The DOI matches its Crossref record; 170 of the 170 references it cites were found in a registry or an index.
Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire
Open accessAbstract
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid molecules and are also involved in numerous critical biological processes. Studies conducted mainly in vertebrates have demonstrated that LC-PUFA can be biosynthesized through the concerted action of two sets of enzymes, namely fatty acyl desaturases (Fads) and elongation of very long-chain fatty acid (Elovl) proteins. While LC-PUFA research is a thriving field, mainly focused on human health, an integrated view regarding the evolution of LC-PUFA biosynthetic genetic machinery in chordates is yet to be produced. Particularly important is to understand whether lineage specific life history trajectories, as well as major biological transitions, or particular genomic processes such as genome duplications have impacted the evolution of LC-PUFA biosynthetic pathways. Here we review the gene repertoire of Fads and Elovl in chordate genomes and the diversity of substrate specificities acquired during evolution. We take advantage of the magnitude of genomic and functional data to show that combination duplication processes and functional plasticity have generated a wide diversity of physiological capacities in extant lineages. A clear evolutionary framework is provided, which will be instrumental for the full clarification of functional capacities between the various vertebrate groups.
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Self-citationSTRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES
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Kabeya, N., Fonseca, M. M., Ferrier, D. E. K., Navarro, J. C., Bay, L. K., Francis, D. S., Tocher, D. R., Castro, L. F. C., & Monroig, Ó. (2018) · Science Advances · doi:10.1126/sciadv.aar6849 · Cited by 365
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Metadata
- Authors
- Castro, L. F. C., Tocher, D. R., & Monroig, O.
- Venue
- Progress in Lipid Research
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 62
- Pages
- 25-40
- ISSN
- 0163-7827 (ISSN-L)
- OpenAlex
- W2225837507
- Cited by
- 450
- References
- 170
- FWCI
- 22.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Castro, L. F. C., Tocher, D. R., & Monroig, O. (2016). Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire. Progress in Lipid Research. https://doi.org/10.1016/j.plipres.2016.01.001
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