.3.208 · Cited by 40 · see citing works
Histologic Examination of the Placenta in the Growth-Retarded Fetus
Rayburn, W. F., Sander, C. H., & Compton, A. A. (1989) · American Journal of Perinatology · doi:10.1055/s-2007-999546 · Cited by 37 · see citing works
Vascular response of the fetal placenta to local occlusion of the maternal placental vasculature.
Stock, M. K., Anderson, D. F., Phernetton, T. M., McLaughlin, M. K., & Rankin, J. H. (1980) · PubMed · Cited by 36 · see citing works
The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery
Talbert, D. G., & Sebire, N. J. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.10.025 · Cited by 35 · see citing works
Self-citation
The Placenta and Low Birth Weight
Sandstedt, B. (1979) · Current topics in pathology · doi:10.1007/978-3-642-67205-7_1 · Cited by 33 · see citing works
Vasoactive Responses of Veins Isolated from the Human Placental Chorionic Plate
Wareing, M., Greenwood, S. L., Taggart, M. J., & Baker, P. N. (2003) · Placenta · doi:10.1016/s0143-4004(03)00108-5 · Cited by 33 · see citing works
Stereological quantification of placental villus vascularization and its relation to umbilical artery Doppler flow in intrauterine growth restriction
Sağol, S., Sağol, Ö., & Özdemir, N. (2002) · Prenatal Diagnosis · doi:10.1002/pd.323 · Cited by 31 · see citing works
THE GROSS AND MICROSCOPIC PATHOLOGY OF THE PREMATURELY DELIVERED PLACENTA
Wigglesworth, J. S. (1962) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1962.tb01323.x · Cited by 31 · see citing works
Microscopic measurement of the placental components in an attempt to assess the malnourished newborn infant
Wong, T.-C., & Latour, J. P. A. (1966) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(66)90032-9 · Cited by 31 · see citing works
The role of intraplacental vascular smooth muscle in the dynamic placenta: a conceptual framework for understanding uteroplacental disease
Sebire, N. J., & Talbert, D. G. (2002) · Medical Hypotheses · doi:10.1054/mehy.2001.1538 · Cited by 30 · see citing works
Self-citation
A pilot study of the frequency and significance of placental villitis
Mortimer, G., MacDonald, D. J., & SMEETH, A. (1985) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1985.tb01403.x · Cited by 30 · see citing works
Morphometric studies of fetal placental stem arteries in hypertensive disorders (‘Toxaemia’) of pregnancy
Heras, J. L., Baskerville, J., Harding, P. G. R., & Haust, M. D. (1985) · Placenta · doi:10.1016/s0143-4004(85)80051-5 · Cited by 29 · see citing works
Chronic Villitis of Unknown Etiology in Twin Gestations
Jacques, S. M., & Qureshi, F. (1994) · Pediatric Pathology · doi:10.3109/15513819409023332 · Cited by 28 · see citing works
Voltage-gated Calcium Channels Mediate Hypoxic Vasoconstriction in the Human Placenta
Jakoubek, V., Bı́bová, J., & Hampl, V. (2005) · Placenta · doi:10.1016/j.placenta.2005.10.006 · Cited by 27 · see citing works
Digital Slide Repositories for Publications
Hipp, J., Lucas, D. R., Emmert‐Buck, M. R., Compton, C. C., & Balis, U. J. (2011) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31821946b6 · Cited by 23 · see citing works
Fetal umbilical vascular response to chronic reductions in uteroplacental blood flow in late-term sheep
Lang, U., Baker, R. S., Khoury, J. C., & Clark, K. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.122849 · Cited by 21 · see citing works
Gross pathology of the placenta in intrauterine growth retardation.
Bjøro, K. (1981) · PubMed · Cited by 20 · see citing works
Placental Morphology of Low-Birth-Weight Infants Born at Term
Garcia, A. G. P. (1982) · Contributions to gynecology and obstetrics · doi:10.1159/000406848 · Cited by 20 · see citing works
THE ROLE OF CHRONIC NON‐SPECIFIC INFLAMMATORY LESIONS OF THE PLACENTA IN INTRA‐UTERINE GROWTH RETARDATION
Bjøro, K., & Myhre, E. S. P. (1984) · Acta Pathologica Microbiologica Scandinavica Series A Pathology · doi:10.1111/j.1699-0463.1984.tb04387.x · Cited by 19 · see citing works
The dynamic placenta: II. Hypothetical model of a fetus driven transplacental water balance mechanism producing low apparent permeability in a highly permeable placenta
Sebire, N. J., & Talbert, D. G. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2003.10.019 · Cited by 16 · see citing works
Self-citation
Umbilical Artery Blood Flow Characteristics in Normal and Growth-Retarded Fetuses
Erskine, R. L. A., & Ritchie, J. W. K. (1986) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198604000-00003 · Cited by 13 · see citing works
Morphometric study of the placental vessels and its correlation with umbilical artery doppler flow
MITRA, S., Venkataseshan, V. S., Vonhaggen, S., Barton, P. J. R., DELSHAD, G., & GIL, J. (1997) · Obstetrics and Gynecology · doi:10.1016/s0029-7844(96)00501-7 · Cited by 13 · see citing works
Fetal thrombotic vasculopathy accompanied by fetal growth restriction
Kim, T., Lee, H., Chung, S., Park, J., & Kwak, J. J. (2013) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2013.818975 · Cited by 3 · see citing works

Flagged first, then by citations

1 of the 108 references couldn’t be matched to a known paper.

