The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
Understanding brain networks and brain organization
Open accessAbstract
What is the relationship between brain and behavior? The answer to this question necessitates characterizing the mapping between structure and function. The aim of this paper is to discuss broad issues surrounding the link between structure and function in the brain that will motivate a network perspective to understanding this question. However, as others in the past, I argue that a network perspective should supplant the common strategy of understanding the brain in terms of individual regions. Whereas this perspective is needed for a fuller characterization of the mind-brain, it should not be viewed as panacea. For one, the challenges posed by the many-to-many mapping between regions and functions is not dissolved by the network perspective. Although the problem is ameliorated, one should not anticipate a one-to-one mapping when the network approach is adopted. Furthermore, decomposition of the brain network in terms of meaningful clusters of regions, such as the ones generated by community-finding algorithms, does not by itself reveal "true" subnetworks. Given the hierarchical and multi-relational relationship between regions, multiple decompositions will offer different "slices" of a broader landscape of networks within the brain. Finally, I described how the function of brain regions can be characterized in a multidimensional manner via the idea of diversity profiles. The concept can also be used to describe the way different brain regions participate in networks.
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“multiple structural network configurations can theoretically give rise to the same apparent aberrations in function – this is essentially the ‘many-to-many mappings’ problem very nicely described in (Pessoa, 2014).”
From Development of large-scale functional networks from birth to adulthood: A guide to the neuroimaging literature (2017) · cites this paper as Pessoa, 2014
In the citing paper
“There are numerous lines of evidence to suggest that brain-behavior relationships are not simply one-to-one (Pessoa, 2014).”
From Investigating functional brain network integrity using a traditional and novel categorical scheme for neurodevelopmental disorders (2019) · cites this paper as Pessoa, 2014
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Cites
A Mathematical Theory of Communication
Shannon, C. E. (1948) · Bell System Technical Journal · doi:10.1002/j.1538-7305.1948.tb01338.x · Cited by 88,486
Collective dynamics of ‘small-world’ networks
Watts, D. J., & Strogatz, S. H. (1998) · Nature · doi:10.1038/30918 · Cited by 43,060
Community structure in social and biological networks
Girvan, M., & Newman, M. E. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122653799 · Cited by 15,502 · cited 1×
“Communities are determined by subdividing a network into groups of nodes, often by maximizing the number of within-group links, and minimizing the number of between-group links [142].”
BackgroundComplex brain networks: graph theoretical analysis of structural and functional systems
Bullmore, E., & Sporns, O. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2575 · Cited by 11,820 · cited 1×
“In the past decade, graph-theoretical analysis of functional neuroimaging data has focused almost exclusively on characterizing the large-scale properties of resting-state data [122,123].”
BackgroundComplex network measures of brain connectivity: Uses and interpretations
Rubinov, M., & Sporns, O. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.003 · Cited by 11,522 · cited 2×
“For detailed treatments, please see [62]; for applications to brain data, please see [66].”
BackgroundResultFunctional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
Thomas Yeo, B. T., Krienen, F. M., Sepulcre, J., Sabuncu, M. R., Lashkari, D., Hollinshead, M., Roffman, J. L., Smoller, J. W., Zöllei, L., Polimeni, J. R., et al. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00338.2011 · Cited by 9,182
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Fox, M. D., Snyder, A. Z., Vincent, J. L., Corbetta, M., Van Essen, D. C., & Raichle, M. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504136102 · Cited by 8,553 · cited 1×
“It is noteworthy, for instance, that the task-positive network and the task-negative network display fairly complementary profiles, matching the intuition that these networks are at times “anti-correlated”[158, 159].”
Parallel organization of functionally segregated circuits linking basal ganglia and cortex
Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.09.030186.002041 · Cited by 8,527 · cited 2×
“Using a similar approach, Postuma and Dagher [120] identified patterns of co-activation between the cortex and striatum that appear to reflect the cortico-striatal loops proposed by Alexander and colleagues [67].”
BackgroundMethodDistributed hierarchical processing in the primate cerebral cortex
Felleman, D. J., & Van Essen, D. C. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1 · Cited by 7,783
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Research works printed but not linked: 1
- Fox, 2005, The human brain is intrinsically organized into dynamic, anticorrelated functional networks, Proc Natl Acad Sci USA, 102, 9673, 10.1073/pnas.0504136102 · DOI · Paper page
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Demystifying cognitive flexibility: Implications for clinical and developmental neuroscience
Dajani, D. R., & Uddin, L. Q. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2015.07.003 · Cited by 1,046
Small-World Brain Networks Revisited
Bassett, D. S., & Bullmore, E. T. (2016) · The Neuroscientist · doi:10.1177/1073858416667720 · Cited by 887
“…of nervous systems since 2006, as evidenced by rapid growth in research articles, reviews and citations related to“brain graphs” and “connectomes” [20–22]; by the publication of several textbooks [23, 24]; and by the recent launch of new specialist journals for network neuroscience [25].”
BackgroundDynamic reconfiguration of frontal brain networks during executive cognition in humans
Braun, U., Schäfer, A., Walter, H., Erk, S., Romanczuk-Seiferth, N., Haddad, L., Schweiger, J. I., Grimm, O., Heinz, A., Tost, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422487112 · Cited by 791
Farahani, F. V., Karwowski, W., & Lighthall, N. R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00585 · Cited by 765
“…approaches have opened new avenues toward studying the neural mechanisms underlying human cognition and behavior from the view of interregional brain interactions (Park and Friston, 2013; Pessoa, 2014; Sporns, 2014; Medaglia et al., 2015; Petersen and Sporns, 2015; Kriegeskorte and Douglas, 2018).”
BackgroundLutz, A., Jha, A. P., Dunne, J. D., & Saron, C. D. (2015) · American Psychologist · doi:10.1037/a0039585 · Cited by 697
“…these phenomenological dimensions and activity in specific brain regions is plausible because studies concerning emotion and cognition have shown that brain regions’ functions are inherently multidimensional, and that structurally different regions can perform the same function (Pessoa, 2014).”
Background
Metadata
- Authors
- Pessoa, L.
- Affiliations
- University of Maryland, College Park (US)
- Corresponding author
- Pessoa, Luiz
- ORCID
- Pessoa, Luiz
- Venue
- Physics of Life Reviews
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 11
- Issue
- 3
- Pages
- 400-435
- ISSN
- 1571-0645 (ISSN-L)
- PMC
- PMC4157099
- OpenAlex
- W2031461126
- Cited by
- 464
- References
- 156
- Citations by year
- 2026: 31 · 2025: 48 · 2024: 47 · 2023: 59 · 2022: 45 · 2021: 37 · 2020: 31 · 2019: 30 · 2018: 26 · 2017: 35 · 2016: 39 · 2015: 19 · 2014: 16
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physics of Life Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Institute of Mental Health (R01MH071589)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- brain networks, brain organization, structure-function mapping, brain-behavior relationship, network perspective, many-to-many mapping, community detection, subnetworks, hierarchical brain organization, brain regions
- MeSH terms
- Algorithms, Animals, Brain, Brain Mapping, Humans, Nerve Net
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