The DOI matches its Crossref record; 375 of the 375 references it cites were found in a registry or an index.
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Open accessAbstract
Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes enwrap the neuronal components of the tripartite synapse, and due to this close interaction they are perfectly positioned to modulate neuronal communication. The interaction between astrocytes and synapses is facilitated by cell adhesion molecules and matricellular proteins, which have been implicated in the formation and functioning of tripartite synapses. The importance of such neuron-astrocyte integration at the synapse is underscored by the emerging role of astrocyte dysfunction in synaptic pathologies such as autism and schizophrenia. Here we review astrocyte-expressed cell adhesion molecules and matricellular molecules that play a role in integration of neurons and astrocytes within the tripartite synapse.
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“For astrocytes in particular, dysregulated communication with neurons can impair synaptic plasticity (31, 32).”
From Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease (2020) · cites this paper as [31]
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Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476
de Bartolomeis, A., Barone, A., Vellucci, L., Mazza, B., Austin, M. C., Iasevoli, F., & Ciccarelli, M. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02976-3 · Cited by 113
Metadata
- Authors
- Hillen, A. E. J., Burbach, J. P. H., & Hol, E. M.
- Affiliations
- University Medical Center Utrecht (NL)
- Netherlands Institute for Neuroscience (NL)
- Corresponding author
- Hol, Elly M.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 165-167
- Pages
- 66-86
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2790000715
- Cited by
- 108
- References
- 375
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 11 · 2023: 17 · 2022: 14 · 2021: 13 · 2020: 19 · 2019: 6 · 2018: 5
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion, other-oa)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion, other-oa)
- Funders
- Autism Speaks (115300)
- European Federation of Pharmaceutical Industries and Associations
- European Commission (2007–2013, 115300)
- Hersenstichting
- Internationale Stichting Alzheimer Onderzoek (08504, 12509)
- Innovative Medicines Initiative (115300)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- astrocytes, tripartite synapse, adhesion molecules, matricellular proteins, astrocyte-neuron interaction, synaptogenesis, synaptic plasticity, astrocyte dysfunction, autism spectrum disorder, schizophrenia
- MeSH terms
- Animals, Astrocytes, Extracellular Matrix, Humans, Membrane Proteins, Synaptic Transmission, Neurons, Synapses, Cell Adhesion Molecules
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