Cited by 1,122Pain Mechanisms and TreatmentsPain Management and Opioid UseMusculoskeletal pain and rehabilitation

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The effect of pain on cognitive function: A review of clinical and preclinical research

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Moriarty, Orla, McGuire, Brian E., Finn, David P.·2011·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2011.01.002

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Abstract

Cognitive impairment is commonly associated with the pain experience. This impairment represents a major obstacle to daily activities and rehabilitation, especially in the chronic pain population. Here we review clinical and preclinical studies that have investigated pain-related alterations in cognition. These include impaired attentional, executive and general cognitive functioning. We describe the anatomical, neurochemical and molecular substrates common to both cognitive processing and supraspinal pain processing, and present the evidence for their involvement in pain-related cognitive impairment. We also examine the added complexity of cognitive impairment caused by analgesic medications and how this can further impact on morbidity in chronic pain patients. The need for a better understanding of the mechanisms of both pain-induced and treatment-related cognitive impairment is highlighted. Further research in this area will aid our understanding of patient symptoms and their underlying pathophysiology, ultimately leading to increased provision of guided therapy.

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GABAA Receptor Subtype Selective Cognition Enhancers
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“The neuroanatomical and neurochemical substrates at which pain and cognitive processing systems overlap (and are likely to interact with one another) will be discussed in light of these possible mechanisms.”
Background
Reversible Cognitive Decline Accompanies Migraine and Cluster Headaches
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Comparative Cognitive Effects of Carbamazepine and Gabapentin in Healthy Senior Adults
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Nociception-Induced Spatial and Temporal Plasticity of Synaptic Connection and Function in the Hippocampal Formation of Rats: a Multi-Electrode Array Recording
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[203]203. Regualation, and Chronic Pain: A Review. Ann Behav Med 37, 173-183.

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“…shown chronic pain to be associated with accelerated loss of gray matter in the prefrontal cortex, meaning that the brain region, which is considered the neural center of executive functioning, physically shrinks in response to chronic pain (Apkarian et al. 2004; Moriarty, McGuire, and Finn 2011).”
Background
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Authors: Moriarty, O., McGuire, B. E., & Finn, D. P.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Finn, David P.
ORCID: Moriarty, Orla
McGuire, Brian E.
Finn, David P.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2011-03
Volume: 93
Issue: 3
Pages: 385-404
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2011.01.002
OpenAlex: W2098284778
Semantic Scholar: 8254dfd524d19bd43732270c9b8b8f8daa033835
Cited by: 1,122
References: 257
Citations by year: 2026: 72 · 2025: 111 · 2024: 102 · 2023: 82 · 2022: 75 · 2021: 110 · 2020: 86 · 2019: 80 · 2018: 78 · 2017: 66 · 2016: 72 · 2015: 64 · 2014: 46 · 2013: 43 · 2012: 21
FWCI: 26.82
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
University of Galway Research Repository (acceptedVersion, cc-by)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (submittedVersion, cc-by-nc-nd)
Research Repository UCD (University College Dublin) (cc-by)
Funders: University College London
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
Keywords: chronic pain, attention, executive function, analgesic side effects, supraspinal pain processing, rehabilitation
MeSH terms: Analgesics, Animals, Brain, Cognition, Cognition Disorders, Humans, Neuropsychological Tests, Pain

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The effect of pain on cognitive function: A review of clinical and preclinical research

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