Sorted by citations

Consensus definition of fetal growth restriction: a Delphi procedure: Consensus definition of FGR
Gordijn, S. J., Beune, I. M., Thilaganathan, B., Papageorghiou, A., Baschat, A. A., Baker, P. N., Silver, R. M., Wynia, K., & Ganzevoort, W. (2016) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.15884 · Cited by 1,638 · see citing works
Pathophysiology of placental-derived fetal growth restriction
Burton, G. J., & Jauniaux, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.577 · Cited by 1,070 · see citing works
ISUOG Practice Guidelines: diagnosis and management of small‐for‐gestational‐age fetus and fetal growth restriction
Lees, C. C., Stampalija, T., Baschat, A. A., da Silva Costa, F., Ferrazzi, E., Figueras, F., Hecher, K., Kingdom, J., Poon, L. C., Salomon, L. J., et al. (2020) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.22134 · Cited by 886 · see citing works
FIGO (International Federation of Gynecology and Obstetrics) initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction
Melamed, N., Baschat, A., Yinon, Y., Athanasiadis, A. P., Mecacci, F., Figueras, F., Berghella, V., Nazareth, A., Tahlak, M., McIntyre, D. H., et al. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13522 · Cited by 590 · see citing works
Diagnosis and surveillance of late-onset fetal growth restriction
Figueras, F., Caradeux, J., Crispi, F., Eixarch, E., Peguero, A., & Gratacos, E. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.003 · Cited by 300 · see citing works
Screening for fetal growth restriction and placental insufficiency
Audette, M. C., & Kingdom, J. C. (2017) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2017.11.004 · Cited by 208 · see citing works
ISUOG Practice Guidelines: role of ultrasound in screening for and follow‐up of pre‐eclampsia
Sotiriadis, A., Hernandez‐Andrade, E. A., Costa, F. D. S., Ghi, T., Glanc, P., Khalil, A. A., Martins, W. P., Odibo, A. O., Papageorghiou, A. T., Salomon, L. J., et al. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20105 · Cited by 215 · see citing works
Abnormal Fetal Growth
Damhuis, S. E., Ganzevoort, W., & Gordijn, S. J. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.02.002 · Cited by 196 · see citing works
The frequency and type of placental histologic lesions in term pregnancies with normal outcome
Romero, R. J., Kim, Y. M., Pacora, P., Kim, C. J., Benshalom-Tirosh, N., Jaiman, S., Bhatti, G., Kim, J.-S., Qureshi, F., Jacques, S. M., et al. (2018) · Journal of Perinatal Medicine · doi:10.1515/jpm-2018-0055 · Cited by 185 · see citing works
A placenta clinic approach to the diagnosis and management of fetal growth restriction
Kingdom, J. C., Audette, M. C., Hobson, S. R., Windrim, R. C., & Morgen, E. K. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.11.575 · Cited by 167 · see citing works
Screening for fetal growth restriction using fetal biometry combined with maternal biomarkers
Gaccioli, F., Aye, I. L. M. H., Sovio, U., Jones, D. S., & Smith, G. C. S. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.12.002 · Cited by 159 · see citing works
The RNA landscape of the human placenta in health and disease
Gong, S., Gaccioli, F., Dopierala, J., Sovio, U., Cook, E., Volders, P., Martens, L., Kirk, P., Richardson, S. T., Smith, G. C. S., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22695-y · Cited by 154 · see citing works
The prediction of late-onset preeclampsia: Results from a longitudinal proteomics study
Erez, O., Romero, R. J., Maymon, E., Chaemsaithong, P., Done, B., Pacora, P., Panaitescu, B., Chaiworapongsa, T., Hassan, S. S., & Tarca, A. L. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181468 · Cited by 120 · see citing works
A maternal serum metabolite ratio predicts fetal growth restriction at term
Sovio, U., Goulding, N., McBride, N., Cook, E., Gaccioli, F., Jones, D. S., Lawlor, D. A., & Smith, G. C. S. (2020) · Nature Medicine · doi:10.1038/s41591-020-0804-9 · Cited by 115 · see citing works
