The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Gene–environment interactions: Key to unraveling the mystery of Parkinson's disease
Open accessAbstract
Parkinson’s disease (PD) is the second most common neurodegenerative disease. The gradual, irreversible loss of dopamine neurons in the substantia nigra isthe signature lesion of PD. Clinical symptoms of PD become apparent when 50–60% of nigral dopamine neurons are lost. PD progresses insidiously for 5–7 years (preclinical period) and then continues to worsen even under the symptomatic treatment. To determine what triggers the disease onset and what drives the chronic, self-propelling neurodegenerative process becomes critical and urgent, since lack of such knowledge impedes the discovery of effective treatments to retard PD progression. At present, available therapeutics only temporarily relieve PD symptoms. While the identification of causative gene defects in familial PD uncovers important genetic influences in this disease, the majority of PD cases are sporadic and idiopathic. The current consensus suggests that PD develops from multiple risk factors including aging, genetic predisposition, and environmental exposure. Here, we briefly review research on the genetic and environmental causes of PD. We also summarize very recent genome-wide association studies on risk gene polymorphisms in the emergence of PD. We highlight the new converging evidence on gene-environment interplay in the development of PD with an emphasis on newly developed multiple-hit PD models involving both genetic lesions and environmental triggers.
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Cited by
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Paillard, T. (2015) · Sports Medicine - Open · doi:10.1186/s40798-015-0016-x · Cited by 90
Cause or Effect: Misregulation of microRNA Pathways in Neurodegeneration
Gascon, E., & Gao, F.-B. (2012) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00048 · Cited by 69
Extracellular Vesicles as Novel Diagnostic and Prognostic Biomarkers for Parkinson’s Disease
Leggio, L., Paternò, G., Vivarelli, S., Falzone, G. G., Giachino, C., Marchetti, B., & Iraci, N. (2021) · Aging and disease · doi:10.14336/ad.2021.0527 · Cited by 55
Glia-derived extracellular vesicles in parkinson’s disease.
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Metadata
- Authors
- Gao, H.-M., & Hong, J.-S.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-06
- Volume
- 94
- Issue
- 1
- Pages
- 1-19
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2039789186
- Cited by
- 165
- References
- 34
- FWCI
- 10.24
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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