The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
Abstract
Although the biological actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and systemic autoimmune disease are well recognized, LPC has not been linked to a specific cell-surface receptor. We show that LPC is a high-affinity ligand for G2A, a lymphocyte-expressed G protein–coupled receptor whose genetic ablation results in the development of autoimmunity. Activation of G2A by LPC increased intracellular calcium concentration, induced receptor internalization, activated ERK mitogen-activated protein kinase, and modified migratory responses of Jurkat T lymphocytes. This finding implicates a role for LPC-G2A interaction in the etiology of inflammatory autoimmune disease and atherosclerosis.
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Cites
1 retracted
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
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Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome
Le, L. Q., Kabarowski, J. H. S., Weng, Z., Satterthwaite, A. B., Harvill, E. T., Jensen, E. R., Miller, J. F., & Witte, O. N. (2001) · Immunity · doi:10.1016/s1074-7613(01)00145-5 · Cited by 215
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Cited by
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Type 1 Diabetes: Etiology, Immunology, and Therapeutic Strategies
Van Belle, T. L., Coppieters, K. T., & Von Herrath, M. G. (2011) · Physiological Reviews · doi:10.1152/physrev.00003.2010 · Cited by 1,022
Lauber, K., Bohn, E., Kröber, S. M., Xiao, Y.-J., Blumenthal, S. G., Lindemann, R. K., Marini, P., Wiedig, C., Zobywalski, A., Baksh, S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00422-7 · Cited by 967
Self-citationLysophospholipid Receptors: Signaling and Biology
Ishii, I., Fukushima, N., Ye, X., & Chun, J. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073731 · Cited by 771
The mechanisms of lysophosphatidylcholine in the development of diseases
Liu, P., Zhu, W., Chen, C., Yan, B., Zhu, L., Chen, X., & Peng, C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117443 · Cited by 579
Metadata
- Authors
- Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y.
- Venue
- Science
- Published
- 2001-07-27
- Volume
- 293
- Issue
- 5530
- Pages
- 702-705
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059511462
- Cited by
- 332
- References
- 20
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y. (2001). Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A. Science. https://doi.org/10.1126/science.1061781
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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