Maternal plasma angiogenic index-1 (placental growth factor/soluble vascular endothelial growth factor receptor-1) is a biomarker for the burden of placental lesions consistent with uteroplacental underperfusion: a longitudinal case-cohort study
Korzeniewski, S. J., Romero, R. J., Chaiworapongsa, T., Chaemsaithong, P., Kim, C. J., Kim, Y. M., Kim, J.-S., Yoon, B. H., Hassan, S. S., & Yeo, L. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.11.015 · Cited by 112 · see citing works
The Possible Role of Placental Morphometry in the Detection of Fetal Growth Restriction
Salavati, N., Smies, M., Ganzevoort, W., CHARLES, A. K., Erwich, J. J., Plösch, T., & Gordijn, S. J. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01884 · Cited by 109 · see citing works
Building consensus and standards in fetal growth restriction studies
Gordijn, S. J., Beune, I. M., & Ganzevoort, W. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.02.002 · Cited by 96 · see citing works
Combined diffusion‐relaxometry microstructure imaging: Current status and future prospects
Slator, P. J., Palombo, M., Miller, K. L., Westin, C., Laun, F. B., Kim, D., Haldar, J. P., Benjamini, D., Lemberskiy, G., Martins, J. P. D. A., et al. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28963 · Cited by 90 · see citing works
Guideline No. 442: Fetal Growth Restriction: Screening, Diagnosis, and Management in Singleton Pregnancies
Kingdom, J. C., Ashwal‏, E., Lausman, A. Y., Liauw, J., Soliman, N., Figueiró-Filho, E. A., Nash, C., Bujold, E., & Melamed, N. (2023) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2023.05.022 · Cited by 89 · see citing works
Maternal sleep-disordered breathing and the risk of delivering small for gestational age infants: a prospective cohort study
Pamidi, S., Marc, I., Simoneau, G., Lavigne, L., Olha, A., Benedetti, A., Sériès, F., Fraser, W. D., Audibert, F., Bujold, E., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-208038 · Cited by 82 · see citing works
Fetal Growth Restriction: Does an Integrated Maternal Hemodynamic-Placental Model Fit Better?
Mecacci, F., Avagliano, L., Lisi, F., Clemenza, S., Serena, C., Vannuccini, S., Rambaldi, M. P., Simeone, S., Ottanelli, S., & Petraglia, F. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00393-2 · Cited by 81 · see citing works
Toward a new taxonomy of obstetrical disease: improved performance of maternal blood biomarkers for the great obstetrical syndromes when classified according to placental pathology
Romero, R. J., Jung, E., Chaiworapongsa, T., Erez, O., Gudicha, D. W., Kim, Y. M., Kim, J.-S., Kim, B., Kusanovic, J. P., Gotsch, F., et al. (2022) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2022.04.015 · Cited by 84 · see citing works
Placenta microstructure and microcirculation imaging with diffusion MRI
Slator, P. J., Hutter, J. M., McCabe, L., Gomes, A. D. S., Price, A. N., Panagiotaki, E., Rutherford, M., Hajnal, J. V., & Alexander, D. C. (2017) · Magnetic Resonance in Medicine · doi:10.1002/mrm.27036 · Cited by 78 · see citing works
Placental hypoxia: The lesions of maternal malperfusion
Parks, W. T. (2014) · Seminars in Perinatology · doi:10.1053/j.semperi.2014.10.003 · Cited by 75 · see citing works
The usefulness of fetal Doppler evaluation in early versus late onset intrauterine growth restriction. Review of the literature.
Mureșan, D., Rotar, I. C., & Stamatian, F. V. (2016) · Medical Ultrasonography · doi:10.11152/mu.2013.2066.181.dop · Cited by 72 · see citing works
Placental MRI and its application to fetal intervention
Aughwane, R., Ingram, E., Johnstone, E., Salomon, L. J., David, A. L., & Melbourne, A. (2019) · Prenatal Diagnosis · doi:10.1002/pd.5526 · Cited by 67 · see citing works
Does low-dose aspirin initiated before 11 weeks’ gestation reduce the rate of preeclampsia?
