The DOI matches its Crossref record; 224 of the 224 references it cites were found in a registry or an index.
Emerging roles of lysophospholipids in health and disease
Open accessAbstract
Lipids are abundant and play essential roles in human health and disease. The main functions of lipids are building blocks for membrane biogenesis. However, lipids are also metabolized to produce signaling molecules. Here, we discuss the emerging roles of circulating lysophospholipids. These lysophospholipids consist of lysoglycerophospholipids and lysosphingolipids. They are both present in cells at low concentration, but their concentrations in extracellular fluids are significantly higher. The biological functions of some of these lysophospholipids have been recently revealed. Remarkably, some of the lysophospholipids play pivotal signaling roles as well as being precursors for membrane biogenesis. Revealing how circulating lysophospholipids are produced, released, transported, and utilized in multi-organ systems is critical to understand their functions. The discovery of enzymes, carriers, transporters, and membrane receptors for these lysophospholipids has shed light on their physiological significance. In this review, we summarize the biological roles of these lysophospholipids via discussing about the proteins regulating their functions. We also discuss about their potential impacts to human health and diseases.
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“Although no specific justification was proposed for this species, unsaturated LPC are often associated with anti-inflammatory activity, thus suggesting the predominant proinflammatory state [85].”
Background
Metadata
- Authors
- Tan, S. T., Ramesh, T., Toh, X. R., & Nguyen, L. N.
- Venue
- Progress in Lipid Research
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 80
- Pages
- 101068
- ISSN
- 0163-7827 (ISSN-L)
- OpenAlex
- W3092829285
- Cited by
- 371
- References
- 224
- FWCI
- 10.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
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