Cited by 253Pregnancy and preeclampsia studiesReproductive System and PregnancyBirth, Development, and Health

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The placenta in fetal growth restriction: What is going wrong?

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Sun, Cherry, Groom, Katie M., Oyston, Charlotte, Chamley, Lawrence W., Clark, Alys R., James, Joanna L.·2020·Placenta

DOI 10.1016/j.placenta.2020.05.003

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Abstract

The placenta is essential for the efficient delivery of nutrients and oxygen from mother to fetus to maintain normal fetal growth. Dysfunctional placental development underpins many pregnancy complications, including fetal growth restriction (FGR) a condition in which the fetus does not reach its growth potential. The FGR placenta is smaller than normal placentae throughout gestation and displays maldevelopment of both the placental villi and the fetal vasculature within these villi. Specialized epithelial cells called trophoblasts exhibit abnormal function and development in FGR placentae. This includes an altered balance between proliferation and apoptotic death, premature cellular senescence, and reduced colonisation of the maternal decidual tissue. Thus, the placenta undergoes aberrant changes at the macroscopic to cellular level in FGR, which can limit exchange capacity and downstream fetal growth. This review aims to compile stereological, in vitro, and imaging data to create a holistic overview of the FGR placenta and its pathophysiology, with a focus on the contribution of trophoblasts.

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Authors: Sun, C., Groom, K. M., Oyston, C., Chamley, L. W., Clark, A. R., & James, J. L.
Affiliations: University of Auckland (NZ)
Corresponding author: Sun, Cherry
ORCID: Sun, Cherry
Groom, Katie M.
Oyston, Charlotte
Clark, Alys R.
James, Joanna L.
Venue: Placenta
Publisher: Elsevier BV
Published: 2020-07
Volume: 96
Pages: 10-18
ISSN: 0143-4004 (ISSN-L)
DOI: 10.1016/j.placenta.2020.05.003
OpenAlex: W3024316689
Cited by: 253
References: 137
Citations by year: 2026: 48 · 2025: 58 · 2024: 52 · 2023: 44 · 2022: 37 · 2021: 10 · 2020: 3
FWCI: 14.25
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Placenta (publishedVersion)
PubMed (publishedVersion)
ResearchSpace (University of Auckland) (submittedVersion, cc-by)
Funders: Nurture Foundation for Reproductive Research
Auckland Medical Research Foundation
Health Research Council of New Zealand
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: fetal growth restriction, placental insufficiency, trophoblast, placental villi, placental vasculature, cellular senescence, stereology, placental pathophysiology
MeSH terms: Animals, Chorionic Villi, Female, Fetal Growth Retardation, Humans, Infant, Newborn, Infant, Small for Gestational Age, Placenta, Placentation, Pregnancy, Trophoblasts

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The placenta in fetal growth restriction: What is going wrong?

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