Chaemsaithong, P., Cuenca-Gómez, D., Plana, N., Gil, M. M., & Poon, L. C. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.08.047 · Cited by 70 · see citing works
Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age
Nobles, C. J., Grantz, K. L., Liu, D., Williams, A., Ouidir, M., Seeni, I., Sherman, S. J., & Mendola, P. (2018) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2018.09.362 · Cited by 68 · see citing works
Fetal cerebral redistribution: a marker of compromise regardless of fetal size
Morales‐Roselló, J., & Khalil, A. A. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15664 · Cited by 66 · see citing works
Placental transcriptional and histologic subtypes of normotensive fetal growth restriction are comparable to preeclampsia
Gibbs, I., Leavey, K., Benton, S. J., Grynspan, D., Bainbridge, S. A., & Cox, B. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.10.003 · Cited by 65 · see citing works
Placental abnormalities differ between small for gestational age fetuses in dichorionic twin and singleton pregnancies
Kibel, M., Kahn, M., Sherman, C., Kingdom, J. C., Zaltz, A., Barrett, J. F. R., & Melamed, N. (2017) · Placenta · doi:10.1016/j.placenta.2017.10.002 · Cited by 64 · see citing works
Pathologic placental lesions in early and late fetal growth restriction
Spinillo, A., Gardella, B., Adamo, L., Muscettola, G., Fiandrino, G., & Cesari, S. (2019) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13699 · Cited by 63 · see citing works
Progress in the understanding of the etiology and predictability of fetal growth restriction
Tang, L. P., He, G., Liu, X., & Xu, W. (2017) · Reproduction · doi:10.1530/rep-16-0287 · Cited by 62 · see citing works
Distinctive patterns of placental lesions in pre‐eclampsia vs small‐for‐gestational age and their association with fetoplacental Doppler
Paulés, C., Youssef, L., Rovira, C., Crovetto, F., Nadal, A., Peguero, A., Figueras, F., Eixarch, E., Crispi, F., Miranda, J., et al. (2019) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20350 · Cited by 62 · see citing works
Examining the link between placental pathology, growth restriction, and stillbirth
Silver, R. M. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.03.004 · Cited by 61 · see citing works
HTR-8/SVneo: A model for epithelial to mesenchymal transition in the human placenta
Msheik, H., Azar, J. H., Sabeh, M. E., Abou-Kheir, W. G., & Daoud, G. (2019) · Placenta · doi:10.1016/j.placenta.2019.12.013 · Cited by 60 · see citing works
In vivo assessment of placental elasticity in intrauterine growth restriction by shear-wave elastography
Habibi, H. A., Davutoğlu, E. A., Kandemirli, S. G., Aslan, M., Özel, A., Ucar, A. K., Zeytun, P., Madazlı, R., & Adaletli, İ. (2017) · European Journal of Radiology · doi:10.1016/j.ejrad.2017.10.007 · Cited by 60 · see citing works
Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction
Zhou, H., Zhao, C., Wang, P., Yang, W., Zhu, H., & Zhang, S. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1107182 · Cited by 59 · see citing works
The Differences Between Early- and Late-Onset Pre-eclampsia
Staff, A. C., & Redman, C. W. G. (2018) · Comprehensive gynecology and obstetrics · doi:10.1007/978-981-10-5891-2_10 · Cited by 60 · see citing works
Cerebral–placental–uterine ratio as novel predictor of late fetal growth restriction: prospective cohort study
MacDonald, T. M., Hui, L., Robinson, A. J., Dane, K. M., Middleton, A., Tong, S. Y. C., & Walker, S. P. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.20150 · Cited by 58 · see citing works
Altered trajectory of neurodevelopment associated with fetal growth restriction
Dudink, I., Hüppi, P. S., Sizonenko, S. V., Castillo-Meléndez, M., Sutherland, A. E., Allison, B. J., & Miller, S. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113885 · Cited by 57 · see citing works
Placental histological patterns and uterine artery Doppler velocimetry in pregnancies complicated by early or late pre-eclampsia
Orabona, R., Donzelli, C., Falchetti, M., Santoro, A., Valcamonico, A., & Frusca, T. (2015) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15799 · Cited by 57 · see citing works
Decidual macrophages and Hofbauer cells in fetal growth restriction
Bezemer, R. E., Faas, M. M., van Goor, H., Gordijn, S. J., & Prins, J. R. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1379537 · Cited by 54 · see citing works
Defining early vs late fetal growth restriction by placental pathology
Aviram, A., Sherman, C., Kingdom, J. C., Zaltz, A., Barrett, J. F. R., & Melamed, N. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13499 · Cited by 54 · see citing works
Placental blood flow sensing and regulation in fetal growth restriction
Morley, L. C., Debant, M., Walker, J. J., Beech, D. J., & Simpson, N. (2021) · Placenta · doi:10.1016/j.placenta.2021.01.007 · Cited by 53 · see citing works
Fetal growth restriction and stillbirth: Biomarkers for identifying at risk fetuses
