The DOI matches its Crossref record; 257 of the 257 references it cites were found in a registry or an index.
The effect of pain on cognitive function: A review of clinical and preclinical research
Open accessAbstract
Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical and preclinical studies that have investigated pain-related alterations in cognition. These include impaired attentional, executive and general cognitive functioning. We describe the anatomical, neurochemical and molecular substrates common to both cognitive processing and supraspinal pain processing, and present the evidence for their involvement in pain-related cognitive impairment. We also examine the added complexity of cognitive impairment caused by analgesic medications and how this can further impact on morbidity in chronic pain patients. The need for a better understanding of the mechanisms of both pain-induced and treatment-related cognitive impairment is highlighted. Further research in this area will aid our understanding of patient symptoms and their underlying pathophysiology, ultimately leading to increased provision of guided therapy.
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“but it comes at a price in the form of reduced executive functioning (Baker et al. 2016; Eccleston and Crombez 1999; Moriarty, McGuire, and Finn 2011).”
From Human Capital and Administrative Burden: The Role of Cognitive Resources in Citizen‐State Interactions (2020) · cites this paper as Moriarty, McGuire, and Finn 2011
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“For instance, brain morphology studies have shown chronic pain to be associated with accelerated loss of gray matter in the prefrontal cortex, meaning that the brain region, which is considered the neural center of executive functioning, physically shrinks in response to chronic pain (Apkarian et al. 2004; Moriarty, McGuire, and Finn 2011).”
From Human Capital and Administrative Burden: The Role of Cognitive Resources in Citizen‐State Interactions (2020) · cites this paper as Moriarty, McGuire, and Finn 2011
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“However, we posit that the very experience of having CP, the associated uncertainty, and the potential drain of pain on cognitive resources [41], are together likely to further muddy the process of threat appraisal and coping skills development.”
From "Why Isn't It Going Away?": A Qualitative Exploration of Worry and Pain Experiences in Adolescents with Chronic Pain. (2021) · cites this paper as [41]
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Metadata
- Authors
- Moriarty, O., McGuire, B. E., & Finn, D. P.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Finn, David P.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 93
- Issue
- 3
- Pages
- 385-404
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2098284778
- Semantic Scholar
- 8254dfd524d19bd43732270c9b8b8f8daa033835
- Cited by
- 1,122
- References
- 257
- Citations by year
- 2026: 72 · 2025: 111 · 2024: 102 · 2023: 82 · 2022: 75 · 2021: 110 · 2020: 86 · 2019: 80 · 2018: 78 · 2017: 66 · 2016: 72 · 2015: 64 · 2014: 46 · 2013: 43 · 2012: 21
- FWCI
- 26.82
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- University of Galway Research Repository (acceptedVersion, cc-by)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
- Research Repository UCD (University College Dublin) (cc-by)
- Funders
- University College London
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- chronic pain, attention, executive function, analgesic side effects, supraspinal pain processing, rehabilitation
- MeSH terms
- Analgesics, Animals, Brain, Cognition, Cognition Disorders, Humans, Neuropsychological Tests, Pain
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