King, V. J., Bennet, L., Stone, P. R., Clark, A., Gunn, A. J., & Dhillon, S. K. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.959750 · Cited by 52 · see citing works
Micro-CT and histological investigation of the spatial pattern of feto-placental vascular density
Aughwane, R., Schaaf, C., Hutchinson, J. C., Virasami, A. K., Zuluaga, M. A., Sebire, N. J., Arthurs, O. J., Vercauteren, T. K., Sebastien Ourselin, A., Melbourne, A., et al. (2019) · Placenta · doi:10.1016/j.placenta.2019.09.014 · Cited by 52 · see citing works
Self-citation
Early onset fetal growth restriction
Nawathe, A. R., & Lees, C. C. (2016) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2016.08.005 · Cited by 51 · see citing works
Population-based trends and risk factors of early- and late-onset preeclampsia in Taiwan 2001–2014
You, S.-H., Cheng, P., Chung, T., Kuo, C., Wu, H., & Chu, P. (2018) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-018-1845-7 · Cited by 55 · see citing works
The human placental proteome secreted into the maternal and fetal circulations in normal pregnancy based on 4‐vessel sampling
Michelsen, T. M., Henriksen, T., Reinhold, D., Powell, T. L., & Jansson, T. (2018) · The FASEB Journal · doi:10.1096/fj.201801193r · Cited by 48 · see citing works
The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health
Hemberger, M., & Dean, W. (2023) · Physiological Reviews · doi:10.1152/physrev.00001.2023 · Cited by 47 · see citing works
IFPA Gábor Than Award Lecture: Recognition of placental failure is key to saving babies' lives
Heazell, A. E. P., Worton, S. A., Higgins, L. E., Ingram, E., Johnstone, E., Jones, R. L., & Sibley, C. P. (2014) · Placenta · doi:10.1016/j.placenta.2014.12.017 · Cited by 47 · see citing works
Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors
Fitzgerald, W., Gomez‐Lopez, N., Erez, O., Romero, R. J., & Margolis, L. B. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.12860 · Cited by 47 · see citing works
The effect of portable HEPA filter air cleaner use during pregnancy on fetal growth: The UGAAR randomized controlled trial
Barn, P. K., Gombojav, E., Оchir, C., Boldbaatar, B., Beejin, B., Naidan, G., Galsuren, J., Legtseg, B., Byambaa, T., Hutcheon, J. A., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.08.036 · Cited by 47 · see citing works
Placental Microarray Profiling Reveals Common mRNA and lncRNA Expression Patterns in Preeclampsia and Intrauterine Growth Restriction
Medina-Bastidas, D., Guzmán‐Huerta, M., Borboa-Olivares, H. J., Ruiz-Cruz, C., Parra-Hernández, S., Pliego, A. F., Salido-Guadarrama, I., Camargo-Marín, L., Arámbula‐Meraz, E., & Estrada‐Gutiérrez, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103597 · Cited by 47 · see citing works
Placental oxygen transport estimated by the hyperoxic placental BOLD MRI response
Sørensen, A., Sinding, M., Peters, D. A., Petersen, A. C., Frøkjær, J. B., Christiansen, O. B., & Uldbjerg, N. (2015) · Physiological Reports · doi:10.14814/phy2.12582 · Cited by 46 · see citing works
The structure and utility of the placental pathology report
Turowski, G. E., Parks, W. T., Arbuckle, S. M., Jacobsen, A. F., & Heazell, A. E. P. (2018) · Apmis · doi:10.1111/apm.12842 · Cited by 46 · see citing works
Hypertensive Disorders of Pregnancy and Fetal Growth Restriction: Clinical Characteristics and Placental Lesions and Possible Preventive Nutritional Targets
Martino, D. D. D., Avagliano, L., Ferrazzi, E. M., Fusè, F., Sterpi, V., Parasiliti, M., Stampalija, T., Zullino, S., Farina, A., Bulfamante, G., et al. (2022) · Nutrients · doi:10.3390/nu14163276 · Cited by 48 · see citing works
Mid-Trimester Maternal Serum AFP and hCG as Markers of Preterm and Term Adverse Pregnancy Outcomes
Tancrède, S., Bujold, E., Giguère, Y., Renald, M.-H., Girouard, J., & Forest, J. (2015) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(15)30331-5 · Cited by 44 · see citing works
A synoptic framework and future directions for placental pathology reporting
Benton, S. J., Lafreniere, A. J., Grynspan, D., & Bainbridge, S. A. (2019) · Placenta · doi:10.1016/j.placenta.2019.01.009 · Cited by 42 · see citing works
Hypoxia‐inducible factor 2 alpha impairs human cytotrophoblast syncytialization: New insights into placental dysfunction and fetal growth restriction
Colson, A., Depoix, C. L., Baldin, P., Hubinont, C., Sonveaux, P., & Debiève, F. (2020) · The FASEB Journal · doi:10.1096/fj.202001681r · Cited by 42 · see citing works
Fetal growth restriction: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data
Easter, S. R., Eckert, L. O., Boghossian, N. S., Spencer, R. N., Oteng‐Ntim, E., Ioannou, C., Patwardhan, M., Harrison, M. S., Khalil, A. A., Gravett, M. G., et al. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.01.042 · Cited by 41 · see citing works
Impaired Fetal Environment and Gestational Age: What Is Driving Mortality in Neonates With Critical Congenital Heart Disease?
Steurer, M. A., Peyvandi, S., Baer, R. J., Oltman, S. P., Chambers, C., Norton, M. E., Ryckman, K. K., Moon‐Grady, A. J., Keller, R. L., SHIBOSKI, S. C., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.119.013194 · Cited by 41 · see citing works
Placental Features of Late-Onset Adverse Pregnancy Outcome
Higgins, L. E., de Castro, N. R., Addo, N., Wareing, M., Greenwood, S. L., Jones, R. L., Sibley, C. P., Johnstone, E., & Heazell, A. E. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129117 · Cited by 38 · see citing works
Assessment of fetal modified myocardial performance index in early‐onset and late‐onset fetal growth restriction
Zhang, L., Han, J., Zhang, N., Li, Z., Wang, J., Xuan, Y., Kagan, K. O., Wu, Q., & Sun, L. (2019) · Echocardiography · doi:10.1111/echo.14364 · Cited by 38 · see citing works
The relationship between human placental morphometry and ultrasonic measurements of utero-placental blood flow and fetal growth
Salavati, N., Sovio, U., Mayo, R. P., Charnock-Jones, D. S., & Smith, G. C. S. (2016) · Placenta · doi:10.1016/j.placenta.2015.12.003 · Cited by 35 · see citing works
Human placental uptake of glutamine and glutamate is reduced in fetal growth restriction
McIntyre, K. R., Vincent, K., Hayward, C. E., Li, X., Sibley, C. P., Desforges, M., Greenwood, S. L., & Dilworth, M. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-72930-7 · Cited by 35 · see citing works
First‐trimester and combined first‐ and second‐trimester prediction of small‐for‐gestational age and late fetal growth restriction
Sotiriadis, A., Figueras, F., Eleftheriades, M. I., Papaioannou, G., Chorozoglou, G., Dinas, K. D., & Papantoniou, N. E. (2018) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.19055 · Cited by 35 · see citing works
Embryonic toxico-pathological effects of meglumine antimoniate using a chick embryo model
Khosravi, A., Sharifi, I., Tavakkoli, H., Derakhshanfar, A., Keyhani, A. R., Salari, Z., Mosallanejad, S. S., & Bamorovat, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196424 · Cited by 34 · see citing works
Angiogenic Factors and Doppler Evaluation in Normally Growing Fetuses at Routine Third-Trimester Scan: Prediction of Subsequent Low Birth Weight
Triunfo, S., Parra-Saavedra, M. A., Rodríguez‐Sureda, V., Crovetto, F., Domı́nguez, C., Gratacós, E., & Figueras, F. (2015) · Fetal Diagnosis and Therapy · doi:10.1159/000440650 · Cited by 33 · see citing works
Circular RNA hsa_circ_0000848 Promotes Trophoblast Cell Migration and Invasion and Inhibits Cell Apoptosis by Sponging hsa-miR-6768-5p
Wang, H., Zhang, J., Xu, Z., Yang, J., Xu, Y., Liu, Y., Li, B., Xie, J., & Li, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00278 · Cited by 32 · see citing works
In vivo textural and morphometric analysis of placental development in healthy & growth-restricted pregnancies using magnetic resonance imaging
Andescavage, N. N., Dahdouh, S., Jacobs, M. B., Yewale, S., Bulas, D., Iqbal, S. N., Baschat, A., & Limperopoulos, C. (2019) · Pediatric Research · doi:10.1038/s41390-019-0311-1 · Cited by 31 · see citing works
Placental pathology and neonatal outcome in small for gestational age pregnancies with and without abnormal umbilical artery Doppler flow
Herman, H. G., Barber, E., Gasnier, R., Gindes, L., Bar, J., Schreiber, L., & Kovo, M. (2018) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2018.01.009 · Cited by 31 · see citing works
Exploring in vivo placental microstructure in healthy and growth-restricted pregnancies through diffusion-weighted magnetic resonance imaging
Andescavage, N. N., You, W., Jacobs, M. B., Kapse, K. J., Quistorff, J. L., Bulas, D., Ahmadzia, H. K., Gimovsky, A. C., Baschat, A., & Limperopoulos, C. (2020) · Placenta · doi:10.1016/j.placenta.2020.03.004 · Cited by 30 · see citing works
Independent influences of maternal obesity and fetal sex on maternal cardiovascular adaptation to pregnancy: a prospective cohort study
Teulings, N. E. W. D., Wood, A. M., Sovio, U., Ozanne, S. E., Smith, G. C. S., & Aiken, C. E. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0627-2 · Cited by 30 · see citing works
Downregulations of circulating miR-31 and miR-21 are associated with preeclampsia
Dong, K., Zhang, X., Ma, L., Gao, N., Tang, H., Jian, F., & Ma, Y. (2019) · Pregnancy Hypertension · doi:10.1016/j.preghy.2019.05.013 · Cited by 29 · see citing works
Comparative Proteomic Profile of the Human Placenta in Normal and Fetal Growth Restriction Subjects
Miao, Z., Chen, M., Hong, W., Ding, H., & Shi, Z. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366371 · Cited by 28 · see citing works
Changes in uterine artery Doppler velocimetry and circulating angiogenic factors in the first half of pregnancies delivering a small‐for‐gestational‐age neonate
Triunfo, S., Crovetto, F., Rodríguez‐Sureda, V., Scazzocchio, E., Crispi, F., Domı́nguez, C., Gratacós, E., & Figueras, F. (2016) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.15978 · Cited by 29 · see citing works
Implications of placental pathology for disease mechanisms; methods, issues and future approaches
Sebire, N. J. (2016) · Placenta · doi:10.1016/j.placenta.2016.05.006 · Cited by 28 · see citing works
Self-citation
Placental Elasticity and Histopathological Findings in Normal and Intra-Uterine Growth Restriction Pregnancies Assessed with Strain Elastography in Ex Vivo Placenta
Durhan, G., Unverdi, H. G., Deveci, C. D., BÜYÜKŞİRECİ, M., Karakaya, J., Değirmenci, T., Bayrak, A., Koşar, P. N., Hücümenoğlu, S., & Ergün, Y. (2016) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2016.08.037 · Cited by 28 · see citing works
Significance of pathological examination of the placenta, with a focus on intrauterine infection and fetal growth restriction
Nakayama, M. (2017) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13430 · Cited by 27 · see citing works
Whole‐transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction
Wang, G., Yu, J., Yang, Y., Liu, X., Zhao, X., Guo, X., Duan, T., Lu, C., & Kang, J. (2020) · Clinical and Translational Medicine · doi:10.1186/s40169-020-0259-0 · Cited by 27 · see citing works
Pathological Role of Reactive Oxygen Species on Female Reproduction
Goutami, L., Jena, S. R., Swain, A., & Samanta, L. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-12966-7_12 · Cited by 26 · see citing works
Placenta-specific epimutation at H19-DMR among common pregnancy complications: its frequency and effect on the expression patterns of H19 and IGF2
Yamaguchi, Y., Tayama, C., Tomikawa, J., Akaishi, R., Kamura, H., Matsuoka, K., Wake, N., Minakami, H., Kato, K., Yamada, T., et al. (2019) · Clinical Epigenetics · doi:10.1186/s13148-019-0712-3 · Cited by 25 · see citing works
Predictive Value of Second-Trimester Biomarkers and Maternal Features for Adverse Pregnancy Outcomes
Yefet, E., Kuzmin, O., Schwartz, N., Basson, F., & Nachum, Z. (2017) · Fetal Diagnosis and Therapy · doi:10.1159/000458409 · Cited by 25 · see citing works
Evaluating the Effect of Pravastatin in Early-Onset Fetal Growth Restriction: A Nonrandomized and Historically Controlled Pilot Study
Carreras, E., Alijotas‐Reig, J., Mendoza, M., Ferrer‐Oliveras, R., Bonacina, E., García‐Manau, P., & Rodó, C. (2020) · American Journal of Perinatology · doi:10.1055/s-0040-1713651 · Cited by 24 · see citing works
Risk stratification for early-onset fetal growth restriction in women with abnormal serum biomarkers: a retrospective cohort study
Ormesher, L., Warrander, L. K., Liu, Y., Thomas, S., Simcox, L. E., Smith, G. C. S., Myers, J., & Johnstone, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-78631-5 · Cited by 24 · see citing works
Rational Design of Nanomedicine for Placental Disorders: Birthing a New Era in Women's Reproductive Health
Geisler, H. C., Safford, H. C., & Mitchell, M. J. (2023) · Small · doi:10.1002/smll.202300852 · Cited by 24 · see citing works
Ultrasound detection of altered placental vascular morphology based on hemodynamic pulse wave reflection
Rahman, A., Zhou, Y., Yee, Y., Dazai, J., Cahill, L. S., Kingdom, J. C., Macgowan, C. K., & Sled, J. G. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00791.2016 · Cited by 24 · see citing works
Plasmacytoma variant translocation 1 ( PVT 1) regulates trophoblast viability, proliferation, and migration and is downregulated in spontaneous abortion
Qin, X., Chen, Y., Chen, S., Liu, X., Zeng, W., Tian, F., Lin, Y., & Fan, C. (2018) · American Journal of Reproductive Immunology · doi:10.1111/aji.13048 · Cited by 24 · see citing works
Vascular changes in fetal growth restriction: clinical relevance and future therapeutics
Sehgal, A., Murthi, P., & Dahlstrom, J. E. (2018) · Journal of Perinatology · doi:10.1038/s41372-018-0287-4 · Cited by 24 · see citing works
Placental pathology and maternal factors associated with stillbirth: An institutional based case-control study in Northern Tanzania
Lema, G. A., Mremi, A., Amsi, P. T., Pyuza, J. J., Alloyce, J. P., Mchome, B. L., & Mlay, P. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243455 · Cited by 24 · see citing works
Placental histopathology and pregnancy outcomes in “early” vs. “late” placental abruption
Gonen, N., Levy, M., Kovo, M., Schreiber, L., Noy, L. K., Volpert, E., Bar, J., & Weiner, E. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00287-3 · Cited by 22 · see citing works
Mechanistic insights into the development of severe fetal growth restriction
Gumina, D. L., & Su, E. J. (2023) · Clinical Science · doi:10.1042/cs20220284 · Cited by 23 · see citing works
Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
Langmia, I. M., Kräker, K., Weiss, S., Haase, N., Schütte, T., Herse, F., & Dechend, R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00215 · Cited by 23 · see citing works
Fetal Growth and Stillbirth
Pagé, J., Blue, N. R., & Silver, R. M. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.03.001 · Cited by 23 · see citing works
Maternal and fetal characteristics affect discrepancies between pregnancy‐dating methods: a population‐based cross‐sectional register study
Kullinger, M., Wesström, J., Kieler, H., & Skalkidou, A. (2016) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13034 · Cited by 22 · see citing works
Specific HIF-2α (Hypoxia-Inducible Factor-2) Inhibitor PT2385 Mitigates Placental Dysfunction In Vitro and in a Rat Model of Preeclampsia (RUPP)
Colson, A., Depoix, C. L., Lambert, I., Leducq, C., Bedin, M., Beukelaer, M. D., Gatto, L., Loriot, A. E., de Nieuwburgh, M. P., Bouhna, K., et al. (2023) · Hypertension · doi:10.1161/hypertensionaha.122.20739 · Cited by 22 · see citing works
Placental growth factor and fetoplacental Doppler indices in combination predict preterm birth reliably in pregnancies complicated by fetal growth restriction
Hong, J., Crawford, K., Cavanagh, E., da Silva Costa, F., & Kumar, S. (2024) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.27513 · Cited by 21 · see citing works
Use of intravoxel incoherent motion MRI to assess placental perfusion in normal and Fetal Growth Restricted pregnancies on their third trimester
Liu, X.-L., Feng, J., Huang, C., Mei, Y., & Xu, Y. (2021) · Placenta · doi:10.1016/j.placenta.2021.12.019 · Cited by 21 · see citing works

Pathologic placental lesions in early and late fetal growth restriction
Spinillo, A., Gardella, B., Adamo, L., Muscettola, G., Fiandrino, G., & Cesari, S. (2019) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13699 · Cited by 63 · see citing works
Association Between Placental Pathology and Early-Onset Fetal Growth Restriction: A Systematic Review
Pinheiro, B., Gonçalves, I. S., & Ramalho, C. M. A. (2024) · Fetal and Pediatric Pathology · doi:10.1080/15513815.2024.2437642 · Cited by 6 · see citing works
Placental Pathology and Its Associations With Clinical Signs in Different Subtypes of Fetal Growth Restriction
Dankó, I., Kelemen, E., Tankó, A., & Cserni, G. (2023) · Pediatric and Developmental Pathology · doi:10.1177/10935266231179587 · Cited by 5 · see citing works
Placental pathology in early-onset fetal growth restriction: insights into fetal growth restriction mechanisms
Bujorescu, D.-L., Rațiu, A., Motoc, M., Cîtu, I. C., Sas, I., Gorun, F. I., Gorun, O. M., Folescu, R., & Gurguş, D. (2023) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.64.2.12 · Cited by 16 · see citing works
Placental histopathology in preterm fetal growth restriction
Sehgal, A., Dahlstrom, J. E., Chan, Y. F., Allison, B. J., Miller, S., & Polglase, G. R. (2018) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.14251 · Cited by 24 · see citing works

Authors: Mifsud, W., & Sebire, N. J.
Affiliations: Great Ormond Street Hospital (GB)
Corresponding author: Sebire, Neil J.
ORCID: Mifsud, William
Sebire, Neil J.
Venue: Fetal Diagnosis and Therapy
Publisher: S. Karger AG
Published: 2014
Volume: 36
Issue: 2
Pages: 117-128
ISSN: 1015-3837 (ISSN-L)
1421-9964
DOI: 10.1159/000359969
OpenAlex: W2084099835
Cited by: 328
References: 108
Citations by year: 2026: 17 · 2025: 20 · 2024: 29 · 2023: 40 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 26 · 2018: 40 · 2017: 16 · 2016: 18 · 2015: 13 · 2014: 3
FWCI: 2.66
Type: journal article
Language: en
Open access: closed
Licence: www.karger.com/Services/SiteLicenses (vor)
www.karger.com/Services/SiteLicenses (tdm)
Locations: Fetal Diagnosis and Therapy (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Health Sciences › Medicine › Psychiatry and Mental health › Neurological Complications and Syndromes
Keywords: placental pathology, fetal growth restriction, early-onset fetal growth restriction, late-onset fetal growth restriction, preterm preeclampsia, uterine artery Doppler, umbilical artery Doppler, extravillous trophoblast invasion
MeSH terms: Female, Fetal Growth Retardation, Fetus, Humans, Placenta, Pregnancy, Fetal Development

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Placental Pathology in Early-Onset and Late-Onset Fetal Growth Restriction

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks